UniProtKB - Q08379 (GOGA2_HUMAN)
Golgin subfamily A member 2
GOLGA2
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- importin-alpha family protein binding Source: UniProtKB
- microtubule binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- syntaxin binding Source: UniProtKB
GO - Biological processi
- asymmetric cell division Source: UniProtKB
- centrosome cycle Source: UniProtKB
- COPII vesicle coating Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- Golgi disassembly Source: UniProtKB
- Golgi organization Source: GO_Central
- Golgi ribbon formation Source: UniProtKB
- microtubule nucleation Source: UniProtKB
- mitotic spindle assembly Source: UniProtKB
- negative regulation of autophagy Source: ParkinsonsUK-UCL
- negative regulation of protein binding Source: UniProtKB
- positive regulation of protein glycosylation Source: ParkinsonsUK-UCL
- positive regulation of ubiquitin protein ligase activity Source: Reactome
- protein glycosylation Source: UniProtKB
- protein homotetramerization Source: UniProtKB
- protein transport Source: UniProtKB-KW
- spindle assembly Source: UniProtKB
- spindle assembly involved in meiosis Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q08379 |
Reactomei | R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
SIGNORi | Q08379 |
Protein family/group databases
MoonDBi | Q08379, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Golgin subfamily A member 2Alternative name(s): 130 kDa cis-Golgi matrix protein1 Publication Short name: GM1302 Publications GM130 autoantigen1 Publication Golgin-951 Publication |
Gene namesi | Name:GOLGA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4425, GOLGA2 |
MIMi | 602580, gene |
neXtProti | NX_Q08379 |
VEuPathDBi | HostDB:ENSG00000167110.16 |
Subcellular locationi
Cytoskeleton
- spindle pole 1 Publication
Golgi apparatus
- cis-Golgi network membrane 1 Publication1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Note: Associates with the mitotic spindle during mitosis (PubMed:26165940).By similarity1 Publication
Cytoskeleton
- microtubule Source: UniProtKB-KW
- mitotic spindle Source: UniProtKB
- spindle pole Source: UniProtKB
Golgi apparatus
- cis-Golgi network Source: UniProtKB
- Golgi apparatus Source: UniProtKB
- Golgi cis cisterna Source: CACAO
- Golgi cisterna membrane Source: UniProtKB
- Golgi membrane Source: Reactome
Other locations
- COPII-coated ER to Golgi transport vesicle Source: UniProtKB
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, MicrotubulePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 18 | R → K: Impaired methylation; when associated with R-30 and R-35. 1 Publication | 1 | |
Mutagenesisi | 26 – 49 | KKKLR…KKKKK → AAALAEYQQANSPGVPTGAA AAAA: Abolishes interaction with importin-alpha. 1 PublicationAdd BLAST | 24 | |
Mutagenesisi | 30 | R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication | 1 | |
Mutagenesisi | 35 | R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication | 1 | |
Mutagenesisi | 37 | S → D: Phosphomimetic mutant. Does not affect interaction with importin-alpha. 1 Publication | 1 | |
Mutagenesisi | 987 | F → A: Abolishes interaction with GORASP1. Abolishes membrane clustering. 1 Publication | 1 | |
Mutagenesisi | 1002 | I → R: Abolishes interaction with GORASP1. Abolishes membrane clustering. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2801 |
OpenTargetsi | ENSG00000167110 |
PharmGKBi | PA28805 |
Miscellaneous databases
Pharosi | Q08379, Tbio |
Genetic variation databases
BioMutai | GOLGA2 |
DMDMi | 294862511 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190054 | 1 – 1002 | Golgin subfamily A member 2Add BLAST | 1002 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | Dimethylated arginine1 Publication | 1 | |
Modified residuei | 30 | Dimethylated arginine1 Publication | 1 | |
Modified residuei | 35 | Dimethylated arginine1 Publication | 1 | |
Modified residuei | 37 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 66 | PhosphoserineCombined sources | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 | |
Modified residuei | 438 | PhosphoserineCombined sources | 1 | |
Modified residuei | 690 | PhosphoserineCombined sources | 1 | |
Modified residuei | 937 | PhosphoserineCombined sources | 1 | |
Modified residuei | 953 | PhosphoserineCombined sources | 1 | |
Modified residuei | 981 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q08379 |
jPOSTi | Q08379 |
MassIVEi | Q08379 |
MaxQBi | Q08379 |
PaxDbi | Q08379 |
PeptideAtlasi | Q08379 |
PRIDEi | Q08379 |
ProteomicsDBi | 58604 [Q08379-1] 58605 [Q08379-2] |
PTM databases
iPTMneti | Q08379 |
PhosphoSitePlusi | Q08379 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167110, Expressed in adenohypophysis and 219 other tissues |
ExpressionAtlasi | Q08379, baseline and differential |
Genevisiblei | Q08379, HS |
Organism-specific databases
HPAi | ENSG00000167110, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer, may assemble into homohexamers (PubMed:26363069). Homotetramer; forms a parallel homotetramer with a flexible rod-like structure that can give rise to I- and Y-shaped conformations (By similarity).
Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989, PubMed:26363069). The homooligomer forms a complex with GORASP1 with a 1:1 stoichiometry (By similarity).
Interacts with RAB1B that has been activated by GTP-binding (PubMed:11306556).
Interacts with p115/USO1; interaction with p115/USO1 inhibits interaction with STX5 and/or RAB1B.
Interacts with STX5 (By similarity).
Interacts with ZFPL1 (PubMed:18323775).
Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (PubMed:19242490).
By similarity6 PublicationsBinary interactionsi
Q08379
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- importin-alpha family protein binding Source: UniProtKB
- microtubule binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109063, 629 interactors |
ComplexPortali | CPX-874, GRASP65-GM130 Golgi stacking complex |
CORUMi | Q08379 |
DIPi | DIP-34271N |
IntActi | Q08379, 600 interactors |
MINTi | Q08379 |
STRINGi | 9606.ENSP00000416097 |
Miscellaneous databases
RNActi | Q08379, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q08379 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | Interaction with p115/USO1By similarityAdd BLAST | 84 | |
Regioni | 992 – 1002 | Interaction with GORASP1/GRASP65By similarityAdd BLAST | 11 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 16 – 892 | Sequence analysisAdd BLAST | 877 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 26 – 49 | Nuclear localization signal1 PublicationAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 46 – 51 | Poly-Lys | 6 | |
Compositional biasi | 449 – 455 | Poly-Pro | 7 | |
Compositional biasi | 704 – 715 | Poly-GluAdd BLAST | 12 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4725, Eukaryota |
GeneTreei | ENSGT00530000062932 |
InParanoidi | Q08379 |
OMAi | HVAAYQQ |
OrthoDBi | 358120at2759 |
PhylomeDBi | Q08379 |
TreeFami | TF316990 |
Family and domain databases
InterProi | View protein in InterPro IPR043937, GM130_C IPR043976, GOLGA_cons_dom IPR024858, Golgin_A |
PANTHERi | PTHR10881, PTHR10881, 1 hit |
Pfami | View protein in Pfam PF19046, GM130_C, 1 hit PF15070, GOLGA2L5, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI
60 70 80 90 100
KNGSNPETTT SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM
110 120 130 140 150
AASQNHDADN VPNLMDETKT FSSTESLRQL SQQLNGLVCE SATCVNGEGP
160 170 180 190 200
ASSANLKDLE SRYQQLAVAL DSSYVTNKQL NITIEKLKQQ NQEITDQLEE
210 220 230 240 250
EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT QHAARQKEGE
260 270 280 290 300
SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
310 320 330 340 350
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ
360 370 380 390 400
QFSSRCEAPD ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL
410 420 430 440 450
KGESAMWRQR MQQMSEQVHT LREEKECSMS RVQELETSLA ELRNQMAEPP
460 470 480 490 500
PPEPPAGPSE VEQQLQAEAE HLRKELEGLA GQLQAQVQDN EGLSRLNREQ
510 520 530 540 550
EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS QNRELKEQLA
560 570 580 590 600
ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
610 620 630 640 650
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL
660 670 680 690 700
QQQEAQGKAV AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG
710 720 730 740 750
LDREEEEDEE EEEEEAVAVP QPMPSIPEDL ESREAMVAFF NSAVASAEEE
760 770 780 790 800
QARLRGQLKE QRVRCRRLAH LLASAQKEPE AAAPAPGTGG DSVCGETHRA
810 820 830 840 850
LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET DTIGEYIALY
860 870 880 890 900
QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
910 920 930 940 950
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR
960 970 980 990 1000
EGSPRDNPTA QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT
VI
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZC06 | B7ZC06_HUMAN | Golgin subfamily A member 2 | GOLGA2 | 461 | Annotation score: | ||
H0Y7B8 | H0Y7B8_HUMAN | Golgin subfamily A member 2 | GOLGA2 | 234 | Annotation score: | ||
A0A087WYC0 | A0A087WYC0_HUMAN | Golgin subfamily A member 2 | GOLGA2 | 286 | Annotation score: | ||
A0A1W2PQY5 | A0A1W2PQY5_HUMAN | Golgin subfamily A member 2 | GOLGA2 | 346 | Annotation score: | ||
A0A6Q8KRG2 | A0A6Q8KRG2_HUMAN | Golgin subfamily A member 2 | GOLGA2 | 990 | Annotation score: | ||
R4GND7 | R4GND7_HUMAN | Golgin subfamily A member 2 | GOLGA2 | 87 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 709 | Missing in AAP35912 (Ref. 6) Curated | 1 | |
Sequence conflicti | 762 | R → S in AAP35912 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033974 | 902 | R → G. Corresponds to variant dbSNP:rs2240961Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007727 | 1 – 382 | Missing in isoform 2. 1 PublicationAdd BLAST | 382 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06147 mRNA Translation: AAA35920.1 AL590708 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87762.1 Sequence problems. BC014188 mRNA Translation: AAH14188.2 BC069268 mRNA Translation: AAH69268.1 Different initiation. AF248953 mRNA Translation: AAF65550.1 BT007248 mRNA Translation: AAP35912.1 Sequence problems. |
PIRi | JH0821 |
RefSeqi | NP_004477.3, NM_004486.4 |
Genome annotation databases
Ensembli | ENST00000611957; ENSP00000478799; ENSG00000167110 [Q08379-1] |
GeneIDi | 2801 |
KEGGi | hsa:2801 |
UCSCi | uc011maw.2, human [Q08379-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06147 mRNA Translation: AAA35920.1 AL590708 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87762.1 Sequence problems. BC014188 mRNA Translation: AAH14188.2 BC069268 mRNA Translation: AAH69268.1 Different initiation. AF248953 mRNA Translation: AAF65550.1 BT007248 mRNA Translation: AAP35912.1 Sequence problems. |
PIRi | JH0821 |
RefSeqi | NP_004477.3, NM_004486.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4REY | X-ray | 1.96 | B | 980-1002 | [»] | |
6IW8 | X-ray | 2.80 | A | 13-60 | [»] | |
6IWA | X-ray | 2.40 | A | 25-52 | [»] | |
6K06 | X-ray | 1.75 | A | 13-60 | [»] | |
SMRi | Q08379 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109063, 629 interactors |
ComplexPortali | CPX-874, GRASP65-GM130 Golgi stacking complex |
CORUMi | Q08379 |
DIPi | DIP-34271N |
IntActi | Q08379, 600 interactors |
MINTi | Q08379 |
STRINGi | 9606.ENSP00000416097 |
Protein family/group databases
MoonDBi | Q08379, Predicted |
PTM databases
iPTMneti | Q08379 |
PhosphoSitePlusi | Q08379 |
Genetic variation databases
BioMutai | GOLGA2 |
DMDMi | 294862511 |
Proteomic databases
EPDi | Q08379 |
jPOSTi | Q08379 |
MassIVEi | Q08379 |
MaxQBi | Q08379 |
PaxDbi | Q08379 |
PeptideAtlasi | Q08379 |
PRIDEi | Q08379 |
ProteomicsDBi | 58604 [Q08379-1] 58605 [Q08379-2] |
Protocols and materials databases
Antibodypediai | 4216, 391 antibodies |
DNASUi | 2801 |
Genome annotation databases
Ensembli | ENST00000611957; ENSP00000478799; ENSG00000167110 [Q08379-1] |
GeneIDi | 2801 |
KEGGi | hsa:2801 |
UCSCi | uc011maw.2, human [Q08379-1] |
Organism-specific databases
CTDi | 2801 |
DisGeNETi | 2801 |
GeneCardsi | GOLGA2 |
HGNCi | HGNC:4425, GOLGA2 |
HPAi | ENSG00000167110, Low tissue specificity |
MIMi | 602580, gene |
neXtProti | NX_Q08379 |
OpenTargetsi | ENSG00000167110 |
PharmGKBi | PA28805 |
VEuPathDBi | HostDB:ENSG00000167110.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4725, Eukaryota |
GeneTreei | ENSGT00530000062932 |
InParanoidi | Q08379 |
OMAi | HVAAYQQ |
OrthoDBi | 358120at2759 |
PhylomeDBi | Q08379 |
TreeFami | TF316990 |
Enzyme and pathway databases
PathwayCommonsi | Q08379 |
Reactomei | R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
SIGNORi | Q08379 |
Miscellaneous databases
BioGRID-ORCSi | 2801, 31 hits in 879 CRISPR screens |
ChiTaRSi | GOLGA2, human |
GeneWikii | GOLGA2 |
GenomeRNAii | 2801 |
Pharosi | Q08379, Tbio |
PROi | PR:Q08379 |
RNActi | Q08379, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167110, Expressed in adenohypophysis and 219 other tissues |
ExpressionAtlasi | Q08379, baseline and differential |
Genevisiblei | Q08379, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043937, GM130_C IPR043976, GOLGA_cons_dom IPR024858, Golgin_A |
PANTHERi | PTHR10881, PTHR10881, 1 hit |
Pfami | View protein in Pfam PF19046, GM130_C, 1 hit PF15070, GOLGA2L5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GOGA2_HUMAN | |
Accessioni | Q08379Primary (citable) accession number: Q08379 Secondary accession number(s): A0A0C4DGS5 Q9NYF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families