UniProtKB - Q08278 (MED7_YEAST)
Mediator of RNA polymerase II transcription subunit 7
MED7
Functioni
Miscellaneous
GO - Molecular functioni
- transcription coregulator activity Source: InterPro
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 7Alternative name(s): Mediator complex subunit 7 |
Gene namesi | Name:MED7 Ordered Locus Names:YOL135C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOL135C |
SGDi | S000005495, MED7 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- core mediator complex Source: SGD
- mediator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096393 | 1 – 222 | Mediator of RNA polymerase II transcription subunit 7Add BLAST | 222 |
Proteomic databases
MaxQBi | Q08278 |
PaxDbi | Q08278 |
PRIDEi | Q08278 |
PTM databases
iPTMneti | Q08278 |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED7 interacts directly with MED1, MED4 and SRB7/MED21.
3 PublicationsBinary interactionsi
Hide detailsQ08278
With | #Exp. | IntAct |
---|---|---|
MED1 [Q12321] | 3 | EBI-10674,EBI-32854 |
MED4 [Q12343] | 4 | EBI-10674,EBI-31503 |
NUT2 [Q06213] | 6 | EBI-10674,EBI-12414 |
SRB7 [P47822] | 5 | EBI-10674,EBI-18046 |
Protein-protein interaction databases
BioGRIDi | 34241, 500 interactors |
ComplexPortali | CPX-3226, Core mediator complex |
DIPi | DIP-1435N |
IntActi | Q08278, 46 interactors |
MINTi | Q08278 |
STRINGi | 4932.YOL135C |
Miscellaneous databases
RNActi | Q08278, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q08278 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08278 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0570, Eukaryota |
GeneTreei | ENSGT00940000165241 |
HOGENOMi | CLU_065214_0_1_1 |
InParanoidi | Q08278 |
OMAi | MCSIIDE |
Family and domain databases
InterProi | View protein in InterPro IPR037212, Med7/Med21-like IPR009244, Mediatior_Med7 |
Pfami | View protein in Pfam PF05983, Med7, 1 hit |
SUPFAMi | SSF140718, SSF140718, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSNDPGNEVS SLYPPPPPYV KFFTQSNLEK LPKYKEKKAA SAKQTAPNNS
60 70 80 90 100
NGGSEEEITC ALDYLIPPPM PKNQQYRAFG SIWQVKDQLP DLESMGLTQL
110 120 130 140 150
YKKSTENEST NYQYKIQELR KLLKSLLLNY LELIGVLSIN PDMYERKVEN
160 170 180 190 200
IRTILVNIHH LLNEYRPHQS RESLIMLLEE QLEYKRGEIR EIEQVCKQVH
210 220
DKLTSIQDTL RTGSQSPPSS SQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95465 Genomic DNA Translation: CAA64734.1 Z74877 Genomic DNA Translation: CAA99156.1 AY692889 Genomic DNA Translation: AAT92908.1 BK006948 Genomic DNA Translation: DAA10650.1 |
PIRi | S66832 |
RefSeqi | NP_014506.1, NM_001183389.1 |
Genome annotation databases
EnsemblFungii | YOL135C_mRNA; YOL135C; YOL135C |
GeneIDi | 853985 |
KEGGi | sce:YOL135C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95465 Genomic DNA Translation: CAA64734.1 Z74877 Genomic DNA Translation: CAA99156.1 AY692889 Genomic DNA Translation: AAT92908.1 BK006948 Genomic DNA Translation: DAA10650.1 |
PIRi | S66832 |
RefSeqi | NP_014506.1, NM_001183389.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YKE | X-ray | 3.30 | A/C | 102-205 | [»] | |
1YKH | X-ray | 3.00 | A | 102-205 | [»] | |
3FBI | X-ray | 2.80 | A/C | 2-83 | [»] | |
3FBN | X-ray | 3.01 | A/C | 2-83 | [»] | |
5OQM | electron microscopy | 5.80 | i | 1-222 | [»] | |
5SVA | electron microscopy | 15.30 | U | 1-222 | [»] | |
SMRi | Q08278 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34241, 500 interactors |
ComplexPortali | CPX-3226, Core mediator complex |
DIPi | DIP-1435N |
IntActi | Q08278, 46 interactors |
MINTi | Q08278 |
STRINGi | 4932.YOL135C |
PTM databases
iPTMneti | Q08278 |
Proteomic databases
MaxQBi | Q08278 |
PaxDbi | Q08278 |
PRIDEi | Q08278 |
Genome annotation databases
EnsemblFungii | YOL135C_mRNA; YOL135C; YOL135C |
GeneIDi | 853985 |
KEGGi | sce:YOL135C |
Organism-specific databases
EuPathDBi | FungiDB:YOL135C |
SGDi | S000005495, MED7 |
Phylogenomic databases
eggNOGi | KOG0570, Eukaryota |
GeneTreei | ENSGT00940000165241 |
HOGENOMi | CLU_065214_0_1_1 |
InParanoidi | Q08278 |
OMAi | MCSIIDE |
Miscellaneous databases
EvolutionaryTracei | Q08278 |
PROi | PR:Q08278 |
RNActi | Q08278, protein |
Family and domain databases
InterProi | View protein in InterPro IPR037212, Med7/Med21-like IPR009244, Mediatior_Med7 |
Pfami | View protein in Pfam PF05983, Med7, 1 hit |
SUPFAMi | SSF140718, SSF140718, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED7_YEAST | |
Accessioni | Q08278Primary (citable) accession number: Q08278 Secondary accession number(s): D6W1T4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD