UniProtKB - Q08465 (YNG1_YEAST)
Protein
Protein YNG1
Gene
YNG1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Histone-binding component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. YNG1 is required for the HAT activity of NuA3 but not for its integrity. Mediates the interaction of SAS3 with nucleosomes.2 Publications
Miscellaneous
Present with 861 molecules/cell in log phase SD medium.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 157 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 158 | Zinc 1By similarity | 1 | |
Metal bindingi | 160 | Zinc 1By similarity | 1 | |
Binding sitei | 168 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 171 | Zinc 2By similarity | 1 | |
Binding sitei | 172 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 176 | Zinc 2By similarity | 1 | |
Binding sitei | 180 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 182 | Zinc 1; via pros nitrogenBy similarity | 1 | |
Metal bindingi | 185 | Zinc 1By similarity | 1 | |
Metal bindingi | 198 | Zinc 2By similarity | 1 | |
Metal bindingi | 202 | Zinc 2By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 204 | PHD-type; degenerateAdd BLAST | 50 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- methylated histone binding Source: UniProtKB
GO - Biological processi
- chromatin organization Source: SGD
- histone acetylation Source: SGD
- positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SCE-3899300, SUMOylation of transcription cofactors R-SCE-6804758, Regulation of TP53 Activity through Acetylation R-SCE-6811555, PI5P Regulates TP53 Acetylation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein YNG1Alternative name(s): ING1 homolog 1 |
Gene namesi | Name:YNG1 Ordered Locus Names:YOR064C ORF Names:YOR29-15 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOR064C |
SGDi | S000005590, YNG1 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- NuA3 histone acetyltransferase complex Source: SGD
- NuA3a histone acetyltransferase complex Source: SGD
- nucleus Source: GO_Central
- Rpd3L complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240248 | 1 – 219 | Protein YNG1Add BLAST | 219 |
Proteomic databases
MaxQBi | Q08465 |
PaxDbi | Q08465 |
PTM databases
iPTMneti | Q08465 |
Interactioni
Subunit structurei
Interacts with H3K4me3 and to a lesser extent with H3K4me2.
Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6.
Interacts with histone H3-K4 trimethylated.
3 PublicationsBinary interactionsi
Hide detailsQ08465
With | #Exp. | IntAct |
---|---|---|
HHT2 [P61830] | 5 | EBI-31890,EBI-8098 |
SAS3 [P34218] | 5 | EBI-31890,EBI-16484 |
TAF14 [P35189] | 3 | EBI-31890,EBI-18920 |
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 34463, 149 interactors |
ComplexPortali | CPX-1810, NuA3 histone acetyltransferase complex |
DIPi | DIP-3833N |
IntActi | Q08465, 6 interactors |
MINTi | Q08465 |
STRINGi | 4932.YOR064C |
Miscellaneous databases
RNActi | Q08465, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q08465 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08465 |
Family & Domainsi
Domaini
The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication
Sequence similaritiesi
Belongs to the ING family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 204 | PHD-type; degenerateAdd BLAST | 50 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1973, Eukaryota |
HOGENOMi | CLU_074406_1_0_1 |
InParanoidi | Q08465 |
OMAi | RSLWLIQ |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
IDEALi | IID50148 |
InterProi | View protein in InterPro IPR028651, ING_fam IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 2 hits |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08465-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHLANENSD SDIRYSFLST LDHLPCELIR SLRLMQTIDL FKNEEDEPGM
60 70 80 90 100
ERACRDLLLV ATYINDLVDD QIHFLKQHKK ELEIQKSVTK NFNSSLENIK
110 120 130 140 150
SKLTLEEPGA YKEPKLLLKI NLKKAKSRER KESITSPTIG INQGDVTEGN
160 170 180 190 200
NNQEEVYCFC RNVSYGPMVA CDNPACPFEW FHYGCVGLKQ APKGKWYCSK
210
DCKEIANQRS KSKRQKRRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z70678 Genomic DNA Translation: CAA94549.1 Z74972 Genomic DNA Translation: CAA99257.1 AY557753 Genomic DNA Translation: AAS56079.1 BK006948 Genomic DNA Translation: DAA10843.1 |
PIRi | S66947 |
RefSeqi | NP_014707.1, NM_001183483.1 |
Genome annotation databases
EnsemblFungii | YOR064C_mRNA; YOR064C; YOR064C |
GeneIDi | 854230 |
KEGGi | sce:YOR064C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z70678 Genomic DNA Translation: CAA94549.1 Z74972 Genomic DNA Translation: CAA99257.1 AY557753 Genomic DNA Translation: AAS56079.1 BK006948 Genomic DNA Translation: DAA10843.1 |
PIRi | S66947 |
RefSeqi | NP_014707.1, NM_001183483.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JMI | NMR | - | A | 141-219 | [»] | |
2JMJ | NMR | - | A | 141-219 | [»] | |
SMRi | Q08465 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34463, 149 interactors |
ComplexPortali | CPX-1810, NuA3 histone acetyltransferase complex |
DIPi | DIP-3833N |
IntActi | Q08465, 6 interactors |
MINTi | Q08465 |
STRINGi | 4932.YOR064C |
PTM databases
iPTMneti | Q08465 |
Proteomic databases
MaxQBi | Q08465 |
PaxDbi | Q08465 |
Genome annotation databases
EnsemblFungii | YOR064C_mRNA; YOR064C; YOR064C |
GeneIDi | 854230 |
KEGGi | sce:YOR064C |
Organism-specific databases
EuPathDBi | FungiDB:YOR064C |
SGDi | S000005590, YNG1 |
Phylogenomic databases
eggNOGi | KOG1973, Eukaryota |
HOGENOMi | CLU_074406_1_0_1 |
InParanoidi | Q08465 |
OMAi | RSLWLIQ |
Enzyme and pathway databases
Reactomei | R-SCE-3899300, SUMOylation of transcription cofactors R-SCE-6804758, Regulation of TP53 Activity through Acetylation R-SCE-6811555, PI5P Regulates TP53 Acetylation |
Miscellaneous databases
EvolutionaryTracei | Q08465 |
PROi | PR:Q08465 |
RNActi | Q08465, protein |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
IDEALi | IID50148 |
InterProi | View protein in InterPro IPR028651, ING_fam IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 2 hits |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YNG1_YEAST | |
Accessioni | Q08465Primary (citable) accession number: Q08465 Secondary accession number(s): D6W2C7, O00025 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD