UniProtKB - Q08380 (LG3BP_HUMAN)
Galectin-3-binding protein
LGALS3BP
Functioni
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
3 PublicationsGO - Molecular functioni
- scavenger receptor activity Source: ProtInc
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- cellular defense response Source: ProtInc
- signal transduction Source: ProtInc
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q08380 |
Reactomei | R-HSA-114608, Platelet degranulation |
SignaLinki | Q08380 |
SIGNORi | Q08380 |
Names & Taxonomyi
Protein namesi | Recommended name: Galectin-3-binding proteinAlternative name(s): Basement membrane autoantigen p105 Lectin galactoside-binding soluble 3-binding protein Mac-2-binding protein Short name: MAC2BP Short name: Mac-2 BP Tumor-associated antigen 90K |
Gene namesi | Name:LGALS3BP Synonyms:M2BP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6564, LGALS3BP |
MIMi | 600626, gene |
neXtProti | NX_Q08380 |
VEuPathDBi | HostDB:ENSG00000108679 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
- extracellular matrix 1 Publication
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: UniProtKB
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- membrane Source: InterPro
- platelet dense granule lumen Source: Reactome
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3959 |
OpenTargetsi | ENSG00000108679 |
PharmGKBi | PA30341 |
Miscellaneous databases
Pharosi | Q08380, Tbio |
Genetic variation databases
BioMutai | LGALS3BP |
DMDMi | 47115668 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 3 PublicationsAdd BLAST | 18 | |
ChainiPRO_0000033230 | 19 – 585 | Galectin-3-binding proteinAdd BLAST | 567 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 113 | Combined sources1 Publication | ||
Disulfide bondi | 62 ↔ 123 | Combined sources1 Publication | ||
Glycosylationi | 69 | N-linked (GlcNAc...) (complex) asparagine7 Publications | 1 | |
Disulfide bondi | 93 ↔ 103 | Combined sources1 Publication | ||
Glycosylationi | 125 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 192 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 362 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 398 | N-linked (GlcNAc...) (complex) asparagine4 Publications | 1 | |
Glycosylationi | 551 | N-linked (GlcNAc...) (complex) asparagine5 Publications | 1 | |
Glycosylationi | 580 | N-linked (GlcNAc...) (complex) asparagine3 Publications | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | CPTAC-534 CPTAC-535 CPTAC-670 non-CPTAC-1125 non-CPTAC-2670 |
EPDi | Q08380 |
jPOSTi | Q08380 |
MassIVEi | Q08380 |
MaxQBi | Q08380 |
PaxDbi | Q08380 |
PeptideAtlasi | Q08380 |
PRIDEi | Q08380 |
ProteomicsDBi | 58606 |
PTM databases
GlyConnecti | 1256, 74 N-Linked glycans (6 sites) |
GlyGeni | Q08380, 9 sites, 86 N-linked glycans (6 sites), 2 O-linked glycans (2 sites) |
iPTMneti | Q08380 |
PhosphoSitePlusi | Q08380 |
SwissPalmi | Q08380 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000108679, Expressed in heart left ventricle and 235 other tissues |
ExpressionAtlasi | Q08380, baseline and differential |
Genevisiblei | Q08380, HS |
Organism-specific databases
HPAi | ENSG00000108679, Low tissue specificity |
Interactioni
Subunit structurei
Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.
Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:29162697). The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).
2 PublicationsBinary interactionsi
Q08380
Protein-protein interaction databases
BioGRIDi | 110150, 242 interactors |
IntActi | Q08380, 136 interactors |
MINTi | Q08380 |
STRINGi | 9606.ENSP00000262776 |
Miscellaneous databases
RNActi | Q08380, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q08380 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08380 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 124 | SRCRPROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 153 – 221 | BTBPROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 260 – 360 | BACKAdd BLAST | 101 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QU48, Eukaryota |
GeneTreei | ENSGT00940000162516 |
HOGENOMi | CLU_032646_0_0_1 |
InParanoidi | Q08380 |
OrthoDBi | 1174057at2759 |
PhylomeDBi | Q08380 |
TreeFami | TF331368 |
Family and domain databases
Gene3Di | 3.10.250.10, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00530, SRCR, 1 hit |
PRINTSi | PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00202, SR, 1 hit |
SUPFAMi | SSF56487, SSF56487, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00420, SRCR_1, 1 hit PS50287, SRCR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD
60 70 80 90 100
NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL
110 120 130 140 150
ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ
160 170 180 190 200
RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE
210 220 230 240 250
CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL
260 270 280 290 300
LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP
310 320 330 340 350
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM
360 370 380 390 400
MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT
410 420 430 440 450
EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP
460 470 480 490 500
SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE
510 520 530 540 550
LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT
560 570 580
NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EP36 | K7EP36_HUMAN | Galectin-3-binding protein | LGALS3BP | 259 | Annotation score: | ||
K7EJD3 | K7EJD3_HUMAN | Galectin-3-binding protein | LGALS3BP | 205 | Annotation score: | ||
K7EJY8 | K7EJY8_HUMAN | Galectin-3-binding protein | LGALS3BP | 144 | Annotation score: | ||
K7ES75 | K7ES75_HUMAN | Galectin-3-binding protein | LGALS3BP | 88 | Annotation score: | ||
K7ESM3 | K7ESM3_HUMAN | Galectin-3-binding protein | LGALS3BP | 209 | Annotation score: | ||
K7EKQ5 | K7EKQ5_HUMAN | Galectin-3-binding protein | LGALS3BP | 210 | Annotation score: | ||
K7ERZ6 | K7ERZ6_HUMAN | Galectin-3-binding protein | LGALS3BP | 131 | Annotation score: | ||
K7EN99 | K7EN99_HUMAN | Galectin-3-binding protein | LGALS3BP | 113 | Annotation score: | ||
K7EQT9 | K7EQT9_HUMAN | Galectin-3-binding protein | LGALS3BP | 48 | Annotation score: | ||
K7ER67 | K7ER67_HUMAN | Galectin-3-binding protein | LGALS3BP | 41 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | V → S AA sequence (PubMed:8757764).Curated | 1 | |
Sequence conflicti | 25 | R → C AA sequence (PubMed:8454062).Curated | 1 | |
Sequence conflicti | 25 | R → P AA sequence (PubMed:8454062).Curated | 1 | |
Sequence conflicti | 26 | L → M AA sequence (PubMed:8757764).Curated | 1 | |
Sequence conflicti | 30 – 31 | GA → ED AA sequence (PubMed:8757764).Curated | 2 | |
Sequence conflicti | 36 | R → H AA sequence (PubMed:8757764).Curated | 1 | |
Sequence conflicti | 36 | R → L AA sequence (PubMed:8454062).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13210 mRNA Translation: AAA36193.1 X79089 mRNA Translation: CAA55699.1 BC002403 mRNA Translation: AAH02403.1 BC002998 mRNA Translation: AAH02998.1 BC015761 mRNA Translation: AAH15761.1 |
CCDSi | CCDS11759.1 |
PIRi | A47161 A55899 |
RefSeqi | NP_005558.1, NM_005567.3 |
Genome annotation databases
Ensembli | ENST00000262776; ENSP00000262776; ENSG00000108679 |
GeneIDi | 3959 |
KEGGi | hsa:3959 |
MANE-Selecti | ENST00000262776.8; ENSP00000262776.2; NM_005567.4; NP_005558.1 |
UCSCi | uc002jwh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13210 mRNA Translation: AAA36193.1 X79089 mRNA Translation: CAA55699.1 BC002403 mRNA Translation: AAH02403.1 BC002998 mRNA Translation: AAH02998.1 BC015761 mRNA Translation: AAH15761.1 |
CCDSi | CCDS11759.1 |
PIRi | A47161 A55899 |
RefSeqi | NP_005558.1, NM_005567.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BY2 | X-ray | 2.00 | A | 19-133 | [»] | |
6GFB | X-ray | 2.08 | A/B | 124-250 | [»] | |
SMRi | Q08380 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110150, 242 interactors |
IntActi | Q08380, 136 interactors |
MINTi | Q08380 |
STRINGi | 9606.ENSP00000262776 |
PTM databases
GlyConnecti | 1256, 74 N-Linked glycans (6 sites) |
GlyGeni | Q08380, 9 sites, 86 N-linked glycans (6 sites), 2 O-linked glycans (2 sites) |
iPTMneti | Q08380 |
PhosphoSitePlusi | Q08380 |
SwissPalmi | Q08380 |
Genetic variation databases
BioMutai | LGALS3BP |
DMDMi | 47115668 |
Proteomic databases
CPTACi | CPTAC-534 CPTAC-535 CPTAC-670 non-CPTAC-1125 non-CPTAC-2670 |
EPDi | Q08380 |
jPOSTi | Q08380 |
MassIVEi | Q08380 |
MaxQBi | Q08380 |
PaxDbi | Q08380 |
PeptideAtlasi | Q08380 |
PRIDEi | Q08380 |
ProteomicsDBi | 58606 |
Protocols and materials databases
Antibodypediai | 604, 420 antibodies from 35 providers |
DNASUi | 3959 |
Genome annotation databases
Ensembli | ENST00000262776; ENSP00000262776; ENSG00000108679 |
GeneIDi | 3959 |
KEGGi | hsa:3959 |
MANE-Selecti | ENST00000262776.8; ENSP00000262776.2; NM_005567.4; NP_005558.1 |
UCSCi | uc002jwh.4, human |
Organism-specific databases
CTDi | 3959 |
DisGeNETi | 3959 |
GeneCardsi | LGALS3BP |
HGNCi | HGNC:6564, LGALS3BP |
HPAi | ENSG00000108679, Low tissue specificity |
MIMi | 600626, gene |
neXtProti | NX_Q08380 |
OpenTargetsi | ENSG00000108679 |
PharmGKBi | PA30341 |
VEuPathDBi | HostDB:ENSG00000108679 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU48, Eukaryota |
GeneTreei | ENSGT00940000162516 |
HOGENOMi | CLU_032646_0_0_1 |
InParanoidi | Q08380 |
OrthoDBi | 1174057at2759 |
PhylomeDBi | Q08380 |
TreeFami | TF331368 |
Enzyme and pathway databases
PathwayCommonsi | Q08380 |
Reactomei | R-HSA-114608, Platelet degranulation |
SignaLinki | Q08380 |
SIGNORi | Q08380 |
Miscellaneous databases
BioGRID-ORCSi | 3959, 12 hits in 1083 CRISPR screens |
ChiTaRSi | LGALS3BP, human |
EvolutionaryTracei | Q08380 |
GeneWikii | LGALS3BP |
GenomeRNAii | 3959 |
Pharosi | Q08380, Tbio |
PROi | PR:Q08380 |
RNActi | Q08380, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108679, Expressed in heart left ventricle and 235 other tissues |
ExpressionAtlasi | Q08380, baseline and differential |
Genevisiblei | Q08380, HS |
Family and domain databases
Gene3Di | 3.10.250.10, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00530, SRCR, 1 hit |
PRINTSi | PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00202, SR, 1 hit |
SUPFAMi | SSF56487, SSF56487, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00420, SRCR_1, 1 hit PS50287, SRCR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LG3BP_HUMAN | |
Accessioni | Q08380Primary (citable) accession number: Q08380 Secondary accession number(s): Q7M4S0 Q9UCI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references