UniProtKB - Q08380 (LG3BP_HUMAN)

BLAST

>sp|Q08380|LG3BP_HUMAN Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1
MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASV
VCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAG
VVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANL
EAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQ
GYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVP
TDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQ
FNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTD
SSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSL
VYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGW
KAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD

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History
Entry version 172 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
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Protein

Galectin-3-binding protein

Gene

LGALS3BP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.3 Publications

GO - Molecular functionⁱ

scavenger receptor activity
Source: ProtInc
Traceable author statementⁱ
- 8390986

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: UniProtKB-KW
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 8034587
platelet degranulation Source: Reactome
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8390986

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation
SIGNORⁱ	Q08380

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Galectin-3-binding protein Alternative name(s): Basement membrane autoantigen p105 Lectin galactoside-binding soluble 3-binding protein Mac-2-binding protein Short name: MAC2BP Short name: Mac-2 BP Tumor-associated antigen 90K
Gene namesⁱ	Name:LGALS3BP Synonyms:M2BP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108679.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6564 LGALS3BP
MIMⁱ	600626 gene
neXtProtⁱ	NX_Q08380

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3959
Open Targets More...OpenTargetsⁱ	ENSG00000108679
PharmGKBⁱ	PA30341

Polymorphism and mutation databases

BioMutaⁱ	LGALS3BP
DMDMⁱ	47115668

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	3 PublicationsAdd BLAST		18
ChainⁱPRO_0000033230	19 – 585	Galectin-3-binding proteinAdd BLAST		567

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 113	Combined sources1 Publication
Disulfide bondⁱ	62 ↔ 123	Combined sources1 Publication
Glycosylationⁱ	69	N-linked (GlcNAc...) (complex) asparagine7 Publications	1
Disulfide bondⁱ	93 ↔ 103	Combined sources1 Publication
Glycosylationⁱ	125	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	192	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	362	N-linked (GlcNAc...) asparagine	1
Glycosylationⁱ	398	N-linked (GlcNAc...) (complex) asparagine4 Publications	1
Glycosylationⁱ	551	N-linked (GlcNAc...) (complex) asparagine5 Publications	1
Glycosylationⁱ	580	N-linked (GlcNAc...) (complex) asparagine3 Publications	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q08380
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q08380
PaxDbⁱ	Q08380
PeptideAtlas More...PeptideAtlasⁱ	Q08380
PRIDEⁱ	Q08380
ProteomicsDBⁱ	58606

PTM databases

GlyConnectⁱ	1256
iPTMnetⁱ	Q08380
PhosphoSitePlusⁱ	Q08380
SwissPalmⁱ	Q08380

Miscellaneous databases

PMAP-CutDBⁱ	Q08380

PMAP-CutDBⁱ

Q08380

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000108679 Expressed in 221 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_LGALS3BP
ExpressionAtlasⁱ	Q08380 baseline and differential
Genevisibleⁱ	Q08380 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002158 HPA000554

HPAⁱ

CAB002158
HPA000554

Interactionⁱ

Subunit structureⁱ

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:29162697). The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).2 Publications

Protein-protein interaction databases

BioGridⁱ	110150, 177 interactors
IntActⁱ	Q08380, 73 interactors
Molecular INTeraction database More...MINTⁱ	Q08380
STRINGⁱ	9606.ENSP00000262776

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	24 – 28	Combined sources	5
Beta strandⁱ	34 – 41	Combined sources	8
Beta strandⁱ	44 – 49	Combined sources	6
Helixⁱ	55 – 64	Combined sources	10
Beta strandⁱ	70 – 74	Combined sources	5
Turnⁱ	76 – 79	Combined sources	4
Beta strandⁱ	86 – 88	Combined sources	3
Helixⁱ	100 – 102	Combined sources	3
Helixⁱ	115 – 117	Combined sources	3
Beta strandⁱ	120 – 123	Combined sources	4
Beta strandⁱ	131 – 134	Combined sources	4
Helixⁱ	136 – 138	Combined sources	3
Helixⁱ	139 – 149	Combined sources	11
Beta strandⁱ	155 – 161	Combined sources	7
Beta strandⁱ	164 – 171	Combined sources	8
Helixⁱ	173 – 176	Combined sources	4
Helixⁱ	180 – 185	Combined sources	6
Beta strandⁱ	191 – 196	Combined sources	6
Helixⁱ	199 – 204	Combined sources	6
Helixⁱ	205 – 214	Combined sources	10
Beta strandⁱ	215 – 219	Combined sources	5
Turnⁱ	221 – 223	Combined sources	3
Helixⁱ	224 – 234	Combined sources	11
Helixⁱ	237 – 246	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q08380
SMRⁱ	Q08380
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q08380

EvolutionaryTraceⁱ

Q08380

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 124	SRCRPROSITE-ProRule annotationAdd BLAST	101
Domainⁱ	153 – 221	BTBPROSITE-ProRule annotationAdd BLAST	69
Domainⁱ	260 – 360	BACKAdd BLAST	101

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IY2Y Eukaryota ENOG410YBYF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063814
HOGENOMⁱ	HOG000113318
HOVERGENⁱ	HBG052323
InParanoidⁱ	Q08380
KEGG Orthology (KO) More...KOⁱ	K17300
OMAⁱ	IGYENKA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MFZ
PhylomeDBⁱ	Q08380
TreeFamⁱ	TF331368

Family and domain databases

Gene3Dⁱ	3.10.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR000210 BTB/POZ_dom IPR001190 SRCR IPR017448 SRCR-like_dom IPR036772 SRCR-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00530 SRCR, 1 hit
PRINTSⁱ	PR00258 SPERACTRCPTR
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00202 SR, 1 hit
SUPFAMⁱ	SSF56487 SSF56487, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00420 SRCR_1, 1 hit PS50287 SRCR_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show all Align All

Q08380-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD 
        60         70         80         90        100
NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL 
       110        120        130        140        150
ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ 
       160        170        180        190        200
RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE 
       210        220        230        240        250
CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL 
       260        270        280        290        300
LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP 
       310        320        330        340        350
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM 
       360        370        380        390        400
MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT 
       410        420        430        440        450
EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP 
       460        470        480        490        500
SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE 
       510        520        530        540        550
LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT 
       560        570        580 
NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD

Length:585

Mass (Da):65,331

Last modified:November 1, 1996 - v1

Checksum:ⁱC488C2E99D77435B

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	K7EJY8	K7EJY8_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	144	Annotation score:
	K7EJD3	K7EJD3_HUMAN	Galectin-3-binding protein Galectin-3-binding protein (Lectin galactoside-binding soluble 3 binding protein isoform 2)	LGALS3BP	205	Annotation score:
	K7ESM3	K7ESM3_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	209	Annotation score:
	K7EKQ5	K7EKQ5_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	210	Annotation score:
	K7EP36	K7EP36_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	259	Annotation score:
	K7ERZ6	K7ERZ6_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	131	Annotation score:
	K7ES75	K7ES75_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	88	Annotation score:
	K7EN99	K7EN99_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	113	Annotation score:
	K7EQT9	K7EQT9_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	48	Annotation score:
	K7EM15	K7EM15_HUMAN	Galectin-3-binding protein Galectin-3-binding protein	LGALS3BP	62	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	19	V → S AA sequence (PubMed:8757764).Curated	1
Sequence conflictⁱ	25	R → C AA sequence (PubMed:8454062).Curated	1
Sequence conflictⁱ	25	R → P AA sequence (PubMed:8454062).Curated	1
Sequence conflictⁱ	26	L → M AA sequence (PubMed:8757764).Curated	1
Sequence conflictⁱ	30 – 31	GA → ED AA sequence (PubMed:8757764).Curated	2
Sequence conflictⁱ	36	R → H AA sequence (PubMed:8757764).Curated	1
Sequence conflictⁱ	36	R → L AA sequence (PubMed:8454062).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13210 mRNA Translation: AAA36193.1 X79089 mRNA Translation: CAA55699.1 BC002403 mRNA Translation: AAH02403.1 BC002998 mRNA Translation: AAH02998.1 BC015761 mRNA Translation: AAH15761.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11759.1
PIRⁱ	A47161 A55899
NCBI Reference Sequences More...RefSeqⁱ	NP_005558.1, NM_005567.3
UniGeneⁱ	Hs.514535

Genome annotation databases

Ensemblⁱ	ENST00000262776; ENSP00000262776; ENSG00000108679
GeneIDⁱ	3959
KEGGⁱ	hsa:3959
UCSC genome browser More...UCSCⁱ	uc002jwh.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q08380	Lectin galactoside-binding soluble 3 binding protein isoform 1 (Fragment)		HUMAN		585	UniRef100_Q08380
LGALS3BP isoform 18 (Fragment)		PANTR		88
Galectin-3-binding protein (Fragment)		HUMAN		259
Galectin-3-binding protein		HUMAN		210
Galectin-3-binding protein (Fragment)		HUMAN		209
+1

