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Protein

Nuclear mRNA export protein THP1

Gene

THP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. THP1 binds to RNA in vitro.3 Publications

Miscellaneous

Present with 1140 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: SGD
  • RNA binding Source: SGD

GO - Biological processi

Keywordsi

Biological processmRNA transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33477-MONOMER

Protein family/group databases

TCDBi3.A.22.1.1 the transcription-coupled trex/tap nuclear mrna export complex (trex) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear mRNA export protein THP1
Alternative name(s):
Bud site selection protein 29
Gene namesi
Name:THP1
Synonyms:BUD29
Ordered Locus Names:YOL072W
ORF Names:O1140
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

SGDiS000005433 THP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002706181 – 455Nuclear mRNA export protein THP1Add BLAST455

Proteomic databases

MaxQBiQ08231
PaxDbiQ08231
PRIDEiQ08231

Interactioni

Subunit structurei

Heterodimer with THP1. The SAC3-THP1 complex interacts with CDC31 and SUS1, and with the mRNA export factor MEX67-MTR2, the TREX complex component SUB2, and the nucleoporin NUP1.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi34329, 168 interactors
ComplexPortaliCPX-1686 TREX-2 complex
CPX-1687 Thp1-Sac3 complex
DIPiDIP-5060N
IntActiQ08231, 6 interactors
MINTiQ08231
STRINGi4932.YOL072W

Structurei

Secondary structure

1455
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ08231
SMRiQ08231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 431PCIPROSITE-ProRule annotationAdd BLAST212

Phylogenomic databases

HOGENOMiHOG000141936
InParanoidiQ08231
OMAiPQLCSNI
OrthoDBiEOG092C45YA

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q08231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMANQLLDE LAHGNFSHLT LNLSQNGREI AILQKQLTGF DDKQLETFVE
60 70 80 90 100
QHPAMPNDTR FKIMCTSFLN YARDVDPWSA WSSSDLIFEF YQCLINCLIN
110 120 130 140 150
DNAPHIEMLI PVATRETEFI INLAGKLDSF HLQLHTRSHQ FLSHISSILS
160 170 180 190 200
RLFNSIKPPR GNASSTNIPG KQRILLYLVN KLNNIYFRIE SPQLCSNIFK
210 220 230 240 250
NFQPKSMLAH FNEYQLDQQI EYRYLLGRYY LLNSQVHNAF VQFNEAFQSL
260 270 280 290 300
LNLPLTNQAI TRNGTRILNY MIPTGLILGK MVKWGPLRPF LSQETIDNWS
310 320 330 340 350
VLYKHVRYGN IQGVSLWLRQ NERHLCARQL LIVLLEKLPM VTYRNLIKTV
360 370 380 390 400
IKSWTTEWGQ NKLPYSLIER VLQLSIGPTF EDPGAQEITI YNGIHSPKNV
410 420 430 440 450
ENVLVTLINL GLLRANCFPQ LQLCVVKKTT MIQEIVPPVN ERITKMFPAH

SHVLW
Length:455
Mass (Da):52,678
Last modified:November 1, 1996 - v1
Checksum:i7026F1F6FCC73FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74814 Genomic DNA Translation: CAA99082.1
BK006948 Genomic DNA Translation: DAA10711.1
PIRiS66765
RefSeqiNP_014569.1, NM_001183327.1

Genome annotation databases

EnsemblFungiiYOL072W; YOL072W; YOL072W
GeneIDi854082
KEGGisce:YOL072W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74814 Genomic DNA Translation: CAA99082.1
BK006948 Genomic DNA Translation: DAA10711.1
PIRiS66765
RefSeqiNP_014569.1, NM_001183327.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T5VX-ray2.90B/E1-455[»]
4TRQX-ray3.10B/E170-455[»]
5G5Pelectron microscopy5.30B1-455[»]
5L3TX-ray4.93B1-455[»]
5UBPX-ray2.30B1-455[»]
ProteinModelPortaliQ08231
SMRiQ08231
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34329, 168 interactors
ComplexPortaliCPX-1686 TREX-2 complex
CPX-1687 Thp1-Sac3 complex
DIPiDIP-5060N
IntActiQ08231, 6 interactors
MINTiQ08231
STRINGi4932.YOL072W

Protein family/group databases

TCDBi3.A.22.1.1 the transcription-coupled trex/tap nuclear mrna export complex (trex) family

Proteomic databases

MaxQBiQ08231
PaxDbiQ08231
PRIDEiQ08231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL072W; YOL072W; YOL072W
GeneIDi854082
KEGGisce:YOL072W

Organism-specific databases

SGDiS000005433 THP1

Phylogenomic databases

HOGENOMiHOG000141936
InParanoidiQ08231
OMAiPQLCSNI
OrthoDBiEOG092C45YA

Enzyme and pathway databases

BioCyciYEAST:G3O-33477-MONOMER

Miscellaneous databases

PROiPR:Q08231

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHP1_YEAST
AccessioniPrimary (citable) accession number: Q08231
Secondary accession number(s): D6W1Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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