Transcription factor GATA-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activating transcription factor binding Source: MGI
• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs."
    Schlesinger J., Schueler M., Grunert M., Fischer J.J., Zhang Q., Krueger T., Lange M., Tonjes M., Dunkel I., Sperling S.R.
    PLoS Genet 7:e1001313-e1001313(2011) [PubMed] [Europe PMC] [Abstract]
• cis-regulatory region sequence-specific DNA binding Source: MGI
• co-SMAD binding Source: MGI
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene."
    Molkentin J.D., Kalvakolanu D.V., Markham B.E.
    Mol Cell Biol 14:4947-4957(1994) [PubMed] [Europe PMC] [Abstract]
  • "Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo."
    Di Lisi R., Millino C., Calabria E., Altruda F., Schiaffino S., Ausoni S.
    J Biol Chem 273:25371-25380(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity Source: MGI
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "SOX7 and GATA-4 are competitive activators of Fgf-3 transcription."
    Murakami A., Shen H., Ishida S., Dickson C.
    J. Biol. Chem. 279:28564-28573(2004) [PubMed] [Europe PMC] [Abstract]
  • "Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo."
    Di Lisi R., Millino C., Calabria E., Altruda F., Schiaffino S., Ausoni S.
    J Biol Chem 273:25371-25380(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • "GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5."
    Garg V., Kathiriya I.S., Barnes R., Schluterman M.K., King I.N., Butler C.A., Rothrock C.R., Eapen R.S., Hirayama-Yamada K., Joo K., Matsuoka R., Cohen J.C., Srivastava D.
    Nature 424:443-447(2003) [PubMed] [Europe PMC] [Abstract]
• NFAT protein binding Source: MGI
• protein kinase binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • "Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes."
    Salisch S.v., Klar M., Thurisch B., Bungert J., Dame C.
    J Cell Mol Med 15:1963-1972(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: MGI
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4."
    Xiang F., Sakata Y., Cui L., Youngblood J.M., Nakagami H., Liao J.K., Liao R., Chin M.T.
    Am J Physiol Heart Circ Physiol 290:H1997-2006(2006) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development."
    Anderson K.M., Anderson D.M., McAnally J.R., Shelton J.M., Bassel-Duby R., Olson E.N.
    Nature 539:433-436(2016) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart."
    Arceci R.J., King A.A., Simon M.C., Orkin S.H., Wilson D.B.
    Mol. Cell. Biol. 13:2235-2246(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  • "Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus."
    McGrew M.J., Bogdanova N., Hasegawa K., Hughes S.H., Kitsis R.N., Rosenthal N.
    Mol Cell Biol 16:4524-4534(1996) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription factor binding Source: MGI
• transcription regulatory region sequence-specific DNA binding Source: MGIInferred from sequence orthologyⁱ
  • "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation."
    Gao X., Sedgwick T., Shi Y.B., Evans T.
    Mol Cell Biol 18:2901-2911(1998) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• aortic valve morphogenesis Source: MGI
• atrial septum morphogenesis Source: MGI
• atrial septum primum morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Spectrum of heart disease associated with murine and human GATA4 mutation."
    Rajagopal S.K., Ma Q., Obler D., Shen J., Manichaikul A., Tomita-Mitchell A., Boardman K., Briggs C., Garg V., Srivastava D., Goldmuntz E., Broman K.W., Benson D.W., Smoot L.B., Pu W.T.
    J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
• atrial septum secundum morphogenesis Source: MGI
• atrioventricular canal development Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development."
    Moskowitz I.P., Wang J., Peterson M.A., Pu W.T., Mackinnon A.C., Oxburgh L., Chu G.C., Sarkar M., Berul C., Smoot L., Robertson E.J., Schwartz R., Seidman J.G., Seidman C.E.
    Proc Natl Acad Sci U S A 108:4006-4011(2011) [PubMed] [Europe PMC] [Abstract]
• atrioventricular valve formation Source: BHF-UCLInferred from genetic interactionⁱ
  • "Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development."
    Moskowitz I.P., Wang J., Peterson M.A., Pu W.T., Mackinnon A.C., Oxburgh L., Chu G.C., Sarkar M., Berul C., Smoot L., Robertson E.J., Schwartz R., Seidman J.G., Seidman C.E.
    Proc Natl Acad Sci U S A 108:4006-4011(2011) [PubMed] [Europe PMC] [Abstract]
• atrioventricular valve morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development."
    Maitra M., Schluterman M.K., Nichols H.A., Richardson J.A., Lo C.W., Srivastava D., Garg V.
    Dev Biol 326:368-377(2009) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice."
    Zhao R., Watt A.J., Battle M.A., Li J., Bondow B.J., Duncan S.A.
    Dev Biol 317:614-619(2008) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle hypertrophy in response to stress Source: MGIInferred from mutant phenotypeⁱ
  • "The transcription factor GATA-6 regulates pathological cardiac hypertrophy."
    van Berlo J.H., Elrod J.W., van den Hoogenhof M.M., York A.J., Aronow B.J., Duncan S.A., Molkentin J.D.
    Circ Res 107:1032-1040(2010) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle tissue development Source: MGIInferred from genetic interactionⁱ
  • "The transcription factor GATA-6 regulates pathological cardiac hypertrophy."
    van Berlo J.H., Elrod J.W., van den Hoogenhof M.M., York A.J., Aronow B.J., Duncan S.A., Molkentin J.D.
    Circ Res 107:1032-1040(2010) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle tissue regeneration Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• cardiac right ventricle morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Spectrum of heart disease associated with murine and human GATA4 mutation."
    Rajagopal S.K., Ma Q., Obler D., Shen J., Manichaikul A., Tomita-Mitchell A., Boardman K., Briggs C., Garg V., Srivastava D., Goldmuntz E., Broman K.W., Benson D.W., Smoot L.B., Pu W.T.
    J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
• cardiac septum development Source: BHF-UCLInferred from genetic interactionⁱ
  • "Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development."
    Moskowitz I.P., Wang J., Peterson M.A., Pu W.T., Mackinnon A.C., Oxburgh L., Chu G.C., Sarkar M., Berul C., Smoot L., Robertson E.J., Schwartz R., Seidman J.G., Seidman C.E.
    Proc Natl Acad Sci U S A 108:4006-4011(2011) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: MGIInferred from mutant phenotypeⁱ
  • "GATA-4:FOG interactions regulate gastric epithelial development in the mouse."
    Jacobsen C.M., Mannisto S., Porter-Tinge S., Genova E., Parviainen H., Heikinheimo M., Adameyko I.I., Tevosian S.G., Wilson D.B.
    Dev Dyn 234:355-362(2005) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell growth involved in cardiac muscle cell development Source: MGI
• cellular response to follicle-stimulating hormone stimulus Source: MGIInferred from direct assayⁱ
  • "Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary."
    Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., Wilson D.B.
    Endocrinology 138:3505-3514(1997) [PubMed] [Europe PMC] [Abstract]
• cellular response to gonadotropin stimulus Source: MGIInferred from direct assayⁱ
  • "Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary."
    Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., Wilson D.B.
    Endocrinology 138:3505-3514(1997) [PubMed] [Europe PMC] [Abstract]
• diaphragm morphogenesis Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Spectrum of heart disease associated with murine and human GATA4 mutation."
    Rajagopal S.K., Ma Q., Obler D., Shen J., Manichaikul A., Tomita-Mitchell A., Boardman K., Briggs C., Garg V., Srivastava D., Goldmuntz E., Broman K.W., Benson D.W., Smoot L.B., Pu W.T.
    J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
• embryonic digestive tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "GATA-4:FOG interactions regulate gastric epithelial development in the mouse."
    Jacobsen C.M., Mannisto S., Porter-Tinge S., Genova E., Parviainen H., Heikinheimo M., Adameyko I.I., Tevosian S.G., Wilson D.B.
    Dev Dyn 234:355-362(2005) [PubMed] [Europe PMC] [Abstract]
• embryonic foregut morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 transcription factor is required for ventral morphogenesis and heart tube formation."
    Kuo C.T., Morrisey E.E., Anandappa R., Sigrist K., Lu M.M., Parmacek M.S., Soudais C., Leiden J.M.
    Genes Dev 11:1048-1060(1997) [PubMed] [Europe PMC] [Abstract]
  • "Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis."
    Molkentin J.D., Lin Q., Duncan S.A., Olson E.N.
