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Entry version 135 (12 Aug 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Sodium-dependent neutral amino acid transporter B(0)AT2

Gene

Slc6a15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-352230, Amino acid transport across the plasma membrane
R-RNO-442660, Na+/Cl- dependent neurotransmitter transporters

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT2
Alternative name(s):
Solute carrier family 6 member 15
Transporter v7-3
sodium- and chloride-dependent neurotransmitter transporter NTT73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc6a15
Synonyms:Ntt73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
628664, Slc6a15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 69CytoplasmicSequence analysisAdd BLAST69
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei70 – 90Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei98 – 117Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini163 – 225ExtracellularSequence analysisAdd BLAST63
Transmembranei226 – 244Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei253 – 270Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei306 – 323Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei335 – 356Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini357 – 452ExtracellularSequence analysisAdd BLAST96
Transmembranei453 – 472Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei496 – 514Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei530 – 550Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei571 – 592Helical; Name=11Sequence analysisAdd BLAST22
Transmembranei620 – 642Helical; Name=12Sequence analysisAdd BLAST23
Topological domaini643 – 729CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002148001 – 729Sodium-dependent neutral amino acid transporter B(0)AT2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei687PhosphoserineBy similarity1
Modified residuei699PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08469

PRoteomics IDEntifications database

More...
PRIDEi
Q08469

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q08469, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08469

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08469

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely distributed in the central nervous system, including the olfactory bulb, the hypothalamus, the cerebral cortex, the hippocampus, and the cerebellum. In addition, intense expression is found in the motor nuclei including the oculomotor nucleus, abducens nucleus, trigeminal motor nucleus, facial nucleus, hypoglossal nucleus and ventral horn of spinal cord. Intense hybridization signals are also observed in the nuclei containing monoaminergic neurons, such as locus coeruleus, the substantia nigra pars compacta, the ventral tegmental area, the dorsal raphe nucleus and the median raphe nucleus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000027468, Expressed in Ammon's horn and 17 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08469, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000032996

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3659, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157277

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006855_7_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08469

KEGG Orthology (KO)

More...
KOi
K05048

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPGNSIY

Database of Orthologous Groups

More...
OrthoDBi
250396at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08469

TreeFam database of animal gene trees

More...
TreeFami
TF352709

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11522, SLC6sbd_SBAT1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042934, B(0)AT2
IPR000175, Na/ntran_symport
IPR002438, Neutral_aa_SLC6
IPR037272, SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616, PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00209, SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00176, NANEUSMPORT
PR01206, ORPHTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070, SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q08469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKNSKVVKR DLDDDVIESV KDLLSNEDSV EDVSKKSELI VDVQEEKDTD
60 70 80 90 100
AEDGSEVDDE RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL
110 120 130 140 150
LPYLILLLVI GIPLFFLELS VGQRIRRGSI GVWNYISPKL GGIGFASCVV
160 170 180 190 200
CYFVALYYNV IIGWTLFYFS QSFQQPLPWD QCPLVKNASH TYIEPECEKS
210 220 230 240 250
SATTYYWYRE ALAISSSISE SGGLNWKMTG CLLAAWVMVC LAMIKGIQSS
260 270 280 290 300
GKIMYFSSLF PYVVLICFLI RSLLLNGSID GIRHMFTPKL EMMLEPKVWR
310 320 330 340 350
EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL
360 370 380 390 400
VVFAVLGFKA NIVNEKCISQ NSEMILKLLK TGNVSWDVIP RHINLSAVTA
410 420 430 440 450
EDYHVVYDII QKVKEEEFAV LHLKACQIED ELNKAVQGTG LAFIAFTEAM
460 470 480 490 500
THFPASPFWS VMFFLMLINL GLGSMFGTIE GIITPVVDTF KVRKEILTVI
510 520 530 540 550
CCLLAFCIGL MFVQRSGNYF VTMFDDYSAT LPLLIVVILE NIAVSFVYGI
560 570 580 590 600
DKFLEDLTDM LGFAPSKYYY YMWKYISPLM LVTLLIASIV NMGLSPPGYN
610 620 630 640 650
AWIKEKASEE FLSYPMWGMV VCFSLMVLAI LPVPVVFVIR RCNLIDDSSG
660 670 680 690 700
NLASVTYKRG RVLKEPVNLD GDDASLIHGK IPSEMSSPNF GKNIYRKQSG
710 720
SPTLDTAPNG RYGIGYLMAD MPDMPESDL
Length:729
Mass (Da):81,596
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECDDC6403741B53E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 3MPK → IP in AAB25532 (PubMed:1363329).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L22022 mRNA Translation: AAA41729.1
S56968 mRNA Translation: AAB25532.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I65413

NCBI Reference Sequences

More...
RefSeqi
NP_758824.1, NM_172321.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000029208; ENSRNOP00000032996; ENSRNOG00000027468
ENSRNOT00000090641; ENSRNOP00000073005; ENSRNOG00000027468

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
282712

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:282712

UCSC genome browser

More...
UCSCi
RGD:628664, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22022 mRNA Translation: AAA41729.1
S56968 mRNA Translation: AAB25532.1
PIRiI65413
RefSeqiNP_758824.1, NM_172321.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032996

PTM databases

GlyGeniQ08469, 3 sites
iPTMnetiQ08469
PhosphoSitePlusiQ08469

Proteomic databases

PaxDbiQ08469
PRIDEiQ08469

Genome annotation databases

EnsembliENSRNOT00000029208; ENSRNOP00000032996; ENSRNOG00000027468
ENSRNOT00000090641; ENSRNOP00000073005; ENSRNOG00000027468
GeneIDi282712
KEGGirno:282712
UCSCiRGD:628664, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55117
RGDi628664, Slc6a15

Phylogenomic databases

eggNOGiKOG3659, Eukaryota
GeneTreeiENSGT00940000157277
HOGENOMiCLU_006855_7_1_1
InParanoidiQ08469
KOiK05048
OMAiMPGNSIY
OrthoDBi250396at2759
PhylomeDBiQ08469
TreeFamiTF352709

Enzyme and pathway databases

ReactomeiR-RNO-352230, Amino acid transport across the plasma membrane
R-RNO-442660, Na+/Cl- dependent neurotransmitter transporters

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q08469

Gene expression databases

BgeeiENSRNOG00000027468, Expressed in Ammon's horn and 17 other tissues
GenevisibleiQ08469, RN

Family and domain databases

CDDicd11522, SLC6sbd_SBAT1, 1 hit
InterProiView protein in InterPro
IPR042934, B(0)AT2
IPR000175, Na/ntran_symport
IPR002438, Neutral_aa_SLC6
IPR037272, SNS_sf
PANTHERiPTHR11616, PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209, SNF, 1 hit
PRINTSiPR00176, NANEUSMPORT
PR01206, ORPHTRNSPORT
SUPFAMiSSF161070, SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS6A15_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08469
Secondary accession number(s): Q63838
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: August 12, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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