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Entry version 187 (17 Jun 2020)
Sequence version 4 (19 Sep 2002)
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Protein

TLE family member 5

Gene

TLE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-4641265 Repression of WNT target genes

SIGNOR Signaling Network Open Resource

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SIGNORi
Q08117

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q08117 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TLE family member 5Curated
Alternative name(s):
Amino-terminal enhancer of split
Short name:
Amino enhancer of split
Gp130-associated protein GAM
Grg-5
Groucho-related protein 5
Protein ESP1
Protein GRG
TLE family member 5, transcriptional modulatorCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLE5Imported
Synonyms:AES, GRG, GRG5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000104964.14

Human Gene Nomenclature Database

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HGNCi
HGNC:307 TLE5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600188 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q08117

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
166

Open Targets

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OpenTargetsi
ENSG00000104964

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24606

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q08117 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AES

Domain mapping of disease mutations (DMDM)

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DMDMi
23503062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508341 – 197TLE family member 5Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei196PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by XIAP/BIRC4.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q08117

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q08117

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q08117

MaxQB - The MaxQuant DataBase

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MaxQBi
Q08117

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q08117

PeptideAtlas

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PeptideAtlasi
Q08117

PRoteomics IDEntifications database

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PRIDEi
Q08117

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58572 [Q08117-1]
58573 [Q08117-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q08117

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08117

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000104964 Expressed in cerebellar vermis and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q08117 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q08117 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000104964 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA.

Interacts with PHF12.

Interacts (via Q domain) with SIX3.

Interacts with SIX6.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q08117
With#Exp.IntAct
ABI2 [Q9NYB9]5EBI-717810,EBI-743598
AEN [Q8WTP8]3EBI-717810,EBI-8637627
ARHGAP32 [A7KAX9]3EBI-717810,EBI-308663
BAHD1 [Q8TBE0]3EBI-717810,EBI-742750
BCL6 [P41182]3EBI-717810,EBI-765407
BHLHE40 [O14503]3EBI-717810,EBI-711810
BIRC7 [Q96CA5]4EBI-717810,EBI-517623
BYSL [Q13895]5EBI-717810,EBI-358049
C1orf109 [Q9NX04]3EBI-717810,EBI-8643161
C1orf216 [Q8TAB5]3EBI-717810,EBI-747505
C1orf94 [Q6P1W5]3EBI-717810,EBI-946029
CALCOCO2 [Q13137]3EBI-717810,EBI-739580
CARD9 [Q9H257]4EBI-717810,EBI-751319
CCDC57 [Q2TAC2]3EBI-717810,EBI-2808286
CCNJL [F6RF56]3EBI-717810,EBI-10177725
CCNK [O75909]3EBI-717810,EBI-739806
CFAP206 [Q8IYR0]3EBI-717810,EBI-749051
CIB3 [Q96Q77]3EBI-717810,EBI-10292696
CPSF7 [Q8N684]3EBI-717810,EBI-746909
CRACR2A [Q9BSW2]4EBI-717810,EBI-739773
CRX [O43186]3EBI-717810,EBI-748171
DDX6 [P26196]3EBI-717810,EBI-351257
DIP2A - isoform 6 [Q14689-6]3EBI-717810,EBI-10233719
EAF1 [Q96JC9]3EBI-717810,EBI-769261
EIF4E2 [O60573]3EBI-717810,EBI-398610
FAM124A [Q86V42]3EBI-717810,EBI-744506
FAM124B [Q9H5Z6]3EBI-717810,EBI-741626
FBF1 - isoform 6 [Q8TES7-6]3EBI-717810,EBI-10244131
FOXP2 [O15409]3EBI-717810,EBI-983612
FRS3 [O43559]3EBI-717810,EBI-725515
FSD2 [A1L4K1]4EBI-717810,EBI-5661036
GFAP [P14136]3EBI-717810,EBI-744302
GOLGA2 [Q08379]3EBI-717810,EBI-618309
GORASP2 [Q9H8Y8]4EBI-717810,EBI-739467
GRB2 [P62993]3EBI-717810,EBI-401755
HNRNPF [P52597]3EBI-717810,EBI-352986
HOMEZ - isoform 2 [Q8IX15-3]3EBI-717810,EBI-10172004
IKZF3 [Q9UKT9]3EBI-717810,EBI-747204
KANK2 [Q63ZY3]3EBI-717810,EBI-2556193
KIFC3 [Q9BVG8]3EBI-717810,EBI-2125614
KRT13 [A1A4E9]3EBI-717810,EBI-10171552
KRT15 [P19012]3EBI-717810,EBI-739566
KRT31 [Q15323]3EBI-717810,EBI-948001
KRT40 [Q6A162]3EBI-717810,EBI-10171697
KRTAP10-7 [P60409]3EBI-717810,EBI-10172290
KRTAP10-8 [P60410]3EBI-717810,EBI-10171774
KRTAP10-9 [P60411]3EBI-717810,EBI-10172052
L3MBTL2 [Q969R5]3EBI-717810,EBI-739909
LDOC1 [O95751]3EBI-717810,EBI-740738
LINC00526 [Q96FQ7]3EBI-717810,EBI-10286106
LMO1 [P25800]3EBI-717810,EBI-8639312
LMO2 [P25791]3EBI-717810,EBI-739696
LMO4 [P61968]3EBI-717810,EBI-2798728
LSM2 [Q9Y333]3EBI-717810,EBI-347416
MAGOHB [Q96A72]3EBI-717810,EBI-746778
MBNL1 [Q86VM6]3EBI-717810,EBI-10225084
MED4 [Q9NPJ6]3EBI-717810,EBI-394607
MFAP1 [P55081]3EBI-717810,EBI-1048159
MIA2 [Q96PC5]3EBI-717810,EBI-1050253
MLX [Q9UH92]4EBI-717810,EBI-741109
MORF4L2 [Q15014]3EBI-717810,EBI-399257
MTUS2 [Q5JR59]3EBI-717810,EBI-742948
NAB2 [Q15742]3EBI-717810,EBI-8641936
NCDN [Q9UBB6]3EBI-717810,EBI-1053490
NEK6 [Q9HC98]3EBI-717810,EBI-740364
NOTCH2NLA [Q7Z3S9]3EBI-717810,EBI-945833
NUDT22 [Q9BRQ3]4EBI-717810,EBI-10297093
OLIG3 [Q7RTU3]3EBI-717810,EBI-10225049
OSGIN1 [Q9UJX0]3EBI-717810,EBI-9057006
PARVG [Q9HBI0]3EBI-717810,EBI-3921217
PPP1R16A [Q96I34]3EBI-717810,EBI-710402
PRKAA1 [Q13131]3EBI-717810,EBI-1181405
PRKAA2 [P54646]3EBI-717810,EBI-1383852
PROP1 [O75360]4EBI-717810,EBI-9027467
PRPF31 [Q8WWY3]3EBI-717810,EBI-1567797
PRR3 [P79522]3EBI-717810,EBI-2803328
PTRH2 [Q9Y3E5]7EBI-717810,EBI-1056751
QARS1 [P47897]3EBI-717810,EBI-347462
QARS1 - isoform 2 [P47897-2]3EBI-717810,EBI-10209725
RBM10 [P98175]3EBI-717810,EBI-721525
RBPMS [Q93062]3EBI-717810,EBI-740322
REL [Q04864]3EBI-717810,EBI-307352
RFX6 [Q8HWS3]3EBI-717810,EBI-746118
RHOXF2 [Q9BQY4]3EBI-717810,EBI-372094
RIMBP3 [Q9UFD9]3EBI-717810,EBI-10182375
RNF31 - isoform 3 [Q96EP0-3]3EBI-717810,EBI-10225152
SCNM1 [Q9BWG6]3EBI-717810,EBI-748391
SDCBP [O00560]3EBI-717810,EBI-727004
SIX1 [Q15475]3EBI-717810,EBI-743675
SKIL [P12757]3EBI-717810,EBI-2902468
SMAD3 [P84022]4EBI-717810,EBI-347161
SNRPC [Q5TAL4]3EBI-717810,EBI-10246938
SOX5 [P35711]3EBI-717810,EBI-3505701
SRPK2 [P78362]3EBI-717810,EBI-593303
STK16 [O75716]3EBI-717810,EBI-749295
STX11 [O75558]3EBI-717810,EBI-714135
TBX3 [O15119]3EBI-717810,EBI-3452216
TCF4 [P15884]3EBI-717810,EBI-533224
TRAF1 [Q13077]3EBI-717810,EBI-359224
TRAF2 [Q12933]3EBI-717810,EBI-355744
TRIM26 [Q12899]3EBI-717810,EBI-2341136
TRIM27 [P14373]4EBI-717810,EBI-719493
TRIM41 [Q8WV44]3EBI-717810,EBI-725997
TSC22D4 [Q8IV54]3EBI-717810,EBI-10261521
TSGA10 [Q9BZW7]3EBI-717810,EBI-744794
TSSK3 [Q96PN8]3EBI-717810,EBI-3918381
U2AF2 [P26368]3EBI-717810,EBI-742339
UBXN11 [Q5T124]3EBI-717810,EBI-746004
VPS37B [Q9H9H4]3EBI-717810,EBI-4400866
VPS37C [A5D8V6]3EBI-717810,EBI-2559305
ZBTB24 [O43167]3EBI-717810,EBI-744471
ZGPAT [Q8N5A5]4EBI-717810,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-717810,EBI-10183064
ZNF576 [Q9H609]3EBI-717810,EBI-3921014
Q9H6143EBI-717810,EBI-10249899
TLE5 - isoform 2 [Q08117-2]
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]6EBI-11741437,EBI-11096309
AGR2 [O95994]3EBI-11741437,EBI-712648
AKAP8L [Q9ULX6]3EBI-11741437,EBI-357530
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-11741437,EBI-12224467
ANKRD11 [X5D778]3EBI-11741437,EBI-17183751
ASB3 - isoform 3 [Q9Y575-3]3EBI-11741437,EBI-14199987
BAG4 [O95429]3EBI-11741437,EBI-2949658
BAHD1 [Q8TBE0]3EBI-11741437,EBI-742750
BHLHE40 [O14503]3EBI-11741437,EBI-711810
BIRC7 [Q96CA5]3EBI-11741437,EBI-517623
BPIFA1 [Q9NP55]5EBI-11741437,EBI-953896
BYSL [Q13895]5EBI-11741437,EBI-358049
C10orf55 [Q5SWW7]3EBI-11741437,EBI-12809220
C11orf1 [Q9H5F2]3EBI-11741437,EBI-718615
C14orf119 [Q9NWQ9]3EBI-11741437,EBI-725606
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-11741437,EBI-11976299
C1orf109 [Q9NX04]3EBI-11741437,EBI-8643161
C1orf94 [Q6P1W5]3EBI-11741437,EBI-946029
C2CD6 [Q53TS8]3EBI-11741437,EBI-739879
CABP2 [Q9NPB3]3EBI-11741437,EBI-12011224
CABP5 [Q9NP86]5EBI-11741437,EBI-10311131
CCDC120 [Q96HB5]6EBI-11741437,EBI-744556
CCNK - isoform 2 [O75909-2]3EBI-11741437,EBI-12010594
CCNO [P22674]3EBI-11741437,EBI-2556878
CIB3 [Q96Q77]3EBI-11741437,EBI-10292696
CLIC3 [O95833]3EBI-11741437,EBI-10192241
CLIP3 [Q96DZ5]3EBI-11741437,EBI-12823145
CNFN [Q9BYD5]3EBI-11741437,EBI-12819063
COA7 [Q96BR5]3EBI-11741437,EBI-6269632
CPSF7 - isoform 3 [Q8N684-3]3EBI-11741437,EBI-11523759
CRACR2A [Q9BSW2]3EBI-11741437,EBI-739773
CRX [O43186]3EBI-11741437,EBI-748171
CSNK2A1 [P68400]3EBI-11741437,EBI-347804
CSTF2 [P33240]3EBI-11741437,EBI-711360
CSTF2T [Q9H0L4]6EBI-11741437,EBI-747012
CT55 [Q8WUE5]3EBI-11741437,EBI-6873363
CTBP2 - isoform 3 [P56545-3]3EBI-11741437,EBI-10171902
CYSRT1 [A8MQ03]3EBI-11741437,EBI-3867333
DAZAP2 [Q15038]3EBI-11741437,EBI-724310
DDX6 [P26196]3EBI-11741437,EBI-351257
DMRT2 [Q9Y5R5]3EBI-11741437,EBI-18072054
DMRT3 [Q9NQL9]3EBI-11741437,EBI-9679045
DMRTB1 [Q96MA1]3EBI-11741437,EBI-954466
DOK6 [Q6PKX4]3EBI-11741437,EBI-2880244
DVL2 [O14641]3EBI-11741437,EBI-740850
DVL3 [Q92997]3EBI-11741437,EBI-739789
DYDC1 [Q8WWB3]3EBI-11741437,EBI-740680
EFEMP2 [O95967]6EBI-11741437,EBI-743414
EFHC1 [Q5JVL4]3EBI-11741437,EBI-743105
EIF1AD [Q8N9N8]3EBI-11741437,EBI-750700
ERF [P50548]3EBI-11741437,EBI-8465203
EXOSC5 [Q9NQT4]3EBI-11741437,EBI-371876
EYA2 - isoform 2 [O00167-2]3EBI-11741437,EBI-12807776
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-11741437,EBI-11986315
FAM168B - isoform 2 [A1KXE4-2]3EBI-11741437,EBI-12193763
FAM214B [Q7L5A3]3EBI-11741437,EBI-745689
FAM217B [Q9NTX9]3EBI-11741437,EBI-19153639
FAM90A1 [Q86YD7]3EBI-11741437,EBI-6658203
FCHSD2 - isoform 3 [O94868-3]3EBI-11741437,EBI-11958845
FHL3 [Q13643]4EBI-11741437,EBI-741101
FOSB [P53539]3EBI-11741437,EBI-2806743
FOXD2 [O60548]3EBI-11741437,EBI-17282008
FOXN1 [O15353]3EBI-11741437,EBI-11319000
FOXP2 [O15409]3EBI-11741437,EBI-983612
FRS3 [O43559]5EBI-11741437,EBI-725515
FSD2 [A1L4K1]3EBI-11741437,EBI-5661036
GATA1 - isoform 2 [P15976-2]5EBI-11741437,EBI-9090198
GCC1 [Q96CN9]3EBI-11741437,EBI-746252
GEM [P55040]3EBI-11741437,EBI-744104
GIGYF1 [O75420]3EBI-11741437,EBI-947774
GLIS2 [Q9BZE0]3EBI-11741437,EBI-7251368
GOLGA2 [Q08379]6EBI-11741437,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-11741437,EBI-5916454
GORASP2 [Q9H8Y8]3EBI-11741437,EBI-739467
GPANK1 [O95872]3EBI-11741437,EBI-751540
GPATCH2L - isoform 2 [Q9NWQ4-1]3EBI-11741437,EBI-11959863
GRN [P28799]3EBI-11741437,EBI-747754
GYS1 [P13807]5EBI-11741437,EBI-740553
HDAC4 - isoform 2 [P56524-2]3EBI-11741437,EBI-11953488
HDHD3 [Q9BSH5]3EBI-11741437,EBI-745201
HELT [A0A087WSW0]4EBI-11741437,EBI-12057631
HEXIM2 [Q96MH2]3EBI-11741437,EBI-5460660
HGS [A0A0S2Z4Q4]3EBI-11741437,EBI-16429135
HGS [O14964]8EBI-11741437,EBI-740220
HHEX [Q03014]3EBI-11741437,EBI-747421
HNRNPF [P52597]3EBI-11741437,EBI-352986
HNRNPK - isoform 2 [P61978-2]5EBI-11741437,EBI-7060731
HOXA1 [P49639]3EBI-11741437,EBI-740785
HOXB5 [P09067]5EBI-11741437,EBI-3893317
HOXC8 [P31273]3EBI-11741437,EBI-1752118
HOXC9 [P31274]3EBI-11741437,EBI-1779423
IKZF3 [Q9UKT9]5EBI-11741437,EBI-747204
INO80B [Q9C086]5EBI-11741437,EBI-715611
INO80E [Q8NBZ0]3EBI-11741437,EBI-769401
INPP5J [Q15735]3EBI-11741437,EBI-10236940
IRX2 [Q9BZI1]3EBI-11741437,EBI-12166369
IRX6 [P78412]5EBI-11741437,EBI-12100506
KANK2 [Q63ZY3]6EBI-11741437,EBI-2556193
KDM1A [O60341]3EBI-11741437,EBI-710124
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-11741437,EBI-14069005
KLF1 [Q13351]3EBI-11741437,EBI-8284732
KLF4 [O43474]3EBI-11741437,EBI-7232405
KLHDC7B [Q96G42]3EBI-11741437,EBI-9478422
KRT34 [O76011]3EBI-11741437,EBI-1047093
KRT35 [Q92764]3EBI-11741437,EBI-1058674
KRT40 [Q6A162]3EBI-11741437,EBI-10171697
KRTAP10-11 [P60412]3EBI-11741437,EBI-10217483
KRTAP10-7 [P60409]3EBI-11741437,EBI-10172290
KRTAP10-8 [P60410]3EBI-11741437,EBI-10171774
KRTAP11-1 [Q8IUC1]3EBI-11741437,EBI-1052037
KRTAP12-2 [P59991]3EBI-11741437,EBI-10176379
KRTAP13-2 [Q52LG2]3EBI-11741437,EBI-11953846
KRTAP13-3 [Q3SY46]5EBI-11741437,EBI-10241252
KRTAP17-1 [Q9BYP8]3EBI-11741437,EBI-11988175
KRTAP19-5 [Q3LI72]3EBI-11741437,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-11741437,EBI-10241353
KRTAP6-2 [Q3LI66]3EBI-11741437,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-11741437,EBI-18394498
KRTAP8-1 [Q8IUC2]3EBI-11741437,EBI-10261141
LDLR [P01130]3EBI-11741437,EBI-988319
LDOC1 [O95751]3EBI-11741437,EBI-740738
LENG8 [Q96PV6]3EBI-11741437,EBI-739546
LHX3 - isoform B [Q9UBR4-2]3EBI-11741437,EBI-12039345
LMO2 - isoform 3 [P25791-3]3EBI-11741437,EBI-11959475
LMO4 [P61968]3EBI-11741437,EBI-2798728
LZTS2 [Q9BRK4]3EBI-11741437,EBI-741037
MAGOHB [Q96A72]3EBI-11741437,EBI-746778
MAPK1 [P28482]3EBI-11741437,EBI-959949
MAPRE3 [Q9UPY8]3EBI-11741437,EBI-726739
MCRS1 [Q96EZ8]3EBI-11741437,EBI-348259
MDFI [Q99750]3EBI-11741437,EBI-724076
MED12L [Q86YW9]3EBI-11741437,EBI-3957138
MED25 [Q71SY5]3EBI-11741437,EBI-394558
MEIS3 - isoform 3 [Q99687-3]3EBI-11741437,EBI-18582591
MFAP1 [P55081]5EBI-11741437,EBI-1048159
MIIP [Q5JXC2]3EBI-11741437,EBI-2801965
MKRN3 [Q13064]5EBI-11741437,EBI-2340269
MLH1 [P40692]3EBI-11741437,EBI-744248
MLLT6 [P55198]3EBI-11741437,EBI-740216
MLX - isoform Beta [Q9UH92-3]3EBI-11741437,EBI-8852072
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-11741437,EBI-10288852
MSS51 [Q4VC12]3EBI-11741437,EBI-11599933
MSX2 [P35548]3EBI-11741437,EBI-6447480
MTUS2 - isoform 2 [Q5JR59-3]6EBI-11741437,EBI-11522433
MYF5 [P13349]3EBI-11741437,EBI-17491620
MYH7B - isoform 2 [A7E2Y1-2]3EBI-11741437,EBI-12813813
MYOG [P15173]3EBI-11741437,EBI-3906629
NAB2 [Q15742]3EBI-11741437,EBI-8641936
NAF1 [Q96HR8]5EBI-11741437,EBI-2515597
NDOR1 [Q9UHB4]3EBI-11741437,EBI-10249760
NDUFB7 [P17568]3EBI-11741437,EBI-1246238
NEK6 - isoform 4 [Q9HC98-4]3EBI-11741437,EBI-11750983
NOTCH2NLC [P0DPK4]3EBI-11741437,EBI-22310682
NUDT22 [Q9BRQ3]3EBI-11741437,EBI-10297093
NUTF2 [P61970]3EBI-11741437,EBI-591778
OLIG3 [Q7RTU3]5EBI-11741437,EBI-10225049
OSGIN1 [Q9UJX0]3EBI-11741437,EBI-9057006
OXER1 [Q8TDS5]3EBI-11741437,EBI-12813389
P4HA3 [Q7Z4N8]3EBI-11741437,EBI-10181968
PARVG [Q9HBI0]5EBI-11741437,EBI-3921217
PATZ1 - isoform 4 [Q9HBE1-4]5EBI-11741437,EBI-11022007
PAX8 [Q06710]3EBI-11741437,EBI-2683132
PAX9 [P55771]3EBI-11741437,EBI-12111000
PCBP1 [Q15365]3EBI-11741437,EBI-946095
PCSK5 - isoform PC6A [Q92824-2]3EBI-11741437,EBI-11956269
PFDN5 [Q99471]3EBI-11741437,EBI-357275
PHF1 [O43189]3EBI-11741437,EBI-530034
PICK1 [Q9NRD5]3EBI-11741437,EBI-79165
PITX1 [P78337]8EBI-11741437,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-11741437,EBI-12138495
PLAGL1 [Q9UM63]3EBI-11741437,EBI-7233410
POLR1C [O15160]3EBI-11741437,EBI-1055079
PRDM14 [Q9GZV8]5EBI-11741437,EBI-3957793
PRDM6 [Q9NQX0]3EBI-11741437,EBI-11320284
PRKAA2 [P54646]3EBI-11741437,EBI-1383852
PRKAB2 [O43741]5EBI-11741437,EBI-1053424
PROP1 [O75360]3EBI-11741437,EBI-9027467
PRPF31 [Q8WWY3]10EBI-11741437,EBI-1567797
PRR3 [P79522]3EBI-11741437,EBI-2803328
PRR35 [P0CG20]5EBI-11741437,EBI-11986293
PSMB1 [P20618]3EBI-11741437,EBI-372273
PSMB4 [P28070]5EBI-11741437,EBI-603350
RAD51D [O75771]3EBI-11741437,EBI-1055693
RBPMS - isoform C [Q93062-3]5EBI-11741437,EBI-740343
RIBC1 [Q8N443]3EBI-11741437,EBI-10265323
RIPPLY1 [Q0D2K3]3EBI-11741437,EBI-10226430
RORB - isoform 1 [Q92753-1]3EBI-11741437,EBI-18560266
RUSC1 [Q9BVN2]3EBI-11741437,EBI-6257312
SAT1 [P21673]3EBI-11741437,EBI-711613
SCNM1 [Q9BWG6]5EBI-11741437,EBI-748391
SERTAD3 [Q9UJW9]3EBI-11741437,EBI-748621
SET - isoform 2 [Q01105-2]3EBI-11741437,EBI-7481343
SF3B4 [Q15427]3EBI-11741437,EBI-348469
SH2B2 - isoform 2 [O14492-2]3EBI-11741437,EBI-19952306
SHFL - isoform 4 [Q9NUL5-4]3EBI-11741437,EBI-11955083
SHISA6 [Q6ZSJ9]3EBI-11741437,EBI-12037847
SIX1 [Q15475]6EBI-11741437,EBI-743675
SIX2 [Q9NPC8]3EBI-11741437,EBI-12695166
SMAD3 [P84022]3EBI-11741437,EBI-347161
SMAD4 [Q13485]3EBI-11741437,EBI-347263
SMARCB1 - isoform B [Q12824-2]3EBI-11741437,EBI-358436
SMARCD1 [Q96GM5]3EBI-11741437,EBI-358489
SNRPA [P09012]3EBI-11741437,EBI-607085
SNRPC [P09234]3EBI-11741437,EBI-766589
SOHLH1 [Q5JUK2]3EBI-11741437,EBI-12288855
SOX5 - isoform 4 [P35711-4]3EBI-11741437,EBI-11954419
SPATA25 [Q9BR10]3EBI-11741437,EBI-12926726
SPG21 [Q9NZD8]3EBI-11741437,EBI-742688
STX11 [O75558]3EBI-11741437,EBI-714135
SUFU [Q9UMX1]3EBI-11741437,EBI-740595
TBX6 [O95947]3EBI-11741437,EBI-2824328
TCEANC - isoform 2 [Q8N8B7-2]3EBI-11741437,EBI-11955057
TCF7L2 - isoform 10 [Q9NQB0-10]3EBI-11741437,EBI-11746252
TEAD4 [Q15561]3EBI-11741437,EBI-747736
TENT5B [Q96A09]6EBI-11741437,EBI-752030
TEX37 [Q96LM6]3EBI-11741437,EBI-743976
TFAP2D [Q7Z6R9]5EBI-11741437,EBI-11952651
THAP7 [Q9BT49]3EBI-11741437,EBI-741350
TIGD3 [Q6B0B8]3EBI-11741437,EBI-12140557
itself5EBI-11741437,EBI-11741437
TRAF1 [Q13077]6EBI-11741437,EBI-359224
TRIB3 [Q96RU7]3EBI-11741437,EBI-492476
TRIM26 [Q12899]3EBI-11741437,EBI-2341136
TRIM41 [Q8WV44]5EBI-11741437,EBI-725997
TRIP6 [Q15654]3EBI-11741437,EBI-742327
TRMT2A [Q8IZ69]3EBI-11741437,EBI-2515774
TSC1 [Q86WV8]3EBI-11741437,EBI-12806590
TSEN15 [Q8WW01]3EBI-11741437,EBI-372432
TSGA10IP [Q3SY00]3EBI-11741437,EBI-10241197
TTC23 - isoform 3 [Q5W5X9-3]3EBI-11741437,EBI-9090990
U2AF2 - isoform 2 [P26368-2]3EBI-11741437,EBI-11097439
UBAP2 [Q5T6F2]3EBI-11741437,EBI-2514383
UBL5 [Q9BZL1]3EBI-11741437,EBI-607755
UBXN11 - isoform 6 [Q5T124-6]3EBI-11741437,EBI-11524408
USP2 [O75604]5EBI-11741437,EBI-743272
USP54 - isoform 6 [Q70EL1-9]3EBI-11741437,EBI-11975223
VEZF1 [Q14119]3EBI-11741437,EBI-11980193
VGLL1 [Q99990]3EBI-11741437,EBI-11983165
VIM [P08670]3EBI-11741437,EBI-353844
VPS37B [Q9H9H4]3EBI-11741437,EBI-4400866
VPS37C [A5D8V6]3EBI-11741437,EBI-2559305
WDYHV1 [Q96HA8]5EBI-11741437,EBI-741158
YTHDF1 [Q9BYJ9]3EBI-11741437,EBI-1051237
ZBTB16 [Q05516]3EBI-11741437,EBI-711925
ZBTB24 [O43167]3EBI-11741437,EBI-744471
ZBTB47 [Q9UFB7]5EBI-11741437,EBI-7781767
ZFHX3 - isoform B [Q15911-2]3EBI-11741437,EBI-10237226
ZGPAT [A0A0S2Z6H0]3EBI-11741437,EBI-16428984
ZGPAT - isoform 2 [Q8N5A5-2]9EBI-11741437,EBI-10183064
ZIC1 [Q15915]3EBI-11741437,EBI-11963196
ZMYND12 [Q9H0C1]3EBI-11741437,EBI-12030590
ZNF330 [Q9Y3S2]5EBI-11741437,EBI-373456
ZNF383 [Q8NA42]3EBI-11741437,EBI-20110775
ZNF408 [Q9H9D4]3EBI-11741437,EBI-347633
ZNF414 [Q96IQ9]5EBI-11741437,EBI-744257
ZNF417 [Q8TAU3]3EBI-11741437,EBI-740727
ZNF467 [Q7Z7K2]3EBI-11741437,EBI-11986485
ZNF48 [Q96MX3]3EBI-11741437,EBI-12006434
ZNF503 [Q96F45]3EBI-11741437,EBI-8832437
ZNF524 [Q96C55]3EBI-11741437,EBI-10283126
ZNF688 [P0C7X2]3EBI-11741437,EBI-4395732
ZNF792 [Q3KQV3]3EBI-11741437,EBI-10240849
ZNF835 [Q9Y2P0]3EBI-11741437,EBI-5667516
ZRANB1 [Q9UGI0]3EBI-11741437,EBI-527853

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
106675, 175 interactors

Protein interaction database and analysis system

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IntActi
Q08117, 385 interactors

Molecular INTeraction database

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MINTi
Q08117

STRING: functional protein association networks

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STRINGi
9606.ENSP00000221561

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q08117 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08117

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni166 – 197CCN domainAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 131Gln-rich (Q domain)Add BLAST131
Compositional biasi132 – 165Gly/Pro-rich (GP domain)Add BLAST34

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Lacks the C-terminal WD repeats.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0639 Eukaryota
ENOG410XPX3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00990000203542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_092092_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q08117

Identification of Orthologs from Complete Genome Data

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OMAi
GDTHQDD

Database for complete collections of gene phylogenies

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PhylomeDBi
Q08117

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance

The PANTHER Classification System

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PANTHERi
PTHR10814 PTHR10814, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03920 TLE_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08117-1) [UniParc]FASTAAdd to basket
Also known as: AES-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL
60 70 80 90 100
ASEKSEMQRH YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH
110 120 130 140 150
QQQVLGAIER AKQVTAPELN SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ
160 170 180 190
PPSLPAVSAG TGLLSLSALG SQAHLSKEDK NGHDGDTHQE DDGEKSD
Length:197
Mass (Da):21,970
Last modified:September 19, 2002 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3851663AA6921A9F
GO
Isoform 2 (identifier: Q08117-2) [UniParc]FASTAAdd to basket
Also known as: AES-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MMFPQSRHS → MCHKNGFPQE...WGNRGPAGCR

Show »
Length:264
Mass (Da):29,091
Checksum:i8E6CD80583D0B82D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELE3K7ELE3_HUMAN
TLE family member 5
TLE5
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQH5K7EQH5_HUMAN
Amino-terminal enhancer of split, i...
TLE5 AES, hCG_2005178
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELQ8K7ELQ8_HUMAN
TLE family member 5
TLE5
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC35517 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30K → T (PubMed:9809752).Curated1
Sequence conflicti30K → T (PubMed:15057824).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011958168A → E. Corresponds to variant dbSNP:rs1802578Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0435271 – 9MMFPQSRHS → MCHKNGFPQEGGITAAFLQK RKLRLSKNHRPARAKVTEHV RGTRPGRATAGPAASTRAAG SLFFDRWGNRGPAGCR in isoform 2. 3 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U04241 mRNA Translation: AAA16223.1
U88832, U88831 Genomic DNA Translation: AAD00654.1
AF072902 mRNA Translation: AAC35517.1 Different initiation.
AK094591 mRNA Translation: BAG52894.1
AK314713 mRNA Translation: BAG37257.1
AC005944 Genomic DNA Translation: AAC72103.1
CH471139 Genomic DNA Translation: EAW69345.1
CH471139 Genomic DNA Translation: EAW69347.1
BC113735 mRNA Translation: AAI13736.1
BC113737 mRNA Translation: AAI13738.1
X73358 mRNA Translation: CAA51768.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12101.1 [Q08117-2]
CCDS12102.1 [Q08117-1]

Protein sequence database of the Protein Information Resource

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PIRi
G01236
S35678
S35679

NCBI Reference Sequences

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RefSeqi
NP_001121.2, NM_001130.5 [Q08117-1]
NP_945320.1, NM_198969.1 [Q08117-2]
NP_945321.1, NM_198970.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000221561; ENSP00000221561; ENSG00000104964 [Q08117-2]
ENST00000327141; ENSP00000317537; ENSG00000104964 [Q08117-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
166

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:166

UCSC genome browser

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UCSCi
uc002lwy.2 human [Q08117-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04241 mRNA Translation: AAA16223.1
U88832, U88831 Genomic DNA Translation: AAD00654.1
AF072902 mRNA Translation: AAC35517.1 Different initiation.
AK094591 mRNA Translation: BAG52894.1
AK314713 mRNA Translation: BAG37257.1
AC005944 Genomic DNA Translation: AAC72103.1
CH471139 Genomic DNA Translation: EAW69345.1
CH471139 Genomic DNA Translation: EAW69347.1
BC113735 mRNA Translation: AAI13736.1
BC113737 mRNA Translation: AAI13738.1
X73358 mRNA Translation: CAA51768.1
CCDSiCCDS12101.1 [Q08117-2]
CCDS12102.1 [Q08117-1]
PIRiG01236
S35678
S35679
RefSeqiNP_001121.2, NM_001130.5 [Q08117-1]
NP_945320.1, NM_198969.1 [Q08117-2]
NP_945321.1, NM_198970.1

3D structure databases

SMRiQ08117
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106675, 175 interactors
IntActiQ08117, 385 interactors
MINTiQ08117
STRINGi9606.ENSP00000221561

Protein family/group databases

MoonDBiQ08117 Predicted

PTM databases

iPTMnetiQ08117
PhosphoSitePlusiQ08117

Polymorphism and mutation databases

BioMutaiAES
DMDMi23503062

Proteomic databases

EPDiQ08117
jPOSTiQ08117
MassIVEiQ08117
MaxQBiQ08117
PaxDbiQ08117
PeptideAtlasiQ08117
PRIDEiQ08117
ProteomicsDBi58572 [Q08117-1]
58573 [Q08117-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10920 375 antibodies

The DNASU plasmid repository

More...
DNASUi
166

Genome annotation databases

EnsembliENST00000221561; ENSP00000221561; ENSG00000104964 [Q08117-2]
ENST00000327141; ENSP00000317537; ENSG00000104964 [Q08117-1]
GeneIDi166
KEGGihsa:166
UCSCiuc002lwy.2 human [Q08117-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
166
DisGeNETi166
EuPathDBiHostDB:ENSG00000104964.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TLE5
HGNCiHGNC:307 TLE5
HPAiENSG00000104964 Low tissue specificity
MIMi600188 gene
neXtProtiNX_Q08117
OpenTargetsiENSG00000104964
PharmGKBiPA24606

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00990000203542
HOGENOMiCLU_092092_0_0_1
InParanoidiQ08117
OMAiGDTHQDD
PhylomeDBiQ08117

Enzyme and pathway databases

ReactomeiR-HSA-4641265 Repression of WNT target genes
SIGNORiQ08117

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
166 3 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AES human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
166
PharosiQ08117 Tbio

Protein Ontology

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PROi
PR:Q08117
RNActiQ08117 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104964 Expressed in cerebellar vermis and 236 other tissues
ExpressionAtlasiQ08117 baseline and differential
GenevisibleiQ08117 HS

Family and domain databases

InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLE5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08117
Secondary accession number(s): B2RBL0
, Q12808, Q14CJ1, Q96TG9, Q9UDY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 19, 2002
Last modified: June 17, 2020
This is version 187 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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