    Genes Dev 11:1061-1072(1997) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube anterior/posterior pattern specification Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 transcription factor is required for ventral morphogenesis and heart tube formation."
    Kuo C.T., Morrisey E.E., Anandappa R., Sigrist K., Lu M.M., Parmacek M.S., Soudais C., Leiden J.M.
    Genes Dev 11:1048-1060(1997) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube development Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 transcription factor is required for ventral morphogenesis and heart tube formation."
    Kuo C.T., Morrisey E.E., Anandappa R., Sigrist K., Lu M.M., Parmacek M.S., Soudais C., Leiden J.M.
    Genes Dev 11:1048-1060(1997) [PubMed] [Europe PMC] [Abstract]
  • "Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis."
    Molkentin J.D., Lin Q., Duncan S.A., Olson E.N.
    Genes Dev 11:1061-1072(1997) [PubMed] [Europe PMC] [Abstract]
• embryonic morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 transcription factor is required for ventral morphogenesis and heart tube formation."
    Kuo C.T., Morrisey E.E., Anandappa R., Sigrist K., Lu M.M., Parmacek M.S., Soudais C., Leiden J.M.
    Genes Dev 11:1048-1060(1997) [PubMed] [Europe PMC] [Abstract]
  • "Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis."
    Molkentin J.D., Lin Q., Duncan S.A., Olson E.N.
    Genes Dev 11:1061-1072(1997) [PubMed] [Europe PMC] [Abstract]
• endocardial cushion development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Spectrum of heart disease associated with murine and human GATA4 mutation."
    Rajagopal S.K., Ma Q., Obler D., Shen J., Manichaikul A., Tomita-Mitchell A., Boardman K., Briggs C., Garg V., Srivastava D., Goldmuntz E., Broman K.W., Benson D.W., Smoot L.B., Pu W.T.
    J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
• endoderm formation Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro."
    Soudais C., Bielinska M., Heikinheimo M., MacArthur C.A., Narita N., Saffitz J.E., Simon M.C., Leiden J.M., Wilson D.B.
    Development 121:3877-3888(1995) [PubMed] [Europe PMC] [Abstract]
• epithelial cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • "Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine."
    Bosse T., Piaseckyj C.M., Burghard E., Fialkovich J.J., Rajagopal S., Pu W.T., Krasinski S.D.
    Mol Cell Biol 26:9060-9070(2006) [PubMed] [Europe PMC] [Abstract]
• gastrulation with mouth forming second Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis."
    Molkentin J.D., Lin Q., Duncan S.A., Olson E.N.
    Genes Dev 11:1061-1072(1997) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from mutant phenotypeⁱ
  • "Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors."
    Crispino J.D., Lodish M.B., Thurberg B.L., Litovsky S.H., Collins T., Molkentin J.D., Orkin S.H.
    Genes Dev 15:839-844(2001) [PubMed] [Europe PMC] [Abstract]
  • "GATA4 is a dosage-sensitive regulator of cardiac morphogenesis."
    Pu W.T., Ishiwata T., Juraszek A.L., Ma Q., Izumo S.
    Dev Biol 275:235-244(2004) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "GATA4 is essential for formation of the proepicardium and regulates cardiogenesis."
    Watt A.J., Battle M.A., Li J., Duncan S.A.
    Proc Natl Acad Sci U S A 101:12573-12578(2004) [PubMed] [Europe PMC] [Abstract]
• heart morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart."
    Heineke J., Auger-Messier M., Xu J., Oka T., Sargent M.A., York A., Klevitsky R., Vaikunth S., Duncan S.A., Aronow B.J., Robbins J., Crombleholme T.M., Cromblehol T.M., Molkentin J.D.
    J Clin Invest 117:3198-3210(2007) [PubMed] [Europe PMC] [Abstract]
• intestinal epithelial cell differentiation Source: MGIInferred from sequence orthologyⁱ
  • "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation."
    Gao X., Sedgwick T., Shi Y.B., Evans T.
    Mol Cell Biol 18:2901-2911(1998) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 is essential for formation of the proepicardium and regulates cardiogenesis."
    Watt A.J., Battle M.A., Li J., Duncan S.A.
    Proc Natl Acad Sci U S A 101:12573-12578(2004) [PubMed] [Europe PMC] [Abstract]
  • "Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal."
    Niakan K.K., Ji H., Maehr R., Vokes S.A., Rodolfa K.T., Sherwood R.I., Yamaki M., Dimos J.T., Chen A.E., Melton D.A., McMahon A.P., Eggan K.
    Genes Dev 24:312-326(2010) [PubMed] [Europe PMC] [Abstract]
  • "GATA4 transcription factor is required for ventral morphogenesis and heart tube formation."
    Kuo C.T., Morrisey E.E., Anandappa R., Sigrist K., Lu M.M., Parmacek M.S., Soudais C., Leiden J.M.
    Genes Dev 11:1048-1060(1997) [PubMed] [Europe PMC] [Abstract]
  • "Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis."
    Molkentin J.D., Lin Q., Duncan S.A., Olson E.N.
    Genes Dev 11:1061-1072(1997) [PubMed] [Europe PMC] [Abstract]
• lung lobe formation Source: MGIInferred from mutant phenotypeⁱ
  • "Gata4 is necessary for normal pulmonary lobar development."
    Ackerman K.G., Wang J., Luo L., Fujiwara Y., Orkin S.H., Beier D.R.
    Am J Respir Cell Mol Biol 36:391-397(2007) [PubMed] [Europe PMC] [Abstract]
• lung morphogenesis Source: BHF-UCLTraceable author statementⁱ
  • "Spectrum of heart disease associated with murine and human GATA4 mutation."
    Rajagopal S.K., Ma Q., Obler D., Shen J., Manichaikul A., Tomita-Mitchell A., Boardman K., Briggs C., Garg V., Srivastava D., Goldmuntz E., Broman K.W., Benson D.W., Smoot L.B., Pu W.T.
    J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: MGI
• mitral valve formation Source: BHF-UCLTraceable author statementⁱ
  • "Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development."
    Katz S.G., Williams A., Yang J., Fujiwara Y., Tsang A.P., Epstein J.A., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 100:14030-14035(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: BHF-UCLInferred from direct assayⁱ
  • "miR-200b targets GATA-4 during cell growth and differentiation."
    Yao C.X., Wei Q.X., Zhang Y.Y., Wang W.P., Xue L.X., Yang F., Zhang S.F., Xiong C.J., Li W.Y., Wei Z.R., Zou Y., Zang M.X.
    RNA Biol 10:465-480(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of autophagy Source: MGI
• negative regulation of cardiac muscle cell apoptotic process Source: BHF-UCLInferred from genetic interactionⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of connective tissue replacement Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of oxidative stress-induced cell death Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: BHF-UCLTraceable author statementⁱ
  • "Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development."
    Katz S.G., Williams A., Yang J., Fujiwara Y., Tsang A.P., Epstein J.A., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 100:14030-14035(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: BHF-UCLInferred from direct assayⁱ
  • "Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart."
    Heineke J., Auger-Messier M., Xu J., Oka T., Sargent M.A., York A., Klevitsky R., Vaikunth S., Duncan S.A., Aronow B.J., Robbins J., Crombleholme T.M., Cromblehol T.M., Molkentin J.D.
    J Clin Invest 117:3198-3210(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of BMP signaling pathway Source: MGI
• positive regulation of cardiac muscle cell proliferation Source: MGIInferred from genetic interactionⁱ
  • "Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development."
    Maitra M., Schluterman M.K., Nichols H.A., Richardson J.A., Lo C.W., Srivastava D., Garg V.
    Dev Biol 326:368-377(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardioblast differentiation Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis."
    Brewer A.C., Alexandrovich A., Mjaatvedt C.H., Shah A.M., Patient R.K., Pizzey J.A.
    Stem Cells Dev 14:425-439(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle Source: BHF-UCLInferred from direct assayⁱ
  • "miR-200b targets GATA-4 during cell growth and differentiation."
    Yao C.X., Wei Q.X., Zhang Y.Y., Wang W.P., Xue L.X., Yang F., Zhang S.F., Xiong C.J., Li W.Y., Wei Z.R., Zou Y., Zang M.X.
    RNA Biol 10:465-480(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • "miR-200b targets GATA-4 during cell growth and differentiation."
    Yao C.X., Wei Q.X., Zhang Y.Y., Wang W.P., Xue L.X., Yang F., Zhang S.F., Xiong C.J., Li W.Y., Wei Z.R., Zou Y., Zang M.X.
