UniProtKB - Q08289 (CACB2_HUMAN)
Voltage-dependent L-type calcium channel subunit beta-2
CACNB2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 549 | Required for CaMK2D-bindingBy similarity | 1 |
GO - Molecular functioni
- actin filament binding Source: BHF-UCL
- calcium channel activity Source: UniProtKB
- voltage-gated calcium channel activity Source: BHF-UCL
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Source: Ensembl
GO - Biological processi
- calcium ion import Source: BHF-UCL
- cardiac conduction Source: Reactome
- chemical synaptic transmission Source: GO_Central
- membrane depolarization during atrial cardiac muscle cell action potential Source: BHF-UCL
- membrane depolarization during AV node cell action potential Source: BHF-UCL
- neuromuscular junction development Source: GO_Central
- positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
- positive regulation of calcium ion transport Source: BHF-UCL
- positive regulation of high voltage-gated calcium channel activity Source: BHF-UCL
- protein localization to plasma membrane Source: BHF-UCL
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of voltage-gated calcium channel activity Source: GO_Central
- visual perception Source: Ensembl
Keywordsi
Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q08289 |
Reactomei | R-HSA-112308, Presynaptic depolarization and calcium channel opening R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-419037, NCAM1 interactions R-HSA-422356, Regulation of insulin secretion R-HSA-5576892, Phase 0 - rapid depolarisation R-HSA-5576893, Phase 2 - plateau phase |
SignaLinki | Q08289 |
SIGNORi | Q08289 |
Protein family/group databases
TCDBi | 8.A.22.1.2, the ca(2+) channel auxiliary subunit Beta types 1-4 (cca-Beta) family |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent L-type calcium channel subunit beta-2Short name: CAB2 Alternative name(s): Calcium channel voltage-dependent subunit beta 2 Lambert-Eaton myasthenic syndrome antigen B Short name: MYSB |
Gene namesi | Name:CACNB2 Synonyms:CACNLB2, MYSB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165995.18 |
HGNCi | HGNC:1402, CACNB2 |
MIMi | 600003, gene |
neXtProti | NX_Q08289 |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- L-type voltage-gated calcium channel complex Source: BHF-UCL
- plasma membrane Source: Reactome
- voltage-gated calcium channel complex Source: BHF-UCL
Other locations
- photoreceptor ribbon synapse Source: Ensembl
- presynapse Source: GOC
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Brugada syndrome 4 (BRGDA4)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044041 | 535 | S → L in BRGDA4; unknown pathological significance; affects channel activity. 1 PublicationCorresponds to variant dbSNP:rs121917812EnsemblClinVar. | 1 |
Keywords - Diseasei
Brugada syndrome, Disease mutationOrganism-specific databases
DisGeNETi | 783 |
GeneReviewsi | CACNB2 |
MalaCardsi | CACNB2 |
MIMi | 611876, phenotype |
OpenTargetsi | ENSG00000165995 |
Orphaneti | 130, Brugada syndrome |
PharmGKBi | PA88 |
Miscellaneous databases
Pharosi | Q08289, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3317336 |
DrugBanki | DB01118, Amiodarone DB09231, Benidipine DB13746, Bioallethrin DB11148, Butamben DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate DB09232, Cilnidipine DB04855, Dronedarone DB00228, Enflurane DB00153, Ergocalciferol DB01023, Felodipine DB13961, Fish oil DB00270, Isradipine DB09236, Lacidipine DB00825, Levomenthol DB00653, Magnesium sulfate DB09238, Manidipine DB01388, Mibefradil DB01110, Miconazole DB00622, Nicardipine DB01115, Nifedipine DB06712, Nilvadipine DB00393, Nimodipine DB00401, Nisoldipine DB01054, Nitrendipine DB00252, Phenytoin DB00243, Ranolazine DB00421, Spironolactone DB00273, Topiramate DB09089, Trimebutine |
Polymorphism and mutation databases
BioMutai | CACNB2 |
DMDMi | 145559447 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144051 | 1 – 660 | Voltage-dependent L-type calcium channel subunit beta-2Add BLAST | 660 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 204 | PhosphoserineBy similarity | 1 | |
Modified residuei | 207 | PhosphoserineBy similarity | 1 | |
Modified residuei | 218 | PhosphoserineBy similarity | 1 | |
Modified residuei | 550 | PhosphoserineBy similarity | 1 | |
Modified residuei | 554 | Phosphothreonine; by CaMK2DBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q08289 |
MassIVEi | Q08289 |
MaxQBi | Q08289 |
PaxDbi | Q08289 |
PeptideAtlasi | Q08289 |
PRIDEi | Q08289 |
ProteomicsDBi | 1694 58586 [Q08289-1] 58587 [Q08289-2] 58588 [Q08289-3] 58589 [Q08289-4] 58590 [Q08289-5] 58591 [Q08289-6] 58592 [Q08289-7] 58593 [Q08289-8] |
PTM databases
iPTMneti | Q08289 |
PhosphoSitePlusi | Q08289 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000165995, Expressed in heart and 192 other tissues |
ExpressionAtlasi | Q08289, baseline and differential |
Genevisiblei | Q08289, HS |
Organism-specific databases
HPAi | ENSG00000165995, Low tissue specificity |
Interactioni
Subunit structurei
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
Interacts with CACNA1C (By similarity).
Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane (PubMed:17525370).
Interacts with TMIGD2 (PubMed:22419821).
Interacts with CAMK2D.
Interacts with CBARP (By similarity).
Interacts with CAMK2A (PubMed:28130356).
By similarity3 PublicationsBinary interactionsi
Hide detailsQ08289
With | #Exp. | IntAct |
---|---|---|
CTBP2 - isoform 3 [P56545-3] | 5 | EBI-2874501,EBI-10171902 |
HEXIM2 [Q96MH2] | 3 | EBI-2874501,EBI-5460660 |
PRMT5 [O14744] | 3 | EBI-2874501,EBI-351098 |
TMEM174 [Q8WUU8] | 3 | EBI-2874501,EBI-10276729 |
Isoform 2d [Q08289-1]
With | #Exp. | IntAct |
---|---|---|
CACNA1C [Q13936] | 4 | EBI-15707999,EBI-1038838 |
GO - Molecular functioni
- actin filament binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107237, 8 interactors |
ComplexPortali | CPX-3195, Cardiac muscle VGCC complex |
IntActi | Q08289, 9 interactors |
MINTi | Q08289 |
STRINGi | 9606.ENSP00000320025 |
Chemistry databases
BindingDBi | Q08289 |
Miscellaneous databases
RNActi | Q08289, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 183 | SH3PROSITE-ProRule annotationAdd BLAST | 70 |
Sequence similaritiesi
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG3812, Eukaryota |
GeneTreei | ENSGT00950000182837 |
HOGENOMi | CLU_021995_3_0_1 |
InParanoidi | Q08289 |
OMAi | IVVYVKI |
OrthoDBi | 926074at2759 |
PhylomeDBi | Q08289 |
TreeFami | TF316195 |
Family and domain databases
CDDi | cd12040, SH3_CACNB2, 1 hit |
InterProi | View protein in InterPro IPR035605, CACNB2_SH3 IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005444, VDCC_L_b2su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01628, LCACHANNELB2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
s (10+)i Sequence
Sequence statusi: Complete.
