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Entry version 188 (22 Apr 2020)
Sequence version 3 (20 Apr 2010)
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Protein

Golgin subfamily A member 2

Gene

GOLGA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).By similarity1 Publication6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

SIGNOR Signaling Network Open Resource

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SIGNORi
Q08379

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q08379 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein1 Publication
Short name:
GM1302 Publications
GM130 autoantigen1 Publication
Golgin-951 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:4425 GOLGA2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602580 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q08379

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18R → K: Impaired methylation; when associated with R-30 and R-35. 1 Publication1
Mutagenesisi26 – 49KKKLR…KKKKK → AAALAEYQQANSPGVPTGAA AAAA: Abolishes interaction with importin-alpha. 1 PublicationAdd BLAST24
Mutagenesisi30R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication1
Mutagenesisi35R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication1
Mutagenesisi37S → D: Phosphomimetic mutant. Does not affect interaction with importin-alpha. 1 Publication1
Mutagenesisi987F → A: Abolishes interaction with GORASP1. Abolishes membrane clustering. 1 Publication1
Mutagenesisi1002I → R: Abolishes interaction with GORASP1. Abolishes membrane clustering. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
2801

Open Targets

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OpenTargetsi
ENSG00000167110

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28805

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q08379 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GOLGA2

Domain mapping of disease mutations (DMDM)

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DMDMi
294862511

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900541 – 1002Golgin subfamily A member 2Add BLAST1002

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Omega-N-methylated arginine1 Publication1
Modified residuei30Dimethylated arginine1 Publication1
Modified residuei35Dimethylated arginine1 Publication1
Modified residuei37PhosphoserineCombined sources1 Publication1
Modified residuei66PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1
Modified residuei981PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by caspases at the onset of apoptosis.1 Publication
Methylation by PRMT5 is required for Golgi ribbon formation. While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear whether Arg-18 is methylated in vivo.1 Publication
Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble (By similarity).By similarity2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q08379

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q08379

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q08379

MaxQB - The MaxQuant DataBase

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MaxQBi
Q08379

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q08379

PeptideAtlas

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PeptideAtlasi
Q08379

PRoteomics IDEntifications database

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PRIDEi
Q08379

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58604 [Q08379-1]
58605 [Q08379-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q08379

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q08379

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000167110 Expressed in adenohypophysis and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q08379 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q08379 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000167110 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, may assemble into homohexamers (PubMed:26363069). Homotetramer; forms a parallel homotetramer with a flexible rod-like structure that can give rise to I- and Y-shaped conformations (By similarity).

Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989, PubMed:26363069). The homooligomer forms a complex with GORASP1 with a 1:1 stoichiometry (By similarity).

Interacts with RAB1B that has been activated by GTP-binding (PubMed:11306556).

Interacts with p115/USO1; interaction with p115/USO1 inhibits interaction with STX5 and/or RAB1B.

Interacts with STX5 (By similarity).

Interacts with ZFPL1 (PubMed:18323775).

Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (PubMed:19242490).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q08379
With#Exp.IntAct
A0A384ME253EBI-618309,EBI-10211777
A8K2R33EBI-618309,EBI-9977437
Non-structural protein 5A (PRO_0000037551) from Hepatitis C virus genotype 1b (isolate Con1).2EBI-618309,EBI-6863748
RNA-directed RNA polymerase NS5 (PRO_0000037946) from Dengue virus type 2 (strain 16681-PDK53).3EBI-618309,EBI-8826488
itself6EBI-618309,EBI-618309
ADAP1 [O75689]3EBI-618309,EBI-714732
AFF4 [Q9UHB7]3EBI-618309,EBI-395282
AFF4 - isoform 2 [Q9UHB7-2]3EBI-618309,EBI-10261324
AKAP9 [Q99996]3EBI-618309,EBI-1048311
ALKBH2 [Q6NS38]3EBI-618309,EBI-2371780
ALKBH3 [Q96Q83]5EBI-618309,EBI-6658697
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-618309,EBI-10187270
ANKHD1 [Q8IWG5]3EBI-618309,EBI-355540
ANKRD11 [X5D778]4EBI-618309,EBI-17183751
ANKRD36 [A1A5B0]3EBI-618309,EBI-14100900
ANKRD36BP1 [Q96IX9]3EBI-618309,EBI-744859
ANKS1A [Q49AR9]3EBI-618309,EBI-11954519
AQP1 [P29972]3EBI-618309,EBI-745213
ARFIP2 [P53365]3EBI-618309,EBI-638194
ARHGAP45 [Q92619]3EBI-618309,EBI-2825900
ARHGEF6 [Q15052]3EBI-618309,EBI-1642523
ARL16 [Q0P5N6]7EBI-618309,EBI-10186132
ARL4A [P40617]6EBI-618309,EBI-2875746
ARPC3 [O15145]6EBI-618309,EBI-351829
ATP5PO [P48047]3EBI-618309,EBI-355815
ATP6V1C2 - isoform 2 [Q8NEY4-2]6EBI-618309,EBI-10270867
ATP6V1D [Q6PJ05]3EBI-618309,EBI-10253919
ATP6V1D [Q8N5Z9]3EBI-618309,EBI-10266952
ATP6V1G1 [O75348]3EBI-618309,EBI-711802
AXIN1 [O15169]3EBI-618309,EBI-710484
BAHD1 [Q8TBE0]3EBI-618309,EBI-742750
BARD1 [A0AVN2]3EBI-618309,EBI-9977322
BARD1 [Q99728]6EBI-618309,EBI-473181
BAZ2B [A0A0A0MR97]3EBI-618309,EBI-11985607
BCAS2 [O75934]9EBI-618309,EBI-1050106
BCL6 [P41182]5EBI-618309,EBI-765407
BCL6B [A8KA13]3EBI-618309,EBI-10174813
BYSL [Q13895]8EBI-618309,EBI-358049
C12orf50 [Q8NA57]7EBI-618309,EBI-10268935
C19orf44 - isoform 2 [Q9H6X5-2]3EBI-618309,EBI-12061599
C1orf109 [Q9NX04]3EBI-618309,EBI-8643161
C2CD6 [Q53TS8]6EBI-618309,EBI-739879
CAB39 [Q9Y376]3EBI-618309,EBI-306905
CAPN7 [Q9Y6W3]3EBI-618309,EBI-1765641
CASS4 - isoform 2 [Q9NQ75-2]3EBI-618309,EBI-12270182
CBX8 [Q9HC52]6EBI-618309,EBI-712912
CCAR1 [Q8IX12]6EBI-618309,EBI-356265
CCDC120 [Q96HB5]3EBI-618309,EBI-744556
CCDC13 [Q8IYE1]3EBI-618309,EBI-10961312
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-618309,EBI-10247802
CCDC150 [Q8NCX0]3EBI-618309,EBI-10269342
CCDC150 - isoform 3 [Q8NCX0-3]3EBI-618309,EBI-12235840
CCDC17 [Q96LX7]3EBI-618309,EBI-719840
CCDC185 [Q8N715]3EBI-618309,EBI-740814
CCDC198 [E9PSE9]3EBI-618309,EBI-11748295
CCDC198 [Q9NVL8]3EBI-618309,EBI-10238351
CCDC70 [Q6NSX1]3EBI-618309,EBI-6873045
CCDC87 [Q9NVE4]6EBI-618309,EBI-749261
CCHCR1 - isoform 3 [Q8TD31-3]8EBI-618309,EBI-10175300
CCNC [P24863]3EBI-618309,EBI-395261
CCNH [P51946]9EBI-618309,EBI-741406
CDC20B [Q86Y33]3EBI-618309,EBI-10260504
CDC20B - isoform 5 [Q86Y33-5]3EBI-618309,EBI-11983537
CDC37 [Q16543]3EBI-618309,EBI-295634
CDC5L [Q99459]6EBI-618309,EBI-374880
CDC7 [O00311]3EBI-618309,EBI-374980
CDC73 [Q6P1J9]12EBI-618309,EBI-930143
CDCA7L [Q96GN5]3EBI-618309,EBI-5278764
CDK18 [Q07002]6EBI-618309,EBI-746238
CDKL3 [Q8IVW4]3EBI-618309,EBI-3919850
CDKL5 [O76039]3EBI-618309,EBI-1752465
CDKN1A [P38936]3EBI-618309,EBI-375077
CENPP [Q6IPU0]3EBI-618309,EBI-10250303
CEP57L1 [Q8IYX8]6EBI-618309,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-618309,EBI-10181988
CEP95 [Q96GE4]3EBI-618309,EBI-372775
CHCHD2 [Q9Y6H1]6EBI-618309,EBI-2321769
CHCHD3 [Q9NX63]3EBI-618309,EBI-743375
CIC [Q96RK0]4EBI-618309,EBI-945857
CINP [Q9BW66]6EBI-618309,EBI-739784
CLIP3 [Q96DZ5]3EBI-618309,EBI-12823145
CORO1A [P31146]3EBI-618309,EBI-1046676
COX5B [P10606]3EBI-618309,EBI-1053725
CRACR2A [Q9BSW2]3EBI-618309,EBI-739773
CSPP1 - isoform 1 [Q1MSJ5-1]3EBI-618309,EBI-10239122
CUL5 [Q93034]3EBI-618309,EBI-1057139
CWF19L2 [Q2TBE0]3EBI-618309,EBI-5453285
CYB5R2 [Q6BCY4]3EBI-618309,EBI-744761
CYB5R2 - isoform 2 [Q6BCY4-2]3EBI-618309,EBI-12102608
DAXX [Q9UER7]8EBI-618309,EBI-77321
DCTN4 [Q9UJW0]7EBI-618309,EBI-2134033
DCX [O43602]4EBI-618309,EBI-8646694
DCX - isoform 2 [O43602-2]3EBI-618309,EBI-14148644
DDX6 [P26196]6EBI-618309,EBI-351257
DEUP1 [Q05D60]6EBI-618309,EBI-748597
DLGAP3 [O95886]3EBI-618309,EBI-1752541
DLGAP5 [Q15398]3EBI-618309,EBI-748280
DMTN [Q08495]3EBI-618309,EBI-715275
DTX2 [Q86UW9]3EBI-618309,EBI-740376
EFCAB6 - isoform 2 [Q5THR3-2]3EBI-618309,EBI-12282559
EFHC1 [Q5JVL4]3EBI-618309,EBI-743105
EGR2 [A0A0S2Z3U4]6EBI-618309,EBI-16431598
EIF3G [O75821]3EBI-618309,EBI-366632
ENKD1 [Q9H0I2]3EBI-618309,EBI-744099
ENPP7 [Q6UWV6]3EBI-618309,EBI-12047821
ESCO2 [Q56NI9]3EBI-618309,EBI-3951849
EXOC8 [Q8IYI6]3EBI-618309,EBI-742102
EXOSC5 [Q9NQT4]3EBI-618309,EBI-371876
FAM110A [Q9BQ89]6EBI-618309,EBI-1752811
FAM124B [Q9H5Z6]3EBI-618309,EBI-741626
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-618309,EBI-11986315
FAM126B [Q8IXS8]3EBI-618309,EBI-8787606
FAM161A [Q3B820]5EBI-618309,EBI-719941
FAM161B [Q96MY7]3EBI-618309,EBI-7225287
FAM184A [Q6P9G8]3EBI-618309,EBI-10253239
FAM193B - isoform 2 [Q96PV7-2]3EBI-618309,EBI-10292648
FAM207A [Q9NSI2]4EBI-618309,EBI-5457304
FAM214A [Q32MH5]3EBI-618309,EBI-2866142
FAM214B [Q7L5A3]3EBI-618309,EBI-745689
FAM50B [Q9Y247]6EBI-618309,EBI-742802
FAM90A1 [Q86YD7]8EBI-618309,EBI-6658203
FBF1 - isoform 6 [Q8TES7-6]3EBI-618309,EBI-10244131
FBXL18 [Q96D16]3EBI-618309,EBI-744419
FBXO28 [Q9NVF7]7EBI-618309,EBI-740282
FIP1L1 [Q6UN15]3EBI-618309,EBI-1021914
FLJ34048 [A4D1I3]3EBI-618309,EBI-10173415
FNDC11 [Q9BVV2]3EBI-618309,EBI-744935
FOXC2 [Q99958]3EBI-618309,EBI-3956892
GADD45GIP1 [Q8TAE8]3EBI-618309,EBI-372506
GAS2L2 [Q8NHY3]3EBI-618309,EBI-7960826
GAS8 [O95995]3EBI-618309,EBI-1052570
GATA2 [P23769]4EBI-618309,EBI-2806671
GATAD2A [Q86YP4]3EBI-618309,EBI-726224
GATAD2B [Q8WXI9]3EBI-618309,EBI-923440
GCC1 [Q96CN9]6EBI-618309,EBI-746252
GEM [P55040]6EBI-618309,EBI-744104
GFAP [P14136]9EBI-618309,EBI-744302
GGN [Q86UU5]3EBI-618309,EBI-10259069
GLYCTK [Q8IVS8]6EBI-618309,EBI-748515
GNG5 [P63218]3EBI-618309,EBI-10220734
GNL3L [Q9NVN8]3EBI-618309,EBI-746682
GORASP2 [Q9H8Y8]7EBI-618309,EBI-739467
GPANK1 [O95872]4EBI-618309,EBI-751540
GPKOW [Q92917]9EBI-618309,EBI-746309
GRB14 [Q14449]3EBI-618309,EBI-2680889
GSE1 [Q14687]9EBI-618309,EBI-372619
GTPBP10 [A4D1E9]3EBI-618309,EBI-5453796
HAUS1 [Q96CS2]3EBI-618309,EBI-2514791
HDAC4 [P56524]3EBI-618309,EBI-308629
HDAC4 - isoform 2 [P56524-2]3EBI-618309,EBI-11953488
HGS [A0A0S2Z4Q4]3EBI-618309,EBI-16429135
HGS [O14964]3EBI-618309,EBI-740220
HOXB5 [P09067]3EBI-618309,EBI-3893317
HOXB9 [P17482]3EBI-618309,EBI-745290
HYLS1 [Q96M11]3EBI-618309,EBI-720016
IFT20 [Q8IY31]3EBI-618309,EBI-744203
IFT27 [Q9BW83]3EBI-618309,EBI-747093
IGFN1 - isoform 5 [Q86VF2-5]3EBI-618309,EBI-11955401
IL16 - isoform 2 [Q14005-2]3EBI-618309,EBI-17178971
INPP5J [Q15735]6EBI-618309,EBI-10236940
IQUB [Q8NA54]3EBI-618309,EBI-10220600
ISCU [Q9H1K1]3EBI-618309,EBI-1047335
ITGB5 [P18084]3EBI-618309,EBI-1223434
ITPKB [P27987]4EBI-618309,EBI-751388
KANK2 [Q63ZY3]7EBI-618309,EBI-2556193
KANSL1 [Q7Z3B3]4EBI-618309,EBI-740244
KAT5 [Q92993]3EBI-618309,EBI-399080
KDM1A [O60341]3EBI-618309,EBI-710124
KIAA1217 - isoform 6 [Q5T5P2-6]6EBI-618309,EBI-10188326
KIFC3 [Q9BVG8]3EBI-618309,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-618309,EBI-14069005
KRT1 [P04264]6EBI-618309,EBI-298429
KRT18 [P05783]7EBI-618309,EBI-297888
KRT6A [P02538]7EBI-618309,EBI-702198
KRT6B [P04259]3EBI-618309,EBI-740907
KRT6C [P48668]3EBI-618309,EBI-2564105
KRT75 [O95678]3EBI-618309,EBI-2949715
L3MBTL2 [Q969R5]3EBI-618309,EBI-739909
LASP1 [Q14847]3EBI-618309,EBI-742828
LATS1 [Q6PJG3]3EBI-618309,EBI-10253976
LCOR [Q96JN0]3EBI-618309,EBI-746045
LCP2 [Q13094]6EBI-618309,EBI-346946
LENG1 [Q96BZ8]8EBI-618309,EBI-726510
LGALS3 [P17931]3EBI-618309,EBI-1170392
LGALS3 [Q6NVH9]3EBI-618309,EBI-10187804
LHX4 [A0A0S2Z5S9]3EBI-618309,EBI-16429099
LIMS2 - isoform 5 [Q7Z4I7-5]3EBI-618309,EBI-10257651
LIN7A [O14910]3EBI-618309,EBI-2513988
LINGO1 [Q96FE5]3EBI-618309,EBI-719955
LMNB2 [Q03252]3EBI-618309,EBI-2830427
LMO1 [P25800]6EBI-618309,EBI-8639312
LMO2 [P25791]3EBI-618309,EBI-739696
LMO3 - isoform 4 [Q8TAP4-4]5EBI-618309,EBI-11742507
LMO4 [P61968]6EBI-618309,EBI-2798728
LYPLA1 [O75608]3EBI-618309,EBI-1052185
LYPLA1 [Q6IAQ1]3EBI-618309,EBI-10249913
LYSMD1 [Q96S90]3EBI-618309,EBI-10293291
MAB21L2 [Q9Y586]3EBI-618309,EBI-6659161
MAGOH [P61326]6EBI-618309,EBI-299134
MAGOHB [Q96A72]6EBI-618309,EBI-746778
MBD3 [O95983]3EBI-618309,EBI-1783068
MBD3 - isoform 2 [O95983-2]3EBI-618309,EBI-11978579
MCM10 - isoform 2 [Q7L590-2]3EBI-618309,EBI-10233517
MCM7 [P33993]3EBI-618309,EBI-355924
MCRS1 [Q96EZ8]3EBI-618309,EBI-348259
MFAP1 [P55081]6EBI-618309,EBI-1048159
MGC50722 [Q8IVT4]3EBI-618309,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-618309,EBI-10172526
MISP [Q8IVT2]3EBI-618309,EBI-2555085
MMTAG2 [Q9BU76]4EBI-618309,EBI-742459
MNAT1 [P51948]3EBI-618309,EBI-716139
MORF4L1 [Q9UBU8]3EBI-618309,EBI-399246
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-618309,EBI-10288852
MORF4L2 [Q15014]3EBI-618309,EBI-399257
MORN3 [Q6PF18]8EBI-618309,EBI-9675802
MOS [P00540]6EBI-618309,EBI-1757866
MSRB3 [Q8IXL7]3EBI-618309,EBI-8634060
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-618309,EBI-10699187
MST4 [Q499L9]3EBI-618309,EBI-6137569
MTFR2 [Q6P444]3EBI-618309,EBI-10252703
MYEF2 - isoform 2 [Q9P2K5-2]6EBI-618309,EBI-10318831
MYOM3 - isoform 2 [Q5VTT5-2]3EBI-618309,EBI-12247808
NCF2 [P19878]9EBI-618309,EBI-489611
NDC80 [O14777]3EBI-618309,EBI-715849
NDEL1 [Q9GZM8]3EBI-618309,EBI-928842
NEBL [O76041]4EBI-618309,EBI-2880203
NEFL [I6L9F6]3EBI-618309,EBI-10178578
NEFL [P07196]3EBI-618309,EBI-475646
NME7 [Q9Y5B8]6EBI-618309,EBI-744782
NOS3 [P29474]6EBI-618309,EBI-1391623
NRIP1 [P48552]3EBI-618309,EBI-746484
NSMF - isoform 2 [Q6X4W1-2]3EBI-618309,EBI-12028784
NUDT21 [O43809]3EBI-618309,EBI-355720
NXT2 [Q9NPJ8]3EBI-618309,EBI-752122
NXT2 - isoform 3 [Q9NPJ8-3]3EBI-618309,EBI-10698339
OAS1 - isoform p41 [P00973-2]3EBI-618309,EBI-12081862
ORC1L [Q96F82]3EBI-618309,EBI-10285558
PACRGL - isoform 2 [Q8N7B6-2]3EBI-618309,EBI-10694433
PARD6B [Q9BYG5]3EBI-618309,EBI-295391
PATL1 [Q86TB9]6EBI-618309,EBI-2562092
PIAS2 [O75928]3EBI-618309,EBI-348555
PIBF1 [Q4G0R1]3EBI-618309,EBI-14066006
PID1 [Q7Z2X4]3EBI-618309,EBI-10256685
PIK3R2 [O00459]3EBI-618309,EBI-346930
PIMREG [Q9BSJ6]3EBI-618309,EBI-2568609
PIN1 [Q13526]6EBI-618309,EBI-714158
PITX1 [P78337]3EBI-618309,EBI-748265
PKN1 [Q16512]6EBI-618309,EBI-602382
PKN3 [Q6P5Z2]3EBI-618309,EBI-1384335
PKP1 - isoform 1 [Q13835-2]3EBI-618309,EBI-9087684
PKP2 - isoform 1 [Q99959-2]3EBI-618309,EBI-10987518
PKP4 [Q99569]3EBI-618309,EBI-726447
PKP4 - isoform 2 [Q99569-2]3EBI-618309,EBI-4324902
PLAAT5 - isoform 3 [Q96KN8-3]6EBI-618309,EBI-10290304
PLEKHA2 [Q9HB19]3EBI-618309,EBI-4401947
POLDIP3 [Q8WUT1]3EBI-618309,EBI-10276663
POLR3C [Q9BUI4]3EBI-618309,EBI-5452779
POM121 - isoform 2 [Q96HA1-2]3EBI-618309,EBI-11956563
POU4F3 [Q15319]3EBI-618309,EBI-12033574
PPP1R16B [Q96T49]6EBI-618309,EBI-10293968
PPP1R18 [Q6NYC8]6EBI-618309,EBI-2557469
PPP1R26 [Q5T8A7]3EBI-618309,EBI-308500
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-618309,EBI-12000762
PQBP1 [O60828]6EBI-618309,EBI-713867
PRAM1 [Q96QH2]3EBI-618309,EBI-2860740
PRKAA1 [Q13131]3EBI-618309,EBI-1181405
PRKAA2 [P54646]3EBI-618309,EBI-1383852
PRKAB2 [O43741]10EBI-618309,EBI-1053424
PRPF18 [Q99633]3EBI-618309,EBI-2798416
PRPF3 [O43395]3EBI-618309,EBI-744322
PRPF31 [Q8WWY3]11EBI-618309,EBI-1567797
PSMA1 [P25786]6EBI-618309,EBI-359352
PSMA4 [P25789]3EBI-618309,EBI-359310
PTPN21 [Q16825]3EBI-618309,EBI-2860264
RAB2A [P61019]7EBI-618309,EBI-752037
RAB2B [Q8WUD1]6EBI-618309,EBI-5542466
RAB39A [Q14964]6EBI-618309,EBI-3048577
RAB39B [Q96DA2]4EBI-618309,EBI-9089467
RAD18 [Q9NS91]3EBI-618309,EBI-2339393
RAMAC [Q9BTL3]3EBI-618309,EBI-744023
RANBP3L [Q86VV4]3EBI-618309,EBI-12028066
RBM17 [Q96I25]8EBI-618309,EBI-740272
RBM22 [Q9NW64]3EBI-618309,EBI-2602260
RBM25 [P49756]3EBI-618309,EBI-2211856
RBM39 - isoform 3 [Q14498-3]3EBI-618309,EBI-6654703
RBM41 [Q96IZ5]6EBI-618309,EBI-740773
RCL1 [Q9Y2P8]3EBI-618309,EBI-11026509
RCOR3 [Q9P2K3]3EBI-618309,EBI-743428
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-618309,EBI-1504830
RGS8 [P57771]3EBI-618309,EBI-10216117
RGS8 - isoform 2 [P57771-2]3EBI-618309,EBI-12058229
RHNO1 [Q9BSD3]3EBI-618309,EBI-9658624
RHOJ [Q9H4E5]3EBI-618309,EBI-6285694
RHPN1 [Q8TCX5]4EBI-618309,EBI-746325
RIBC1 [Q8N443]3EBI-618309,EBI-10265323
RIN1 [Q13671]3EBI-618309,EBI-366017
RITA1 [Q96K30]4EBI-618309,EBI-2836148
RNF135 [Q8IUD6]6EBI-618309,EBI-9916363
RNF169 [Q8NCN4]3EBI-618309,EBI-6380946
RNF213 - isoform 4 [Q63HN8-6]3EBI-618309,EBI-10248548
RNF6 [A0A0S2Z4G9]6EBI-618309,EBI-16428950
RSPH14 [Q9UHP6]6EBI-618309,EBI-748350
RSRC2 - isoform 2 [Q7L4I2-2]3EBI-618309,EBI-10256202
RTP5 [Q14D33]3EBI-618309,EBI-10217913
RXRB [A0A0S2Z4M5]3EBI-618309,EBI-16436147
RXRB - isoform 2 [P28702-3]6EBI-618309,EBI-16429492
SAMD4A [Q9UPU9]3EBI-618309,EBI-1047497
SAP30BP [Q9UHR5]3EBI-618309,EBI-751683
SCAF8 [Q9UPN6]4EBI-618309,EBI-7954236
SCEL [O95171]4EBI-618309,EBI-7543896
SCNM1 [Q9BWG6]5EBI-618309,EBI-748391
SECISBP2 [Q96T21]3EBI-618309,EBI-954116
SELENOV [P59797]3EBI-618309,EBI-10216195
SFRS2 [Q6NXQ0]3EBI-618309,EBI-10251550
SH2D4A [Q9H788]6EBI-618309,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-618309,EBI-10308083
SH3RF2 [Q08AM8]3EBI-618309,EBI-10225873
SH3RF2 [Q8TEC5]4EBI-618309,EBI-2130111
SHC3 [Q92529]3EBI-618309,EBI-79084
SHISA6 [Q6ZSJ9]3EBI-618309,EBI-12037847
SLU7 [O95391]6EBI-618309,EBI-750559
SMARCE1 [Q969G3]6EBI-618309,EBI-455078
SMCP [P49901]3EBI-618309,EBI-750494
SMG9 [Q9H0W8]3EBI-618309,EBI-2872322
SNAP47 [Q5SQN1]3EBI-618309,EBI-10244848
SNF8 [Q96H20]3EBI-618309,EBI-747719
SNRPB - isoform SM-B [P14678-2]3EBI-618309,EBI-372475
SNRPB2 [P08579]3EBI-618309,EBI-1053651
SNRPC [Q5TAL4]3EBI-618309,EBI-10246938
SNW1 [Q13573]6EBI-618309,EBI-632715
SNX18 [Q96RF0]3EBI-618309,EBI-298169
SORBS2 - isoform 10 [O94875-10]3EBI-618309,EBI-12037893
SPATA18 [Q8TC71]3EBI-618309,EBI-11334239
SPATA2 [Q9UM82]4EBI-618309,EBI-744066
SPATA22 [Q8NHS9]3EBI-618309,EBI-7067260
SPG21 [Q9NZD8]3EBI-618309,EBI-742688
STAC [Q99469]3EBI-618309,EBI-2652799
STAMBPL1 [Q96FJ0]3EBI-618309,EBI-745021
STK25 [O00506]15EBI-618309,EBI-618295
STK26 [Q9P289]5EBI-618309,EBI-618239
SUDS3 [Q9H7L9]3EBI-618309,EBI-540496
SUGP2 - isoform 3 [Q8IX01-3]3EBI-618309,EBI-12317645
SYNPO2L - isoform 2 [Q9H987-2]3EBI-618309,EBI-12082116
SYT17 [Q9BSW7]3EBI-618309,EBI-745392
SYT6 - isoform 2 [Q5T7P8-2]6EBI-618309,EBI-10246152
TAB2 [Q9NYJ8]3EBI-618309,EBI-358708
TBC1D22B [Q9NU19]5EBI-618309,EBI-8787464
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-618309,EBI-17455779
TBP [Q32MN6]6EBI-618309,EBI-10239991
TCEA2 [Q15560]6EBI-618309,EBI-710310
TCEANC [Q8N8B7]3EBI-618309,EBI-954696
