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Protein

Golgin subfamily A member 3

Gene

GOLGA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Golgi auto-antigen; probably involved in maintaining Golgi structure.

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • transporter activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 3
Alternative name(s):
Golgi complex-associated protein of 170 kDa
Short name:
GCP170
Golgin-160
Gene namesi
Name:GOLGA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000090615.12
HGNCiHGNC:4426 GOLGA3
MIMi602581 gene
neXtProtiNX_Q08378

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59D → A: Abolishes cleavage by caspase-2. 1 Publication1
Mutagenesisi121L → A: Loss of interaction with GOPC; when associated with A-128 and A-135. 1 Publication1
Mutagenesisi128L → A: Loss of interaction with GOPC; when associated with A-121 and A-135. 1 Publication1
Mutagenesisi135L → A: Loss of interaction with GOPC; when associated with A-121 and A-128. 1 Publication1
Mutagenesisi139D → A: Abolishes cleavage by caspase-3. 1 Publication1
Mutagenesisi311D → A: Abolishes cleavage by caspase-7. 1 Publication1

Organism-specific databases

DisGeNETi2802
OpenTargetsiENSG00000090615
PharmGKBiPA28807

Polymorphism and mutation databases

BioMutaiGOLGA3
DMDMi32470610

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900571 – 1498Golgin subfamily A member 3Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1392PhosphoserineCombined sources1

Post-translational modificationi

Cleaved by caspases in apoptotic cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Cleavage; by caspase-22
Sitei139 – 140Cleavage; by caspase-32
Sitei311 – 312Cleavage; by caspase-72

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ08378
MaxQBiQ08378
PaxDbiQ08378
PeptideAtlasiQ08378
PRIDEiQ08378
ProteomicsDBi58601
58602 [Q08378-2]
58603 [Q08378-4]

PTM databases

iPTMnetiQ08378
PhosphoSitePlusiQ08378

Miscellaneous databases

PMAP-CutDBiQ08378

Expressioni

Tissue specificityi

Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.1 Publication

Gene expression databases

BgeeiENSG00000090615 Expressed in 246 organ(s), highest expression level in tendon
CleanExiHS_GOLGA3
ExpressionAtlasiQ08378 baseline and differential
GenevisibleiQ08378 HS

Organism-specific databases

HPAiHPA039809
HPA040044

Interactioni

Subunit structurei

Homodimer. Interacts with GOLGA7. Isoform 1 interacts with GOPC while isoform 3 does not.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109064, 45 interactors
IntActiQ08378, 27 interactors
STRINGi9606.ENSP00000204726

Structurei

3D structure databases

ProteinModelPortaliQ08378
SMRiQ08378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 141Interaction with GOPC1 PublicationAdd BLAST21
Regioni172 – 257Golgi-targeting domainAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili394 – 1459Sequence analysisAdd BLAST1066

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 95Pro-richAdd BLAST76
Compositional biasi538 – 744Gln-richAdd BLAST207
Compositional biasi1231 – 1369Gln-richAdd BLAST139

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFW4 Eukaryota
ENOG410YGSW LUCA
GeneTreeiENSGT00730000111197
HOVERGENiHBG051753
InParanoidiQ08378
OMAiHESMSSW
OrthoDBiEOG091G0D2X
PhylomeDBiQ08378
TreeFamiTF332014

Family and domain databases

InterProiView protein in InterPro
IPR033288 Golga3
PANTHERiPTHR18902:SF26 PTHR18902:SF26, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08378-1) [UniParc]FASTAAdd to basket
Also known as: Golgin-160B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGASAEQDG LQEDRSHSGP SSLPEAPLKP PGPLVPPDQQ DKVQCAEVNR
60 70 80 90 100
ASTEGESPDG PGQGGLCQNG PTPPFPDPPS SLDPTTSPVG PDASPGVAGF
110 120 130 140 150
HDNLRKSQGT SAEGSVRKEA LQSLRLSLPM QETQLCSTDS PLPLEKEEQV
160 170 180 190 200
RLQARKWLEE QLKQYRVKRQ QERSSQPATK TRLFSTLDPE LMLNPENLPR
210 220 230 240 250
ASTLAMTKEY SFLRTSVPRG PKVGSLGLPA HPREKKTSKS SKIRSLADYR
260 270 280 290 300
TEDSNAGNSG GNVPAPDSTK GSLKQNRSSA ASVVSEISLS PDTDDRLENT
310 320 330 340 350
SLAGDSVSEV DGNDSDSSSY SSASTRGTYG ILSKTVGTQD TPYMVNGQEI
360 370 380 390 400
PADTLGQFPS IKDVLQAAAA EHQDQGQEVN GEVRSRRDSI CSSVSLESSA
410 420 430 440 450
AETQEEMLQV LKEKMRLEGQ LEALSLEASQ ALKEKAELQA QLAALSTKLQ
460 470 480 490 500
AQVECSHSSQ QRQDSLSSEV DTLKQSCWDL ERAMTDLQNM LEAKNASLAS
510 520 530 540 550
SNNDLQVAEE QYQRLMAKVE DMQRSMLSKD NTVHDLRQQM TALQSQLQQV
560 570 580 590 600
QLERTTLTSK LKASQAEISS LQSVRQWYQQ QLALAQEARV RLQGEMAHIQ
610 620 630 640 650
VGQMTQAGLL EHLKLENVSL SQQLTETQHR SMKEKGRIAA QLQGIEADML
660 670 680 690 700
DQEAAFMQIQ EAKTMVEEDL QRRLEEFEGE RERLQRMADS AASLEQQLEQ
710 720 730 740 750
VKLTLLQRDQ QLEALQQEHL DLMKQLTLTQ EALQSREQSL DALQTHYDEL
760 770 780 790 800
QARLGELQGE AASREDTICL LQNEKIILEA ALQAAKSGKE ELDRGARRLE
810 820 830 840 850
EGTEETSETL EKLREELAIK SGQVEHLQQE TAALKKQMQK IKEQFLQQKV
860 870 880 890 900
MVEAYRRDAT SKDQLISELK ATRKRLDSEL KELRQELMQV HGEKRTAEAE
910 920 930 940 950
LSRLHREVAQ VRQHMADLEG HLQSAQKERD EMETHLQSLQ FDKEQMVAVT
960 970 980 990 1000
EANEALKKQI EELQQEARKA ITEQKQKMRR LGSDLTSAQK EMKTKHKAYE
1010 1020 1030 1040 1050
NAVGILSRRL QEALAAKEAA DAELGQLRAQ GGSSDSSLAL HERIQALEAE
1060 1070 1080 1090 1100
LQAVSHSKTL LEKELQEVIA LTSQELEESR EKVLELEDEL QESRGFRKKI
1110 1120 1130 1140 1150
KRLEESNKKL ALELEHEKGK LTGLGQSNAA LREHNSILET ALAKREADLV
1160 1170 1180 1190 1200
QLNLQVQAVL QRKEEEDRQM KHLVQALQAS LEKEKEKVNS LKEQVAAAKV
1210 1220 1230 1240 1250
EAGHNRRHFK AASLELSEVK KELQAKEHLV QKLQAEADDL QIREGKHSQE
1260 1270 1280 1290 1300
IAQFQAELAE ARAQLQLLQK QLDEQLSKQP VGNQEMENLK WEVDQKEREI
1310 1320 1330 1340 1350
QSLKQQLDLT EQQGRKELEG LQQLLQNVKS ELEMAQEDLS MTQKDKFMLQ
1360 1370 1380 1390 1400
AKVSELKNNM KTLLQQNQQL KLDLRRGAAK TRKEPKGEAS SSNPATPIKI
1410 1420 1430 1440 1450
PDCPVPASLL EELLRPPPAV SKEPLKNLNS CLQQLKQEMD SLQRQMEEHA
1460 1470 1480 1490
LTVHESLSSW TPLEPATASP VPPGGHAGPR GDPQRHSQSR ASKEGPGE
Length:1,498
Mass (Da):167,355
Last modified:July 3, 2003 - v2
Checksum:i4B95CDCFD3D64667
GO
Isoform 2 (identifier: Q08378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1382-1390: RKEPKGEAS → VLRPASLPG
     1391-1498: Missing.

Note: No experimental confirmation available. May be due to an intron retention.
Show »
Length:1,390
Mass (Da):155,683
Checksum:iA7A2BA5DD87ACE30
GO
Isoform 3 (identifier: Q08378-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1134: LQESRGFRKK...GQSNAALREH → VRPGHLLWRQ...SVATFGVATF
     1135-1498: Missing.

Note: No experimental confirmation available.
Show »
Length:1,134
Mass (Da):126,129
Checksum:i29EB52DCDD5B21D1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV43A0A087WV43_HUMAN
Golgin subfamily A member 3
GOLGA3
84Annotation score:

Sequence cautioni

The sequence AAA35921 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH60826 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA23661 differs from that shown. Reason: Frameshift at position 1378.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159E → K in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti609L → I in BAA23661 (PubMed:9295333).Curated1
Sequence conflicti746H → R in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti785A → V in AAA35921 (PubMed:15489334).Curated1
Sequence conflicti932M → V in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1017K → R in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1281V → A in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1315R → W in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1443Q → R in AAL93149 (PubMed:10791974).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02015370G → E. Corresponds to variant dbSNP:rs2291256Ensembl.1
Natural variantiVAR_021901264P → L. Corresponds to variant dbSNP:rs3741486Ensembl.1
Natural variantiVAR_0201541185K → R. Corresponds to variant dbSNP:rs2291260Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380001090 – 1134LQESR…ALREH → VRPGHLLWRQRGAGHVSPGH AATRETRRTKLHRVPSVATF GVATF in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0380011135 – 1498Missing in isoform 3. 1 PublicationAdd BLAST364
Alternative sequenceiVSP_0077281382 – 1390RKEPKGEAS → VLRPASLPG in isoform 2. 1 Publication9
Alternative sequenceiVSP_0077291391 – 1498Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63997 mRNA Translation: BAA23661.1 Frameshift.
AF485338 mRNA Translation: AAL93149.1
AB027133 mRNA Translation: BAB71953.1
BC060826 mRNA Translation: AAH60826.1 Sequence problems.
BC142658 mRNA Translation: AAI42659.1
BC146675 mRNA Translation: AAI46676.1
L06148 mRNA Translation: AAA35921.1 Different initiation.
CCDSiCCDS53846.1 [Q08378-4]
CCDS9281.1 [Q08378-1]
PIRiJH0820
RefSeqiNP_001166028.1, NM_001172557.1 [Q08378-4]
NP_005886.2, NM_005895.3 [Q08378-1]
XP_006719799.1, XM_006719736.3 [Q08378-1]
XP_006719800.1, XM_006719737.3 [Q08378-1]
UniGeneiHs.507333

Genome annotation databases

EnsembliENST00000204726; ENSP00000204726; ENSG00000090615 [Q08378-1]
ENST00000450791; ENSP00000410378; ENSG00000090615 [Q08378-1]
ENST00000456883; ENSP00000409303; ENSG00000090615 [Q08378-2]
ENST00000545875; ENSP00000442603; ENSG00000090615 [Q08378-4]
GeneIDi2802
KEGGihsa:2802
UCSCiuc001ukz.1 human [Q08378-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63997 mRNA Translation: BAA23661.1 Frameshift.
AF485338 mRNA Translation: AAL93149.1
AB027133 mRNA Translation: BAB71953.1
BC060826 mRNA Translation: AAH60826.1 Sequence problems.
BC142658 mRNA Translation: AAI42659.1
BC146675 mRNA Translation: AAI46676.1
L06148 mRNA Translation: AAA35921.1 Different initiation.
CCDSiCCDS53846.1 [Q08378-4]
CCDS9281.1 [Q08378-1]
PIRiJH0820
RefSeqiNP_001166028.1, NM_001172557.1 [Q08378-4]
NP_005886.2, NM_005895.3 [Q08378-1]
XP_006719799.1, XM_006719736.3 [Q08378-1]
XP_006719800.1, XM_006719737.3 [Q08378-1]
UniGeneiHs.507333

3D structure databases

ProteinModelPortaliQ08378
SMRiQ08378
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109064, 45 interactors
IntActiQ08378, 27 interactors
STRINGi9606.ENSP00000204726

PTM databases

iPTMnetiQ08378
PhosphoSitePlusiQ08378

Polymorphism and mutation databases

BioMutaiGOLGA3
DMDMi32470610

Proteomic databases

EPDiQ08378
MaxQBiQ08378
PaxDbiQ08378
PeptideAtlasiQ08378
PRIDEiQ08378
ProteomicsDBi58601
58602 [Q08378-2]
58603 [Q08378-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000204726; ENSP00000204726; ENSG00000090615 [Q08378-1]
ENST00000450791; ENSP00000410378; ENSG00000090615 [Q08378-1]
ENST00000456883; ENSP00000409303; ENSG00000090615 [Q08378-2]
ENST00000545875; ENSP00000442603; ENSG00000090615 [Q08378-4]
GeneIDi2802
KEGGihsa:2802
UCSCiuc001ukz.1 human [Q08378-1]

Organism-specific databases

CTDi2802
DisGeNETi2802
EuPathDBiHostDB:ENSG00000090615.12
GeneCardsiGOLGA3
HGNCiHGNC:4426 GOLGA3
HPAiHPA039809
HPA040044
MIMi602581 gene
neXtProtiNX_Q08378
OpenTargetsiENSG00000090615
PharmGKBiPA28807
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFW4 Eukaryota
ENOG410YGSW LUCA
GeneTreeiENSGT00730000111197
HOVERGENiHBG051753
InParanoidiQ08378
OMAiHESMSSW
OrthoDBiEOG091G0D2X
PhylomeDBiQ08378
TreeFamiTF332014

Miscellaneous databases

ChiTaRSiGOLGA3 human
GeneWikiiGOLGA3
GenomeRNAii2802
PMAP-CutDBiQ08378
PROiPR:Q08378
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090615 Expressed in 246 organ(s), highest expression level in tendon
CleanExiHS_GOLGA3
ExpressionAtlasiQ08378 baseline and differential
GenevisibleiQ08378 HS

Family and domain databases

InterProiView protein in InterPro
IPR033288 Golga3
PANTHERiPTHR18902:SF26 PTHR18902:SF26, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOGA3_HUMAN
AccessioniPrimary (citable) accession number: Q08378
Secondary accession number(s): A5PKX6
, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 3, 2003
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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