This entry describes 10 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 10 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVQRDMSKSP PTAAAAVAQE IQMELLENVA PAGALGAAAQ SYGKGARRKN
60 70 80 90 100
RFKGSDGSTS SDTTSNSFVR QGSADSYTSR PSDSDVSLEE DREAVRREAE
110 120 130 140 150
RQAQAQLEKA KTKPVAFAVR TNVSYSAAHE DDVPVPGMAI SFEAKDFLHV
160 170 180 190 200
KEKFNNDWWI GRLVKEGCEI GFIPSPVKLE NMRLQHEQRA KQGKFYSSKS
210 220 230 240 250
GGNSSSSLGD IVPSSRKSTP PSSAIDIDAT GLDAEENDIP ANHRSPKPSA
260 270 280 290 300
NSVTSPHSKE KRMPFFKKTE HTPPYDVVPS MRPVVLVGPS LKGYEVTDMM
310 320 330 340 350
QKALFDFLKH RFEGRISITR VTADISLAKR SVLNNPSKHA IIERSNTRSS
360 370 380 390 400
LAEVQSEIER IFELARTLQL VVLDADTINH PAQLSKTSLA PIIVYVKISS
410 420 430 440 450
PKVLQRLIKS RGKSQAKHLN VQMVAADKLA QCPPELFDVI LDENQLEDAC
460 470 480 490 500
EHLADYLEAY WKATHPPSSS LPNPLLSRTL ATSSLPLSPT LASNSQGSQG
510 520 530 540 550
DQRTDRSAPI RSASQAEEEP SVEPVKKSQH RSSSSAPHHN HRSGTSRGLS
560 570 580 590 600
RQETFDSETQ ESRDSAYVEP KEDYSHDHVD HYASHRDHNH RDETHGSSDH
610 620 630 640 650
RHRESRHRSR DVDREQDHNE CNKQRSRHKS KDRYCEKDGE VISKKRNEAG
660
EWNRDVYIRQ
The sequence of this isoform differs from the canonical sequence as follows:
1-71: MVQRDMSKSP...DTTSNSFVRQ → MQCCGLVHRRRVRVSY
The sequence of this isoform differs from the canonical sequence as follows:
1-71: MVQRDMSKSP...DTTSNSFVRQ → MLDRRLIAPQTKYIIPG
The sequence of this isoform differs from the canonical sequence as follows:
1-40: MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQ → MNQGSGLDLLKI
The sequence of this isoform differs from the canonical sequence as follows:
1-71: MVQRDMSKSP...DTTSNSFVRQ → MKATWIRLLKRAKGGRLKNSDIC
The sequence of this isoform differs from the canonical sequence as follows:
1-71: MVQRDMSKSP...DTTSNSFVRQ → MQCCGLVHRRRVRVSY
224-268: AIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK → AKQKQKS
The sequence of this isoform differs from the canonical sequence as follows:
224-268: AIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK → AKQKQKS
The sequence of this isoform differs from the canonical sequence as follows:
224-268: AIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK → GAKSADEQDQWKTAGLFWRFT
The sequence of this isoform differs from the canonical sequence as follows:
1-40: MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQ → MNQGSGLDLLKI
224-268: AIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK → GAKSADEQDQWKTAGLFWRFT
The sequence of this isoform differs from the canonical sequence as follows:
1-71: MVQRDMSKSP...DTTSNSFVRQ → MLDRRLIAPQTKYIIPG
224-268: AIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK → GAKSADEQDQWKTAGLFWRFT
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVX5 | A0A087WVX5_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 581 | Annotation score: | ||
A0A494C0B2 | A0A494C0B2_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 574 | Annotation score: | ||
A0A494C184 | A0A494C184_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 600 | Annotation score: | ||
A0A2R8Y555 | A0A2R8Y555_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 584 | Annotation score: | ||
A0A2U3TZM7 | A0A2U3TZM7_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 529 | Annotation score: | ||
Q6TME0 | Q6TME0_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 176 | Annotation score: | ||
A0A2R8Y7A6 | A0A2R8Y7A6_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 220 | Annotation score: | ||
