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Protein

RNA exonuclease 4

Gene

REX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.2 Publications

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: SGD
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • ribosomal large subunit assembly Source: SGD
  • rRNA processing Source: SGD

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processrRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33483-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Gene namesi
Name:REX4
Ordered Locus Names:YOL080C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL080C
SGDiS000005440 REX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317021 – 289RNA exonuclease 4Add BLAST289

Proteomic databases

MaxQBiQ08237
PaxDbiQ08237
PRIDEiQ08237

Interactioni

Protein-protein interaction databases

BioGridi34322, 71 interactors
DIPiDIP-5458N
IntActiQ08237, 8 interactors
STRINGi4932.YOL080C

Structurei

3D structure databases

ProteinModelPortaliQ08237
SMRiQ08237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 273ExonucleaseAdd BLAST153

Sequence similaritiesi

Belongs to the REXO4 family.Curated

Phylogenomic databases

GeneTreeiENSGT00520000055542
HOGENOMiHOG000182422
InParanoidiQ08237
KOiK18327
OMAiTMLLYKS
OrthoDBiEOG092C2R0D

Family and domain databases

CDDicd06144 REX4_like, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR037431 REX4_DEDDh_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q08237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSSNWQAL LASESNPTSN GKNKQSNRKI RNVKKVSKTV NVSSTTQYAP
60 70 80 90 100
RKRKNGSKIM DMVYNMNKEI SKHEKDKLEG KVFEFNPNKA NTSTTIKEPV
110 120 130 140 150
KVGISEDTRI NSNKSKEIGK YIAMDCEFVG VGPEGKESAL ARISIVNYFG
160 170 180 190 200
HVVLDEFVKP REKVVEWRTW VSGIKPEHMK NAITFKEAQK KTADILEGRI
210 220 230 240 250
LVGHALKHDL EALMLSHPKS LLRDTSRHLP FRKLYAKGKT PSLKKLTREV
260 270 280
LKISIQEGEH SSVEDARATM LLYKKEKTEF EKIHRNTFN
Length:289
Mass (Da):32,895
Last modified:November 1, 1996 - v1
Checksum:iB4DC2FA3BA1B7FCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74822 Genomic DNA Translation: CAA99090.1
BK006948 Genomic DNA Translation: DAA10704.1
PIRiS66773
RefSeqiNP_014561.1, NM_001183334.1

Genome annotation databases

EnsemblFungiiYOL080C; YOL080C; YOL080C
GeneIDi854075
KEGGisce:YOL080C

Similar proteinsi

Entry informationi

Entry nameiREXO4_YEAST
AccessioniPrimary (citable) accession number: Q08237
Secondary accession number(s): D6W1Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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