TCEANC - isoform 2 [Q8N8B7-2]3EBI-618309,EBI-11955057
TCF19 [D2IYK5]3EBI-618309,EBI-10176552
TCF19 [Q9Y242]5EBI-618309,EBI-7413767
TCF7L2 - isoform 10 [Q9NQB0-10]3EBI-618309,EBI-11746252
TCL1A [P56279]8EBI-618309,EBI-749995
TEAD4 [D3DUQ6]3EBI-618309,EBI-10176734
TEAD4 [Q15561]6EBI-618309,EBI-747736
TEPSIN [Q96N21]3EBI-618309,EBI-11139477
TEX9 [A0A0S2Z5Z9]3EBI-618309,EBI-16431655
TEX9 [Q8N6V9]3EBI-618309,EBI-746341
TFAP4 [Q01664]6EBI-618309,EBI-2514218
THAP7 [Q9BT49]4EBI-618309,EBI-741350
TLE5 [Q08117]3EBI-618309,EBI-717810
TLE5 - isoform 2 [Q08117-2]6EBI-618309,EBI-11741437
TPM1 [P09493]3EBI-618309,EBI-351158
TPM1 - isoform 10 [P09493-10]3EBI-618309,EBI-12123928
TPM1 - isoform 5 [P09493-5]3EBI-618309,EBI-10196387
TPRX1 - isoform 2 [Q8N7U7-2]3EBI-618309,EBI-14115717
TPX2 [Q9ULW0]6EBI-618309,EBI-1037322
TRAF4 [Q9BUZ4]5EBI-618309,EBI-3650647
TRIM14 [Q14142]3EBI-618309,EBI-2820256
TRIM29 [Q14134]5EBI-618309,EBI-702370
TRIM42 [Q8IWZ5]3EBI-618309,EBI-5235829
TSC22D4 [Q8IV54]3EBI-618309,EBI-10261521
TSGA10 [Q9BZW7]3EBI-618309,EBI-744794
TSGA10IP [Q3SY00]3EBI-618309,EBI-10241197
TSHZ2 [Q9NRE2]3EBI-618309,EBI-10687282
TSHZ3 [Q63HK5]3EBI-618309,EBI-9053916
TSSC4 [Q9Y5U2]3EBI-618309,EBI-717229
TSSK3 [Q96PN8]6EBI-618309,EBI-3918381
TTC23 [Q5W5X9]3EBI-618309,EBI-6447954
TTC23 - isoform 3 [Q5W5X9-3]3EBI-618309,EBI-9090990
TTC25 [Q96NG3]3EBI-618309,EBI-1046387
TTC9C [Q8N5M4]3EBI-618309,EBI-2851213
TTPA [P49638]3EBI-618309,EBI-10210710
TXLNA [P40222]3EBI-618309,EBI-359793
TXLNB [Q8N3L3]3EBI-618309,EBI-6116822
UBE2I [P63279]4EBI-618309,EBI-80168
UBE2U [Q5VVX9]4EBI-618309,EBI-2130181
UBE3C [Q15386]3EBI-618309,EBI-1058871
UBTFL1 [P0CB47]3EBI-618309,EBI-17208936
USP15 - isoform 2 [Q9Y4E8-2]3EBI-618309,EBI-12041225
USP2 [O75604]6EBI-618309,EBI-743272
UTP14C [Q08E77]3EBI-618309,EBI-10225961
UTP14C [Q5TAP6]5EBI-618309,EBI-11737646
UTP23 [Q9BRU9]3EBI-618309,EBI-5457544
VEZF1 [Q14119]3EBI-618309,EBI-11980193
VPS28 [Q548N1]3EBI-618309,EBI-10243107
VPS28 [Q9UK41]6EBI-618309,EBI-727424
VPS37C [A5D8V6]3EBI-618309,EBI-2559305
WASHC3 [Q9Y3C0]6EBI-618309,EBI-712969
WDYHV1 [Q96HA8]8EBI-618309,EBI-741158
WHRN [Q9P202]3EBI-618309,EBI-310886
YJU2 [Q9BW85]8EBI-618309,EBI-10300345
ZBTB16 [Q05516]8EBI-618309,EBI-711925
ZBTB4 [Q9P1Z0]3EBI-618309,EBI-2564133
ZBTB42 [B2RXF5]3EBI-618309,EBI-12287587
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-618309,EBI-14104088
ZDHHC17 [Q8IUH5]3EBI-618309,EBI-524753
ZFC3H1 [G3V1X1]3EBI-618309,EBI-6448783
ZFHX3 - isoform B [Q15911-2]3EBI-618309,EBI-10237226
ZFP2 [Q6ZN57]3EBI-618309,EBI-7236323
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-618309,EBI-8656416
ZGPAT [A0A0S2Z6H0]6EBI-618309,EBI-16428984
ZGPAT [Q8N5A5]3EBI-618309,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]12EBI-618309,EBI-10183064
ZMAT2 [Q96NC0]6EBI-618309,EBI-2682299
ZNF124 [Q15973]3EBI-618309,EBI-2555767
ZNF250 - isoform 3 [P15622-3]8EBI-618309,EBI-10177272
ZNF280C [Q8ND82]3EBI-618309,EBI-8831272
ZNF3 [P17036]3EBI-618309,EBI-1640965
ZNF35 [P13682]3EBI-618309,EBI-11041653
ZNF410 [Q86VK4]3EBI-618309,EBI-720304
ZNF414 [Q96IQ9]7EBI-618309,EBI-744257
ZNF417 [Q8TAU3]6EBI-618309,EBI-740727
ZNF438 [Q7Z4V0]3EBI-618309,EBI-11962468
ZNF48 [Q96MX3]3EBI-618309,EBI-12006434
ZNF488 [Q96MN9]4EBI-618309,EBI-948288
ZNF512B [Q96KM6]3EBI-618309,EBI-1049952
ZNF524 [Q96C55]3EBI-618309,EBI-10283126
ZNF572 [Q7Z3I7]6EBI-618309,EBI-10172590
ZNF581 [Q9P0T4]3EBI-618309,EBI-745520
ZNF587 [Q96SQ5]3EBI-618309,EBI-6427977
ZNF648 [Q5T619]3EBI-618309,EBI-11985915
ZNF688 [A0A0S2Z5X4]6EBI-618309,EBI-16429014
ZNF688 [A0A0S2Z6P0]3EBI-618309,EBI-16429989
ZNF774 [Q6NX45]7EBI-618309,EBI-10251462
ZNF835 [Q9Y2P0]3EBI-618309,EBI-5667516
ZZZ3 [Q8IYH5]3EBI-618309,EBI-2795524

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109063, 499 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q08379

Database of interacting proteins

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DIPi
DIP-34271N

Protein interaction database and analysis system

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IntActi
Q08379, 596 interactors

Molecular INTeraction database

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MINTi
Q08379

STRING: functional protein association networks

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STRINGi
9606.ENSP00000416097

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q08379 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11002
Legend: HelixTurnBeta strandPDB Structure known for this area
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3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08379

Database of comparative protein structure models

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ModBasei
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Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 84Interaction with p115/USO1By similarityAdd BLAST84
Regioni992 – 1002Interaction with GORASP1/GRASP65By similarityAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 892Sequence analysisAdd BLAST877

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi26 – 49Nuclear localization signal1 PublicationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 51Poly-Lys6
Compositional biasi449 – 455Poly-Pro7
Compositional biasi704 – 715Poly-GluAdd BLAST12

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with long coiled-coil domains.By similarity
The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INYK Eukaryota
ENOG4111MFD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000062932

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q08379

KEGG Orthology (KO)

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KOi
K20358

Identification of Orthologs from Complete Genome Data

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OMAi
HVAAYQQ

Database of Orthologous Groups

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OrthoDBi
358120at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q08379

TreeFam database of animal gene trees

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TreeFami
TF316990

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024858 Golgin_A

The PANTHER Classification System

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PANTHERi
PTHR10881 PTHR10881, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15070 GOLGA2L5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI
60 70 80 90 100
KNGSNPETTT SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM
110 120 130 140 150
AASQNHDADN VPNLMDETKT FSSTESLRQL SQQLNGLVCE SATCVNGEGP
160 170 180 190 200
ASSANLKDLE SRYQQLAVAL DSSYVTNKQL NITIEKLKQQ NQEITDQLEE
210 220 230 240 250
EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT QHAARQKEGE
260 270 280 290 300
SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
310 320 330 340 350
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ
360 370 380 390 400
QFSSRCEAPD ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL
410 420 430 440 450
KGESAMWRQR MQQMSEQVHT LREEKECSMS RVQELETSLA ELRNQMAEPP
460 470 480 490 500
PPEPPAGPSE VEQQLQAEAE HLRKELEGLA GQLQAQVQDN EGLSRLNREQ
510 520 530 540 550
EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS QNRELKEQLA
560 570 580 590 600
ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
610 620 630 640 650
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL
660 670 680 690 700
QQQEAQGKAV AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG
710 720 730 740 750
LDREEEEDEE EEEEEAVAVP QPMPSIPEDL ESREAMVAFF NSAVASAEEE
760 770 780 790 800
QARLRGQLKE QRVRCRRLAH LLASAQKEPE AAAPAPGTGG DSVCGETHRA
810 820 830 840 850
LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET DTIGEYIALY
860 870 880 890 900
QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
910 920 930 940 950
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR
960 970 980 990 1000
EGSPRDNPTA QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT

VI
Length:1,002
Mass (Da):113,086
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD067145C5092237
GO
Isoform 2 (identifier: Q08379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Show »
Length:620
Mass (Da):70,473
Checksum:i54B31A0FBB42BFC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZC06B7ZC06_HUMAN
Golgin subfamily A member 2
GOLGA2
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7B8H0Y7B8_HUMAN
Golgin subfamily A member 2
GOLGA2
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQY5A0A1W2PQY5_HUMAN
Golgin subfamily A member 2
GOLGA2
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Q2TH77A0A2Q2TH77_HUMAN
Golgin subfamily A member 2
GOLGA2
990Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYC0A0A087WYC0_HUMAN
Golgin subfamily A member 2
GOLGA2
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GND7R4GND7_HUMAN
Golgin subfamily A member 2
GOLGA2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH69268 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAP35912 differs from that shown. Sequence differs from that shown after position 826 due to an internal deletion.Curated
The sequence EAW87762 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti709Missing in AAP35912 (Ref. 6) Curated1
Sequence conflicti762R → S in AAP35912 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033974902R → G. Corresponds to variant dbSNP:rs2240961Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0077271 – 382Missing in isoform 2. 1 PublicationAdd BLAST382

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L06147 mRNA Translation: AAA35920.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87762.1 Sequence problems.
BC014188 mRNA Translation: AAH14188.2
BC069268 mRNA Translation: AAH69268.1 Different initiation.
AF248953 mRNA Translation: AAF65550.1
BT007248 mRNA Translation: AAP35912.1 Sequence problems.

Protein sequence database of the Protein Information Resource

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PIRi
JH0821

NCBI Reference Sequences

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RefSeqi
NP_004477.3, NM_004486.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000421699; ENSP00000416097; ENSG00000167110 [Q08379-1]
ENST00000611957; ENSP00000478799; ENSG00000167110 [Q08379-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2801

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2801

UCSC genome browser

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UCSCi
uc011maw.2 human [Q08379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06147 mRNA Translation: AAA35920.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87762.1 Sequence problems.
BC014188 mRNA Translation: AAH14188.2
BC069268 mRNA Translation: AAH69268.1 Different initiation.
AF248953 mRNA Translation: AAF65550.1
BT007248 mRNA Translation: AAP35912.1 Sequence problems.
PIRiJH0821
RefSeqiNP_004477.3, NM_004486.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4REYX-ray1.96B980-1002[»]
6IW8X-ray2.80A13-60[»]
6IWAX-ray2.40A25-52[»]
6K06X-ray1.75A13-60[»]
SMRiQ08379
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109063, 499 interactors
CORUMiQ08379
DIPiDIP-34271N
IntActiQ08379, 596 interactors
MINTiQ08379
STRINGi9606.ENSP00000416097

Protein family/group databases

MoonDBiQ08379 Predicted

PTM databases

iPTMnetiQ08379
PhosphoSitePlusiQ08379

Polymorphism and mutation databases

BioMutaiGOLGA2
DMDMi294862511

Proteomic databases

EPDiQ08379
jPOSTiQ08379
MassIVEiQ08379
MaxQBiQ08379
PaxDbiQ08379
PeptideAtlasiQ08379
PRIDEiQ08379
ProteomicsDBi58604 [Q08379-1]
58605 [Q08379-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4216 384 antibodies

The DNASU plasmid repository

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DNASUi
2801

Genome annotation databases

EnsembliENST00000421699; ENSP00000416097; ENSG00000167110 [Q08379-1]
ENST00000611957; ENSP00000478799; ENSG00000167110 [Q08379-1]
GeneIDi2801
KEGGihsa:2801
UCSCiuc011maw.2 human [Q08379-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2801
DisGeNETi2801

GeneCards: human genes, protein and diseases

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GeneCardsi
GOLGA2
HGNCiHGNC:4425 GOLGA2
HPAiENSG00000167110 Low tissue specificity
MIMi602580 gene
neXtProtiNX_Q08379
OpenTargetsiENSG00000167110
PharmGKBiPA28805

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INYK Eukaryota
ENOG4111MFD LUCA
GeneTreeiENSGT00530000062932
InParanoidiQ08379
KOiK20358
OMAiHVAAYQQ
OrthoDBi358120at2759
PhylomeDBiQ08379
TreeFamiTF316990

Enzyme and pathway databases

ReactomeiR-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORiQ08379

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GOLGA2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GOLGA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2801
PharosiQ08379 Tbio

Protein Ontology

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PROi
PR:Q08379
RNActiQ08379 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167110 Expressed in adenohypophysis and 205 other tissues
ExpressionAtlasiQ08379 baseline and differential
GenevisibleiQ08379 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08379
Secondary accession number(s): A0A0C4DGS5
, Q6GRM9, Q9BRB0, Q9NYF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 20, 2010
Last modified: April 22, 2020
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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