A0A2R8YFX9 | A0A2R8YFX9_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 240 | Annotation score: | ||
A0A494C0C3 | A0A494C0C3_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 150 | Annotation score: | ||
A0A494C1Q6 | A0A494C1Q6_HUMAN | Calcium channel voltage-dependent s... | CACNB2 | 232 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | D → N in AAQ97608 (PubMed:14762176).Curated | 1 | |
Sequence conflicti | 69 | V → L in AAD33729 (Ref. 5) Curated | 1 | |
Sequence conflicti | 100 – 101 | ER → Q in AAD33729 (Ref. 5) Curated | 2 | |
Sequence conflicti | 122 | N → D in AAD33729 (Ref. 5) Curated | 1 | |
Sequence conflicti | 364 | L → V in AAD33729 (Ref. 5) Curated | 1 | |
Sequence conflicti | 364 | L → V in AAD33730 (Ref. 5) Curated | 1 | |
Sequence conflicti | 406 | R → T in AAD33729 (Ref. 5) Curated | 1 | |
Sequence conflicti | 406 | R → T in AAD33730 (Ref. 5) Curated | 1 | |
Sequence conflicti | 501 | D → H in AAD33729 (Ref. 5) Curated | 1 | |
Sequence conflicti | 501 | D → H in AAD33730 (Ref. 5) Curated | 1 | |
Sequence conflicti | 524 | P → G in AAD33729 (Ref. 5) Curated | 1 | |
Sequence conflicti | 524 | P → G in AAD33730 (Ref. 5) Curated | 1 | |
Sequence conflicti | 624 | Q → QQ in AAD33729 (Ref. 5) Curated | 1 | |
Sequence conflicti | 624 | Q → QQ in AAD33730 (Ref. 5) Curated | 1 | |
Sequence conflicti | 659 | R → P in AAB53332 (PubMed:9254841).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAG01473 (PubMed:12042350).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAL16948 (PubMed:12042350).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAL16951 (PubMed:12042350).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAL16950 (PubMed:12042350).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAQ97606 (PubMed:14762176).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAQ97607 (PubMed:14762176).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAQ97608 (PubMed:14762176).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAQ97609 (PubMed:14762176).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAQ97610 (PubMed:14762176).Curated | 1 | |
Sequence conflicti | 659 | R → P in AAL73495 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036350 | 99 | A → G in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs745502425Ensembl. | 1 | |
Natural variantiVAR_044041 | 535 | S → L in BRGDA4; unknown pathological significance; affects channel activity. 1 PublicationCorresponds to variant dbSNP:rs121917812EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000627 | 1 – 71 | MVQRD…SFVRQ → MQCCGLVHRRRVRVSY in isoform 2a and isoform 2f. 5 PublicationsAdd BLAST | 71 | |
Alternative sequenceiVSP_000628 | 1 – 71 | MVQRD…SFVRQ → MLDRRLIAPQTKYIIPG in isoform 2b and isoform 2cN4. 2 PublicationsAdd BLAST | 71 | |
Alternative sequenceiVSP_000629 | 1 – 71 | MVQRD…SFVRQ → MKATWIRLLKRAKGGRLKNS DIC in isoform 2e. 1 PublicationAdd BLAST | 71 | |
Alternative sequenceiVSP_000626 | 1 – 40 | MVQRD…GAAAQ → MNQGSGLDLLKI in isoform 2c and isoform 2cN2. 2 PublicationsAdd BLAST | 40 | |
Alternative sequenceiVSP_000630 | 224 – 268 | AIDID…PFFKK → AKQKQKS in isoform 2f and isoform 2g. 2 PublicationsAdd BLAST | 45 | |
Alternative sequenceiVSP_000631 | 224 – 268 | AIDID…PFFKK → GAKSADEQDQWKTAGLFWRF T in isoform 2h, isoform 2cN2 and isoform 2cN4. 2 PublicationsAdd BLAST | 45 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q08289 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107237, 8 interactors |
ComplexPortali | CPX-3195, Cardiac muscle VGCC complex |
IntActi | Q08289, 9 interactors |
MINTi | Q08289 |
STRINGi | 9606.ENSP00000320025 |
Chemistry databases
BindingDBi | Q08289 |
ChEMBLi | CHEMBL3317336 |
DrugBanki | DB01118, Amiodarone DB09231, Benidipine DB13746, Bioallethrin DB11148, Butamben DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate DB09232, Cilnidipine DB04855, Dronedarone DB00228, Enflurane DB00153, Ergocalciferol DB01023, Felodipine DB13961, Fish oil DB00270, Isradipine DB09236, Lacidipine DB00825, Levomenthol DB00653, Magnesium sulfate DB09238, Manidipine DB01388, Mibefradil DB01110, Miconazole DB00622, Nicardipine DB01115, Nifedipine DB06712, Nilvadipine DB00393, Nimodipine DB00401, Nisoldipine DB01054, Nitrendipine DB00252, Phenytoin DB00243, Ranolazine DB00421, Spironolactone DB00273, Topiramate DB09089, Trimebutine |
Protein family/group databases
TCDBi | 8.A.22.1.2, the ca(2+) channel auxiliary subunit Beta types 1-4 (cca-Beta) family |
PTM databases
iPTMneti | Q08289 |
PhosphoSitePlusi | Q08289 |
Polymorphism and mutation databases
BioMutai | CACNB2 |
DMDMi | 145559447 |
Proteomic databases
jPOSTi | Q08289 |
MassIVEi | Q08289 |
MaxQBi | Q08289 |
PaxDbi | Q08289 |
PeptideAtlasi | Q08289 |
PRIDEi | Q08289 |
ProteomicsDBi | 1694 58586 [Q08289-1] 58587 [Q08289-2] 58588 [Q08289-3] 58589 [Q08289-4] 58590 [Q08289-5] 58591 [Q08289-6] 58592 [Q08289-7] 58593 [Q08289-8] |
Protocols and materials databases
ABCDi | Q08289, 1 sequenced antibody |
Antibodypediai | 12067, 554 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 783 |
DisGeNETi | 783 |
EuPathDBi | HostDB:ENSG00000165995.18 |
GeneCardsi | CACNB2 |
GeneReviewsi | CACNB2 |
HGNCi | HGNC:1402, CACNB2 |
HPAi | ENSG00000165995, Low tissue specificity |
MalaCardsi | CACNB2 |
MIMi | 600003, gene 611876, phenotype |
neXtProti | NX_Q08289 |
OpenTargetsi | ENSG00000165995 |
Orphaneti | 130, Brugada syndrome |
PharmGKBi | PA88 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3812, Eukaryota |
GeneTreei | ENSGT00950000182837 |
HOGENOMi | CLU_021995_3_0_1 |
InParanoidi | Q08289 |
OMAi | IVVYVKI |
OrthoDBi | 926074at2759 |
PhylomeDBi | Q08289 |
TreeFami | TF316195 |
Enzyme and pathway databases
PathwayCommonsi | Q08289 |
Reactomei | R-HSA-112308, Presynaptic depolarization and calcium channel opening R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-419037, NCAM1 interactions R-HSA-422356, Regulation of insulin secretion R-HSA-5576892, Phase 0 - rapid depolarisation R-HSA-5576893, Phase 2 - plateau phase |
SignaLinki | Q08289 |
SIGNORi | Q08289 |
Miscellaneous databases
BioGRID-ORCSi | 783, 4 hits in 843 CRISPR screens |
ChiTaRSi | CACNB2, human |
GeneWikii | CACNB2 |
GenomeRNAii | 783 |
Pharosi | Q08289, Tbio |
PROi | PR:Q08289 |
RNActi | Q08289, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165995, Expressed in heart and 192 other tissues |
ExpressionAtlasi | Q08289, baseline and differential |
Genevisiblei | Q08289, HS |
Family and domain databases
CDDi | cd12040, SH3_CACNB2, 1 hit |
InterProi | View protein in InterPro IPR035605, CACNB2_SH3 IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005444, VDCC_L_b2su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01628, LCACHANNELB2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CACB2_HUMAN | |
Accessioni | Q08289Primary (citable) accession number: Q08289 Secondary accession number(s): A6PVM5 Q9Y341 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations