UniProtKB - Q08209 (PP2BA_HUMAN)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
PPP3CA
Functioni
Miscellaneous
Catalytic activityi
Cofactori
Protein has several cofactor binding sites:- Fe3+6 PublicationsNote: Binds 1 Fe3+ ion per subunit.6 Publications
- Zn2+6 PublicationsNote: Binds 1 zinc ion per subunit.6 Publications
Activity regulationi
Kineticsi
- KM=2.04 µM for NFATC11 Publication
- KM=2.22 µM for DARPP321 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 90 | IronCombined sources6 Publications | 1 | |
Metal bindingi | 92 | Iron; via tele nitrogenCombined sources6 Publications | 1 | |
Metal bindingi | 118 | IronCombined sources6 Publications | 1 | |
Metal bindingi | 118 | ZincCombined sources6 Publications | 1 | |
Metal bindingi | 150 | ZincCombined sources6 Publications | 1 | |
Active sitei | 151 | Proton donor1 Publication | 1 | |
Metal bindingi | 199 | Zinc; via tele nitrogenCombined sources6 Publications | 1 | |
Metal bindingi | 281 | Zinc; via pros nitrogenCombined sources6 Publications | 1 |
GO - Molecular functioni
- ATPase binding Source: ARUK-UCL
- calcium ion binding Source: UniProtKB
- calmodulin binding Source: UniProtKB
- calmodulin-dependent protein phosphatase activity Source: UniProtKB
- cyclosporin A binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein dimerization activity Source: UniProtKB
- protein serine/threonine phosphatase activity Source: UniProtKB
GO - Biological processi
- aging Source: Ensembl
- brain development Source: Ensembl
- calcineurin-mediated signaling Source: UniProtKB
- calcineurin-NFAT signaling cascade Source: UniProtKB
- calcium ion transport Source: Ensembl
- cardiac muscle hypertrophy in response to stress Source: Ensembl
- cellular response to glucose stimulus Source: Ensembl
- dephosphorylation Source: UniProtKB
- excitatory postsynaptic potential Source: Ensembl
- Fc-epsilon receptor signaling pathway Source: Reactome
- G1/S transition of mitotic cell cycle Source: Ensembl
- multicellular organismal response to stress Source: Ensembl
- negative regulation of chromatin binding Source: Ensembl
- negative regulation of dendrite morphogenesis Source: Ensembl
- negative regulation of insulin secretion Source: Ensembl
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
- peptidyl-serine dephosphorylation Source: UniProtKB
- positive regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
- positive regulation of cell adhesion Source: ARUK-UCL
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of connective tissue replacement Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: Ensembl
- positive regulation of endocytosis Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- postsynaptic modulation of chemical synaptic transmission Source: Ensembl
- protein dephosphorylation Source: UniProtKB
- protein import into nucleus Source: Ensembl
- response to amphetamine Source: Ensembl
- response to calcium ion Source: UniProtKB
- skeletal muscle fiber development Source: Ensembl
- skeletal muscle tissue regeneration Source: BHF-UCL
- T cell activation Source: UniProtKB
- transition between fast and slow fiber Source: Ensembl
- Wnt signaling pathway, calcium modulating pathway Source: Reactome
- wound healing Source: BHF-UCL
Keywordsi
Molecular function | Calmodulin-binding, Hydrolase, Protein phosphatase |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q08209 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-2025928, Calcineurin activates NFAT R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-4086398, Ca2+ pathway R-HSA-5607763, CLEC7A (Dectin-1) induces NFAT activation |
SIGNORi | Q08209 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC:3.1.3.161 Publication4 Publications)Alternative name(s): CAM-PRP catalytic subunit Calmodulin-dependent calcineurin A subunit alpha isoform |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138814.16 |
HGNCi | HGNC:9314, PPP3CA |
MIMi | 114105, gene |
neXtProti | NX_Q08209 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
- sarcolemma By similarity
Other locations
- Cytoplasm 2 Publications
- Z line By similarity
- dendritic spine 1 Publication
Note: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca2+-channel activation (PubMed:22343722).By similarity1 Publication
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- extrinsic component of plasma membrane Source: ARUK-UCL
- plasma membrane Source: ARUK-UCL
- sarcolemma Source: UniProtKB-SubCell
Other locations
- calcineurin complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- dendritic spine Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
- slit diaphragm Source: Ensembl
- Z disc Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, SynapsePathology & Biotechi
Involvement in diseasei
Epileptic encephalopathy, infantile or early childhood, 1 (IECEE1)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080348 | 92 | H → R in IECEE1. 2 PublicationsCorresponds to variant dbSNP:rs1553925558EnsemblClinVar. | 1 | |
Natural variantiVAR_081900 | 150 | N → I in IECEE1. 1 Publication | 1 | |
Natural variantiVAR_081901 | 234 | D → E in IECEE1. 1 Publication | 1 | |
Natural variantiVAR_080349 | 281 | H → Q in IECEE1. 1 PublicationCorresponds to variant dbSNP:rs199706529EnsemblClinVar. | 1 | |
Natural variantiVAR_080350 | 282 | E → K in IECEE1. 1 PublicationCorresponds to variant dbSNP:rs1553923787EnsemblClinVar. | 1 | |
Natural variantiVAR_080351 | 445 – 521 | Missing in IECEE1. 1 PublicationAdd BLAST | 77 | |
Natural variantiVAR_080352 | 447 | A → T in IECEE1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1553920374EnsemblClinVar. | 1 |
Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development (ACCIID)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081902 | 470 | F → L in ACCIID. 1 PublicationCorresponds to variant dbSNP:rs1560567347EnsemblClinVar. | 1 | |
Natural variantiVAR_081903 | 473 | A → T in ACCIID. 1 PublicationCorresponds to variant dbSNP:rs1560567337EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 288 | Y → F: Partial loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with F-341. 1 Publication | 1 | |
Mutagenesisi | 288 | Y → N or A: Loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with F-341. 1 Publication | 1 | |
Mutagenesisi | 328 – 332 | Missing : Loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with F-341. 1 Publication | 5 | |
Mutagenesisi | 341 | Y → F: Resistant to cyclosporin A-mediated inhibition. Loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with N-288, A-228 or 328-V--R-332 DEL. Partial loss in Ca(2+)-mediated transcription factor NFAT activation; when associated with F-288. 1 Publication | 1 |
Keywords - Diseasei
Craniosynostosis, Disease mutation, Dwarfism, Epilepsy, Mental retardationOrganism-specific databases
DisGeNETi | 5530 |
MalaCardsi | PPP3CA |
MIMi | 617711, phenotype 618265, phenotype |
OpenTargetsi | ENSG00000138814 |
Orphaneti | 178469, Autosomal dominant non-syndromic intellectual disability 565858, Craniosynostosis-microretrognathia-severe intellectual disability syndrome 442835, Undetermined early-onset epileptic encephalopathy |
PharmGKBi | PA33678 |
Miscellaneous databases
Pharosi | Q08209, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4445 |
DrugBanki | DB08231, Myristic acid |
DrugCentrali | Q08209 |
Polymorphism and mutation databases
BioMutai | PPP3CA |
DMDMi | 1352673 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000058822 | 2 – 521 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformAdd BLAST | 520 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 224 | 3'-nitrotyrosineBy similarity | 1 | |
Modified residuei | 469 | PhosphoserineBy similarity | 1 | |
Modified residuei | 492 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Nitration, PhosphoproteinProteomic databases
EPDi | Q08209 |
jPOSTi | Q08209 |
MassIVEi | Q08209 |
MaxQBi | Q08209 |
PaxDbi | Q08209 |
PeptideAtlasi | Q08209 |
PRIDEi | Q08209 |
ProteomicsDBi | 2488 58579 [Q08209-1] 58580 [Q08209-2] 58581 [Q08209-3] 88 |
PTM databases
DEPODi | PPP3CA |
iPTMneti | Q08209 |
MetOSitei | Q08209 |
PhosphoSitePlusi | Q08209 |
SwissPalmi | Q08209 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000138814, Expressed in caudate nucleus and 253 other tissues |
ExpressionAtlasi | Q08209, baseline and differential |
Genevisiblei | Q08209, HS |
Organism-specific databases
HPAi | ENSG00000138814, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca2+-binding subunit (also known as calcineurin B) (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:27974827). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca2+ intracellular levels, forms a complex composed of PPP3CA/calcineurin A, calcineurin B and calmodulin (By similarity).
Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:27974827).
Interacts (via calmodulin-binding domain) with CALM1/calmodulin; the interaction depends on calmodulin binding to Ca2+ (PubMed:18384083, Ref. 30, PubMed:19404396, PubMed:25144868).
Forms a complex composed of MYOZ2 and ACTN1 (By similarity). Within the complex interacts with MYOZ2 (PubMed:11114196).
Interacts with MYOZ1 (PubMed:11114196).
Interacts with MYOZ3 (PubMed:11842093).
Interacts with CIB1; the interaction increases upon cardiomyocyte hypertrophy (By similarity).
Interacts with CHP1 and CHP2 (By similarity).
Interacts with CRTC1 (PubMed:30611118).
Interacts with CRTC2 (PubMed:15454081, PubMed:30611118).
Interacts with DNM1L; the interaction dephosphorylates DNM1L and promotes its translocation to mitochondria (PubMed:18838687).
Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity).
Interacts (constitutively active form) with SYNPO2 (PubMed:17923693).
Interacts with scaffold protein AKAP5 (via IAIIIT motif); the interaction recruits PPP3CA to the plasma membrane following L-type Ca2+-channel activation (PubMed:22343722).
Interacts with NFATC2 (PubMed:26248042).
Interacts with RCAN3 (PubMed:26248042).
Interacts with PPIA (PubMed:12218175, PubMed:12357034).
Interacts with RCAN1 (PubMed:12809556).
Interacts with UNC119 (By similarity).
By similarity19 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 352 | Interaction with PxVP motif in substrate2 Publications | 1 |
Binary interactionsi
Hide detailsQ08209
Isoform 1 [Q08209-1]
Isoform 2 [Q08209-2]
GO - Molecular functioni
- ATPase binding Source: ARUK-UCL
- calmodulin binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- protein dimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111522, 88 interactors |
ComplexPortali | CPX-1003, Calcineurin-Calmodulin complex, alpha-R1 variant CPX-1048, Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1114, Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-674, Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant |
CORUMi | Q08209 |
DIPi | DIP-6095N |
ELMi | Q08209 |
IntActi | Q08209, 56 interactors |
MINTi | Q08209 |
STRINGi | 9606.ENSP00000378323 |
Chemistry databases
BindingDBi | Q08209 |
Miscellaneous databases
RNActi | Q08209, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q08209 |
SMRi | Q08209 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08209 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 56 – 340 | CatalyticCuratedAdd BLAST | 285 | |
Regioni | 327 – 336 | Interaction with PxIxIF motif in substrate5 Publications | 10 | |
Regioni | 341 – 369 | Calcineurin B binding6 PublicationsAdd BLAST | 29 | |
Regioni | 392 – 406 | Calmodulin-binding4 PublicationsAdd BLAST | 15 | |
Regioni | 407 – 414 | Autoinhibitory segmentBy similarity | 8 | |
Regioni | 465 – 487 | Autoinhibitory domain1 PublicationAdd BLAST | 23 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 307 – 311 | SAPNY motif1 Publication | 5 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0375, Eukaryota |
GeneTreei | ENSGT00940000156306 |
HOGENOMi | CLU_962966_0_0_1 |
InParanoidi | Q08209 |
OMAi | WSLKIWY |
PhylomeDBi | Q08209 |
TreeFami | TF105557 |
Family and domain databases
CDDi | cd07416, MPP_PP2B, 1 hit |
DisProti | DP00092 |
Gene3Di | 3.60.21.10, 1 hit |
IDEALi | IID00069 |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041751, MPP_PP2B IPR043360, PP2B IPR006186, Ser/Thr-sp_prot-phosphatase |
PANTHERi | PTHR45673, PTHR45673, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL
60 70 80 90 100
MKEGRLEESV ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK
110 120 130 140 150
LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWALKILY PKTLFLLRGN
160 170 180 190 200
HECRHLTEYF TFKQECKIKY SERVYDACMD AFDCLPLAAL MNQQFLCVHG
210 220 230 240 250
GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG NEKTQEHFTH
260 270 280 290 300
NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
310 320 330 340 350
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF
360 370 380 390 400
TWSLPFVGEK VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI
410 420 430 440 450
RAIGKMARVF SVLREESESV LTLKGLTPTG MLPSGVLSGG KQTLQSATVE
460 470 480 490 500
AIEADEAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM PSDANLNSIN
510 520
KALTSETNGT DSNGSNSSNI Q
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ETC2 | E7ETC2_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 423 | Annotation score: | ||
E9PK68 | E9PK68_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 147 | Annotation score: | ||
E9PPC8 | E9PPC8_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 132 | Annotation score: | ||
H0YAB4 | H0YAB4_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 16 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080348 | 92 | H → R in IECEE1. 2 PublicationsCorresponds to variant dbSNP:rs1553925558EnsemblClinVar. | 1 | |
Natural variantiVAR_081900 | 150 | N → I in IECEE1. 1 Publication | 1 | |
Natural variantiVAR_081901 | 234 | D → E in IECEE1. 1 Publication | 1 | |
Natural variantiVAR_080349 | 281 | H → Q in IECEE1. 1 PublicationCorresponds to variant dbSNP:rs199706529EnsemblClinVar. | 1 | |
Natural variantiVAR_080350 | 282 | E → K in IECEE1. 1 PublicationCorresponds to variant dbSNP:rs1553923787EnsemblClinVar. | 1 | |
Natural variantiVAR_080351 | 445 – 521 | Missing in IECEE1. 1 PublicationAdd BLAST | 77 | |
Natural variantiVAR_080352 | 447 | A → T in IECEE1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1553920374EnsemblClinVar. | 1 | |
Natural variantiVAR_081902 | 470 | F → L in ACCIID. 1 PublicationCorresponds to variant dbSNP:rs1560567347EnsemblClinVar. | 1 | |
Natural variantiVAR_081903 | 473 | A → T in ACCIID. 1 PublicationCorresponds to variant dbSNP:rs1560567337EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054467 | 20 – 86 | Missing in isoform 5. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_047755 | 87 – 318 | Missing in isoform 4. 1 PublicationAdd BLAST | 232 | |
Alternative sequenceiVSP_043378 | 318 – 359 | Missing in isoform 3. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_018562 | 448 – 457 | Missing in isoform 2 and isoform 3. 3 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14778 mRNA Translation: AAA02631.1 EU192652 mRNA Translation: ABW74484.1 EU192653 mRNA Translation: ABW74485.1 AY904364 mRNA Translation: AAY17314.1 AK290532 mRNA Translation: BAF83221.1 AL353950 mRNA Translation: CAB89253.1 AB451338 mRNA Translation: BAG70152.1 AB451487 mRNA Translation: BAG70301.1 AC092671 Genomic DNA No translation available. AP001816 Genomic DNA No translation available. AP001870 Genomic DNA No translation available. AP001939 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06125.1 CH471057 Genomic DNA Translation: EAX06124.1 BC025714 mRNA Translation: AAH25714.1 |
CCDSi | CCDS34037.1 [Q08209-1] CCDS47113.1 [Q08209-3] CCDS47114.1 [Q08209-2] |
PIRi | S35067 |
RefSeqi | NP_000935.1, NM_000944.4 [Q08209-1] NP_001124163.1, NM_001130691.1 [Q08209-2] NP_001124164.1, NM_001130692.1 [Q08209-3] |
Genome annotation databases
Ensembli | ENST00000323055; ENSP00000320580; ENSG00000138814 [Q08209-3] ENST00000394853; ENSP00000378322; ENSG00000138814 [Q08209-2] ENST00000394854; ENSP00000378323; ENSG00000138814 [Q08209-1] ENST00000512215; ENSP00000422781; ENSG00000138814 [Q08209-4] |
GeneIDi | 5530 |
KEGGi | hsa:5530 |
UCSCi | uc003hvu.3, human [Q08209-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Calcineurin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14778 mRNA Translation: AAA02631.1 EU192652 mRNA Translation: ABW74484.1 EU192653 mRNA Translation: ABW74485.1 AY904364 mRNA Translation: AAY17314.1 AK290532 mRNA Translation: BAF83221.1 AL353950 mRNA Translation: CAB89253.1 AB451338 mRNA Translation: BAG70152.1 AB451487 mRNA Translation: BAG70301.1 AC092671 Genomic DNA No translation available. AP001816 Genomic DNA No translation available. AP001870 Genomic DNA No translation available. AP001939 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06125.1 CH471057 Genomic DNA Translation: EAX06124.1 BC025714 mRNA Translation: AAH25714.1 |
CCDSi | CCDS34037.1 [Q08209-1] CCDS47113.1 [Q08209-3] CCDS47114.1 [Q08209-2] |
PIRi | S35067 |
RefSeqi | NP_000935.1, NM_000944.4 [Q08209-1] NP_001124163.1, NM_001130691.1 [Q08209-2] NP_001124164.1, NM_001130692.1 [Q08209-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AUI | X-ray | 2.10 | A | 1-521 | [»] | |
1M63 | X-ray | 2.80 | A/E | 1-372 | [»] | |
1MF8 | X-ray | 3.10 | A | 20-392 | [»] | |
2JOG | NMR | - | A | 21-347 | [»] | |
2JZI | NMR | - | B | 391-414 | [»] | |
2P6B | X-ray | 2.30 | A/C | 1-380 | [»] | |
2R28 | X-ray | 1.86 | C/D | 389-413 | [»] | |
2W73 | X-ray | 1.45 | K/L/M/O | 395-411 | [»] | |
3LL8 | X-ray | 2.00 | A/C | 14-370 | [»] | |
4F0Z | X-ray | 1.70 | A | 1-370 | [»] | |
4Q5U | X-ray | 1.95 | C | 391-414 | [»] | |
5C1V | X-ray | 3.35 | A/B | 2-346 | [»] | |
5SVE | X-ray | 2.60 | A | 1-370 | [»] | |
6NUC | X-ray | 1.90 | A | 1-370 | [»] | |
6NUF | X-ray | 1.90 | A | 1-370 | [»] | |
6NUU | X-ray | 2.30 | A | 1-370 | [»] | |
6UUQ | X-ray | 1.85 | A | 26-339 | [»] | |
BMRBi | Q08209 | |||||
SMRi | Q08209 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111522, 88 interactors |
ComplexPortali | CPX-1003, Calcineurin-Calmodulin complex, alpha-R1 variant CPX-1048, Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1114, Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-674, Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant |
CORUMi | Q08209 |
DIPi | DIP-6095N |
ELMi | Q08209 |
IntActi | Q08209, 56 interactors |
MINTi | Q08209 |
STRINGi | 9606.ENSP00000378323 |
Chemistry databases
BindingDBi | Q08209 |
ChEMBLi | CHEMBL4445 |
DrugBanki | DB08231, Myristic acid |
DrugCentrali | Q08209 |
PTM databases
DEPODi | PPP3CA |
iPTMneti | Q08209 |
MetOSitei | Q08209 |
PhosphoSitePlusi | Q08209 |
SwissPalmi | Q08209 |
Polymorphism and mutation databases
BioMutai | PPP3CA |
DMDMi | 1352673 |
Proteomic databases
EPDi | Q08209 |
jPOSTi | Q08209 |
MassIVEi | Q08209 |
MaxQBi | Q08209 |
PaxDbi | Q08209 |
PeptideAtlasi | Q08209 |
PRIDEi | Q08209 |
ProteomicsDBi | 2488 58579 [Q08209-1] 58580 [Q08209-2] 58581 [Q08209-3] 88 |
Protocols and materials databases
Antibodypediai | 2193, 565 antibodies |
DNASUi | 5530 |
Genome annotation databases
Ensembli | ENST00000323055; ENSP00000320580; ENSG00000138814 [Q08209-3] ENST00000394853; ENSP00000378322; ENSG00000138814 [Q08209-2] ENST00000394854; ENSP00000378323; ENSG00000138814 [Q08209-1] ENST00000512215; ENSP00000422781; ENSG00000138814 [Q08209-4] |
GeneIDi | 5530 |
KEGGi | hsa:5530 |
UCSCi | uc003hvu.3, human [Q08209-1] |
Organism-specific databases
CTDi | 5530 |
DisGeNETi | 5530 |
EuPathDBi | HostDB:ENSG00000138814.16 |
GeneCardsi | PPP3CA |
HGNCi | HGNC:9314, PPP3CA |
HPAi | ENSG00000138814, Tissue enhanced (brain) |
MalaCardsi | PPP3CA |
MIMi | 114105, gene 617711, phenotype 618265, phenotype |
neXtProti | NX_Q08209 |
OpenTargetsi | ENSG00000138814 |
Orphaneti | 178469, Autosomal dominant non-syndromic intellectual disability 565858, Craniosynostosis-microretrognathia-severe intellectual disability syndrome 442835, Undetermined early-onset epileptic encephalopathy |
PharmGKBi | PA33678 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0375, Eukaryota |
GeneTreei | ENSGT00940000156306 |
HOGENOMi | CLU_962966_0_0_1 |
InParanoidi | Q08209 |
OMAi | WSLKIWY |
PhylomeDBi | Q08209 |
TreeFami | TF105557 |
Enzyme and pathway databases
PathwayCommonsi | Q08209 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-2025928, Calcineurin activates NFAT R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-4086398, Ca2+ pathway R-HSA-5607763, CLEC7A (Dectin-1) induces NFAT activation |
SIGNORi | Q08209 |
Miscellaneous databases
BioGRID-ORCSi | 5530, 1 hit in 844 CRISPR screens |
ChiTaRSi | PPP3CA, human |
EvolutionaryTracei | Q08209 |
GeneWikii | PPP3CA |
GenomeRNAii | 5530 |
Pharosi | Q08209, Tchem |
PROi | PR:Q08209 |
RNActi | Q08209, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138814, Expressed in caudate nucleus and 253 other tissues |
ExpressionAtlasi | Q08209, baseline and differential |
Genevisiblei | Q08209, HS |
Family and domain databases
CDDi | cd07416, MPP_PP2B, 1 hit |
DisProti | DP00092 |
Gene3Di | 3.60.21.10, 1 hit |
IDEALi | IID00069 |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041751, MPP_PP2B IPR043360, PP2B IPR006186, Ser/Thr-sp_prot-phosphatase |
PANTHERi | PTHR45673, PTHR45673, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP2BA_HUMAN | |
Accessioni | Q08209Primary (citable) accession number: Q08209 Secondary accession number(s): A1A441 Q8TAW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 217 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations