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Protein

Zinc finger and BTB domain-containing protein 14

Gene

Zbtb14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity). Transcriptional repressor of MYC and thymidine kinase promoters.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 14
Alternative name(s):
Zinc finger protein 161
Short name:
Zfp-161
Zinc finger protein 5
Short name:
ZF5
Gene namesi
Name:Zbtb14
Synonyms:Zfp-5, Zfp161, Zfp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1195345 Zbtb14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473181 – 449Zinc finger and BTB domain-containing protein 14Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ08376
PaxDbiQ08376
PeptideAtlasiQ08376
PRIDEiQ08376

PTM databases

iPTMnetiQ08376
PhosphoSitePlusiQ08376

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000049672 Expressed in 282 organ(s), highest expression level in pituitary gland
CleanExiMM_ZFP161
ExpressionAtlasiQ08376 baseline and differential
GenevisibleiQ08376 MM

Interactioni

Subunit structurei

Interacts with ZBTB21.By similarity

Protein-protein interaction databases

BioGridi204642, 1 interactor
STRINGi10090.ENSMUSP00000054897

Structurei

3D structure databases

ProteinModelPortaliQ08376
SMRiQ08376
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 102BTBPROSITE-ProRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 66Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 179Asp/Glu-rich (acidic)Add BLAST26

Domaini

The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00810000125416
HOGENOMiHOG000136853
HOVERGENiHBG054222
InParanoidiQ08376
OMAiKMIEHMG
OrthoDBiEOG091G06U1
PhylomeDBiQ08376
TreeFamiTF333100

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q08376-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH
60 70 80 90 100
RCVLAACSTY FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV
110 120 130 140 150
KKEDVNLMMS SGQILGIRFL DKLCSQKRDV SSPDESNGQS KSKYCLKLNR
160 170 180 190 200
PIGDAADAQD DDVEEIGDQD DSPSDDTVEG TPPSQEDGKS PTTTLRVQEA
210 220 230 240 250
ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT FNDGMSEVKD
260 270 280 290 300
EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT
310 320 330 340 350
ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK
360 370 380 390 400
HERVHSNERP FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK
410 420 430 440
ASDLKRHENN MHSERKQVTP SAIQSETEQL QAAAMAAEAE QQLETIACS
Length:449
Mass (Da):50,899
Last modified:November 1, 1996 - v1
Checksum:i288E76CB689948D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15325 mRNA Translation: AAA02940.1
BC052017 mRNA Translation: AAH52017.1
CCDSiCCDS37682.1
PIRiS41647
RefSeqiNP_033573.1, NM_009547.2
XP_006524275.1, XM_006524212.2
XP_011244726.1, XM_011246424.2
UniGeneiMm.29434

Genome annotation databases

EnsembliENSMUST00000062369; ENSMUSP00000054897; ENSMUSG00000049672
ENSMUST00000112674; ENSMUSP00000108294; ENSMUSG00000049672
ENSMUST00000112676; ENSMUSP00000108296; ENSMUSG00000049672
GeneIDi22666
KEGGimmu:22666
UCSCiuc008dkt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15325 mRNA Translation: AAA02940.1
BC052017 mRNA Translation: AAH52017.1
CCDSiCCDS37682.1
PIRiS41647
RefSeqiNP_033573.1, NM_009547.2
XP_006524275.1, XM_006524212.2
XP_011244726.1, XM_011246424.2
UniGeneiMm.29434

3D structure databases

ProteinModelPortaliQ08376
SMRiQ08376
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204642, 1 interactor
STRINGi10090.ENSMUSP00000054897

PTM databases

iPTMnetiQ08376
PhosphoSitePlusiQ08376

Proteomic databases

EPDiQ08376
PaxDbiQ08376
PeptideAtlasiQ08376
PRIDEiQ08376

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062369; ENSMUSP00000054897; ENSMUSG00000049672
ENSMUST00000112674; ENSMUSP00000108294; ENSMUSG00000049672
ENSMUST00000112676; ENSMUSP00000108296; ENSMUSG00000049672
GeneIDi22666
KEGGimmu:22666
UCSCiuc008dkt.1 mouse

Organism-specific databases

CTDi7541
MGIiMGI:1195345 Zbtb14

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00810000125416
HOGENOMiHOG000136853
HOVERGENiHBG054222
InParanoidiQ08376
OMAiKMIEHMG
OrthoDBiEOG091G06U1
PhylomeDBiQ08376
TreeFamiTF333100

Miscellaneous databases

PROiPR:Q08376
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049672 Expressed in 282 organ(s), highest expression level in pituitary gland
CleanExiMM_ZFP161
ExpressionAtlasiQ08376 baseline and differential
GenevisibleiQ08376 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT14_MOUSE
AccessioniPrimary (citable) accession number: Q08376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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