    RNA Biol 10:465-480(2013) [PubMed] [Europe PMC] [Abstract]
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5."
    Garg V., Kathiriya I.S., Barnes R., Schluterman M.K., King I.N., Butler C.A., Rothrock C.R., Eapen R.S., Hirayama-Yamada K., Joo K., Matsuoka R., Cohen J.C., Srivastava D.
    Nature 424:443-447(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5."
    Garg V., Kathiriya I.S., Barnes R., Schluterman M.K., King I.N., Butler C.A., Rothrock C.R., Eapen R.S., Hirayama-Yamada K., Joo K., Matsuoka R., Cohen J.C., Srivastava D.
    Nature 424:443-447(2003) [PubMed] [Europe PMC] [Abstract]
  • "Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes."
    Salisch S.v., Klar M., Thurisch B., Bungert J., Dame C.
    J Cell Mol Med 15:1963-1972(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular endothelial growth factor production Source: BHF-UCLInferred from direct assayⁱ
  • "Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart."
    Heineke J., Auger-Messier M., Xu J., Oka T., Sargent M.A., York A., Klevitsky R., Vaikunth S., Duncan S.A., Aronow B.J., Robbins J., Crombleholme T.M., Cromblehol T.M., Molkentin J.D.
    J Clin Invest 117:3198-3210(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cardiac muscle cell contraction Source: MGI
• regulation of cardiac muscle cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Morphogenesis of the right ventricle requires myocardial expression of Gata4."
    Zeisberg E.M., Ma Q., Juraszek A.L., Moses K., Schwartz R.J., Izumo S., Pu W.T.
    J Clin Invest 115:1522-1531(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: MGIInferred from direct assayⁱ
  • "Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation."
    Trivedi C.M., Zhu W., Wang Q., Jia C., Kee H.J., Li L., Hannenhalli S., Epstein J.A.
    Dev Cell 19:450-459(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of protein kinase B signaling Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo."
    Di Lisi R., Millino C., Calabria E., Altruda F., Schiaffino S., Ausoni S.
    J Biol Chem 273:25371-25380(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression."
    Anttonen M., Ketola I., Parviainen H., Pusa A.K., Heikinheimo M.
    Biol Reprod 68:1333-1340(2003) [PubMed] [Europe PMC] [Abstract]
  • "Differential expression and function of Tbx5 and Tbx20 in cardiac development."
    Plageman T.F. Jr., Yutzey K.E.
    J Biol Chem 279:19026-19034(2004) [PubMed] [Europe PMC] [Abstract]
  • "SOX7 and GATA-4 are competitive activators of Fgf-3 transcription."
    Murakami A., Shen H., Ishida S., Dickson C.
    J. Biol. Chem. 279:28564-28573(2004) [PubMed] [Europe PMC] [Abstract]
  • "Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene."
    Molkentin J.D., Kalvakolanu D.V., Markham B.E.
    Mol Cell Biol 14:4947-4957(1994) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart."
    Arceci R.J., King A.A., Simon M.C., Orkin S.H., Wilson D.B.
    Mol. Cell. Biol. 13:2235-2246(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• response to drug Source: MGI
• response to estrogen Source: MGIInferred from direct assayⁱ
  • "Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary."
    Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., Wilson D.B.
    Endocrinology 138:3505-3514(1997) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: MGI
• response to retinoic acid Source: BHF-UCLInferred from direct assayⁱ
  • "Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells."
    Su D., Gudas L.J.
    Exp Hematol 36:624-641(2008) [PubMed] [Europe PMC] [Abstract]
• seminiferous tubule development Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 regulates Sertoli cell function and fertility in adult male mice."
    Kyronlahti A., Euler R., Bielinska M., Schoeller E.L., Moley K.H., Toppari J., Heikinheimo M., Wilson D.B.
    Mol Cell Endocrinol 333:85-95(2011) [PubMed] [Europe PMC] [Abstract]
• Sertoli cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 regulates Sertoli cell function and fertility in adult male mice."
    Kyronlahti A., Euler R., Bielinska M., Schoeller E.L., Moley K.H., Toppari J., Heikinheimo M., Wilson D.B.
    Mol Cell Endocrinol 333:85-95(2011) [PubMed] [Europe PMC] [Abstract]
• signal transduction involved in regulation of gene expression Source: MGIInferred from direct assayⁱ
  • "ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification."
