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Entry version 182 (18 Sep 2019)
Sequence version 1 (01 Oct 1994)
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Protein

Quinone oxidoreductase

Gene

CRYZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53NADP1 Publication1
Binding sitei181NADP; via amide nitrogen1 Publication1
Binding sitei200NADP1 Publication1
Binding sitei229NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi158 – 161NADP1 Publication4
Nucleotide bindingi246 – 249NADP1 Publication4
Nucleotide bindingi269 – 271NADP1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, RNA-binding
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.27 2681
1.6.5.5 2681

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRYZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2419 CRYZ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
123691 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08257

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1429

Open Targets

More...
OpenTargetsi
ENSG00000116791

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26925

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q08257

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6118

Drug and drug target database

More...
DrugBanki
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB09061 Cannabidiol
DB00266 Dicoumarol
DB14009 Medical Cannabis
DB14011 Nabiximols

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRYZ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
585013

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001609062 – 329Quinone oxidoreductaseAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei296N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q08257

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q08257

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q08257

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08257

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08257

PeptideAtlas

More...
PeptideAtlasi
Q08257

PRoteomics IDEntifications database

More...
PRIDEi
Q08257

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1584
58584 [Q08257-1]
58585 [Q08257-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00000792

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08257

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08257

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q08257

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Only very low amounts in the lens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116791 Expressed in 229 organ(s), highest expression level in nephron tubule

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q08257 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08257 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021921
HPA023290

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107816, 31 interactors

Protein interaction database and analysis system

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IntActi
Q08257, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000399805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08257

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q08257

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1197 Eukaryota
COG0604 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154882

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294672

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08257

KEGG Orthology (KO)

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KOi
K00344

Identification of Orthologs from Complete Genome Data

More...
OMAi
THIATRE

Database of Orthologous Groups

More...
OrthoDBi
863952at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08257

TreeFam database of animal gene trees

More...
TreeFami
TF314255

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00829 PKS_ER, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATGQKLMRA VRVFEFGGPE VLKLRSDIAV PIPKDHQVLI KVHACGVNPV
60 70 80 90 100
ETYIRSGTYS RKPLLPYTPG SDVAGVIEAV GDNASAFKKG DRVFTSSTIS
110 120 130 140 150
GGYAEYALAA DHTVYKLPEK LDFKQGAAIG IPYFTAYRAL IHSACVKAGE
160 170 180 190 200
SVLVHGASGG VGLAACQIAR AYGLKILGTA GTEEGQKIVL QNGAHEVFNH
210 220 230 240 250
REVNYIDKIK KYVGEKGIDI IIEMLANVNL SKDLSLLSHG GRVIVVGSRG
260 270 280 290 300
TIEINPRDTM AKESSIIGVT LFSSTKEEFQ QYAAALQAGM EIGWLKPVIG
310 320
SQYPLEKVAE AHENIIHGSG ATGKMILLL
Length:329
Mass (Da):35,207
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68C1828911486D4E
GO
Isoform 2 (identifier: Q08257-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MATGQ → MHLLS
     6-142: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):20,421
Checksum:iCA6C67D141CDD8B5
GO
Isoform 3 (identifier: Q08257-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-244: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):31,528
Checksum:i6062614A6DCB2A9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NP24A6NP24_HUMAN
Quinone oxidoreductase
CRYZ
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JH92C9JH92_HUMAN
Quinone oxidoreductase
CRYZ
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti105E → G in AK314813 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02291366P → S1 PublicationCorresponds to variant dbSNP:rs11551729Ensembl.1
Natural variantiVAR_022914176I → V1 PublicationCorresponds to variant dbSNP:rs3819946Ensembl.1
Natural variantiVAR_048200183E → K. Corresponds to variant dbSNP:rs17095822Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0429271 – 5MATGQ → MHLLS in isoform 2. 1 Publication5
Alternative sequenceiVSP_0429286 – 142Missing in isoform 2. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_046425211 – 244Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L13278 mRNA Translation: AAA36536.1
L31526
, L31521, L31522, L31523, L31524, L31525 Genomic DNA Translation: AAK40311.1
AB209714 mRNA Translation: BAD92951.1
AK223150 mRNA Translation: BAD96870.1
AK223201 mRNA Translation: BAD96921.1
BX647883 mRNA Translation: CAI46072.1
AK314813 mRNA No translation available.
AC091611 Genomic DNA No translation available.
AC135803 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06409.1
CH471059 Genomic DNA Translation: EAX06410.1
CH471059 Genomic DNA Translation: EAX06411.1
CH471059 Genomic DNA Translation: EAX06412.1
BC039578 mRNA Translation: AAH39578.1
BC070058 mRNA Translation: AAH70058.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44162.1 [Q08257-3]
CCDS44163.1 [Q08257-2]
CCDS665.1 [Q08257-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
PN0448

NCBI Reference Sequences

More...
RefSeqi
NP_001123514.1, NM_001130042.1 [Q08257-1]
NP_001123515.1, NM_001130043.1 [Q08257-3]
NP_001128231.1, NM_001134759.1 [Q08257-2]
NP_001880.2, NM_001889.3 [Q08257-1]
XP_005270548.1, XM_005270491.4 [Q08257-2]
XP_011539049.1, XM_011540747.1 [Q08257-1]
XP_016855856.1, XM_017000367.1 [Q08257-3]
XP_016855857.1, XM_017000368.1 [Q08257-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340866; ENSP00000339399; ENSG00000116791 [Q08257-1]
ENST00000370871; ENSP00000359908; ENSG00000116791 [Q08257-3]
ENST00000370872; ENSP00000359909; ENSG00000116791 [Q08257-2]
ENST00000417775; ENSP00000399805; ENSG00000116791 [Q08257-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1429

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1429

UCSC genome browser

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UCSCi
uc001dgj.4 human [Q08257-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13278 mRNA Translation: AAA36536.1
L31526
, L31521, L31522, L31523, L31524, L31525 Genomic DNA Translation: AAK40311.1
AB209714 mRNA Translation: BAD92951.1
AK223150 mRNA Translation: BAD96870.1
AK223201 mRNA Translation: BAD96921.1
BX647883 mRNA Translation: CAI46072.1
AK314813 mRNA No translation available.
AC091611 Genomic DNA No translation available.
AC135803 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06409.1
CH471059 Genomic DNA Translation: EAX06410.1
CH471059 Genomic DNA Translation: EAX06411.1
CH471059 Genomic DNA Translation: EAX06412.1
BC039578 mRNA Translation: AAH39578.1
BC070058 mRNA Translation: AAH70058.1
CCDSiCCDS44162.1 [Q08257-3]
CCDS44163.1 [Q08257-2]
CCDS665.1 [Q08257-1]
PIRiPN0448
RefSeqiNP_001123514.1, NM_001130042.1 [Q08257-1]
NP_001123515.1, NM_001130043.1 [Q08257-3]
NP_001128231.1, NM_001134759.1 [Q08257-2]
NP_001880.2, NM_001889.3 [Q08257-1]
XP_005270548.1, XM_005270491.4 [Q08257-2]
XP_011539049.1, XM_011540747.1 [Q08257-1]
XP_016855856.1, XM_017000367.1 [Q08257-3]
XP_016855857.1, XM_017000368.1 [Q08257-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YB5X-ray1.85A/B1-329[»]
SMRiQ08257
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107816, 31 interactors
IntActiQ08257, 11 interactors
STRINGi9606.ENSP00000399805

Chemistry databases

ChEMBLiCHEMBL6118
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB09061 Cannabidiol
DB00266 Dicoumarol
DB14009 Medical Cannabis
DB14011 Nabiximols

PTM databases

iPTMnetiQ08257
PhosphoSitePlusiQ08257
SwissPalmiQ08257

Polymorphism and mutation databases

BioMutaiCRYZ
DMDMi585013

2D gel databases

REPRODUCTION-2DPAGEiIPI00000792

Proteomic databases

EPDiQ08257
jPOSTiQ08257
MassIVEiQ08257
MaxQBiQ08257
PaxDbiQ08257
PeptideAtlasiQ08257
PRIDEiQ08257
ProteomicsDBi1584
58584 [Q08257-1]
58585 [Q08257-2]

Genome annotation databases

EnsembliENST00000340866; ENSP00000339399; ENSG00000116791 [Q08257-1]
ENST00000370871; ENSP00000359908; ENSG00000116791 [Q08257-3]
ENST00000370872; ENSP00000359909; ENSG00000116791 [Q08257-2]
ENST00000417775; ENSP00000399805; ENSG00000116791 [Q08257-1]
GeneIDi1429
KEGGihsa:1429
UCSCiuc001dgj.4 human [Q08257-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1429
DisGeNETi1429

GeneCards: human genes, protein and diseases

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GeneCardsi
CRYZ
HGNCiHGNC:2419 CRYZ
HPAiHPA021921
HPA023290
MIMi123691 gene
neXtProtiNX_Q08257
OpenTargetsiENSG00000116791
PharmGKBiPA26925

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1197 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00940000154882
HOGENOMiHOG000294672
InParanoidiQ08257
KOiK00344
OMAiTHIATRE
OrthoDBi863952at2759
PhylomeDBiQ08257
TreeFamiTF314255

Enzyme and pathway databases

BRENDAi1.3.1.27 2681
1.6.5.5 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CRYZ human
EvolutionaryTraceiQ08257

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CRYZ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1429
PharosiQ08257

Protein Ontology

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PROi
PR:Q08257

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116791 Expressed in 229 organ(s), highest expression level in nephron tubule
ExpressionAtlasiQ08257 baseline and differential
GenevisibleiQ08257 HS

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQOR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08257
Secondary accession number(s): A6NN60
, D3DQ76, Q53FT0, Q59EU7, Q5HYE7, Q6NSK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 18, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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