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UniProtKB - Q08379 (GOGA2_HUMAN)

Protein

Golgin subfamily A member 2

Gene

GOLGA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).By similarity1 Publication6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • importin-alpha family protein binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • syntaxin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q08379

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q08379 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein1 Publication
Short name:
GM1302 Publications
GM130 autoantigen1 Publication
Golgin-951 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000167110.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:4425 GOLGA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602580 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q08379

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18R → K: Impaired methylation; when associated with R-30 and R-35. 1 Publication1
Mutagenesisi26 – 49KKKLR…KKKKK → AAALAEYQQANSPGVPTGAA AAAA: Abolishes interaction with importin-alpha. 1 PublicationAdd BLAST24
Mutagenesisi30R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication1
Mutagenesisi35R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication1
Mutagenesisi37S → D: Phosphomimetic mutant. Does not affect interaction with importin-alpha. 1 Publication1
Mutagenesisi987F → A: Abolishes interaction with GORASP1. Abolishes membrane clustering. 1 Publication1
Mutagenesisi1002I → R: Abolishes interaction with GORASP1. Abolishes membrane clustering. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		2801

Open Targets

More...OpenTargetsi		ENSG00000167110

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28805

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GOLGA2

Domain mapping of disease mutations (DMDM)

More...DMDMi		294862511

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900541 – 1002Golgin subfamily A member 2Add BLAST1002

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Omega-N-methylated arginine1 Publication1
Modified residuei30Dimethylated arginine1 Publication1
Modified residuei35Dimethylated arginine1 Publication1
Modified residuei37PhosphoserineCombined sources1 Publication1
Modified residuei66PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1
Modified residuei981PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by caspases at the onset of apoptosis.1 Publication
Methylation by PRMT5 is required for Golgi ribbon formation. While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear whether Arg-18 is methylated in vivo.1 Publication
Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble (By similarity).By similarity2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q08379

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q08379

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q08379

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q08379

PeptideAtlas

More...PeptideAtlasi		Q08379

PRoteomics IDEntifications database

More...PRIDEi		Q08379

ProteomicsDB human proteome resource

More...ProteomicsDBi		58604
58605 [Q08379-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q08379

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q08379

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167110 Expressed in 206 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

More...CleanExi		HS_GOLGA2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q08379 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q08379 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB015421
HPA021178
HPA021230
HPA021799

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, may assemble into homohexamers (PubMed:26363069). Homotetramer; forms a parallel homotetramer with a flexible rod-like structure that can give rise to I- and Y-shaped conformations (By similarity). Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989, PubMed:26363069). The homooligomer forms a complex with GORASP1 with a 1:1 stoichiometry (By similarity). Interacts with RAB1B that has been activated by GTP-binding (PubMed:11306556). Interacts with p115/USO1; interaction with p115/USO1 inhibits interaction with STX5 and/or RAB1B. Interacts with STX5 (By similarity). Interacts with ZFPL1 (PubMed:18323775). Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (PubMed:19242490).By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-618309,EBI-618309
A8K2R33EBI-618309,EBI-9977437
P299913EBI-618309,EBI-8826488From Dengue virus type 2 (strain 16681-PDK53).
Q9WMX22EBI-618309,EBI-6863748From Hepatitis C virus genotype 1b (isolate Con1).
ADAP1O756893EBI-618309,EBI-714732
AESQ081173EBI-618309,EBI-717810
AESQ08117-25EBI-618309,EBI-11741437
AFF4Q9UHB73EBI-618309,EBI-395282
AFF4Q9UHB7-23EBI-618309,EBI-10261324
AKAP9Q999963EBI-618309,EBI-1048311
ALKBH3Q96Q833EBI-618309,EBI-6658697
AMOTL2Q9Y2J4-43EBI-618309,EBI-10187270
ANKRD36BP1Q96IX95EBI-618309,EBI-744859
ARL16Q0P5N65EBI-618309,EBI-10186132
ARL4AP406175EBI-618309,EBI-2875746
ARPC3O151455EBI-618309,EBI-351829
ATP6V1C2Q8NEY4-25EBI-618309,EBI-10270867
ATP6V1DQ6PJ053EBI-618309,EBI-10253919
ATP6V1DQ8N5Z93EBI-618309,EBI-10266952
ATP6V1G1O753483EBI-618309,EBI-711802
AXIN1O151693EBI-618309,EBI-710484
BAHD1Q8TBE03EBI-618309,EBI-742750
BARD1A0AVN23EBI-618309,EBI-9977322
BARD1Q997285EBI-618309,EBI-473181
BCAS2O759347EBI-618309,EBI-1050106
BCL6P411824EBI-618309,EBI-765407
BCL6BA8KA133EBI-618309,EBI-10174813
BYSLQ138957EBI-618309,EBI-358049
C12orf50Q8NA575EBI-618309,EBI-10268935
C1orf109Q9NX043EBI-618309,EBI-8643161
C2CD6Q53TS85EBI-618309,EBI-739879
CBX8Q9HC525EBI-618309,EBI-712912
CCAR1Q8IX125EBI-618309,EBI-356265
CCDC146Q8IYE0-23EBI-618309,EBI-10247802
CCDC150Q8NCX03EBI-618309,EBI-10269342
CCDC17Q96LX73EBI-618309,EBI-719840
CCDC198Q9NVL83EBI-618309,EBI-10238351
CCDC70Q6NSX13EBI-618309,EBI-6873045
CCDC87Q9NVE45EBI-618309,EBI-749261
CCHCR1Q8TD31-37EBI-618309,EBI-10175300
CCNCP248633EBI-618309,EBI-395261
CCNHP519465EBI-618309,EBI-741406
CDC20BQ86Y333EBI-618309,EBI-10260504
CDC5LQ994595EBI-618309,EBI-374880
CDC73Q6P1J910EBI-618309,EBI-930143
CDK18Q070025EBI-618309,EBI-746238
CDKL3Q8IVW43EBI-618309,EBI-3919850
CENPPQ6IPU03EBI-618309,EBI-10250303
CEP57L1Q8IYX85EBI-618309,EBI-1104570
CEP57L1Q8IYX8-23EBI-618309,EBI-10181988
CHCHD2Q9Y6H15EBI-618309,EBI-2321769
CHCHD3Q9NX633EBI-618309,EBI-743375
CICQ96RK03EBI-618309,EBI-945857
CINPQ9BW665EBI-618309,EBI-739784
CORO1AP311463EBI-618309,EBI-1046676
CSPP1Q1MSJ5-13EBI-618309,EBI-10239122
CUL5Q930343EBI-618309,EBI-1057139
CYB5R2Q6BCY43EBI-618309,EBI-744761
DAXXQ9UER77EBI-618309,EBI-77321
DCTN4Q9UJW07EBI-618309,EBI-2134033
DCXO436024EBI-618309,EBI-8646694
DDX6P261965EBI-618309,EBI-351257
DEUP1Q05D606EBI-618309,EBI-748597
DLGAP5Q153983EBI-618309,EBI-748280
DMTNQ084953EBI-618309,EBI-715275
DTX2Q86UW93EBI-618309,EBI-740376
EFHC1Q5JVL43EBI-618309,EBI-743105
EGR2A0A0S2Z3U46EBI-618309,EBI-16431598
EIF3GO758213EBI-618309,EBI-366632
EXOSC5Q9NQT43EBI-618309,EBI-371876
FAM110AQ9BQ895EBI-618309,EBI-1752811
FAM124BQ9H5Z63EBI-618309,EBI-741626
FAM126BQ8IXS83EBI-618309,EBI-8787606
FAM161AQ3B8204EBI-618309,EBI-719941
FAM184AQ6P9G83EBI-618309,EBI-10253239
FAM193BQ96PV7-23EBI-618309,EBI-10292648
FAM207AQ9NSI23EBI-618309,EBI-5457304
FAM214AQ32MH53EBI-618309,EBI-2866142
FAM50BQ9Y2473EBI-618309,EBI-742802
FAM90A1Q86YD77EBI-618309,EBI-6658203
FBF1Q8TES7-63EBI-618309,EBI-10244131
FBXL18Q96D163EBI-618309,EBI-744419
FBXO28Q9NVF76EBI-618309,EBI-740282
FIP1L1Q6UN153EBI-618309,EBI-1021914
FLJ34048A4D1I33EBI-618309,EBI-10173415
FNDC11Q9BVV23EBI-618309,EBI-744935
GATA2P237693EBI-618309,EBI-2806671
GATAD2BQ8WXI93EBI-618309,EBI-923440
GCC1Q96CN95EBI-618309,EBI-746252
GEMP550405EBI-618309,EBI-744104
GFAPP141368EBI-618309,EBI-744302
GLYCTKQ8IVS85EBI-618309,EBI-748515
GNG5P632183EBI-618309,EBI-10220734
GORASP2Q9H8Y86EBI-618309,EBI-739467
GPANK1O958723EBI-618309,EBI-751540
GPKOWQ929175EBI-618309,EBI-746309
GSE1Q146876EBI-618309,EBI-372619
GTPBP10A4D1E93EBI-618309,EBI-5453796
HAUS1Q96CS23EBI-618309,EBI-2514791
HCTP4Q643R03EBI-618309,EBI-10248808
HDAC4P565243EBI-618309,EBI-308629
HGSA0A0S2Z4Q43EBI-618309,EBI-16429135
HGSO149643EBI-618309,EBI-740220
HOXB9P174823EBI-618309,EBI-745290
HRASLS5Q96KN8-35EBI-618309,EBI-10290304
HYLS1Q96M113EBI-618309,EBI-720016
IFT20Q8IY313EBI-618309,EBI-744203
IFT27Q9BW833EBI-618309,EBI-747093
INPP5JQ157355EBI-618309,EBI-10236940
ISCUQ9H1K13EBI-618309,EBI-1047335
ITPKBP279874EBI-618309,EBI-751388
KANK2Q63ZY36EBI-618309,EBI-2556193
KANSL1Q7Z3B34EBI-618309,EBI-740244
KAT5Q929933EBI-618309,EBI-399080
KIAA1217Q5T5P2-65EBI-618309,EBI-10188326
KIFC3Q9BVG83EBI-618309,EBI-2125614
KRT1P042645EBI-618309,EBI-298429
KRT18P057836EBI-618309,EBI-297888
KRT6AP025386EBI-618309,EBI-702198
KRT6BP042593EBI-618309,EBI-740907
KRT6CP486683EBI-618309,EBI-2564105
LASP1Q148473EBI-618309,EBI-742828
LATS1Q6PJG33EBI-618309,EBI-10253976
LCORQ96JN03EBI-618309,EBI-746045
LCP2Q130945EBI-618309,EBI-346946
LENG1Q96BZ87EBI-618309,EBI-726510
LGALS3P179313EBI-618309,EBI-1170392
LGALS3Q6NVH93EBI-618309,EBI-10187804
LHX4A0A0S2Z5S93EBI-618309,EBI-16429099
LIMS2Q7Z4I7-53EBI-618309,EBI-10257651
LIN7AO149103EBI-618309,EBI-2513988
LINGO1Q96FE53EBI-618309,EBI-719955
LMO1P258005EBI-618309,EBI-8639312
LMO2P257913EBI-618309,EBI-739696
LMO3Q8TAP4-44EBI-618309,EBI-11742507
LMO4P619685EBI-618309,EBI-2798728
LYPLA1Q6IAQ13EBI-618309,EBI-10249913
LYSMD1Q96S903EBI-618309,EBI-10293291
MAB21L2Q9Y5863EBI-618309,EBI-6659161
MAGOHP613265EBI-618309,EBI-299134
MAGOHBQ96A725EBI-618309,EBI-746778
MBD3O959833EBI-618309,EBI-1783068
MCM10Q7L590-23EBI-618309,EBI-10233517
MCM7P339933EBI-618309,EBI-355924
MFAP1P550815EBI-618309,EBI-1048159
MID2Q9UJV3-23EBI-618309,EBI-10172526
MMTAG2Q9BU764EBI-618309,EBI-742459
MNAT1P519483EBI-618309,EBI-716139
MORF4L1Q9UBU83EBI-618309,EBI-399246
MORF4L2Q150143EBI-618309,EBI-399257
MORN3Q6PF185EBI-618309,EBI-9675802
MOSP005405EBI-618309,EBI-1757866
MSRB3Q8IXL73EBI-618309,EBI-8634060
MST4Q499L93EBI-618309,EBI-6137569
MTFR2Q6P4443EBI-618309,EBI-10252703
MYEF2Q9P2K5-25EBI-618309,EBI-10318831
NCF2P198789EBI-618309,EBI-489611
NDEL1Q9GZM83EBI-618309,EBI-928842
NEBLO760413EBI-618309,EBI-2880203
NEFLI6L9F63EBI-618309,EBI-10178578
NEFLP071963EBI-618309,EBI-475646
NME7Q9Y5B85EBI-618309,EBI-744782
NOS3P294745EBI-618309,EBI-1391623
NUDT21O438095EBI-618309,EBI-355720
NXT2Q9NPJ83EBI-618309,EBI-752122
ORC1LQ96F823EBI-618309,EBI-10285558
PARD6BQ9BYG53EBI-618309,EBI-295391
PATL1Q86TB95EBI-618309,EBI-2562092
PIAS2O759283EBI-618309,EBI-348555
PID1Q7Z2X43EBI-618309,EBI-10256685
PIK3R2O004593EBI-618309,EBI-346930
PIMREGQ9BSJ63EBI-618309,EBI-2568609
PIN1Q135265EBI-618309,EBI-714158
PITX1P783373EBI-618309,EBI-748265
PKN1Q165125EBI-618309,EBI-602382
PKP4Q995693EBI-618309,EBI-726447
POLDIP3Q8WUT13EBI-618309,EBI-10276663
PPP1R16BQ96T495EBI-618309,EBI-10293968
PPP1R18Q6NYC85EBI-618309,EBI-2557469
PQBP1O608286EBI-618309,EBI-713867
PRKAA1Q131313EBI-618309,EBI-1181405
PRKAB2O437417EBI-618309,EBI-1053424
PRPF31Q8WWY310EBI-618309,EBI-1567797
PSMA1P257865EBI-618309,EBI-359352
PSMA4P257893EBI-618309,EBI-359310
RAB2AP610196EBI-618309,EBI-752037
RAB2BQ8WUD15EBI-618309,EBI-5542466
RAB39AQ149645EBI-618309,EBI-3048577
RAB39BQ96DA23EBI-618309,EBI-9089467
RBM17Q96I256EBI-618309,EBI-740272
RBM39Q14498-33EBI-618309,EBI-6654703
RBM41Q96IZ55EBI-618309,EBI-740773
RCOR3Q9P2K33EBI-618309,EBI-743428
RGS8P577713EBI-618309,EBI-10216117
RHNO1Q9BSD33EBI-618309,EBI-9658624
RIBC1Q8N4433EBI-618309,EBI-10265323
RITA1Q96K304EBI-618309,EBI-2836148
RNF135Q8IUD65EBI-618309,EBI-9916363
RNF213Q63HN8-63EBI-618309,EBI-10248548
RNF6A0A0S2Z4G96EBI-618309,EBI-16428950
RSPH14Q9UHP65EBI-618309,EBI-748350
RSRC2Q7L4I2-23EBI-618309,EBI-10256202
RTP5Q14D333EBI-618309,EBI-10217913
RXRBA0A0S2Z4M53EBI-618309,EBI-16436147
RXRBP28702-36EBI-618309,EBI-16429492
SAMD4AQ9UPU93EBI-618309,EBI-1047497
SAP30BPQ9UHR53EBI-618309,EBI-751683
SCAF8Q9UPN63EBI-618309,EBI-7954236
SCELO951714EBI-618309,EBI-7543896
SCNM1Q9BWG65EBI-618309,EBI-748391
SECISBP2Q96T213EBI-618309,EBI-954116
SELENOVP597973EBI-618309,EBI-10216195
SFRS2Q6NXQ03EBI-618309,EBI-10251550
SH2D4AQ9H7885EBI-618309,EBI-747035
SH2D4AQ9H788-23EBI-618309,EBI-10308083
SH3RF2Q08AM83EBI-618309,EBI-10225873
SHC3Q925293EBI-618309,EBI-79084
SLU7O953915EBI-618309,EBI-750559
SMARCE1Q969G35EBI-618309,EBI-455078
SMCPP499013EBI-618309,EBI-750494
SNAP47Q5SQN13EBI-618309,EBI-10244848
SNF8Q96H203EBI-618309,EBI-747719
SNRPBP14678-23EBI-618309,EBI-372475
SNRPB2P085793EBI-618309,EBI-1053651
SNRPCQ5TAL43EBI-618309,EBI-10246938
SNW1Q135735EBI-618309,EBI-632715
SPATA2Q9UM823EBI-618309,EBI-744066
SPATA22Q8NHS93EBI-618309,EBI-7067260
STAMBPL1Q96FJ03EBI-618309,EBI-745021
STK25O0050613EBI-618309,EBI-618295
STK26Q9P2894EBI-618309,EBI-618239
SYT6Q5T7P8-25EBI-618309,EBI-10246152
TBC1D22BQ9NU194EBI-618309,EBI-8787464
TBPQ32MN65EBI-618309,EBI-10239991
TCEA2Q155605EBI-618309,EBI-710310
TCEANCQ8N8B73EBI-618309,EBI-954696
TCF19D2IYK53EBI-618309,EBI-10176552
TCF19Q9Y2423EBI-618309,EBI-7413767
TCL1AP562797EBI-618309,EBI-749995
TEAD4D3DUQ63EBI-618309,EBI-10176734
TEAD4Q155615EBI-618309,EBI-747736
TEX9A0A0S2Z5Z93EBI-618309,EBI-16431655
TEX9Q8N6V93EBI-618309,EBI-746341
TFAP4Q016645EBI-618309,EBI-2514218
THAP7Q9BT493EBI-618309,EBI-741350
TPM1P094933EBI-618309,EBI-351158
TPM1P09493-103EBI-618309,EBI-12123928
TPM1P09493-53EBI-618309,EBI-10196387
TRAF4Q9BUZ44EBI-618309,EBI-3650647
TRIM29Q141345EBI-618309,EBI-702370
TRIM42Q8IWZ53EBI-618309,EBI-5235829
TSC22D4Q8IV543EBI-618309,EBI-10261521
TSSC4Q9Y5U23EBI-618309,EBI-717229
TSSK3Q96PN85EBI-618309,EBI-3918381
TTC23Q5W5X93EBI-618309,EBI-6447954
TTC25Q96NG33EBI-618309,EBI-1046387
TTC9CQ8N5M43EBI-618309,EBI-2851213
TXLNAP402223EBI-618309,EBI-359793
UBE2IP632794EBI-618309,EBI-80168
UBE2UQ5VVX94EBI-618309,EBI-2130181
UBE3CQ153863EBI-618309,EBI-1058871
USP2O756045EBI-618309,EBI-743272
UTP14CQ08E773EBI-618309,EBI-10225961
UTP14CQ5TAP64EBI-618309,EBI-11737646
VPS28Q548N13EBI-618309,EBI-10243107
VPS28Q9UK416EBI-618309,EBI-727424
VPS37CA5D8V63EBI-618309,EBI-2559305
WASHC3Q9Y3C05EBI-618309,EBI-712969
WDYHV1Q96HA87EBI-618309,EBI-741158
YJU2Q9BW857EBI-618309,EBI-10300345
ZBTB16Q055167EBI-618309,EBI-711925
ZDHHC17Q8IUH53EBI-618309,EBI-524753
ZFC3H1G3V1X13EBI-618309,EBI-6448783
ZFP2Q6ZN573EBI-618309,EBI-7236323
ZFYVE26Q68DK2-53EBI-618309,EBI-8656416
ZGPATA0A0S2Z6H06EBI-618309,EBI-16428984
ZGPATQ8N5A53EBI-618309,EBI-3439227
ZGPATQ8N5A5-211EBI-618309,EBI-10183064
ZMAT2Q96NC05EBI-618309,EBI-2682299
ZNF124Q159733EBI-618309,EBI-2555767
ZNF250P15622-37EBI-618309,EBI-10177272
ZNF410Q86VK43EBI-618309,EBI-720304
ZNF414Q96IQ95EBI-618309,EBI-744257
ZNF417Q8TAU33EBI-618309,EBI-740727
ZNF488Q96MN93EBI-618309,EBI-948288
ZNF572Q7Z3I76EBI-618309,EBI-10172590
ZNF581Q9P0T43EBI-618309,EBI-745520
ZNF587Q96SQ53EBI-618309,EBI-6427977
ZNF688A0A0S2Z5X46EBI-618309,EBI-16429014
ZNF688A0A0S2Z6P03EBI-618309,EBI-16429989
ZNF774Q6NX455EBI-618309,EBI-10251462

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109063, 378 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q08379

Database of interacting proteins

More...DIPi		DIP-34271N

Protein interaction database and analysis system

More...IntActi		Q08379, 561 interactors

Molecular INTeraction database

More...MINTi		Q08379

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000416097

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4REYX-ray1.96B980-1002[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q08379

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q08379

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 84Interaction with p115/USO1By similarityAdd BLAST84
Regioni992 – 1002Interaction with GORASP1/GRASP65By similarityAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 892Sequence analysisAdd BLAST877

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi26 – 49Nuclear localization signal1 PublicationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 51Poly-Lys6
Compositional biasi449 – 455Poly-Pro7
Compositional biasi704 – 715Poly-GluAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with long coiled-coil domains.By similarity
The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410INYK Eukaryota
ENOG4111MFD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000062932

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000218631

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051752

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q08379

KEGG Orthology (KO)

More...KOi		K20358

Identification of Orthologs from Complete Genome Data

More...OMAi		FERHEFQ

Database of Orthologous Groups

More...OrthoDBi		358120at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q08379

TreeFam database of animal gene trees

More...TreeFami		TF316990

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024858 Golgin_A

The PANTHER Classification System

More...PANTHERi		PTHR10881 PTHR10881, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15070 GOLGA2L5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI 
        60         70         80         90        100
KNGSNPETTT SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM 
       110        120        130        140        150
AASQNHDADN VPNLMDETKT FSSTESLRQL SQQLNGLVCE SATCVNGEGP 
       160        170        180        190        200
ASSANLKDLE SRYQQLAVAL DSSYVTNKQL NITIEKLKQQ NQEITDQLEE 
       210        220        230        240        250
EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT QHAARQKEGE 
       260        270        280        290        300
SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL 
       310        320        330        340        350
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ 
       360        370        380        390        400
QFSSRCEAPD ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL 
       410        420        430        440        450
KGESAMWRQR MQQMSEQVHT LREEKECSMS RVQELETSLA ELRNQMAEPP 
       460        470        480        490        500
PPEPPAGPSE VEQQLQAEAE HLRKELEGLA GQLQAQVQDN EGLSRLNREQ 
       510        520        530        540        550
EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS QNRELKEQLA 
       560        570        580        590        600
ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL 
       610        620        630        640        650
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL 
       660        670        680        690        700
QQQEAQGKAV AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG 
       710        720        730        740        750
LDREEEEDEE EEEEEAVAVP QPMPSIPEDL ESREAMVAFF NSAVASAEEE 
       760        770        780        790        800
QARLRGQLKE QRVRCRRLAH LLASAQKEPE AAAPAPGTGG DSVCGETHRA 
       810        820        830        840        850
LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET DTIGEYIALY 
       860        870        880        890        900
QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH 
       910        920        930        940        950
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR 
       960        970        980        990       1000
EGSPRDNPTA QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT 

VI
Length:1,002
Mass (Da):113,086
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD067145C5092237
GO
Isoform 2 (identifier: Q08379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Show »
Length:620
Mass (Da):70,473
Checksum:i54B31A0FBB42BFC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZC06B7ZC06_HUMAN
Golgin subfamily A member 2
GOLGA2
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYC0A0A087WYC0_HUMAN
Golgin subfamily A member 2
GOLGA2
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7B8H0Y7B8_HUMAN
Golgin subfamily A member 2
GOLGA2
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GND7R4GND7_HUMAN
Golgin subfamily A member 2
GOLGA2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQY5A0A1W2PQY5_HUMAN
Golgin subfamily A member 2
GOLGA2
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Q2TH77A0A2Q2TH77_HUMAN
Golgin subfamily A member 2
GOLGA2
990Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH69268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAP35912 differs from that shown. Sequence differs from that shown after position 826 due to an internal deletion.Curated
The sequence EAW87762 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti709Missing in AAP35912 (Ref. 6) Curated1
Sequence conflicti762R → S in AAP35912 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033974902R → G. Corresponds to variant dbSNP:rs2240961Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0077271 – 382Missing in isoform 2. 1 PublicationAdd BLAST382

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L06147 mRNA Translation: AAA35920.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87762.1 Sequence problems.
BC014188 mRNA Translation: AAH14188.2
BC069268 mRNA Translation: AAH69268.1 Different initiation.
AF248953 mRNA Translation: AAF65550.1
BT007248 mRNA Translation: AAP35912.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		JH0821

NCBI Reference Sequences

More...RefSeqi		NP_004477.3, NM_004486.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.155827

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000421699; ENSP00000416097; ENSG00000167110 [Q08379-1]
ENST00000611957; ENSP00000478799; ENSG00000167110 [Q08379-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2801

UCSC genome browser

More...UCSCi		uc011maw.2 human [Q08379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06147 mRNA Translation: AAA35920.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87762.1 Sequence problems.
BC014188 mRNA Translation: AAH14188.2
BC069268 mRNA Translation: AAH69268.1 Different initiation.
AF248953 mRNA Translation: AAF65550.1
BT007248 mRNA Translation: AAP35912.1 Sequence problems.
PIRiJH0821
RefSeqiNP_004477.3, NM_004486.4
UniGeneiHs.155827

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4REYX-ray1.96B980-1002[»]
ProteinModelPortaliQ08379
SMRiQ08379
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109063, 378 interactors
CORUMiQ08379
DIPiDIP-34271N
IntActiQ08379, 561 interactors
MINTiQ08379
STRINGi9606.ENSP00000416097

Protein family/group databases

MoonDBiQ08379 Predicted

PTM databases

iPTMnetiQ08379
PhosphoSitePlusiQ08379

Polymorphism and mutation databases

BioMutaiGOLGA2
DMDMi294862511

Proteomic databases

EPDiQ08379
jPOSTiQ08379
MaxQBiQ08379
PaxDbiQ08379
PeptideAtlasiQ08379
PRIDEiQ08379
ProteomicsDBi58604
58605 [Q08379-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2801
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421699; ENSP00000416097; ENSG00000167110 [Q08379-1]
ENST00000611957; ENSP00000478799; ENSG00000167110 [Q08379-1]
GeneIDi2801
KEGGihsa:2801
UCSCiuc011maw.2 human [Q08379-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2801
DisGeNETi2801
EuPathDBiHostDB:ENSG00000167110.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		GOLGA2

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0010915
HIX0017404
HIX0177625
HIX0177626
HGNCiHGNC:4425 GOLGA2
HPAiCAB015421
HPA021178
HPA021230
HPA021799
MIMi602580 gene
neXtProtiNX_Q08379
OpenTargetsiENSG00000167110
PharmGKBiPA28805

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410INYK Eukaryota
ENOG4111MFD LUCA
GeneTreeiENSGT00530000062932
HOGENOMiHOG000218631
HOVERGENiHBG051752
InParanoidiQ08379
KOiK20358
OMAiFERHEFQ
OrthoDBi358120at2759
PhylomeDBiQ08379
TreeFamiTF316990

Enzyme and pathway databases

ReactomeiR-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORiQ08379

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GOLGA2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GOLGA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2801

Protein Ontology

More...PROi		PR:Q08379

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167110 Expressed in 206 organ(s), highest expression level in adenohypophysis
CleanExiHS_GOLGA2
ExpressionAtlasiQ08379 baseline and differential
GenevisibleiQ08379 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08379
Secondary accession number(s): A0A0C4DGS5
, Q6GRM9, Q9BRB0, Q9NYF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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