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Protein

Adenylate kinase 4

Gene

ADK-B

more
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.By similarity

Catalytic activityi

ATP + AMP = 2 ADP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61AMPBy similarity1
Binding sitei66AMPBy similarity1
Binding sitei122AMPBy similarity1
Binding sitei157ATPBy similarity1
Binding sitei190AMPBy similarity1
Binding sitei201AMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 45ATPBy similarity6
Nucleotide bindingi87 – 89AMPBy similarity3
Nucleotide bindingi115 – 118AMPBy similarity4

GO - Molecular functioni

  • adenylate kinase activity Source: Gramene
  • ATP binding Source: Gramene

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase 4 (EC:2.7.4.3)
Alternative name(s):
ATP-AMP transphosphorylase 4
ATP:AMP phosphotransferase
Adenylate kinase B
Short name:
AK B
Adenylate monophosphate kinase 4
Gene namesi
Name:ADK-B
Ordered Locus Names:Os11g0312400Imported, LOC_Os11g20790Curated
AND
Ordered Locus Names:Os11g0312220Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001589431 – 243Adenylate kinase 4Add BLAST243

Proteomic databases

PaxDbiQ08480
PRIDEiQ08480

Expressioni

Gene expression databases

GenevisibleiQ08480 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os11g20790.1

Structurei

3D structure databases

ProteinModelPortaliQ08480
SMRiQ08480
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 89NMPbindBy similarityAdd BLAST30
Regioni156 – 193LIDBy similarityAdd BLAST38

Sequence similaritiesi

Belongs to the adenylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG3078 Eukaryota
COG0563 LUCA
HOGENOMiHOG000238772
InParanoidiQ08480
KOiK00939
OMAiTIFQRKR
OrthoDBiEOG09360K2G

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
InterProiView protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR027417 P-loop_NTPase
PANTHERiPTHR23359 PTHR23359, 1 hit
PfamiView protein in Pfam
PF05191 ADK_lid, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01351 adk, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q08480-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAANLEDV PSMDLMNELL RRMKCSSKPD KRLILVGPPG SGKGTQSPII
60 70 80 90 100
KDEYCLCHLA TGDMLRAAVA AKTPLGVKAK EAMDKGELVS DDLVVGIIDE
110 120 130 140 150
AMKKPSCQKG FILDGFPRTV VQAQKLDEML EKKGTKVDKV LNFAIDDSIL
160 170 180 190 200
EERITGRWIH PSSGRSYHTK FAPPKVPGVD DVTGEPLIQR KDDTAEVLKS
210 220 230 240
RLEAFHKQTE PVIDYYSKKA LVANLHAEKP PKEVTAEVQK VLS
Length:243
Mass (Da):26,675
Last modified:October 1, 1994 - v1
Checksum:iB1BE4878F85D250E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10335 mRNA Translation: BAA01181.1
AC137922 Genomic DNA Translation: AAX96124.1
DP000010 Genomic DNA Translation: ABA92960.1
AP008217 Genomic DNA Translation: BAF28122.1
AP014967 Genomic DNA Translation: BAT13742.1
AP014967 Genomic DNA Translation: BAT13739.1
CM000148 Genomic DNA Translation: EAZ18200.1
AK073605 mRNA Translation: BAG93546.1
RefSeqiXP_015615329.1, XM_015759843.1
XP_015615393.1, XM_015759907.1
UniGeneiOs.7990

Genome annotation databases

EnsemblPlantsiOs11t0312220-00; Os11t0312220-00; Os11g0312220
Os11t0312400-01; Os11t0312400-01; Os11g0312400
GeneIDi107276068
4350358
GrameneiOs11t0312220-00; Os11t0312220-00; Os11g0312220
Os11t0312400-01; Os11t0312400-01; Os11g0312400
KEGGiosa:107276068
osa:4350358

Similar proteinsi

Entry informationi

Entry nameiKAD4_ORYSJ
AccessioniPrimary (citable) accession number: Q08480
Secondary accession number(s): A0A0P0Y1T6, Q0IT43, Q53MA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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