Protein	Similar proteins		Species	Score	Length	Source
Q08380	Galectin-3-binding protein		PONAB		584	UniRef90_Q08380
Lectin galactoside-binding soluble 3 binding protein isoform 1 (Fragment)		HUMAN		585
LGALS3BP isoform 18 (Fragment)		PANTR		88
Uncharacterized protein		PAPAN		719
Uncharacterized protein		MACMU		633
+33

Protein	Similar proteins		Species	Score	Length	Source
Q08380	Galectin-3-binding protein		PONAB		584	UniRef50_Q08380
Galectin-3-binding protein		MOUSE		577
Lectin galactoside-binding soluble 3 binding protein isoform 1 (Fragment)		HUMAN		585
LGALS3BP isoform 18 (Fragment)		PANTR		88
Uncharacterized protein		PAPAN		719
+85

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13210 mRNA Translation: AAA36193.1 X79089 mRNA Translation: CAA55699.1 BC002403 mRNA Translation: AAH02403.1 BC002998 mRNA Translation: AAH02998.1 BC015761 mRNA Translation: AAH15761.1
CCDSⁱ	CCDS11759.1
PIRⁱ	A47161 A55899
RefSeqⁱ	NP_005558.1, NM_005567.3
UniGeneⁱ	Hs.514535

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BY2	X-ray	2.00	A	19-133	[»]
	6GFB	X-ray	2.08	A/B	124-250	[»]
ProteinModelPortalⁱ	Q08380
SMRⁱ	Q08380
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110150, 177 interactors
IntActⁱ	Q08380, 73 interactors
MINTⁱ	Q08380
STRINGⁱ	9606.ENSP00000262776

PTM databases

GlyConnectⁱ	1256
iPTMnetⁱ	Q08380
PhosphoSitePlusⁱ	Q08380
SwissPalmⁱ	Q08380

Polymorphism and mutation databases

BioMutaⁱ	LGALS3BP
DMDMⁱ	47115668

Proteomic databases

EPDⁱ	Q08380
MaxQBⁱ	Q08380
PaxDbⁱ	Q08380
PeptideAtlasⁱ	Q08380
PRIDEⁱ	Q08380
ProteomicsDBⁱ	58606

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3959
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262776; ENSP00000262776; ENSG00000108679
GeneIDⁱ	3959
KEGGⁱ	hsa:3959
UCSCⁱ	uc002jwh.4 human

Organism-specific databases

CTDⁱ	3959
DisGeNETⁱ	3959
EuPathDBⁱ	HostDB:ENSG00000108679.12
GeneCardsⁱ	LGALS3BP
HGNCⁱ	HGNC:6564 LGALS3BP
HPAⁱ	CAB002158 HPA000554
MIMⁱ	600626 gene
neXtProtⁱ	NX_Q08380
OpenTargetsⁱ	ENSG00000108679
PharmGKBⁱ	PA30341
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IY2Y Eukaryota ENOG410YBYF LUCA
GeneTreeⁱ	ENSGT00530000063814
HOGENOMⁱ	HOG000113318
HOVERGENⁱ	HBG052323
InParanoidⁱ	Q08380
KOⁱ	K17300
OMAⁱ	IGYENKA
OrthoDBⁱ	EOG091G0MFZ
PhylomeDBⁱ	Q08380
TreeFamⁱ	TF331368

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation
SIGNORⁱ	Q08380

Miscellaneous databases

ChiTaRSⁱ	LGALS3BP human
EvolutionaryTraceⁱ	Q08380
GeneWikiⁱ	LGALS3BP
GenomeRNAiⁱ	3959
PMAP-CutDBⁱ	Q08380
Protein Ontology More...PROⁱ	PR:Q08380
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108679 Expressed in 221 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_LGALS3BP
ExpressionAtlasⁱ	Q08380 baseline and differential
Genevisibleⁱ	Q08380 HS

Family and domain databases

Gene3Dⁱ	3.10.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR000210 BTB/POZ_dom IPR001190 SRCR IPR017448 SRCR-like_dom IPR036772 SRCR-like_dom_sf
Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00530 SRCR, 1 hit
PRINTSⁱ	PR00258 SPERACTRCPTR
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00202 SR, 1 hit
SUPFAMⁱ	SSF56487 SSF56487, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00420 SRCR_1, 1 hit PS50287 SRCR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LG3BP_HUMAN
Accessionⁱ	Q08380Primary (citable) accession number: Q08380 Secondary accession number(s): Q7M4S0 , Q9UCH8, Q9UCH9, Q9UCI0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q08380 (LG3BP_HUMAN)

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Galectin-3-binding protein

LGALS3BP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