Interleukin-5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Cloning and expression of interleukin-5 from rats."
    He X.Y., Verma N., Chen J., Plain K., Hall B.
    Transplant Proc 31:1574-1576(1999) [PubMed] [Europe PMC] [Abstract]
  • "Analysis of biological activities of recombinant rat interleukin-5."
    Ishihara K., Nittoh T., Satoh I., Ohuchi K.
    Int Arch Allergy Immunol 120 Suppl 1:11-14(1999) [PubMed] [Europe PMC] [Abstract]
  • "Generation of rat eosinophils by recombinant rat interleukin-5 in vitro and in vivo."
    Ishihara K., Satoh I., Mue S., Ohuchi K.
    Biochim Biophys Acta 1501:25-32(2000) [PubMed] [Europe PMC] [Abstract]
• growth factor activity Source: UniProtKB-KW
• interleukin-5 receptor binding Source: RGDInferred from direct assayⁱ
  • "Cloning and expression of interleukin-5 from rats."
    He X.Y., Verma N., Chen J., Plain K., Hall B.
    Transplant Proc 31:1574-1576(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cytokine-mediated signaling pathway Source: RGDInferred from direct assayⁱ
  • "Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-induced prolongation of rat eosinophil survival."
    Ishihara K., Satoh I., Mue S., Ohuchi K.
    Biochim Biophys Acta 1536:73-84(2001) [PubMed] [Europe PMC] [Abstract]
• immune response Source: InterPro
• inflammatory response Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification."
    Haddad e.l.-B., Underwood S.L., Dabrowski D., Birrell M.A., McCluskie K., Battram C.H., Pecoraro M., Foster M.L., Belvisi M.G.
    J Immunol 168:3004-3016(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of B cell proliferation Source: RGDInferred from direct assayⁱ
  • "Analysis of biological activities of recombinant rat interleukin-5."
    Ishihara K., Nittoh T., Satoh I., Ohuchi K.
    Int Arch Allergy Immunol 120 Suppl 1:11-14(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from direct assayⁱ
  • "Cloning and expression of interleukin-5 from rats."
    He X.Y., Verma N., Chen J., Plain K., Hall B.
    Transplant Proc 31:1574-1576(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: RGD
• positive regulation of eosinophil differentiation Source: RGDInferred from direct assayⁱ
  • "Analysis of biological activities of recombinant rat interleukin-5."
    Ishihara K., Nittoh T., Satoh I., Ohuchi K.
    Int Arch Allergy Immunol 120 Suppl 1:11-14(1999) [PubMed] [Europe PMC] [Abstract]
  • "Generation of rat eosinophils by recombinant rat interleukin-5 in vitro and in vivo."
    Ishihara K., Satoh I., Mue S., Ohuchi K.
    Biochim Biophys Acta 1501:25-32(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of immunoglobulin secretion Source: RGD
• positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
• positive regulation of podosome assembly Source: RGD
• positive regulation of receptor signaling pathway via JAK-STAT Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Analysis of the prolongation of rat eosinophil survival induced by recombinant rat interleukin-5."
    Ishihara K., Satoh I., Ohuchi K.
    Int Arch Allergy Immunol 122 Suppl 1:36-39(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cytokine activity Source: RGDInferred from direct assayⁱ
  • "Cloning and expression of interleukin-5 from rats."
    He X.Y., Verma N., Chen J., Plain K., Hall B.
    Transplant Proc 31:1574-1576(1999) [PubMed] [Europe PMC] [Abstract]
  • "Analysis of biological activities of recombinant rat interleukin-5."
    Ishihara K., Nittoh T., Satoh I., Ohuchi K.
    Int Arch Allergy Immunol 120 Suppl 1:11-14(1999) [PubMed] [Europe PMC] [Abstract]
  • "Generation of rat eosinophils by recombinant rat interleukin-5 in vitro and in vivo."
    Ishihara K., Satoh I., Mue S., Ohuchi K.
    Biochim Biophys Acta 1501:25-32(2000) [PubMed] [Europe PMC] [Abstract]
• growth factor activity Source: UniProtKB-KW
• interleukin-5 receptor binding Source: RGDInferred from direct assayⁱ
  • "Cloning and expression of interleukin-5 from rats."
    He X.Y., Verma N., Chen J., Plain K., Hall B.
    Transplant Proc 31:1574-1576(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MRMLLCLNVL TLSCVWAIAM EIPMSTVVKE TLIQLSTHRA LLTSNETMRL 
        60         70         80         90        100
PVPTHKNHQL CIGEIFQGLD ILKNQTVRGG TVEILFQNLS LIKKYIDGQK 
       110        120        130 
EKCGEERRKT RHFLDYLQEF LGVMSTEWAM EV                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families