Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/arginine-rich splicing factor 4

Gene

SRSF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 4
Alternative name(s):
Pre-mRNA-splicing factor SRP75
SRP001LB
Splicing factor, arginine/serine-rich 4
Gene namesi
Name:SRSF4
Synonyms:SFRS4, SRP75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116350.16
HGNCiHGNC:10786 SRSF4
MIMi601940 gene
neXtProtiNX_Q08170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6429
OpenTargetsiENSG00000116350
PharmGKBiPA35702

Polymorphism and mutation databases

BioMutaiSRSF4
DMDMi20981726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819251 – 494Serine/arginine-rich splicing factor 4Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ08170
MaxQBiQ08170
PaxDbiQ08170
PeptideAtlasiQ08170
PRIDEiQ08170
ProteomicsDBi58574

PTM databases

iPTMnetiQ08170
PhosphoSitePlusiQ08170
SwissPalmiQ08170

Expressioni

Gene expression databases

BgeeiENSG00000116350 Expressed in 231 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SFRS4
ExpressionAtlasiQ08170 baseline and differential
GenevisibleiQ08170 HS

Organism-specific databases

HPAiHPA050975

Interactioni

Subunit structurei

Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRA2BP629953EBI-722621,EBI-725485

Protein-protein interaction databases

BioGridi112327, 46 interactors
CORUMiQ08170
IntActiQ08170, 29 interactors
MINTiQ08170
STRINGi9606.ENSP00000362900

Structurei

3D structure databases

ProteinModelPortaliQ08170
SMRiQ08170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 72RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini104 – 177RRM 2PROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi72 – 97Gly-rich (hinge region)Add BLAST26
Compositional biasi179 – 494Arg/Ser-rich (RS domain)Add BLAST316

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00910000144049
HOVERGENiHBG002295
InParanoidiQ08170
KOiK12893
OMAiKSKDHAE
OrthoDBiEOG091G0R9W
PhylomeDBiQ08170
TreeFamiTF351335

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q08170-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD
60 70 80 90 100
AVYELNGKDL CGERVIVEHA RGPRRDGSYG SGRSGYGYRR SGRDKYGPPT
110 120 130 140 150
RTEYRLIVEN LSSRCSWQDL KDYMRQAGEV TYADAHKGRK NEGVIEFVSY
160 170 180 190 200
SDMKRALEKL DGTEVNGRKI RLVEDKPGSR RRRSYSRSRS HSRSRSRSRH
210 220 230 240 250
SRKSRSRSGS SKSSHSKSRS RSRSGSRSRS KSRSRSQSRS RSKKEKSRSP
260 270 280 290 300
SKEKSRSRSH SAGKSRSKSK DQAEEKIQNN DNVGKPKSRS PSRHKSKSKS
310 320 330 340 350
RSRSQERRVE EEKRGSVSRG RSQEKSLRQS RSRSRSKGGS RSRSRSRSKS
360 370 380 390 400
KDKRKGRKRS REESRSRSRS RSKSERSRKR GSKRDSKAGS SKKKKKEDTD
410 420 430 440 450
RSQSRSPSRS VSKEREHAKS ESSQREGRGE SENAGTNQET RSRSRSNSKS
460 470 480 490
KPNLPSESRS RSKSASKTRS RSKSRSRSAS RSPSRSRSRS HSRS
Length:494
Mass (Da):56,678
Last modified:May 15, 2002 - v2
Checksum:i5BBAB917C218C20A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SEM4A0A0D9SEM4_HUMAN
Serine/arginine-rich-splicing facto...
SRSF4
378Annotation score:
S4R2X6S4R2X6_HUMAN
Serine/arginine-rich-splicing facto...
SRSF4
160Annotation score:
A0A0D9SGD2A0A0D9SGD2_HUMAN
Serine/arginine-rich-splicing facto...
SRSF4
45Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35N → D AA sequence (PubMed:1577277).Curated1
Sequence conflicti318 – 322SRGRS → EQGQE in AAA36649 (PubMed:8321209).Curated5
Sequence conflicti436 – 438TNQ → RNE in AAA36649 (PubMed:8321209).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052230253E → D1 PublicationCorresponds to variant dbSNP:rs2230679Ensembl.1
Natural variantiVAR_052231338G → A1 PublicationCorresponds to variant dbSNP:rs2230677Ensembl.1
Natural variantiVAR_052232356G → S1 PublicationCorresponds to variant dbSNP:rs2230678Ensembl.1
Natural variantiVAR_052233438Q → E. Corresponds to variant dbSNP:rs1049928Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14076 mRNA Translation: AAA36649.1
BT007415 mRNA Translation: AAP36083.1
AL590729 Genomic DNA No translation available.
AL357500 Genomic DNA No translation available.
BC002781 mRNA Translation: AAH02781.1
AC004236 Genomic DNA Translation: AAC04476.1
CCDSiCCDS333.1
PIRiA48133
RefSeqiNP_005617.2, NM_005626.4
UniGeneiHs.469970

Genome annotation databases

EnsembliENST00000373795; ENSP00000362900; ENSG00000116350
GeneIDi6429
KEGGihsa:6429
UCSCiuc001bro.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14076 mRNA Translation: AAA36649.1
BT007415 mRNA Translation: AAP36083.1
AL590729 Genomic DNA No translation available.
AL357500 Genomic DNA No translation available.
BC002781 mRNA Translation: AAH02781.1
AC004236 Genomic DNA Translation: AAC04476.1
CCDSiCCDS333.1
PIRiA48133
RefSeqiNP_005617.2, NM_005626.4
UniGeneiHs.469970

3D structure databases

ProteinModelPortaliQ08170
SMRiQ08170
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112327, 46 interactors
CORUMiQ08170
IntActiQ08170, 29 interactors
MINTiQ08170
STRINGi9606.ENSP00000362900

PTM databases

iPTMnetiQ08170
PhosphoSitePlusiQ08170
SwissPalmiQ08170

Polymorphism and mutation databases

BioMutaiSRSF4
DMDMi20981726

Proteomic databases

EPDiQ08170
MaxQBiQ08170
PaxDbiQ08170
PeptideAtlasiQ08170
PRIDEiQ08170
ProteomicsDBi58574

Protocols and materials databases

DNASUi6429
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373795; ENSP00000362900; ENSG00000116350
GeneIDi6429
KEGGihsa:6429
UCSCiuc001bro.4 human

Organism-specific databases

CTDi6429
DisGeNETi6429
EuPathDBiHostDB:ENSG00000116350.16
GeneCardsiSRSF4
H-InvDBiHIX0160019
HGNCiHGNC:10786 SRSF4
HPAiHPA050975
MIMi601940 gene
neXtProtiNX_Q08170
OpenTargetsiENSG00000116350
PharmGKBiPA35702
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00910000144049
HOVERGENiHBG002295
InParanoidiQ08170
KOiK12893
OMAiKSKDHAE
OrthoDBiEOG091G0R9W
PhylomeDBiQ08170
TreeFamiTF351335

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSiSRSF4 human
GeneWikiiSFRS4
GenomeRNAii6429
PROiPR:Q08170
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116350 Expressed in 231 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SFRS4
ExpressionAtlasiQ08170 baseline and differential
GenevisibleiQ08170 HS

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSRSF4_HUMAN
AccessioniPrimary (citable) accession number: Q08170
Secondary accession number(s): Q5VXP1, Q9BUA4, Q9UEB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 15, 2002
Last modified: November 7, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again