    Lee D., Park C., Lee H., Lugus J.J., Kim S.H., Arentson E., Chung Y.S., Gomez G., Kyba M., Lin S., Janknecht R., Lim D.S., Choi K.
    Cell Stem Cell 2:497-507(2008) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C."
    Al Madhoun A.S., Mehta V., Li G., Figeys D., Wiper-Bergeron N., Skerjanc I.S.
    EMBO J 30:2477-2489(2011) [PubMed] [Europe PMC] [Abstract]
• SMAD protein signal transduction Source: MGIInferred from direct assayⁱ
  • "The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo."
    Sirard C., de la Pompa J.L., Elia A., Itie A., Mirtsos C., Cheung A., Hahn S., Wakeham A., Schwartz L., Kern S.E., Rossant J., Mak T.W.
    Genes Dev 12:107-119(1998) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "GATA4 regulates Sertoli cell function and fertility in adult male mice."
    Kyronlahti A., Euler R., Bielinska M., Schoeller E.L., Moley K.H., Toppari J., Heikinheimo M., Wilson D.B.
    Mol Cell Endocrinol 333:85-95(2011) [PubMed] [Europe PMC] [Abstract]
• transdifferentiation Source: MGI
• tricuspid valve formation Source: BHF-UCLTraceable author statementⁱ
  • "Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development."
    Katz S.G., Williams A., Yang J., Fujiwara Y., Tsang A.P., Epstein J.A., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 100:14030-14035(2003) [PubMed] [Europe PMC] [Abstract]
• tube morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice."
    Zhao R., Watt A.J., Battle M.A., Li J., Bondow B.J., Duncan S.A.
    Dev Biol 317:614-619(2008) [PubMed] [Europe PMC] [Abstract]
• vasculogenesis involved in coronary vascular morphogenesis Source: DFLATTraceable author statementⁱ
  • "Epicardial-myocardial signaling directing coronary vasculogenesis."
    Olivey H.E., Svensson E.C.
    Circ Res 106:818-832(2010) [PubMed] [Europe PMC] [Abstract]
• ventricular cardiac muscle tissue development Source: MGIInferred from genetic interactionⁱ
  • "Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development."
    Maitra M., Schluterman M.K., Nichols H.A., Richardson J.A., Lo C.W., Srivastava D., Garg V.
    Dev Biol 326:368-377(2009) [PubMed] [Europe PMC] [Abstract]
• ventricular septum development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Spectrum of heart disease associated with murine and human GATA4 mutation."
    Rajagopal S.K., Ma Q., Obler D., Shen J., Manichaikul A., Tomita-Mitchell A., Boardman K., Briggs C., Garg V., Srivastava D., Goldmuntz E., Broman K.W., Benson D.W., Smoot L.B., Pu W.T.
    J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: BHF-UCLInferred from direct assayⁱ
  • "Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection."
    Yu B., Kim H.W., Gong M., Wang J., Millard R.W., Wang Y., Ashraf M., Xu M.
    Int J Cardiol 182:349-360(2015) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: MGI
• co-SMAD binding Source: MGI
• NFAT protein binding Source: MGI
• protein kinase binding Source: MGI
• RNA polymerase II transcription factor binding Source: MGI
• transcription factor binding Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG 
        60         70         80         90        100
LSYLQGGGSA AAAGTTSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT 
       110        120        130        140        150
PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYGSGGGAAG AGLAGREQYG 
       160        170        180        190        200
RPGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPGR 
       210        220        230        240        250
HPNLDMFDDF SEGRECVNCG AMSTPLWRRD GTGHYLCNAC GLYHKMNGIN 
       260        270        280        290        300
RPLIKPQRRL SASRRVGLSC ANCQTTTTTL WRRNAEGEPV CNACGLYMKL 
       310        320        330        340        350
HGVPRPLAMR KEGIQTRKRK PKNLNKSKTP AGPAGETLPP SSGASSGNSS 
       360        370        380        390        400
NATSSSSSSE EMRPIKTEPG LSSHYGHSSS MSQTFSTVSG HGPSIHPVLS 
       410        420        430        440 
ALKLSPQGYA SPVTQTSQAS SKQDSWNSLV LADSHGDIIT A          

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot