UniProtKB - Q08209 (PP2BA_HUMAN)
Protein
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene
PPP3CA
Organism
Homo sapiens (Human)
Status
Functioni
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).By similarity9 Publications
Miscellaneous
Although African swine fever virus infects pigs and not humans, human PPP3CA has been used for the crystallization. PPP3CA interacts with African swine fever virus Mal-047/A238L (via PKIIIT and FLCVK motifs); the interaction does not block catalytic activity per se but inhibits PPP3CA function by blocking the access to the two substrate recognition sites.1 Publication
Catalytic activityi
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication4 Publications
Cofactori
Protein has several cofactor binding sites:- Fe3+6 PublicationsNote: Binds 1 Fe3+ ion per subunit.6 Publications
- Zn2+6 PublicationsNote: Binds 1 zinc ion per subunit.6 Publications
Activity regulationi
Activated by Ca2+-bound calmodulin following an increase in intracellular Ca2+. At low Ca2+ concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca2+. In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca2+ causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A. The subsequent binding of Ca2+-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A. Inhibited by immunosuppressant drug FK506 (tacrolimus) in complex with FKBP12 and also by immunosuppressant drug cyclosporin A (CsA) in complex with PPIA/cyclophilin A; the inhibition is Ca2+-dependent (PubMed:26248042).By similarity1 Publication
Kineticsi
- KM=2.04 µM for NFATC11 Publication
- KM=2.22 µM for DARPP321 Publication
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Metal bindingi | 90 | IronCombined sources6 Publications | 1 | |
| Metal bindingi | 92 | Iron; via tele nitrogenCombined sources6 Publications | 1 | |
| Metal bindingi | 118 | IronCombined sources6 Publications | 1 | |
| Metal bindingi | 118 | ZincCombined sources6 Publications | 1 | |
| Metal bindingi | 150 | ZincCombined sources6 Publications | 1 | |
| Active sitei | 151 | Proton donor1 Publication | 1 | |
| Metal bindingi | 199 | Zinc; via tele nitrogenCombined sources6 Publications | 1 | |
| Metal bindingi | 281 | Zinc; via pros nitrogenCombined sources6 Publications | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- calmodulin binding Source: UniProtKB
- calmodulin-dependent protein phosphatase activity Source: UniProtKB
- cyclosporin A binding Source: UniProtKB
- drug binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- protein dimerization activity Source: UniProtKB
- protein heterodimerization activity Source: Ensembl
- protein serine/threonine phosphatase activity Source: UniProtKB
GO - Biological processi
- brain development Source: Ensembl
- calcineurin-mediated signaling Source: GO_Central
- calcineurin-NFAT signaling cascade Source: UniProtKB
- calcium ion transport Source: Ensembl
- cardiac muscle hypertrophy in response to stress Source: Ensembl
- cellular response to drug Source: UniProtKB
- cellular response to glucose stimulus Source: Ensembl
- dephosphorylation Source: UniProtKB
- excitatory postsynaptic potential Source: Ensembl
- Fc-epsilon receptor signaling pathway Source: Reactome
- G1/S transition of mitotic cell cycle Source: Ensembl
- multicellular organismal response to stress Source: Ensembl
- negative regulation of chromatin binding Source: Ensembl
- negative regulation of dendrite morphogenesis Source: Ensembl
- negative regulation of insulin secretion Source: Ensembl
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
- positive regulation of calcineurin-NFAT signaling cascade Source: Ensembl
- positive regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
- positive regulation of cell adhesion Source: ARUK-UCL
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of connective tissue replacement Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: Ensembl
- positive regulation of endocytosis Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- postsynaptic modulation of chemical synaptic transmission Source: Ensembl
- protein dephosphorylation Source: UniProtKB
- protein import into nucleus Source: Ensembl
- response to amphetamine Source: Ensembl
- response to calcium ion Source: UniProtKB
- skeletal muscle fiber development Source: Ensembl
- T cell activation Source: UniProtKB
- transition between fast and slow fiber Source: Ensembl
- Wnt signaling pathway, calcium modulating pathway Source: Reactome
Keywordsi
| Molecular function | Calmodulin-binding, Hydrolase, Protein phosphatase |
| Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
| Reactomei | R-HSA-180024 DARPP-32 events R-HSA-2025928 Calcineurin activates NFAT R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-4086398 Ca2+ pathway R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation |
| SIGNORi | Q08209 |
Names & Taxonomyi
| Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC:3.1.3.161 Publication4 Publications)Alternative name(s): CAM-PRP catalytic subunit Calmodulin-dependent calcineurin A subunit alpha isoform |
| Gene namesi | |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000138814.16 |
| HGNCi | HGNC:9314 PPP3CA |
| MIMi | 114105 gene |
| neXtProti | NX_Q08209 |
Subcellular locationi
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Epileptic encephalopathy, infantile or early childhood, 1 (IECEE1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE1 is an autosomal dominant condition with onset of seizures between the first weeks and first years of life.
See also OMIM:617711| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_080348 | 92 | H → R in IECEE1; unknown pathological significance. 1 Publication | 1 | |
| Natural variantiVAR_080349 | 281 | H → Q in IECEE1; unknown pathological significance. 1 Publication | 1 | |
| Natural variantiVAR_080350 | 282 | E → K in IECEE1; unknown pathological significance. 1 Publication | 1 | |
| Natural variantiVAR_080351 | 445 – 521 | Missing in IECEE1; unknown pathological significance. 1 PublicationAdd BLAST | 77 | |
| Natural variantiVAR_080352 | 447 | A → T in IECEE1; unknown pathological significance. 1 Publication | 1 |
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 288 | Y → F: Partial loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with F-341. 1 Publication | 1 | |
| Mutagenesisi | 288 | Y → N or A: Loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with F-341. 1 Publication | 1 | |
| Mutagenesisi | 328 – 332 | Missing : Loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with F-341. 1 Publication | 5 | |
| Mutagenesisi | 341 | Y → F: Resistant to cyclosporin A-mediated inhibition. Loss of Ca(2+)-mediated transcription factor NFAT activation; when associated with N-288, A-228 or 328-V--R-332 DEL. Partial loss in Ca(2+)-mediated transcription factor NFAT activation; when associated with F-288. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, EpilepsyOrganism-specific databases
| DisGeNETi | 5530 |
| MalaCardsi | PPP3CA |
| MIMi | 617711 phenotype |
| OpenTargetsi | ENSG00000138814 |
| Orphaneti | 178469 Autosomal dominant non-syndromic intellectual disability 442835 Undetermined early-onset epileptic encephalopathy |
| PharmGKBi | PA33678 |
Chemistry databases
| ChEMBLi | CHEMBL4445 |
| DrugBanki | DB08231 MYRISTIC ACID |
Polymorphism and mutation databases
| BioMutai | PPP3CA |
| DMDMi | 1352673 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Initiator methioninei | RemovedCombined sources | |||
| ChainiPRO_0000058822 | 2 – 521 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformAdd BLAST | 520 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
| Modified residuei | 224 | Nitrated tyrosineBy similarity | 1 | |
| Modified residuei | 469 | PhosphoserineBy similarity | 1 | |
| Modified residuei | 492 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Nitration, PhosphoproteinProteomic databases
| EPDi | Q08209 |
| MaxQBi | Q08209 |
| PaxDbi | Q08209 |
| PeptideAtlasi | Q08209 |
| PRIDEi | Q08209 |
| ProteomicsDBi | 58579 58580 [Q08209-2] 58581 [Q08209-3] |
PTM databases
| DEPODi | Q08209 |
| iPTMneti | Q08209 |
| PhosphoSitePlusi | Q08209 |
| SwissPalmi | Q08209 |
Miscellaneous databases
| PMAP-CutDBi | Q08209 |
Expressioni
Gene expression databases
| Bgeei | ENSG00000138814 Expressed in 244 organ(s), highest expression level in caudate nucleus |
| CleanExi | HS_PPP3CA |
| ExpressionAtlasi | Q08209 baseline and differential |
| Genevisiblei | Q08209 HS |
Organism-specific databases
| HPAi | CAB018581 HPA012778 |
Interactioni
Subunit structurei
Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca2+-binding subunit (also known as calcineurin B) (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:27974827). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca2+ intracellular levels, forms a complex composed of PPP3CA/calcineurin A, calcineurin B and calmodulin (By similarity). Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:27974827). Interacts (via calmodulin-binding domain) with CALM1/calmodulin; the interaction depends on calmodulin binding to Ca2+ (PubMed:18384083, Ref. 28, PubMed:19404396, PubMed:25144868). Forms a complex composed of MYOZ2 and ACTN1 (By similarity). Within the complex interacts with MYOZ2 (PubMed:11114196). Interacts with MYOZ1 (PubMed:11114196). Interacts with MYOZ3 (PubMed:11842093). Interacts with CIB1; the interaction increases upon cardiomyocyte hypertrophy (By similarity). Interacts with CHP1 and CHP2 (By similarity). Interacts with CRTC2 (PubMed:15454081). Interacts with DNM1L; the interaction dephosphorylates DNM1L and promotes its translocation to mitochondria (PubMed:18838687). Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity). Interacts (constitutively active form) with SYNPO2 (PubMed:17923693). Interacts with scaffold protein AKAP5 (via IAIIIT motif); the interaction recruits PPP3CA to the plasma membrane following L-type Ca2+-channel activation (PubMed:22343722). Interacts with NFATC2 (PubMed:26248042). Interacts with RCAN3 (PubMed:26248042). Interacts with PPIA (PubMed:12218175, PubMed:12357034). Interacts with RCAN1 (PubMed:12809556).By similarity18 Publications
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sitei | 352 | Interaction with PxVP motif in substrate2 Publications | 1 |
Binary interactionsi
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- protein dimerization activity Source: UniProtKB
- protein heterodimerization activity Source: Ensembl
Protein-protein interaction databases
| BioGridi | 111522, 70 interactors |
| ComplexPortali | CPX-1003 Calcineurin-Calmodulin complex, alpha-R1 variant CPX-1048 Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1114 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-674 Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant |
| CORUMi | Q08209 |
| DIPi | DIP-6095N |
| ELMi | Q08209 |
| IntActi | Q08209, 29 interactors |
| MINTi | Q08209 |
| STRINGi | 9606.ENSP00000378323 |
Chemistry databases
| BindingDBi | Q08209 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| DisProti | DP00092 |
| ProteinModelPortali | Q08209 |
| SMRi | Q08209 |
| ModBasei | Search... |
| MobiDBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | Q08209 |
Family & Domainsi
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 56 – 340 | CatalyticCuratedAdd BLAST | 285 | |
| Regioni | 327 – 336 | Interaction with PxIxIF motif in substrate5 Publications | 10 | |
| Regioni | 341 – 369 | Calcineurin B binding6 PublicationsAdd BLAST | 29 | |
| Regioni | 392 – 406 | Calmodulin-binding4 PublicationsAdd BLAST | 15 | |
| Regioni | 407 – 414 | Autoinhibitory segmentBy similarity | 8 | |
| Regioni | 465 – 487 | Autoinhibitory domain1 PublicationAdd BLAST | 23 |
Motif
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Motifi | 307 – 311 | SAPNY motif1 Publication | 5 |
Domaini
The autoinhibitory domain prevents access to the catalytic site.By similarity
The autoinhibitory segment prevents access to the substrate binding site.By similarity
Possible isomerization of Pro-309 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA.1 Publication
Sequence similaritiesi
Phylogenomic databases
| eggNOGi | KOG0375 Eukaryota COG0639 LUCA |
| GeneTreei | ENSGT00530000063087 |
| HOGENOMi | HOG000172699 |
| HOVERGENi | HBG002819 |
| InParanoidi | Q08209 |
| KOi | K04348 |
| OMAi | LWSLKIW |
| OrthoDBi | EOG091G094R |
| PhylomeDBi | Q08209 |
| TreeFami | TF105557 |
Family and domain databases
| Gene3Di | 3.60.21.10, 1 hit |
| InterProi | View protein in InterPro IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like IPR006186 Ser/Thr-sp_prot-phosphatase |
| Pfami | View protein in Pfam PF00149 Metallophos, 1 hit |
| PRINTSi | PR00114 STPHPHTASE |
| SMARTi | View protein in SMART SM00156 PP2Ac, 1 hit |
| PROSITEi | View protein in PROSITE PS00125 SER_THR_PHOSPHATASE, 1 hit |
Sequences (5+)i
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q08209-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL
60 70 80 90 100
MKEGRLEESV ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK
110 120 130 140 150
LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWALKILY PKTLFLLRGN
160 170 180 190 200
HECRHLTEYF TFKQECKIKY SERVYDACMD AFDCLPLAAL MNQQFLCVHG
210 220 230 240 250
GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG NEKTQEHFTH
260 270 280 290 300
NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
310 320 330 340 350
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF
360 370 380 390 400
TWSLPFVGEK VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI
410 420 430 440 450
RAIGKMARVF SVLREESESV LTLKGLTPTG MLPSGVLSGG KQTLQSATVE
460 470 480 490 500
AIEADEAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM PSDANLNSIN
510 520
KALTSETNGT DSNGSNSSNI Q
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| E7ETC2 | E7ETC2_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 423 | Annotation score: | ||
| E9PK68 | E9PK68_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 147 | Annotation score: | ||
| E9PPC8 | E9PPC8_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 132 | Annotation score: | ||
| H0YAB4 | H0YAB4_HUMAN | Serine/threonine-protein phosphatas... | PPP3CA | 16 | Annotation score: |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_080348 | 92 | H → R in IECEE1; unknown pathological significance. 1 Publication | 1 | |
| Natural variantiVAR_080349 | 281 | H → Q in IECEE1; unknown pathological significance. 1 Publication | 1 | |
| Natural variantiVAR_080350 | 282 | E → K in IECEE1; unknown pathological significance. 1 Publication | 1 | |
| Natural variantiVAR_080351 | 445 – 521 | Missing in IECEE1; unknown pathological significance. 1 PublicationAdd BLAST | 77 | |
| Natural variantiVAR_080352 | 447 | A → T in IECEE1; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_054467 | 20 – 86 | Missing in isoform 5. 1 PublicationAdd BLAST | 67 | |
| Alternative sequenceiVSP_047755 | 87 – 318 | Missing in isoform 4. 1 PublicationAdd BLAST | 232 | |
| Alternative sequenceiVSP_043378 | 318 – 359 | Missing in isoform 3. 1 PublicationAdd BLAST | 42 | |
