Transcription factor GATA-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activating transcription factor binding Source: MGI
• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 21379568
• co-SMAD binding Source: MGI
• DNA binding Source: MGIInferred from direct assayⁱ
  • 15539431
  • 8007990
  • 9738004
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • 15082719
  • 9738004
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • 12845333
• enhancer sequence-specific DNA binding Source: MGI
• NFAT protein binding Source: MGI
• protein kinase binding Source: MGI
• proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • 21029371
• RNA polymerase II regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 16603706
• RNA polymerase II transcription factor binding Source: MGI
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 8455608
  • 8754853
• transcription coactivator activity Source: MGI
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: BHF-UCLInferred from direct assayⁱ
  • 17975667
• transcription factor binding Source: MGI
• transcription regulatory region DNA binding Source: MGIInferred from sequence orthologyⁱ
  • 9566909
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• anatomical structure formation involved in morphogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• animal organ morphogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• aortic valve morphogenesis Source: MGI
• atrial septum morphogenesis Source: MGI
• atrial septum primum morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17643447
• atrial septum secundum morphogenesis Source: MGI
• atrioventricular canal development Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 21330551
• atrioventricular valve formation Source: BHF-UCLInferred from genetic interactionⁱ
  • 21330551
• atrioventricular valve morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 19084512
• BMP signaling pathway Source: MGIInferred from direct assayⁱ
  • 17360443
• canonical Wnt signaling pathway Source: MGIInferred from direct assayⁱ
  • 17360443
• cardiac muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 18400219
• cardiac muscle hypertrophy in response to stress Source: MGIInferred from mutant phenotypeⁱ
  • 20705924
• cardiac muscle tissue development Source: MGIInferred from genetic interactionⁱ
  • 20705924
• cardiac muscle tissue regeneration Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• cardiac right ventricle morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 17643447
• cardiac septum development Source: BHF-UCLInferred from genetic interactionⁱ
  • 21330551
• cell-cell signaling Source: MGIInferred from mutant phenotypeⁱ
  • 16127717
• cell development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cell growth involved in cardiac muscle cell development Source: MGI
• cellular response to follicle-stimulating hormone stimulus Source: MGIInferred from direct assayⁱ
  • 9231805
• cellular response to gonadotropin stimulus Source: MGIInferred from direct assayⁱ
  • 9231805
• diaphragm morphogenesis Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 17643447
• embryonic digestive tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 16127717
• embryonic foregut morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 9136932
  • 9136933
• embryonic heart tube anterior/posterior pattern specification Source: MGIInferred from mutant phenotypeⁱ
  • 9136932
• embryonic heart tube development Source: MGIInferred from mutant phenotypeⁱ
  • 9136932
  • 9136933
• embryonic morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 9136932
  • 9136933
• endocardial cushion development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 17643447
• endoderm formation Source: MGIInferred from mutant phenotypeⁱ
  • 8582296
• epithelial cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • 16940177
• gastrulation with mouth forming second Source: MGIInferred from mutant phenotypeⁱ
  • 9136933
• heart development Source: MGIInferred from mutant phenotypeⁱ
  • 11297508
  • 15464586
• heart looping Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 15310850
• heart morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 17975667
• intestinal epithelial cell differentiation Source: MGIInferred from sequence orthologyⁱ
  • 9566909
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 15310850
  • 20123909
  • 9136932
  • 9136933
• lung lobe formation Source: MGIInferred from mutant phenotypeⁱ
  • 17142311
• lung morphogenesis Source: BHF-UCLTraceable author statementⁱ
  • 17643447
• male gonad development Source: MGI
• mitral valve formation Source: BHF-UCLTraceable author statementⁱ
  • 14614148
• negative regulation of apoptotic process Source: BHF-UCLInferred from direct assayⁱ
  • 23558708
• negative regulation of apoptotic signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• negative regulation of autophagy Source: MGI
• negative regulation of cardiac muscle cell apoptotic process Source: BHF-UCLInferred from genetic interactionⁱ
  • 25590961
• negative regulation of connective tissue replacement Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• negative regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• negative regulation of oxidative stress-induced cell death Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• outflow tract morphogenesis Source: BHF-UCLTraceable author statementⁱ
  • 14614148
• positive regulation of angiogenesis Source: BHF-UCLInferred from direct assayⁱ
  • 17975667
• positive regulation of BMP signaling pathway Source: MGI
• positive regulation of cardiac muscle cell proliferation Source: MGIInferred from genetic interactionⁱ
  • 19084512
• positive regulation of cardioblast differentiation Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 16137232
• positive regulation of cell cycle Source: BHF-UCLInferred from direct assayⁱ
  • 23558708
• positive regulation of ERK1 and ERK2 cascade Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• positive regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • 23558708
  • 25590961
• positive regulation of protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 12845333
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • 21029371
• positive regulation of vascular endothelial growth factor production Source: BHF-UCLInferred from direct assayⁱ
  • 17975667
• regulation of cardiac muscle cell contraction Source: MGI
• regulation of cardiac muscle cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 15902305
• regulation of gene expression Source: MGIInferred from direct assayⁱ
  • 20833366
• regulation of protein kinase B signaling Source: BHF-UCLInferred from direct assayⁱ
  • 25590961
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • 9738004
• regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 12606418
  • 14978031
  • 15082719
  • 8007990
  • 8455608
• response to drug Source: MGI
• response to estrogen Source: MGIInferred from direct assayⁱ
  • 9231805
• response to mechanical stimulus Source: MGI
• response to retinoic acid Source: BHF-UCLInferred from direct assayⁱ
  • 18439490
• seminiferous tubule development Source: MGIInferred from mutant phenotypeⁱ
  • 21172404
• Sertoli cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 21172404
• signal transduction involved in regulation of gene expression Source: MGIInferred from direct assayⁱ
  • 18462699
• skeletal muscle cell differentiation Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 21556048
• SMAD protein signal transduction Source: MGIInferred from direct assayⁱ
  • 9420335
• spermatogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 21172404
• tissue development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • 12845333
• transdifferentiation Source: MGI
• tricuspid valve formation Source: BHF-UCLTraceable author statementⁱ
  • 14614148
• tube morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 18400219
• vasculogenesis involved in coronary vascular morphogenesis Source: DFLATTraceable author statementⁱ
  • 20299672
• ventricular cardiac muscle tissue development Source: MGIInferred from genetic interactionⁱ
  • 19084512
• ventricular septum development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 17643447

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: MGI
• co-SMAD binding Source: MGI
• NFAT protein binding Source: MGI
• protein kinase binding Source: MGI
• RNA polymerase II transcription factor binding Source: MGI
• transcription factor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG 
        60         70         80         90        100
LSYLQGGGSA AAAGTTSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT 
       110        120        130        140        150
PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYGSGGGAAG AGLAGREQYG 
       160        170        180        190        200
RPGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPGR 
       210        220        230        240        250
HPNLDMFDDF SEGRECVNCG AMSTPLWRRD GTGHYLCNAC GLYHKMNGIN 
       260        270        280        290        300
RPLIKPQRRL SASRRVGLSC ANCQTTTTTL WRRNAEGEPV CNACGLYMKL 
       310        320        330        340        350
HGVPRPLAMR KEGIQTRKRK PKNLNKSKTP AGPAGETLPP SSGASSGNSS 
       360        370        380        390        400
NATSSSSSSE EMRPIKTEPG LSSHYGHSSS MSQTFSTVSG HGPSIHPVLS 
       410        420        430        440 
ALKLSPQGYA SPVTQTSQAS SKQDSWNSLV LADSHGDIIT A          

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot