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Entry version 150 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Sodium-dependent phosphate transporter 2

Gene

SLC20A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427652 Sodium-coupled phosphate cotransporters
R-HSA-5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.20.2.3 the inorganic phosphate transporter (pit) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Gibbon ape leukemia virus receptor 2
Short name:
GLVR-2
Phosphate transporter 2
Short name:
PiT-2
Short name:
Pit2
Short name:
hPit2
Solute carrier family 20 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC20A2
Synonyms:GLVR2, PIT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10947 SLC20A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
158378 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08357

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 5ExtracellularSequence analysis5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 46CytoplasmicSequence analysisAdd BLAST20
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 86ExtracellularSequence analysisAdd BLAST19
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 109CytoplasmicSequence analysis2
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 142ExtracellularSequence analysisAdd BLAST12
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 190CytoplasmicSequence analysisAdd BLAST27
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 213ExtracellularSequence analysis2
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 482CytoplasmicSequence analysisAdd BLAST248
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 530ExtracellularSequence analysisAdd BLAST27
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 571CytoplasmicSequence analysisAdd BLAST20
Transmembranei572 – 586HelicalSequence analysisAdd BLAST15
Topological domaini587 – 593ExtracellularSequence analysis7
Transmembranei594 – 609HelicalSequence analysisAdd BLAST16
Topological domaini610 – 621CytoplasmicSequence analysisAdd BLAST12
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 652ExtracellularSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Basal ganglia calcification, idiopathic, 1 (IBGC1)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
See also OMIM:213600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07225511I → L in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs201836672Ensembl.1
Natural variantiVAR_07225628D → N in IBGC1; Impairs phosphate transport; no effect on retroviral receptor function. 3 Publications1
Natural variantiVAR_06754542Missing in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_07225751A → V in IBGC1. 1 Publication1
Natural variantiVAR_07225862L → P in IBGC1. 1 Publication1
Natural variantiVAR_07225971R → H in IBGC1. 1 Publication1
Natural variantiVAR_072260115T → M in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs775911275Ensembl.1
Natural variantiVAR_075396184P → L in IBGC1; unknown pathological significance. 1 Publication1
Natural variantiVAR_075397194N → S in IBGC1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748252183Ensembl.1
Natural variantiVAR_072261382R → Q in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs200010919Ensembl.1
Natural variantiVAR_072262434S → W in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs1357615935Ensembl.1
Natural variantiVAR_067546498G → R in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_072263502H → Q in IBGC1. 1 Publication1
Natural variantiVAR_072264568P → L in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs763252801Ensembl.1
Natural variantiVAR_075398571G → S in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs1388992742Ensembl.1
Natural variantiVAR_067547575E → K in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant dbSNP:rs387906653EnsemblClinVar.1
Natural variantiVAR_067548595T → M in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant dbSNP:rs387906654EnsemblClinVar.1
Natural variantiVAR_067549601S → L in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant dbSNP:rs387906652EnsemblClinVar.1
Natural variantiVAR_067550601S → W in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant dbSNP:rs387906652EnsemblClinVar.1
Natural variantiVAR_072265637S → R in IBGC1. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi55E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications1
Mutagenesisi55E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-91 and Q-575. 2 Publications1
Mutagenesisi81N → V: Abolishes N-glycosylation. 1 Publication1
Mutagenesisi91E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-575. 1 Publication1
Mutagenesisi506D → N: Impairs phosphate transport; no effect on retroviral receptor function. 1 Publication1
Mutagenesisi575E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications1
Mutagenesisi575E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-91. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6575

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC20A2

MalaCards human disease database

More...
MalaCardsi
SLC20A2
MIMi213600 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000168575

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1980 Bilateral striopallidodentate calcinosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35834

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC20A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74735615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003412681 – 652Sodium-dependent phosphate transporter 2Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei253PhosphoserineBy similarity1
Modified residuei256PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q08357

