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UniProtKB - Q08188 (TGM3_HUMAN)

Entry version 199 (10 Feb 2021)
Sequence version 4 (01 Sep 2009)
Previous versions | rss
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Protein

Protein-glutamine gamma-glutamyltransferase E

Gene

TGM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+2 PublicationsNote: Binds 3 Ca2+ cations per subunit. Binds 1 Ca2+ as a zymogen, and binds 2 more Ca2+ cations, or other divalent metal cations, after proteolytic processing.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi222Calcium 1; via carbonyl oxygen2 Publications1
Metal bindingi225Calcium 12 Publications1
Metal bindingi227Calcium 1; via carbonyl oxygen2 Publications1
Metal bindingi228Calcium 12 Publications1
Metal bindingi230Calcium 1; via carbonyl oxygen2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei273PROSITE-ProRule annotation1
Metal bindingi302Calcium 22 Publications1
Metal bindingi304Calcium 22 Publications1
Metal bindingi306Calcium 22 Publications1
Metal bindingi308Calcium 2; via carbonyl oxygen2 Publications1
Metal bindingi325Calcium 22 Publications1
Active sitei331PROSITE-ProRule annotation1
Active sitei354PROSITE-ProRule annotation1
Metal bindingi394Calcium 32 Publications1
Metal bindingi416Calcium 3; via carbonyl oxygen2 Publications1
Metal bindingi444Calcium 32 Publications1
Metal bindingi449Calcium 32 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processKeratinization
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.13, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q08188

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase E (EC:2.3.2.133 Publications)
Alternative name(s):
Transglutaminase E
Short name:
TG(E)
Short name:
TGE
Short name:
TGase E
Transglutaminase-3
Short name:
TGase-3
Cleaved into the following 2 chains:
Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain
Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGM3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11779, TGM3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600238, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q08188

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125780.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Uncombable hair syndrome 2 (UHS2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of uncombable hair syndrome, a condition characterized by scalp hair that is impossible to comb due to the haphazard arrangement of the hair bundles. A characteristic morphologic feature is a triangular to reniform to heart shape on cross-sections, and a groove, canal or flattening along the entire length of the hair. Most individuals are affected early in childhood and the hair takes on a spun-glass appearance with the hair becoming dry, curly, glossy, lighter in color, and progressively uncombable. The hair growth rate can range from slow to normal, and the condition improves with age.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		7053

MalaCards human disease database

More...MalaCardsi		TGM3
MIMi617251, phenotype

Open Targets

More...OpenTargetsi		ENSG00000125780

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1410, Uncombable hair syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36492

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q08188, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3363

Drug and drug target database

More...DrugBanki		DB01864, 5'-Guanosine-Diphosphate-Monothiophosphate
DB03152, B-2-Octylglucoside
DB04315, Guanosine-5'-Diphosphate
DB01972, Guanosine-5'-Monophosphate
DB00130, L-Glutamine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TGM3

Domain mapping of disease mutations (DMDM)

More...DMDMi		257051080

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000336522 – 467Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chainAdd BLAST466
ChainiPRO_0000033653468 – 693Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chainAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei111PhosphotyrosineCombined sources1
Modified residuei112PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 (PubMed:8099584) or between Pro-465 and Phe-466 (PubMed:16565075). Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV (PubMed:16565075).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei467 – 468Cleavage; by CTSL2

Keywords - PTMi

Acetylation, Phosphoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q08188

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q08188

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q08188

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q08188

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q08188

PeptideAtlas

More...PeptideAtlasi		Q08188

PRoteomics IDEntifications database

More...PRIDEi		Q08188

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58578

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q08188

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q08188

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q08188

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125780, Expressed in lower esophagus mucosa and 125 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q08188, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125780, Group enriched (esophagus, lymphoid tissue, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112911, 42 interactors

Protein interaction database and analysis system

More...IntActi		Q08188, 24 interactors

Molecular INTeraction database

More...MINTi		Q08188

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370867

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q08188

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q08188, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1693
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q08188

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q08188

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transglutaminase superfamily. Transglutaminase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUPB, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013435_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q08188

Identification of Orthologs from Complete Genome Data

More...OMAi		GWNFGQY

Database of Orthologous Groups

More...OrthoDBi		297055at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q08188

TreeFam database of animal gene trees

More...TreeFami		TF324278

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits
3.90.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR038765, Papain-like_cys_pep_sf
IPR002931, Transglutaminase-like
IPR036985, Transglutaminase-like_sf
IPR023608, Transglutaminase_animal
IPR013808, Transglutaminase_AS
IPR008958, Transglutaminase_C
IPR036238, Transglutaminase_C_sf
IPR001102, Transglutaminase_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00927, Transglut_C, 2 hits
PF01841, Transglut_core, 1 hit
PF00868, Transglut_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000459, TGM_EBP42, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00460, TGc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49309, SSF49309, 2 hits
SSF54001, SSF54001, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00547, TRANSGLUTAMINASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q08188-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS 
        60         70         80         90        100
NERLEFIVST GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI 
       110        120        130        140        150
SSPASAPIGR YTMALQIFSQ GGISSVKLGT FILLFNPWLN VDSVFMGNHA 
       160        170        180        190        200
EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ FEEDILSICL SILDRSLNFR 
       210        220        230        240        250
RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT YTGGRDPRSW 
       260        270        280        290        300
NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA 
       310        320        330        340        350
HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW 
       360        370        380        390        400
QVLDATPQER SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW 
       410        420        430        440        450
LYDNTTGKQW KNSVNSHTIG RYISTKAVGS NARMDVTDKY KYPEGSDQER 
       460        470        480        490        500
QVFQKALGKL KPNTPFAATS SMGLETEEQE PSIIGKLKVA GMLAVGKEVN 
       510        520        530        540        550
LVLLLKNLSR DTKTVTVNMT AWTIIYNGTL VHEVWKDSAT MSLDPEEEAE 
       560        570        580        590        600
HPIKISYAQY EKYLKSDNMI RITAVCKVPD ESEVVVERDI ILDNPTLTLE 
       610        620        630        640        650
VLNEARVRKP VNVQMLFSNP LDEPVRDCVL MVEGSGLLLG NLKIDVPTLG 
       660        670        680        690 
PKEGSRVRFD ILPSRSGTKQ LLADFSCNKF PAIKAMLSID VAE
Length:693
Mass (Da):76,632
Last modified:September 1, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAFAC0C9A8AA5FD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58 – 59VS → DT in AAA61155 (PubMed:8099584).Curated2
Sequence conflicti251N → G in AAA61155 (PubMed:8099584).Curated1
Sequence conflicti324S → G in BAF84040 (PubMed:14702039).Curated1
Sequence conflicti346S → P in AAA61155 (PubMed:8099584).Curated1
Sequence conflicti674D → G in BAF84040 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04006713T → K6 PublicationsCorresponds to variant dbSNP:rs214803Ensembl.1
Natural variantiVAR_040068163I → L1 PublicationCorresponds to variant dbSNP:rs6048066Ensembl.1
Natural variantiVAR_040069249S → N1 PublicationCorresponds to variant dbSNP:rs214814Ensembl.1
Natural variantiVAR_040070562K → R1 PublicationCorresponds to variant dbSNP:rs1042617Ensembl.1
Natural variantiVAR_040071654G → R5 PublicationsCorresponds to variant dbSNP:rs214830Ensembl.1
Natural variantiVAR_055360687L → M1 PublicationCorresponds to variant dbSNP:rs45581032Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L10386 mRNA Translation: AAA61155.1
AK290324 mRNA Translation: BAF83013.1
AK291351 mRNA Translation: BAF84040.1
AK315236 mRNA Translation: BAG37663.1
EF102483 Genomic DNA Translation: ABK41960.1
AL031678 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10601.1
CH471133 Genomic DNA Translation: EAX10602.1
BC109075 mRNA Translation: AAI09076.1
BC109076 mRNA Translation: AAI09077.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33435.1

Protein sequence database of the Protein Information Resource

More...PIRi		A45991

NCBI Reference Sequences

More...RefSeqi		NP_003236.3, NM_003245.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381458; ENSP00000370867; ENSG00000125780

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7053

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7053

UCSC genome browser

More...UCSCi		uc002wfx.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10386 mRNA Translation: AAA61155.1
AK290324 mRNA Translation: BAF83013.1
AK291351 mRNA Translation: BAF84040.1
AK315236 mRNA Translation: BAG37663.1
EF102483 Genomic DNA Translation: ABK41960.1
AL031678 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10601.1
CH471133 Genomic DNA Translation: EAX10602.1
BC109075 mRNA Translation: AAI09076.1
BC109076 mRNA Translation: AAI09077.1
CCDSiCCDS33435.1
PIRiA45991
RefSeqiNP_003236.3, NM_003245.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L9MX-ray2.10A/B2-693[»]
1L9NX-ray2.10A/B2-693[»]
1NUDX-ray2.70A/B2-693[»]
1NUFX-ray2.70A2-693[»]
1NUGX-ray2.40A/B2-693[»]
SMRiQ08188
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112911, 42 interactors
IntActiQ08188, 24 interactors
MINTiQ08188
STRINGi9606.ENSP00000370867

Chemistry databases

BindingDBiQ08188
ChEMBLiCHEMBL3363
DrugBankiDB01864, 5'-Guanosine-Diphosphate-Monothiophosphate
DB03152, B-2-Octylglucoside
DB04315, Guanosine-5'-Diphosphate
DB01972, Guanosine-5'-Monophosphate
DB00130, L-Glutamine

PTM databases

iPTMnetiQ08188
PhosphoSitePlusiQ08188

Genetic variation databases

BioMutaiTGM3
DMDMi257051080

Proteomic databases

EPDiQ08188
jPOSTiQ08188
MassIVEiQ08188
MaxQBiQ08188
PaxDbiQ08188
PeptideAtlasiQ08188
PRIDEiQ08188
ProteomicsDBi58578
TopDownProteomicsiQ08188

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1375, 305 antibodies

Genome annotation databases

EnsembliENST00000381458; ENSP00000370867; ENSG00000125780
GeneIDi7053
KEGGihsa:7053
UCSCiuc002wfx.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7053
DisGeNETi7053

GeneCards: human genes, protein and diseases

More...GeneCardsi		TGM3
HGNCiHGNC:11779, TGM3
HPAiENSG00000125780, Group enriched (esophagus, lymphoid tissue, tongue)
MalaCardsiTGM3
MIMi600238, gene
617251, phenotype
neXtProtiNX_Q08188
OpenTargetsiENSG00000125780
Orphaneti1410, Uncombable hair syndrome
PharmGKBiPA36492
VEuPathDBiHostDB:ENSG00000125780.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUPB, Eukaryota
GeneTreeiENSGT01010000222463
HOGENOMiCLU_013435_1_0_1
InParanoidiQ08188
OMAiGWNFGQY
OrthoDBi297055at2759
PhylomeDBiQ08188
TreeFamiTF324278

Enzyme and pathway databases

BRENDAi2.3.2.13, 2681
PathwayCommonsiQ08188

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7053, 1 hit in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TGM3, human
EvolutionaryTraceiQ08188

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TGM3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7053
PharosiQ08188, Tchem

Protein Ontology

More...PROi		PR:Q08188
RNActiQ08188, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125780, Expressed in lower esophagus mucosa and 125 other tissues
GenevisibleiQ08188, HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR038765, Papain-like_cys_pep_sf
IPR002931, Transglutaminase-like
IPR036985, Transglutaminase-like_sf
IPR023608, Transglutaminase_animal
IPR013808, Transglutaminase_AS
IPR008958, Transglutaminase_C
IPR036238, Transglutaminase_C_sf
IPR001102, Transglutaminase_N
PfamiView protein in Pfam
PF00927, Transglut_C, 2 hits
PF01841, Transglut_core, 1 hit
PF00868, Transglut_N, 1 hit
PIRSFiPIRSF000459, TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460, TGc, 1 hit
SUPFAMiSSF49309, SSF49309, 2 hits
SSF54001, SSF54001, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547, TRANSGLUTAMINASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08188
Secondary accession number(s): A8K5N6
, B2RCR6, D3DVX1, O95933, Q32ML9, Q32MM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 1, 2009
Last modified: February 10, 2021
This is version 199 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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