| Alternative sequenceiVSP_018562 | 448 – 457 | Missing in isoform 2 and isoform 3. 3 Publications | 10 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14778 mRNA Translation: AAA02631.1 EU192652 mRNA Translation: ABW74484.1 EU192653 mRNA Translation: ABW74485.1 AY904364 mRNA Translation: AAY17314.1 AK290532 mRNA Translation: BAF83221.1 AL353950 mRNA Translation: CAB89253.1 AB451338 mRNA Translation: BAG70152.1 AB451487 mRNA Translation: BAG70301.1 AC092671 Genomic DNA No translation available. AP001816 Genomic DNA No translation available. AP001870 Genomic DNA No translation available. AP001939 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06125.1 CH471057 Genomic DNA Translation: EAX06124.1 BC025714 mRNA Translation: AAH25714.1 |
| CCDSi | CCDS34037.1 [Q08209-1] CCDS47113.1 [Q08209-3] CCDS47114.1 [Q08209-2] |
| PIRi | S35067 |
| RefSeqi | NP_000935.1, NM_000944.4 [Q08209-1] NP_001124163.1, NM_001130691.1 [Q08209-2] NP_001124164.1, NM_001130692.1 [Q08209-3] |
| UniGenei | Hs.435512 |
Genome annotation databases
| Ensembli | ENST00000323055; ENSP00000320580; ENSG00000138814 [Q08209-3] ENST00000394853; ENSP00000378322; ENSG00000138814 [Q08209-2] ENST00000394854; ENSP00000378323; ENSG00000138814 [Q08209-1] ENST00000512215; ENSP00000422781; ENSG00000138814 [Q08209-4] |
| GeneIDi | 5530 |
| KEGGi | hsa:5530 |
| UCSCi | uc003hvu.3 human [Q08209-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
| Wikipedia Calcineurin entry |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14778 mRNA Translation: AAA02631.1 EU192652 mRNA Translation: ABW74484.1 EU192653 mRNA Translation: ABW74485.1 AY904364 mRNA Translation: AAY17314.1 AK290532 mRNA Translation: BAF83221.1 AL353950 mRNA Translation: CAB89253.1 AB451338 mRNA Translation: BAG70152.1 AB451487 mRNA Translation: BAG70301.1 AC092671 Genomic DNA No translation available. AP001816 Genomic DNA No translation available. AP001870 Genomic DNA No translation available. AP001939 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06125.1 CH471057 Genomic DNA Translation: EAX06124.1 BC025714 mRNA Translation: AAH25714.1 |
| CCDSi | CCDS34037.1 [Q08209-1] CCDS47113.1 [Q08209-3] CCDS47114.1 [Q08209-2] |
| PIRi | S35067 |
| RefSeqi | NP_000935.1, NM_000944.4 [Q08209-1] NP_001124163.1, NM_001130691.1 [Q08209-2] NP_001124164.1, NM_001130692.1 [Q08209-3] |
| UniGenei | Hs.435512 |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1AUI | X-ray | 2.10 | A | 1-521 | [»] | |
| 1M63 | X-ray | 2.80 | A/E | 1-372 | [»] | |
| 1MF8 | X-ray | 3.10 | A | 20-392 | [»] | |
| 2JOG | NMR | - | A | 21-347 | [»] | |
| 2JZI | NMR | - | B | 391-414 | [»] | |
| 2P6B | X-ray | 2.30 | A/C | 1-380 | [»] | |
| 2R28 | X-ray | 1.86 | C/D | 389-413 | [»] | |
| 2W73 | X-ray | 1.45 | K/L/M/O | 395-411 | [»] | |
| 3LL8 | X-ray | 2.00 | A/C | 14-370 | [»] | |
| 4F0Z | X-ray | 1.70 | A | 1-370 | [»] | |
| 4Q5U | X-ray | 1.95 | C | 391-414 | [»] | |
| 5C1V | X-ray | 3.35 | A/B | 2-346 | [»] | |
| 5SVE | X-ray | 2.60 | A | 1-370 | [»] | |
| DisProti | DP00092 | |||||
| ProteinModelPortali | Q08209 | |||||
| SMRi | Q08209 | |||||
| ModBasei | Search... | |||||
| MobiDBi | Search... | |||||
Protein-protein interaction databases
| BioGridi | 111522, 70 interactors |
| ComplexPortali | CPX-1003 Calcineurin-Calmodulin complex, alpha-R1 variant CPX-1048 Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1114 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-674 Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant |
| CORUMi | Q08209 |
| DIPi | DIP-6095N |
| ELMi | Q08209 |
| IntActi | Q08209, 29 interactors |
| MINTi | Q08209 |
| STRINGi | 9606.ENSP00000378323 |
Chemistry databases
| BindingDBi | Q08209 |
| ChEMBLi | CHEMBL4445 |
| DrugBanki | DB08231 MYRISTIC ACID |
PTM databases
| DEPODi | Q08209 |
| iPTMneti | Q08209 |
| PhosphoSitePlusi | Q08209 |
| SwissPalmi | Q08209 |
Polymorphism and mutation databases
| BioMutai | PPP3CA |
| DMDMi | 1352673 |
Proteomic databases
| EPDi | Q08209 |
| MaxQBi | Q08209 |
| PaxDbi | Q08209 |
| PeptideAtlasi | Q08209 |
| PRIDEi | Q08209 |
| ProteomicsDBi | 58579 58580 [Q08209-2] 58581 [Q08209-3] |
Protocols and materials databases
| DNASUi | 5530 |
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
| Ensembli | ENST00000323055; ENSP00000320580; ENSG00000138814 [Q08209-3] ENST00000394853; ENSP00000378322; ENSG00000138814 [Q08209-2] ENST00000394854; ENSP00000378323; ENSG00000138814 [Q08209-1] ENST00000512215; ENSP00000422781; ENSG00000138814 [Q08209-4] |
| GeneIDi | 5530 |
| KEGGi | hsa:5530 |
| UCSCi | uc003hvu.3 human [Q08209-1] |
Organism-specific databases
| CTDi | 5530 |
| DisGeNETi | 5530 |
| EuPathDBi | HostDB:ENSG00000138814.16 |
| GeneCardsi | PPP3CA |
| HGNCi | HGNC:9314 PPP3CA |
| HPAi | CAB018581 HPA012778 |
| MalaCardsi | PPP3CA |
| MIMi | 114105 gene 617711 phenotype |
| neXtProti | NX_Q08209 |
| OpenTargetsi | ENSG00000138814 |
| Orphaneti | 178469 Autosomal dominant non-syndromic intellectual disability 442835 Undetermined early-onset epileptic encephalopathy |
| PharmGKBi | PA33678 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG0375 Eukaryota COG0639 LUCA |
| GeneTreei | ENSGT00530000063087 |
| HOGENOMi | HOG000172699 |
| HOVERGENi | HBG002819 |
| InParanoidi | Q08209 |
| KOi | K04348 |
| OMAi | LWSLKIW |
| OrthoDBi | EOG091G094R |
| PhylomeDBi | Q08209 |
| TreeFami | TF105557 |
Enzyme and pathway databases
| Reactomei | R-HSA-180024 DARPP-32 events R-HSA-2025928 Calcineurin activates NFAT R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-4086398 Ca2+ pathway R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation |
| SIGNORi | Q08209 |
Miscellaneous databases
| ChiTaRSi | PPP3CA human |
| EvolutionaryTracei | Q08209 |
| GeneWikii | PPP3CA |
| GenomeRNAii | 5530 |
| PMAP-CutDBi | Q08209 |
| PROi | PR:Q08209 |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000138814 Expressed in 244 organ(s), highest expression level in caudate nucleus |
| CleanExi | HS_PPP3CA |
| ExpressionAtlasi | Q08209 baseline and differential |
| Genevisiblei | Q08209 HS |
Family and domain databases
| Gene3Di | 3.60.21.10, 1 hit |
| InterProi | View protein in InterPro IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like IPR006186 Ser/Thr-sp_prot-phosphatase |
| Pfami | View protein in Pfam PF00149 Metallophos, 1 hit |
| PRINTSi | PR00114 STPHPHTASE |
| SMARTi | View protein in SMART SM00156 PP2Ac, 1 hit |
| PROSITEi | View protein in PROSITE PS00125 SER_THR_PHOSPHATASE, 1 hit |
| ProtoNeti | Search... |
Entry informationi
| Entry namei | PP2BA_HUMAN | |
| Accessioni | Q08209Primary (citable) accession number: Q08209 Secondary accession number(s): A1A441 Q8TAW9 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
| Last sequence update: | February 1, 1996 | |
| Last modified: | November 7, 2018 | |
| This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references