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q08357

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08357

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08357

PeptideAtlas

More...
PeptideAtlasi
Q08357

PRoteomics IDEntifications database

More...
PRIDEi
Q08357

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58600

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08357

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08357

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Increased by phosphate depletion in osteosarcoma cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168575 Expressed in 224 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q08357 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08357 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026540

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112463, 15 interactors

Protein interaction database and analysis system

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IntActi
Q08357, 5 interactors

Molecular INTeraction database

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MINTi
Q08357

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340465

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2493 Eukaryota
COG0306 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014879

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231892

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q08357

KEGG Orthology (KO)

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KOi
K14640

Identification of Orthologs from Complete Genome Data

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OMAi
SQVQWGW

Database of Orthologous Groups

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OrthoDBi
712010at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08357

TreeFam database of animal gene trees

More...
TreeFami
TF314426

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001204 Phos_transporter

The PANTHER Classification System

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PANTHERi
PTHR11101 PTHR11101, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01384 PHO4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q08357-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GTKGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGL LFVLIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLVL PMWAIALISF GVALLFAFFV WLFVCPWMRR KITGKLQKEG
260 270 280 290 300
ALSRVSDESL SKVQEAESPV FKELPGAKAN DDSTIPLTGA AGETLGTSEG
310 320 330 340 350
TSAGSHPRAA YGRALSMTHG SVKSPISNGT FGFDGHTRSD GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHK IHIDRGPEEK PAQESNYRLL RRNNSYTCYT AAICGLPVHA
410 420 430 440 450
TFRAADSSAP EDSEKLVGDT VSYSKKRLRY DSYSSYCNAV AEAEIEAEEG
460 470 480 490 500
GVEMKLASEL ADPDQPREDP AEEEKEEKDA PEVHLLFHFL QVLTACFGSF
510 520 530 540 550
AHGGNDVSNA IGPLVALWLI YKQGGVTQEA ATPVWLLFYG GVGICTGLWV
560 570 580 590 600
WGRRVIQTMG KDLTPITPSS GFTIELASAF TVVIASNIGL PVSTTHCKVG
610 620 630 640 650
SVVAVGWIRS RKAVDWRLFR NIFVAWFVTV PVAGLFSAAV MALLMYGILP

YV
Length:652
Mass (Da):70,392
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0A870C7927DE39C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGG8E5RGG8_HUMAN
Sodium-dependent phosphate transpor...
SLC20A2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGM8E5RGM8_HUMAN
Sodium-dependent phosphate transpor...
SLC20A2
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGJ6E5RGJ6_HUMAN
Sodium-dependent phosphate transpor...
SLC20A2
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIX1E5RIX1_HUMAN
Sodium-dependent phosphate transpor...
SLC20A2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJW9E5RJW9_HUMAN
Sodium-dependent phosphate transpor...
SLC20A2
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07225511I → L in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs201836672Ensembl.1
Natural variantiVAR_07225628D → N in IBGC1; Impairs phosphate transport; no effect on retroviral receptor function. 3 Publications1
Natural variantiVAR_06754542Missing in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_07225751A → V in IBGC1. 1 Publication1
Natural variantiVAR_07225862L → P in IBGC1. 1 Publication1
Natural variantiVAR_07225971R → H in IBGC1. 1 Publication1
Natural variantiVAR_072260115T → M in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs775911275Ensembl.1
Natural variantiVAR_075396184P → L in IBGC1; unknown pathological significance. 1 Publication1
Natural variantiVAR_075397194N → S in IBGC1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748252183Ensembl.1
Natural variantiVAR_072261382R → Q in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs200010919Ensembl.1
Natural variantiVAR_072262434S → W in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs1357615935Ensembl.1
Natural variantiVAR_067546498G → R in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_072263502H → Q in IBGC1. 1 Publication1
Natural variantiVAR_072264568P → L in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs763252801Ensembl.1
Natural variantiVAR_075398571G → S in IBGC1. 1 PublicationCorresponds to variant dbSNP:rs1388992742Ensembl.1
Natural variantiVAR_067547575E → K in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant dbSNP:rs387906653EnsemblClinVar.1
Natural variantiVAR_067548595T → M in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant dbSNP:rs387906654EnsemblClinVar.1
Natural variantiVAR_067549601S → L in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant dbSNP:rs387906652EnsemblClinVar.1
Natural variantiVAR_067550601S → W in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant dbSNP:rs387906652EnsemblClinVar.1
Natural variantiVAR_072265637S → R in IBGC1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L20852 mRNA Translation: AAA18018.1
AK291202 mRNA Translation: BAF83891.1
BC028600 mRNA Translation: AAH28600.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6132.1

Protein sequence database of the Protein Information Resource

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PIRi
A37000

NCBI Reference Sequences

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RefSeqi
NP_001244109.1, NM_001257180.1
NP_001244110.1, NM_001257181.1
NP_006740.1, NM_006749.4
XP_005273670.1, XM_005273613.3
XP_016869237.1, XM_017013748.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000342228; ENSP00000340465; ENSG00000168575
ENST00000520179; ENSP00000429712; ENSG00000168575
ENST00000520262; ENSP00000429754; ENSG00000168575

Database of genes from NCBI RefSeq genomes

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GeneIDi
6575

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6575

UCSC genome browser

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UCSCi
uc003xpe.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20852 mRNA Translation: AAA18018.1
AK291202 mRNA Translation: BAF83891.1
BC028600 mRNA Translation: AAH28600.1
CCDSiCCDS6132.1
PIRiA37000
RefSeqiNP_001244109.1, NM_001257180.1
NP_001244110.1, NM_001257181.1
NP_006740.1, NM_006749.4
XP_005273670.1, XM_005273613.3
XP_016869237.1, XM_017013748.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112463, 15 interactors
IntActiQ08357, 5 interactors
MINTiQ08357
STRINGi9606.ENSP00000340465

Protein family/group databases

TCDBi2.A.20.2.3 the inorganic phosphate transporter (pit) family

PTM databases

iPTMnetiQ08357
PhosphoSitePlusiQ08357

Polymorphism and mutation databases

BioMutaiSLC20A2
DMDMi74735615

Proteomic databases

EPDiQ08357
jPOSTiQ08357
MaxQBiQ08357
PaxDbiQ08357
PeptideAtlasiQ08357
PRIDEiQ08357
ProteomicsDBi58600

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6575
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342228; ENSP00000340465; ENSG00000168575
ENST00000520179; ENSP00000429712; ENSG00000168575
ENST00000520262; ENSP00000429754; ENSG00000168575
GeneIDi6575
KEGGihsa:6575
UCSCiuc003xpe.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6575
DisGeNETi6575

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC20A2
GeneReviewsiSLC20A2
HGNCiHGNC:10947 SLC20A2
HPAiHPA026540
MalaCardsiSLC20A2
MIMi158378 gene
213600 phenotype
neXtProtiNX_Q08357
OpenTargetsiENSG00000168575
Orphaneti1980 Bilateral striopallidodentate calcinosis
PharmGKBiPA35834

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2493 Eukaryota
COG0306 LUCA
GeneTreeiENSGT00390000014879
HOGENOMiHOG000231892
InParanoidiQ08357
KOiK14640
OMAiSQVQWGW
OrthoDBi712010at2759
PhylomeDBiQ08357
TreeFamiTF314426

Enzyme and pathway databases

ReactomeiR-HSA-427652 Sodium-coupled phosphate cotransporters
R-HSA-5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC20A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC20A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6575

Protein Ontology

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PROi
PR:Q08357

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168575 Expressed in 224 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ08357 baseline and differential
GenevisibleiQ08357 HS

Family and domain databases

InterProiView protein in InterPro
IPR001204 Phos_transporter
PANTHERiPTHR11101 PTHR11101, 1 hit
PfamiView protein in Pfam
PF01384 PHO4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS20A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08357
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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