UniProtKB - Q08426 (ECHP_HUMAN)
Peroxisomal bifunctional enzyme
EHHADH
Functioni
Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (By similarity).
Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity).
Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity).
With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:15060085).
Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity).
Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (PubMed:15060085).
By similarity1 Publication1 PublicationMiscellaneous
Catalytic activityi
- EC:4.2.1.171 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:4.2.1.17By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:5.3.3.8By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:5.3.3.8By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:1.1.1.351 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the backward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the backwardBy similarity direction.
Activity regulationi
Kineticsi
- KM=0.3 µM for (3S)-hydroxyhexadecanedioyl-CoA1 Publication
- KM=10 µM for (3S)-hydroxyhexadecanoyl-CoA1 Publication
: fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 101 | Substrate; via amide nitrogenBy similarity | 1 | |
Sitei | 104 | Important for catalytic activityBy similarity | 1 | |
Sitei | 124 | Important for catalytic activityBy similarity | 1 |
GO - Molecular functioni
- 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB
- dodecenoyl-CoA delta-isomerase activity Source: UniProtKB
- enoyl-CoA hydratase activity Source: UniProtKB
- enzyme binding Source: UniProtKB
- intramolecular oxidoreductase activity, transposing C=C bonds Source: UniProtKB
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB
- long-chain-enoyl-CoA hydratase activity Source: Reactome
- NAD+ binding Source: InterPro
GO - Biological processi
- fatty acid beta-oxidation Source: UniProtKB
- fatty acid beta-oxidation using acyl-CoA oxidase Source: Reactome
Keywordsi
Molecular function | Isomerase, Lyase, Multifunctional enzyme, Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | Q08426 |
Reactomei | R-HSA-390247, Beta-oxidation of very long chain fatty acids R-HSA-9033241, Peroxisomal protein import |
SABIO-RKi | Q08426 |
SignaLinki | Q08426 |
UniPathwayi | UPA00659 |
Chemistry databases
SwissLipidsi | SLP:000000543 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal bifunctional enzymeCuratedShort name: PBE Short name: PBFE Alternative name(s): L-bifunctional protein1 Publication Short name: LBP1 Publication Multifunctional enzyme 1 Short name: MFE1 Including the following 2 domains: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3247, EHHADH |
MIMi | 607037, gene |
neXtProti | NX_Q08426 |
VEuPathDBi | HostDB:ENSG00000113790 |
Subcellular locationi
Peroxisome
- Peroxisome Curated
Cytosol
- cytosol Source: Reactome
Peroxisome
- peroxisomal matrix Source: Reactome
- peroxisome Source: UniProtKB
Keywords - Cellular componenti
PeroxisomePathology & Biotechi
Involvement in diseasei
Fanconi renotubular syndrome 3 (FRTS3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070949 | 3 | E → K in FRTS3; the mutant is mistargeted to mitochondria; results in impaired mitochondrial oxidative phosphorylation and defects in the transport of fluids across the epithelium of renal proximal tubular cells. 1 PublicationCorresponds to variant dbSNP:rs398124646EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 165 | K → Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-171; Q-346 and Q-584. 1 Publication | 1 | |
Mutagenesisi | 171 | K → Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-165; Q-346 and Q-584. 1 Publication | 1 | |
Mutagenesisi | 346 | K → Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-165; Q-171 and Q-584. 1 Publication | 1 | |
Mutagenesisi | 584 | K → Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-165; Q-171 and Q-346. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1962 |
MalaCardsi | EHHADH |
MIMi | 615605, phenotype |
OpenTargetsi | ENSG00000113790 |
Orphaneti | 300, Bifunctional enzyme deficiency 3337, Primary Fanconi renotubular syndrome |
PharmGKBi | PA27682 |
Miscellaneous databases
Pharosi | Q08426, Tbio |
Chemistry databases
DrugBanki | DB00157, NADH |
Genetic variation databases
BioMutai | EHHADH |
DMDMi | 223590229 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000109247 | 1 – 723 | Peroxisomal bifunctional enzymeAdd BLAST | 723 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 165 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 165 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 171 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 219 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 219 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 250 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 280 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 290 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 346 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 350 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 464 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 532 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 548 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 577 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 584 | N6-acetyllysine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 584 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 591 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 591 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 710 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 710 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 718 | PhosphoserineCombined sources | 1 | |
Modified residuei | 722 | N6-succinyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q08426 |
jPOSTi | Q08426 |
MassIVEi | Q08426 |
MaxQBi | Q08426 |
PaxDbi | Q08426 |
PeptideAtlasi | Q08426 |
PRIDEi | Q08426 |
ProteomicsDBi | 58608 [Q08426-1] 58609 [Q08426-2] |
PTM databases
iPTMneti | Q08426 |
PhosphoSitePlusi | Q08426 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000113790, Expressed in liver and 214 other tissues |
ExpressionAtlasi | Q08426, baseline and differential |
Genevisiblei | Q08426, HS |
Organism-specific databases
HPAi | ENSG00000113790, Group enriched (kidney, liver) |
Interactioni
Subunit structurei
Monomer.
By similarityBinary interactionsi
Q08426
GO - Molecular functioni
- enzyme binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108282, 151 interactors |
IntActi | Q08426, 122 interactors |
STRINGi | 9606.ENSP00000231887 |
Miscellaneous databases
RNActi | Q08426, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 282 | Enoyl-CoA hydratase / isomeraseAdd BLAST | 282 | |
Regioni | 283 – 572 | 3-hydroxyacyl-CoA dehydrogenaseAdd BLAST | 290 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 721 – 723 | Microbody targeting signal | 3 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1683, Eukaryota |
GeneTreei | ENSGT00940000157516 |
HOGENOMi | CLU_009834_16_3_1 |
InParanoidi | Q08426 |
OMAi | TGAGWPF |
OrthoDBi | 219667at2759 |
PhylomeDBi | Q08426 |
TreeFami | TF316708 |
Family and domain databases
InterProi | View protein in InterPro IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR029045, ClpP/crotonase-like_dom_sf IPR018376, Enoyl-CoA_hyd/isom_CS IPR001753, Enoyl-CoA_hydra/iso IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 2 hits PF02737, 3HCDH_N, 1 hit PF00378, ECH_1, 1 hit |
SUPFAMi | SSF48179, SSF48179, 2 hits SSF51735, SSF51735, 1 hit SSF52096, SSF52096, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit PS00166, ENOYL_COA_HYDRATASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEYTRLHNA LALIRLRNPP VNAISTTLLR DIKEGLQKAV IDHTIKAIVI
60 70 80 90 100
CGAEGKFSAG ADIRGFSAPR TFGLTLGHVV DEIQRNEKPV VAAIQGMAFG
110 120 130 140 150
GGLELALGCH YRIAHAEAQV GLPEVTLGLL PGARGTQLLP RLTGVPAALD
160 170 180 190 200
LITSGRRILA DEALKLGILD KVVNSDPVEE AIRFAQRVSD QPLESRRLCN
210 220 230 240 250
KPIQSLPNMD SIFSEALLKM RRQHPGCLAQ EACVRAVQAA VQYPYEVGIK
260 270 280 290 300
KEEELFLYLL QSGQARALQY AFFAERKANK WSTPSGASWK TASARPVSSV
310 320 330 340 350
GVVGLGTMGR GIVISFARAR IPVIAVDSDK NQLATANKMI TSVLEKEASK
360 370 380 390 400
MQQSGHPWSG PKPRLTSSVK ELGGVDLVIE AVFEEMSLKK QVFAELSAVC
410 420 430 440 450
KPEAFLCTNT SALDVDEIAS STDRPHLVIG THFFSPAHVM KLLEVIPSQY
460 470 480 490 500
SSPTTIATVM NLSKKIKKIG VVVGNCFGFV GNRMLNPYYN QAYFLLEEGS
510 520 530 540 550
KPEEVDQVLE EFGFKMGPFR VSDLAGLDVG WKSRKGQGLT GPTLLPGTPA
560 570 580 590 600
RKRGNRRYCP IPDVLCELGR FGQKTGKGWY QYDKPLGRIH KPDPWLSKFL
610 620 630 640 650
SRYRKTHHIE PRTISQDEIL ERCLYSLINE AFRILGEGIA ASPEHIDVVY
660 670 680 690 700
LHGYGWPRHK GGPMFYASTV GLPTVLEKLQ KYYRQNPDIP QLEPSDYLKK
710 720
LASQGNPPLK EWQSLAGSPS SKL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JJE0 | C9JJE0_HUMAN | Peroxisomal bifunctional enzyme | EHHADH | 76 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 117 | E → D in AAA53289 (PubMed:8188243).Curated | 1 | |
Sequence conflicti | 656 – 657 | WP → CA in AAA53289 (PubMed:8188243).Curated | 2 | |
Sequence conflicti | 656 – 657 | WP → CA in AAB19482 (PubMed:15489334).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070949 | 3 | E → K in FRTS3; the mutant is mistargeted to mitochondria; results in impaired mitochondrial oxidative phosphorylation and defects in the transport of fluids across the epithelium of renal proximal tubular cells. 1 PublicationCorresponds to variant dbSNP:rs398124646EnsemblClinVar. | 1 | |
Natural variantiVAR_054329 | 40 | V → G1 PublicationCorresponds to variant dbSNP:rs1062551Ensembl. | 1 | |
Natural variantiVAR_054330 | 41 | I → R1 PublicationCorresponds to variant dbSNP:rs1062552Ensembl. | 1 | |
Natural variantiVAR_047132 | 75 | T → I1 PublicationCorresponds to variant dbSNP:rs1062553Ensembl. | 1 | |
Natural variantiVAR_047133 | 274 | A → T1 PublicationCorresponds to variant dbSNP:rs2302819Ensembl. | 1 | |
Natural variantiVAR_054331 | 325 | A → G1 PublicationCorresponds to variant dbSNP:rs1062555Ensembl. | 1 | |
Natural variantiVAR_054332 | 598 | K → T2 PublicationsCorresponds to variant dbSNP:rs1042437Ensembl. | 1 | |
Natural variantiVAR_047134 | 606 | T → P2 PublicationsCorresponds to variant dbSNP:rs1042438Ensembl. | 1 | |
Natural variantiVAR_047135 | 685 | Q → K. Corresponds to variant dbSNP:rs11919970Ensembl. | 1 | |
Natural variantiVAR_047136 | 715 | L → S. Corresponds to variant dbSNP:rs11927618EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042811 | 1 – 96 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07077 mRNA Translation: AAA53289.1 AJ427345 , AJ427346, AJ427347, AJ427348, AJ427349, AJ427350, AJ427351 Genomic DNA Translation: CAD22483.1 AK291798 mRNA Translation: BAF84487.1 AK223460 mRNA Translation: BAD97180.1 AK301521 mRNA Translation: BAG63025.1 AC007934 Genomic DNA No translation available. AC128680 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78229.1 CH471052 Genomic DNA Translation: EAW78230.1 BC038948 mRNA Translation: AAH38948.1 BC110460 mRNA Translation: AAI10461.1 S50245 mRNA Translation: AAB19482.1 |
CCDSi | CCDS33901.1 [Q08426-1] CCDS54694.1 [Q08426-2] |
PIRi | A49613 |
RefSeqi | NP_001159887.1, NM_001166415.1 [Q08426-2] NP_001957.2, NM_001966.3 [Q08426-1] XP_011510819.1, XM_011512517.1 |
Genome annotation databases
Ensembli | ENST00000231887.8; ENSP00000231887.3; ENSG00000113790.11 ENST00000456310.5; ENSP00000387746.1; ENSG00000113790.11 [Q08426-2] |
GeneIDi | 1962 |
KEGGi | hsa:1962 |
MANE-Selecti | ENST00000231887.8; ENSP00000231887.3; NM_001966.4; NP_001957.2 |
UCSCi | uc003fpf.3, human [Q08426-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07077 mRNA Translation: AAA53289.1 AJ427345 , AJ427346, AJ427347, AJ427348, AJ427349, AJ427350, AJ427351 Genomic DNA Translation: CAD22483.1 AK291798 mRNA Translation: BAF84487.1 AK223460 mRNA Translation: BAD97180.1 AK301521 mRNA Translation: BAG63025.1 AC007934 Genomic DNA No translation available. AC128680 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78229.1 CH471052 Genomic DNA Translation: EAW78230.1 BC038948 mRNA Translation: AAH38948.1 BC110460 mRNA Translation: AAI10461.1 S50245 mRNA Translation: AAB19482.1 |
CCDSi | CCDS33901.1 [Q08426-1] CCDS54694.1 [Q08426-2] |
PIRi | A49613 |
RefSeqi | NP_001159887.1, NM_001166415.1 [Q08426-2] NP_001957.2, NM_001966.3 [Q08426-1] XP_011510819.1, XM_011512517.1 |
3D structure databases
AlphaFoldDBi | Q08426 |
SMRi | Q08426 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108282, 151 interactors |
IntActi | Q08426, 122 interactors |
STRINGi | 9606.ENSP00000231887 |
Chemistry databases
DrugBanki | DB00157, NADH |
SwissLipidsi | SLP:000000543 |
PTM databases
iPTMneti | Q08426 |
PhosphoSitePlusi | Q08426 |
Genetic variation databases
BioMutai | EHHADH |
DMDMi | 223590229 |
Proteomic databases
EPDi | Q08426 |
jPOSTi | Q08426 |
MassIVEi | Q08426 |
MaxQBi | Q08426 |
PaxDbi | Q08426 |
PeptideAtlasi | Q08426 |
PRIDEi | Q08426 |
ProteomicsDBi | 58608 [Q08426-1] 58609 [Q08426-2] |
Protocols and materials databases
Antibodypediai | 33832, 336 antibodies from 30 providers |
DNASUi | 1962 |
Genome annotation databases
Ensembli | ENST00000231887.8; ENSP00000231887.3; ENSG00000113790.11 ENST00000456310.5; ENSP00000387746.1; ENSG00000113790.11 [Q08426-2] |
GeneIDi | 1962 |
KEGGi | hsa:1962 |
MANE-Selecti | ENST00000231887.8; ENSP00000231887.3; NM_001966.4; NP_001957.2 |
UCSCi | uc003fpf.3, human [Q08426-1] |
Organism-specific databases
CTDi | 1962 |
DisGeNETi | 1962 |
GeneCardsi | EHHADH |
HGNCi | HGNC:3247, EHHADH |
HPAi | ENSG00000113790, Group enriched (kidney, liver) |
MalaCardsi | EHHADH |
MIMi | 607037, gene 615605, phenotype |
neXtProti | NX_Q08426 |
OpenTargetsi | ENSG00000113790 |
Orphaneti | 300, Bifunctional enzyme deficiency 3337, Primary Fanconi renotubular syndrome |
PharmGKBi | PA27682 |
VEuPathDBi | HostDB:ENSG00000113790 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1683, Eukaryota |
GeneTreei | ENSGT00940000157516 |
HOGENOMi | CLU_009834_16_3_1 |
InParanoidi | Q08426 |
OMAi | TGAGWPF |
OrthoDBi | 219667at2759 |
PhylomeDBi | Q08426 |
TreeFami | TF316708 |
Enzyme and pathway databases
UniPathwayi | UPA00659 |
PathwayCommonsi | Q08426 |
Reactomei | R-HSA-390247, Beta-oxidation of very long chain fatty acids R-HSA-9033241, Peroxisomal protein import |
SABIO-RKi | Q08426 |
SignaLinki | Q08426 |
Miscellaneous databases
BioGRID-ORCSi | 1962, 10 hits in 1082 CRISPR screens |
ChiTaRSi | EHHADH, human |
GenomeRNAii | 1962 |
Pharosi | Q08426, Tbio |
PROi | PR:Q08426 |
RNActi | Q08426, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113790, Expressed in liver and 214 other tissues |
ExpressionAtlasi | Q08426, baseline and differential |
Genevisiblei | Q08426, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR029045, ClpP/crotonase-like_dom_sf IPR018376, Enoyl-CoA_hyd/isom_CS IPR001753, Enoyl-CoA_hydra/iso IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 2 hits PF02737, 3HCDH_N, 1 hit PF00378, ECH_1, 1 hit |
SUPFAMi | SSF48179, SSF48179, 2 hits SSF51735, SSF51735, 1 hit SSF52096, SSF52096, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit PS00166, ENOYL_COA_HYDRATASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ECHP_HUMAN | |
Accessioni | Q08426Primary (citable) accession number: Q08426 Secondary accession number(s): A8K6Y3 Q58EZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 25, 2022 | |
This is version 209 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families