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Entry version 178 (18 Sep 2019)
Sequence version 2 (03 Jul 2003)
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Protein

Golgin subfamily A member 3

Gene

GOLGA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Golgi auto-antigen; probably involved in maintaining Golgi structure.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 3
Alternative name(s):
Golgi complex-associated protein of 170 kDa
Short name:
GCP170
Golgin-160
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4426 GOLGA3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602581 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08378

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59D → A: Abolishes cleavage by caspase-2. 1 Publication1
Mutagenesisi121L → A: Loss of interaction with GOPC; when associated with A-128 and A-135. 1 Publication1
Mutagenesisi128L → A: Loss of interaction with GOPC; when associated with A-121 and A-135. 1 Publication1
Mutagenesisi135L → A: Loss of interaction with GOPC; when associated with A-121 and A-128. 1 Publication1
Mutagenesisi139D → A: Abolishes cleavage by caspase-3. 1 Publication1
Mutagenesisi311D → A: Abolishes cleavage by caspase-7. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2802

Open Targets

More...
OpenTargetsi
ENSG00000090615

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28807

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGA3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32470610

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900571 – 1498Golgin subfamily A member 3Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1392PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by caspases in apoptotic cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei59 – 60Cleavage; by caspase-22
Sitei139 – 140Cleavage; by caspase-32
Sitei311 – 312Cleavage; by caspase-72

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q08378

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q08378

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q08378

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08378

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08378

PeptideAtlas

More...
PeptideAtlasi
Q08378

PRoteomics IDEntifications database

More...
PRIDEi
Q08378

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58601 [Q08378-1]
58602 [Q08378-2]
58603 [Q08378-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08378

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08378

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q08378

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090615 Expressed in 246 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08378 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08378 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039809
HPA040044

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with GOLGA7.

Isoform 1 interacts with GOPC while isoform 3 does not.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109064, 59 interactors

Protein interaction database and analysis system

More...
IntActi
Q08378, 40 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000204726

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08378

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni121 – 141Interaction with GOPC1 PublicationAdd BLAST21
Regioni172 – 257Golgi-targeting domainAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili394 – 1459Sequence analysisAdd BLAST1066

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 95Pro-richAdd BLAST76
Compositional biasi538 – 744Gln-richAdd BLAST207
Compositional biasi1231 – 1369Gln-richAdd BLAST139

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFW4 Eukaryota
ENOG410YGSW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08378

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSKMMLE

Database of Orthologous Groups

More...
OrthoDBi
87408at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08378

TreeFam database of animal gene trees

More...
TreeFami
TF332014

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033288 Golga3

The PANTHER Classification System

More...
PANTHERi
PTHR18902:SF26 PTHR18902:SF26, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08378-1) [UniParc]FASTAAdd to basket
Also known as: Golgin-160B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGASAEQDG LQEDRSHSGP SSLPEAPLKP PGPLVPPDQQ DKVQCAEVNR
60 70 80 90 100
ASTEGESPDG PGQGGLCQNG PTPPFPDPPS SLDPTTSPVG PDASPGVAGF
110 120 130 140 150
HDNLRKSQGT SAEGSVRKEA LQSLRLSLPM QETQLCSTDS PLPLEKEEQV
160 170 180 190 200
RLQARKWLEE QLKQYRVKRQ QERSSQPATK TRLFSTLDPE LMLNPENLPR
210 220 230 240 250
ASTLAMTKEY SFLRTSVPRG PKVGSLGLPA HPREKKTSKS SKIRSLADYR
260 270 280 290 300
TEDSNAGNSG GNVPAPDSTK GSLKQNRSSA ASVVSEISLS PDTDDRLENT
310 320 330 340 350
SLAGDSVSEV DGNDSDSSSY SSASTRGTYG ILSKTVGTQD TPYMVNGQEI
360 370 380 390 400
PADTLGQFPS IKDVLQAAAA EHQDQGQEVN GEVRSRRDSI CSSVSLESSA
410 420 430 440 450
AETQEEMLQV LKEKMRLEGQ LEALSLEASQ ALKEKAELQA QLAALSTKLQ
460 470 480 490 500
AQVECSHSSQ QRQDSLSSEV DTLKQSCWDL ERAMTDLQNM LEAKNASLAS
510 520 530 540 550
SNNDLQVAEE QYQRLMAKVE DMQRSMLSKD NTVHDLRQQM TALQSQLQQV
560 570 580 590 600
QLERTTLTSK LKASQAEISS LQSVRQWYQQ QLALAQEARV RLQGEMAHIQ
610 620 630 640 650
VGQMTQAGLL EHLKLENVSL SQQLTETQHR SMKEKGRIAA QLQGIEADML
660 670 680 690 700
DQEAAFMQIQ EAKTMVEEDL QRRLEEFEGE RERLQRMADS AASLEQQLEQ
710 720 730 740 750
VKLTLLQRDQ QLEALQQEHL DLMKQLTLTQ EALQSREQSL DALQTHYDEL
760 770 780 790 800
QARLGELQGE AASREDTICL LQNEKIILEA ALQAAKSGKE ELDRGARRLE
810 820 830 840 850
EGTEETSETL EKLREELAIK SGQVEHLQQE TAALKKQMQK IKEQFLQQKV
860 870 880 890 900
MVEAYRRDAT SKDQLISELK ATRKRLDSEL KELRQELMQV HGEKRTAEAE
910 920 930 940 950
LSRLHREVAQ VRQHMADLEG HLQSAQKERD EMETHLQSLQ FDKEQMVAVT
960 970 980 990 1000
EANEALKKQI EELQQEARKA ITEQKQKMRR LGSDLTSAQK EMKTKHKAYE
1010 1020 1030 1040 1050
NAVGILSRRL QEALAAKEAA DAELGQLRAQ GGSSDSSLAL HERIQALEAE
1060 1070 1080 1090 1100
LQAVSHSKTL LEKELQEVIA LTSQELEESR EKVLELEDEL QESRGFRKKI
1110 1120 1130 1140 1150
KRLEESNKKL ALELEHEKGK LTGLGQSNAA LREHNSILET ALAKREADLV
1160 1170 1180 1190 1200
QLNLQVQAVL QRKEEEDRQM KHLVQALQAS LEKEKEKVNS LKEQVAAAKV
1210 1220 1230 1240 1250
EAGHNRRHFK AASLELSEVK KELQAKEHLV QKLQAEADDL QIREGKHSQE
1260 1270 1280 1290 1300
IAQFQAELAE ARAQLQLLQK QLDEQLSKQP VGNQEMENLK WEVDQKEREI
1310 1320 1330 1340 1350
QSLKQQLDLT EQQGRKELEG LQQLLQNVKS ELEMAQEDLS MTQKDKFMLQ
1360 1370 1380 1390 1400
AKVSELKNNM KTLLQQNQQL KLDLRRGAAK TRKEPKGEAS SSNPATPIKI
1410 1420 1430 1440 1450
PDCPVPASLL EELLRPPPAV SKEPLKNLNS CLQQLKQEMD SLQRQMEEHA
1460 1470 1480 1490
LTVHESLSSW TPLEPATASP VPPGGHAGPR GDPQRHSQSR ASKEGPGE
Length:1,498
Mass (Da):167,355
Last modified:July 3, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B95CDCFD3D64667
GO
Isoform 2 (identifier: Q08378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1382-1390: RKEPKGEAS → VLRPASLPG
     1391-1498: Missing.

Note: No experimental confirmation available. May be due to an intron retention.
Show »
Length:1,390
Mass (Da):155,683
Checksum:iA7A2BA5DD87ACE30
GO
Isoform 3 (identifier: Q08378-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1134: LQESRGFRKK...GQSNAALREH → VRPGHLLWRQ...SVATFGVATF
     1135-1498: Missing.

Note: No experimental confirmation available.
Show »
Length:1,134
Mass (Da):126,129
Checksum:i29EB52DCDD5B21D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C129A0A494C129_HUMAN
Golgin subfamily A member 3
GOLGA3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV43A0A087WV43_HUMAN
Golgin subfamily A member 3
GOLGA3
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35921 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH60826 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA23661 differs from that shown. Reason: Frameshift at position 1378.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159E → K in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti609L → I in BAA23661 (PubMed:9295333).Curated1
Sequence conflicti746H → R in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti785A → V in AAA35921 (PubMed:15489334).Curated1
Sequence conflicti932M → V in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1017K → R in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1281V → A in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1315R → W in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1443Q → R in AAL93149 (PubMed:10791974).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02015370G → E. Corresponds to variant dbSNP:rs2291256Ensembl.1
Natural variantiVAR_021901264P → L. Corresponds to variant dbSNP:rs3741486Ensembl.1
Natural variantiVAR_0201541185K → R. Corresponds to variant dbSNP:rs2291260Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0380001090 – 1134LQESR…ALREH → VRPGHLLWRQRGAGHVSPGH AATRETRRTKLHRVPSVATF GVATF in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0380011135 – 1498Missing in isoform 3. 1 PublicationAdd BLAST364
Alternative sequenceiVSP_0077281382 – 1390RKEPKGEAS → VLRPASLPG in isoform 2. 1 Publication9
Alternative sequenceiVSP_0077291391 – 1498Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D63997 mRNA Translation: BAA23661.1 Frameshift.
AF485338 mRNA Translation: AAL93149.1
AB027133 mRNA Translation: BAB71953.1
BC060826 mRNA Translation: AAH60826.1 Sequence problems.
BC142658 mRNA Translation: AAI42659.1
BC146675 mRNA Translation: AAI46676.1
L06148 mRNA Translation: AAA35921.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS53846.1 [Q08378-4]
CCDS9281.1 [Q08378-1]

Protein sequence database of the Protein Information Resource

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PIRi
JH0820

NCBI Reference Sequences

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RefSeqi
NP_001166028.1, NM_001172557.1 [Q08378-4]
NP_005886.2, NM_005895.3 [Q08378-1]
XP_006719799.1, XM_006719736.3 [Q08378-1]
XP_006719800.1, XM_006719737.3 [Q08378-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000204726; ENSP00000204726; ENSG00000090615 [Q08378-1]
ENST00000450791; ENSP00000410378; ENSG00000090615 [Q08378-1]
ENST00000456883; ENSP00000409303; ENSG00000090615 [Q08378-2]
ENST00000545875; ENSP00000442603; ENSG00000090615 [Q08378-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2802

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2802

UCSC genome browser

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UCSCi
uc001ukz.1 human [Q08378-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63997 mRNA Translation: BAA23661.1 Frameshift.
AF485338 mRNA Translation: AAL93149.1
AB027133 mRNA Translation: BAB71953.1
BC060826 mRNA Translation: AAH60826.1 Sequence problems.
BC142658 mRNA Translation: AAI42659.1
BC146675 mRNA Translation: AAI46676.1
L06148 mRNA Translation: AAA35921.1 Different initiation.
CCDSiCCDS53846.1 [Q08378-4]
CCDS9281.1 [Q08378-1]
PIRiJH0820
RefSeqiNP_001166028.1, NM_001172557.1 [Q08378-4]
NP_005886.2, NM_005895.3 [Q08378-1]
XP_006719799.1, XM_006719736.3 [Q08378-1]
XP_006719800.1, XM_006719737.3 [Q08378-1]

3D structure databases

SMRiQ08378
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109064, 59 interactors
IntActiQ08378, 40 interactors
STRINGi9606.ENSP00000204726

PTM databases

iPTMnetiQ08378
PhosphoSitePlusiQ08378

Polymorphism and mutation databases

BioMutaiGOLGA3
DMDMi32470610

Proteomic databases

EPDiQ08378
jPOSTiQ08378
MassIVEiQ08378
MaxQBiQ08378
PaxDbiQ08378
PeptideAtlasiQ08378
PRIDEiQ08378
ProteomicsDBi58601 [Q08378-1]
58602 [Q08378-2]
58603 [Q08378-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000204726; ENSP00000204726; ENSG00000090615 [Q08378-1]
ENST00000450791; ENSP00000410378; ENSG00000090615 [Q08378-1]
ENST00000456883; ENSP00000409303; ENSG00000090615 [Q08378-2]
ENST00000545875; ENSP00000442603; ENSG00000090615 [Q08378-4]
GeneIDi2802
KEGGihsa:2802
UCSCiuc001ukz.1 human [Q08378-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2802
DisGeNETi2802

GeneCards: human genes, protein and diseases

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GeneCardsi
GOLGA3
HGNCiHGNC:4426 GOLGA3
HPAiHPA039809
HPA040044
MIMi602581 gene
neXtProtiNX_Q08378
OpenTargetsiENSG00000090615
PharmGKBiPA28807

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFW4 Eukaryota
ENOG410YGSW LUCA
GeneTreeiENSGT00950000183078
InParanoidiQ08378
OMAiHSKMMLE
OrthoDBi87408at2759
PhylomeDBiQ08378
TreeFamiTF332014

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GOLGA3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GOLGA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2802

Pharos

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Pharosi
Q08378
PMAP-CutDBiQ08378

Protein Ontology

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PROi
PR:Q08378

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090615 Expressed in 246 organ(s), highest expression level in tendon
ExpressionAtlasiQ08378 baseline and differential
GenevisibleiQ08378 HS

Family and domain databases

InterProiView protein in InterPro
IPR033288 Golga3
PANTHERiPTHR18902:SF26 PTHR18902:SF26, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08378
Secondary accession number(s): A5PKX6
, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 3, 2003
Last modified: September 18, 2019
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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