UniProtKB - Q08281 (RTC1_YEAST)
Protein
Restriction of telomere capping protein 1
Gene
RTC1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in a process influencing telomere capping.2 Publications
Miscellaneous
Present with 606 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1293 – 1335 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of TORC1 signaling Source: SGD
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Restriction of telomere capping protein 1Alternative name(s): SEH-associated protein 2 |
Gene namesi | Name:RTC1 Synonyms:SEA2 Ordered Locus Names:YOL138C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005498, RTC1 |
VEuPathDBi | FungiDB:YOL138C |
Subcellular locationi
Vacuole
- Vacuole membrane 2 Publications; Peripheral membrane protein 2 Publications
Cytosol
- cytosol Source: SGD
Vacuole
- extrinsic component of fungal-type vacuolar membrane Source: SGD
- fungal-type vacuole Source: SGD
Other locations
- Seh1-associated complex Source: SGD
Keywords - Cellular componenti
Membrane, VacuolePathology & Biotechi
Disruption phenotypei
Leads to short telomeres.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223528 | 1 – 1341 | Restriction of telomere capping protein 1Add BLAST | 1341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1036 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1080 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1087 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1089 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1123 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1133 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q08281 |
PaxDbi | Q08281 |
PRIDEi | Q08281 |
PTM databases
iPTMneti | Q08281 |
Interactioni
Subunit structurei
Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.
Interacts with ribosomes.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 34238, 237 interactors |
ComplexPortali | CPX-3231, SEA complex |
IntActi | Q08281, 42 interactors |
MINTi | Q08281 |
STRINGi | 4932.YOL138C |
Miscellaneous databases
RNActi | Q08281, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 207 – 248 | WD 1Add BLAST | 42 | |
Repeati | 256 – 296 | WD 2Add BLAST | 41 | |
Repeati | 305 – 342 | WD 3Add BLAST | 38 | |
Repeati | 367 – 406 | WD 4Add BLAST | 40 | |
Repeati | 439 – 486 | WD 5Add BLAST | 48 | |
Repeati | 489 – 527 | WD 6Add BLAST | 39 | |
Repeati | 843 – 883 | WD 7Add BLAST | 41 | |
Repeati | 1129 – 1169 | WD 8Add BLAST | 41 | |
Repeati | 1216 – 1255 | WD 9Add BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 753 – 765 | Poly-AspAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the WD repeat RTC1 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1293 – 1335 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Repeat, WD repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0269, Eukaryota |
GeneTreei | ENSGT00940000159396 |
HOGENOMi | CLU_008512_0_0_1 |
InParanoidi | Q08281 |
OMAi | GGRDGKC |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR037590, WDR24 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR46200, PTHR46200, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 2 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 2 hits PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08281-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLSPHVENA SIPKGSTPIP KNRNVSSIGK GEFLGSSSSN NSSFRMNHYS
60 70 80 90 100
NSGQPSVLDS IRRPNLTPTF SYSNGVYMPE SHRTSSFNDS YLPYDKNPYA
110 120 130 140 150
KTTGSMSNKS NMKIKTKKNA INTNTRKSSG LIYTTKVDKE LSSIDKVNDP
160 170 180 190 200
NINGLVCAGK THLGLYKFSP SDRSIKCVHD FITPNSNTST RGTTSLLPKL
210 220 230 240 250
SKRTRQNKFS TIADVKTGFN NYKNCIAVCN NSTAISIYDL NKSSSIDNPL
260 270 280 290 300
ITSLCEHTRS INSFDFNMVE SNLIISGGQD SCVKIWDLRS NKSKSSNRSD
310 320 330 340 350
ISINTASDSI RDVKWMPGYN FASKNDQGSS TYGNLKSGYK FASIHDSGYL
360 370 380 390 400
LKFDLRQPAQ YEKKLNAHTG PGLCLNWHPN QEYIATGGRD GKCCLWFVGD
410 420 430 440 450
NANAAENTVL NYGNSPSLHA PNTSLNNSGS LAFPKLTINT GYPVTKLKFK
460 470 480 490 500
PAYSSNIYNS LLGISSMGDE AEVRIYSLAR KYIPKHVLLS ETPSLGLVWW
510 520 530 540 550
DENLIFNIDK GTRINGWDIN KEPTVLENLS KNTTTWRDLD GNGLLSVDQE
560 570 580 590 600
IGSYEVVEPE LQPTSSTTCK KHPGTIKNPK NGNPENQGII GGIKKGFSHT
610 620 630 640 650
GLTSFTPERP PTLKAGPTFS TKSLTLASGA SSFNSSSASL TSLTPQTENR
660 670 680 690 700
EEIAIEPPCI ITLDIPQIFN NIRLTKIAHS RKKNVISESS SMKNSPVEKF
710 720 730 740 750
KYLARQLKFS YIREHNVSDS ADTAYKNDIE NIDVVKNATE THGDNTTTTN
760 770 780 790 800
NNDDGDDDDD DDDDDKIIES HLLKKYNFPE NNTWATLMNE KVNNKKSKRN
810 820 830 840 850
SSSSREFDEK DVRSSISSIS ASRQSHDRAR KIDKNVEAEL QEKIQTLVDL
860 870 880 890 900
ISIATHNASV YLSIDDLTNF KIWILIRDSL LWDLKWMTSS QISSDNASNM
910 920 930 940 950
DANESSDFEA GENLKTGKEF PEEDGAGTSG AESLVEERPQ AFRANSDEPS
960 970 980 990 1000
DAEKKPVSKL KEQLKNTEII PYAQPNEDSD EVLTKLKELQ NQRLESRTKM
1010 1020 1030 1040 1050
GETVSDDVII EEDEHEHQEE EQPHDSPTKS AQFHASPIAK SIPILQKREH
1060 1070 1080 1090 1100
RKSFIDTFML HSPNGYNGDT DIGNEDDNIS PRFTYNSVSP RSKVSSLQSY
1110 1120 1130 1140 1150
ATTTSQLETF KKLSSHTAPI IGSPRHAPSR PDSIGREQLS SSLTKKLAKC
1160 1170 1180 1190 1200
KKIIADPPWD TKKLIKQLYN QATETGNVVL TVNILFLFQT IYQITEIDIA
1210 1220 1230 1240 1250
KDAIAHFLLL LHRYELFGIA ADVLKYCPFE DIMGSEGDQS SIRLFCERCG
1260 1270 1280 1290 1300
ELITNESSKE KLRAEAQQTG NKKIMDKFGY WYCDSCKKKN TSCVLCERPL
1310 1320 1330 1340
KKLTMVILPC GHEGHFQCIQ EWFLDENEQE CPGGCPGVAF I
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 393 | C → S in CAA64732 (PubMed:8896270).Curated | 1 | |
Sequence conflicti | 393 | C → S in CAA99159 (PubMed:9169874).Curated | 1 | |
Sequence conflicti | 548 | D → G in CAA64732 (PubMed:8896270).Curated | 1 | |
Sequence conflicti | 548 | D → G in CAA99159 (PubMed:9169874).Curated | 1 | |
Sequence conflicti | 1222 | D → DV in CAA64732 (PubMed:8896270).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95465 Genomic DNA Translation: CAA64732.1 Z74880 Genomic DNA Translation: CAA99159.1 BK006948 Genomic DNA Translation: DAA10647.2 |
PIRi | S66835 |
RefSeqi | NP_014503.2, NM_001183392.2 |
Genome annotation databases
EnsemblFungii | YOL138C_mRNA; YOL138C; YOL138C |
GeneIDi | 853982 |
KEGGi | sce:YOL138C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95465 Genomic DNA Translation: CAA64732.1 Z74880 Genomic DNA Translation: CAA99159.1 BK006948 Genomic DNA Translation: DAA10647.2 |
PIRi | S66835 |
RefSeqi | NP_014503.2, NM_001183392.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 34238, 237 interactors |
ComplexPortali | CPX-3231, SEA complex |
IntActi | Q08281, 42 interactors |
MINTi | Q08281 |
STRINGi | 4932.YOL138C |
PTM databases
iPTMneti | Q08281 |
Proteomic databases
MaxQBi | Q08281 |
PaxDbi | Q08281 |
PRIDEi | Q08281 |
Genome annotation databases
EnsemblFungii | YOL138C_mRNA; YOL138C; YOL138C |
GeneIDi | 853982 |
KEGGi | sce:YOL138C |
Organism-specific databases
SGDi | S000005498, RTC1 |
VEuPathDBi | FungiDB:YOL138C |
Phylogenomic databases
eggNOGi | KOG0269, Eukaryota |
GeneTreei | ENSGT00940000159396 |
HOGENOMi | CLU_008512_0_0_1 |
InParanoidi | Q08281 |
OMAi | GGRDGKC |
Miscellaneous databases
PROi | PR:Q08281 |
RNActi | Q08281, protein |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR037590, WDR24 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR46200, PTHR46200, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 2 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 2 hits PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTC1_YEAST | |
Accessioni | Q08281Primary (citable) accession number: Q08281 Secondary accession number(s): D6W1T1, Q92271 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | September 21, 2011 | |
Last modified: | April 7, 2021 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - SIMILARITY comments
Index of protein domains and families