UniProtKB - Q08331 (CALB2_MOUSE)
Protein
Calretinin
Gene
Calb2
Organism
Mus musculus (Mouse)
Status
Functioni
Calretinin is a calcium-binding protein which is abundant in auditory neurons.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 29 – 40 | 1CuratedAdd BLAST | 12 | |
Calcium bindingi | 76 – 87 | 2; possibly ancestralCuratedAdd BLAST | 12 | |
Calcium bindingi | 120 – 131 | 3CuratedAdd BLAST | 12 | |
Calcium bindingi | 164 – 175 | 4CuratedAdd BLAST | 12 | |
Calcium bindingi | 208 – 219 | 5CuratedAdd BLAST | 12 | |
Calcium bindingi | 251 – 262 | 6; possibly ancestralCuratedAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: MGI
GO - Biological processi
- regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of long-term synaptic potentiation Source: GO_Central
- regulation of presynaptic cytosolic calcium ion concentration Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: CalretininShort name: CR |
Gene namesi | Name:Calb2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101914, Calb2 |
Subcellular locationi
Cytoskeleton
- cuticular plate Source: MGI
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- synaptic membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- dendrite Source: GO_Central
- gap junction Source: MGI
- neuron projection Source: GO_Central
- stereocilium Source: MGI
- synapse Source: GO_Central
- terminal bouton Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073480 | 1 – 271 | CalretininAdd BLAST | 271 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 214 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q08331 |
MaxQBi | Q08331 |
PaxDbi | Q08331 |
PeptideAtlasi | Q08331 |
PRIDEi | Q08331 |
2D gel databases
UCD-2DPAGEi | Q08331 |
PTM databases
iPTMneti | Q08331 |
PhosphoSitePlusi | Q08331 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000003657, Expressed in olfactory bulb and 154 other tissues |
ExpressionAtlasi | Q08331, baseline and differential |
Genevisiblei | Q08331, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 198450, 5 interactors |
IntActi | Q08331, 2 interactors |
STRINGi | 10090.ENSMUSP00000003754 |
Miscellaneous databases
RNActi | Q08331, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 51 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 63 – 98 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 107 – 142 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 151 – 186 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 195 – 230 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 235 – 270 | EF-hand 6PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the calbindin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00950000183108 |
HOGENOMi | CLU_054826_1_1_1 |
InParanoidi | Q08331 |
OrthoDBi | 979297at2759 |
PhylomeDBi | Q08331 |
TreeFami | TF325083 |
Family and domain databases
CDDi | cd16177, EFh_HEF_CR, 1 hit |
InterProi | View protein in InterPro IPR029646, CALB2 IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR19972:SF4, PTHR19972:SF4, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 5 hits PS50222, EF_HAND_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q08331-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK
60 70 80 90 100
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL
110 120 130 140 150
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP
160 170 180 190 200
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF
210 220 230 240 250
NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL
260 270
AEAGKLYRKD LEIVLCSEPP V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8CCS7 | Q8CCS7_MOUSE | Calretinin | Calb2 | 242 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037969 Genomic DNA Translation: BAA90701.1 BC017646 mRNA Translation: AAH17646.1 U34818 Genomic DNA Translation: AAA84429.1 X73985 mRNA Translation: CAA52163.1 |
CCDSi | CCDS22661.1 |
PIRi | S41476 |
RefSeqi | NP_031612.1, NM_007586.1 |
Genome annotation databases
Ensembli | ENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657 |
GeneIDi | 12308 |
KEGGi | mmu:12308 |
UCSCi | uc009nko.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037969 Genomic DNA Translation: BAA90701.1 BC017646 mRNA Translation: AAH17646.1 U34818 Genomic DNA Translation: AAA84429.1 X73985 mRNA Translation: CAA52163.1 |
CCDSi | CCDS22661.1 |
PIRi | S41476 |
RefSeqi | NP_031612.1, NM_007586.1 |
3D structure databases
SMRi | Q08331 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198450, 5 interactors |
IntActi | Q08331, 2 interactors |
STRINGi | 10090.ENSMUSP00000003754 |
PTM databases
iPTMneti | Q08331 |
PhosphoSitePlusi | Q08331 |
2D gel databases
UCD-2DPAGEi | Q08331 |
Proteomic databases
jPOSTi | Q08331 |
MaxQBi | Q08331 |
PaxDbi | Q08331 |
PeptideAtlasi | Q08331 |
PRIDEi | Q08331 |
Protocols and materials databases
ABCDi | Q08331, 2 sequenced antibodies |
Antibodypediai | 1545, 630 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657 |
GeneIDi | 12308 |
KEGGi | mmu:12308 |
UCSCi | uc009nko.1, mouse |
Organism-specific databases
CTDi | 794 |
MGIi | MGI:101914, Calb2 |
Phylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00950000183108 |
HOGENOMi | CLU_054826_1_1_1 |
InParanoidi | Q08331 |
OrthoDBi | 979297at2759 |
PhylomeDBi | Q08331 |
TreeFami | TF325083 |
Miscellaneous databases
BioGRID-ORCSi | 12308, 0 hits in 17 CRISPR screens |
ChiTaRSi | Calb2, mouse |
PROi | PR:Q08331 |
RNActi | Q08331, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000003657, Expressed in olfactory bulb and 154 other tissues |
ExpressionAtlasi | Q08331, baseline and differential |
Genevisiblei | Q08331, MM |
Family and domain databases
CDDi | cd16177, EFh_HEF_CR, 1 hit |
InterProi | View protein in InterPro IPR029646, CALB2 IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR19972:SF4, PTHR19972:SF4, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 5 hits PS50222, EF_HAND_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CALB2_MOUSE | |
Accessioni | Q08331Primary (citable) accession number: Q08331 Secondary accession number(s): Q60964, Q9JM81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | April 27, 2001 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families