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Protein

Platelet endothelial cell adhesion molecule

Gene

Pecam1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity). Modulates bradykinin receptor BDKRB2 activation (By similarity). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity). Induces susceptibility to atherosclerosis (PubMed:19048083).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114608 Platelet degranulation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-210990 PECAM1 interactions
R-MMU-216083 Integrin cell surface interactions
R-MMU-432142 Platelet sensitization by LDL
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet endothelial cell adhesion molecule
Short name:
PECAM-1
Alternative name(s):
CD_antigen: CD31
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pecam1
Synonyms:Pecam, Pecam-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97537 Pecam1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 590ExtracellularSequence analysisAdd BLAST573
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei591 – 609HelicalSequence analysisAdd BLAST19
Topological domaini610 – 727CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show reduced atherosclerotic lesions. There is down-regulation of ICAM-1 in endothelial cells at the lesion periphery, and reduced disruption of Cx43 junctional staining at arterial branch points and in the descending aorta.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi679Y → F: Reduces tyrosine phosphorylation by FER by about 60%. 1 Publication1
Mutagenesisi702Y → F: Reduces tyrosine phosphorylation by FER by about 60%. 1 Publication1
Mutagenesisi717Y → F: No significant effect on phosphorylation by FER. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 171 PublicationAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001489618 – 727Platelet endothelial cell adhesion moleculeAdd BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 99PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi142 ↔ 195PROSITE-ProRule annotation
Disulfide bondi245 ↔ 293PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi336 ↔ 375PROSITE-ProRule annotation
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi360N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi420 ↔ 465PROSITE-ProRule annotation
Glycosylationi424N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi512 ↔ 561PROSITE-ProRule annotation
Glycosylationi540N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi611S-palmitoyl cysteineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei679Phosphotyrosine; by FER1 Publication1
Modified residuei702Phosphotyrosine; by FERCombined sources1 Publication1
Modified residuei718PhosphoserineBy similarity1
Modified residuei723PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser and Tyr residues by src kinases after cellular activation (PubMed:16731527). Upon activation, phosphorylated on Ser-718 which probably initiates the dissociation of the membrane-interaction segment (residues 698-718) from the cell membrane allowing the sequential phosphorylation of Tyr-702 and Tyr-679 (By similarity). Constitutively phosphorylated on Ser-723 in resting platelets (By similarity). Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (PubMed:16731527). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (By similarity).By similarity1 Publication
Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08481

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08481

PeptideAtlas

More...
PeptideAtlasi
Q08481

PRoteomics IDEntifications database

More...
PRIDEi
Q08481

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08481

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08481

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q08481

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 3 are expressed in lung and platelets.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020717 Expressed in 189 organ(s), highest expression level in embryo mesenchyme (mouse)

CleanEx database of gene expression profiles

More...
CleanExi
MM_PECAM1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08481 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08481 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ. Interacts with PTPN11; Tyr-702 is critical for PTPN11 recruitment. Interacts with FER. Interacts with CD177; the interaction is Ca2+-dependent; the interaction is direct.By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q08481, 5 interactors

Molecular INTeraction database

More...
MINTi
Q08481

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000079664

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q08481

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08481

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 126Ig-like C2-type 1Add BLAST87
Domaini135 – 213Ig-like C2-type 2Add BLAST79
Domaini225 – 309Ig-like C2-type 3Add BLAST85
Domaini315 – 391Ig-like C2-type 4Add BLAST77
Domaini413 – 472Ig-like C2-type 5Add BLAST60
Domaini488 – 578Ig-like C2-type 6Add BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni698 – 718Membrane-bound segment which detaches upon phosphorylationBy similarityAdd BLAST21
Regioni710 – 727May play a role in cytoprotective signalingBy similarityAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi677 – 682ITIM motif 1By similarity6
Motifi700 – 705ITIM motif 2By similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II37 Eukaryota
ENOG4111F9A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153219

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049132

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059434

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08481

KEGG Orthology (KO)

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KOi
K06471

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTCKVEA

TreeFam database of animal gene trees

More...
TreeFami
TF338229

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08481-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLALGLTLV LYASLQAEEN SFTINSIHME SLPSWEVMNG QQLTLECLVD
60 70 80 90 100
ISTTSKSRSQ HRVLFYKDDA MVYNVTSREH TESYVIPQAR VFHSGKYKCT
110 120 130 140 150
VMLNNKEKTT IEYEVKVHGV SKPKVTLDKK EVTEGGVVTV NCSLQEEKPP
160 170 180 190 200
IFFKIEKLEV GTKFVKRRID KTSNENFVLM EFPIEAQDHV LVFRCQAGIL
210 220 230 240 250
SGFKLQESEP IRSEYVTVQE SFSTPKFEIK PPGMIIEGDQ LHIRCIVQVT
260 270 280 290 300
HLVQEFTEII IQKDKAIVAT SKQSSEAVYS VMAMVEYSGH YTCKVESNRI
310 320 330 340 350
SKASSIMVNI TELFPKPKLE FSSSRLDQGE LLDLSCSVSG TPVANFTIQK
360 370 380 390 400
EETVLSQYQN FSKIAEESDS GEYSCTAGIG KVVKRSGLVP IQVCEMLSKP
410 420 430 440 450
SIFHDAKSEI IKGHAIGISC QSENGTAPIT YHLMKAKSDF QTLEVTSNDP
460 470 480 490 500
ATFTDKPTRD MEYQCRADNC HSHPAVFSEI LRVRVIAPVD EVVISILSSN
510 520 530 540 550
EVQSGSEMVL RCSVKEGTSP ITFQFYKEKE DRPFHQAVVN DTQAFWHNKQ
560 570 580 590 600
ASKKQEGQYY CTASNRASSM RTSPRSSTLA VRVFLAPWKK GLIAVVVIGV
610 620 630 640 650
VIATLIVAAK CYFLRKAKAK QKPVEMSRPA APLLNSNSEK ISEPSVEANS
660 670 680 690 700
HYGYDDVSGN DAVKPINQNK DPQNMDVEYT EVEVSSLEPH QALGTRATET
710 720
VYSEIRKVDP NLMENRYSRT EGSLNGT
Length:727
Mass (Da):81,263
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34C04752D199BAA5
GO
Isoform 2 (identifier: Q08481-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     692-727: ALGTRATETVYSEIRKVDPNLMENRYSRTEGSLNGT → ENGRLP

Show »
Length:697
Mass (Da):77,917
Checksum:iEF8538025C1AB55F
GO
Isoform 3 (identifier: Q08481-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     711-727: NLMENRYSRTEGSLNGT → KNGRLP

Show »
Length:716
Mass (Da):80,004
Checksum:iE4D281B5523017B6
GO
Isoform 4 (identifier: Q08481-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-219: Missing.

Show »
Length:626
Mass (Da):69,823
Checksum:i0CF4D64C49CE468B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ARB3B1ARB3_MOUSE
Platelet endothelial cell adhesion ...
Pecam1 mCG_2881
732Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARA9B1ARA9_MOUSE
Platelet endothelial cell adhesion ...
Pecam1
317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18E → T AA sequence (PubMed:1415479).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038723119 – 219Missing in isoform 4. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_038724692 – 727ALGTR…SLNGT → ENGRLP in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_038725711 – 727NLMEN…SLNGT → KNGRLP in isoform 3. CuratedAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L06039 mRNA Translation: AAA16230.1
AK169431 mRNA Translation: BAE41172.1
AL603664 Genomic DNA Translation: CAM18558.1
AL603664 Genomic DNA Translation: CAM18559.1
AL603664 Genomic DNA Translation: CAM18560.1
CH466558 Genomic DNA Translation: EDL34303.1
CH466558 Genomic DNA Translation: EDL34304.1
CH466558 Genomic DNA Translation: EDL34305.1
BC008519 mRNA Translation: AAH08519.1
BC085502 mRNA Translation: AAH85502.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25558.1 [Q08481-2]
CCDS25559.1 [Q08481-3]
CCDS79068.1 [Q08481-4]
CCDS79069.1 [Q08481-1]

NCBI Reference Sequences

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RefSeqi
NP_001027550.1, NM_001032378.2 [Q08481-2]
NP_001292086.1, NM_001305157.1 [Q08481-1]
NP_001292087.1, NM_001305158.1 [Q08481-4]
NP_032842.2, NM_008816.3 [Q08481-3]
XP_011247094.1, XM_011248792.1 [Q08481-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.343951

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000080853; ENSMUSP00000079664; ENSMUSG00000020717 [Q08481-3]
ENSMUST00000103069; ENSMUSP00000099358; ENSMUSG00000020717 [Q08481-2]
ENSMUST00000106796; ENSMUSP00000102408; ENSMUSG00000020717 [Q08481-1]
ENSMUST00000183610; ENSMUSP00000138959; ENSMUSG00000020717 [Q08481-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18613

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18613

UCSC genome browser

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UCSCi
uc007lze.2 mouse [Q08481-1]
uc007lzf.2 mouse [Q08481-3]
uc007lzg.2 mouse [Q08481-2]
uc007lzh.2 mouse [Q08481-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

PECAM-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06039 mRNA Translation: AAA16230.1
AK169431 mRNA Translation: BAE41172.1
AL603664 Genomic DNA Translation: CAM18558.1
AL603664 Genomic DNA Translation: CAM18559.1
AL603664 Genomic DNA Translation: CAM18560.1
CH466558 Genomic DNA Translation: EDL34303.1
CH466558 Genomic DNA Translation: EDL34304.1
CH466558 Genomic DNA Translation: EDL34305.1
BC008519 mRNA Translation: AAH08519.1
BC085502 mRNA Translation: AAH85502.1
CCDSiCCDS25558.1 [Q08481-2]
CCDS25559.1 [Q08481-3]
CCDS79068.1 [Q08481-4]
CCDS79069.1 [Q08481-1]
RefSeqiNP_001027550.1, NM_001032378.2 [Q08481-2]
NP_001292086.1, NM_001305157.1 [Q08481-1]
NP_001292087.1, NM_001305158.1 [Q08481-4]
NP_032842.2, NM_008816.3 [Q08481-3]
XP_011247094.1, XM_011248792.1 [Q08481-1]
UniGeneiMm.343951

3D structure databases

ProteinModelPortaliQ08481
SMRiQ08481
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ08481, 5 interactors
MINTiQ08481
STRINGi10090.ENSMUSP00000079664

PTM databases

iPTMnetiQ08481
PhosphoSitePlusiQ08481
SwissPalmiQ08481

Proteomic databases

MaxQBiQ08481
PaxDbiQ08481
PeptideAtlasiQ08481
PRIDEiQ08481

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080853; ENSMUSP00000079664; ENSMUSG00000020717 [Q08481-3]
ENSMUST00000103069; ENSMUSP00000099358; ENSMUSG00000020717 [Q08481-2]
ENSMUST00000106796; ENSMUSP00000102408; ENSMUSG00000020717 [Q08481-1]
ENSMUST00000183610; ENSMUSP00000138959; ENSMUSG00000020717 [Q08481-4]
GeneIDi18613
KEGGimmu:18613
UCSCiuc007lze.2 mouse [Q08481-1]
uc007lzf.2 mouse [Q08481-3]
uc007lzg.2 mouse [Q08481-2]
uc007lzh.2 mouse [Q08481-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5175
MGIiMGI:97537 Pecam1

Phylogenomic databases

eggNOGiENOG410II37 Eukaryota
ENOG4111F9A LUCA
GeneTreeiENSGT00940000153219
HOGENOMiHOG000049132
HOVERGENiHBG059434
InParanoidiQ08481
KOiK06471
OMAiYTCKVEA
TreeFamiTF338229

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-210990 PECAM1 interactions
R-MMU-216083 Integrin cell surface interactions
R-MMU-432142 Platelet sensitization by LDL
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pecam1 mouse

Protein Ontology

More...
PROi
PR:Q08481

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020717 Expressed in 189 organ(s), highest expression level in embryo mesenchyme (mouse)
CleanExiMM_PECAM1
ExpressionAtlasiQ08481 baseline and differential
GenevisibleiQ08481 MM

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPECA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08481
Secondary accession number(s): B1ARB1
, B1ARB2, Q3TES6, Q922E0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 5, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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