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Protein

Regulator of G-protein signaling 1

Gene

RGS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).By similarity2 Publications

GO - Molecular functioni

  • calmodulin binding Source: ProtInc
  • G-protein alpha-subunit binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 1
Short name:
RGS1
Alternative name(s):
B-cell activation protein BL341 Publication
Early response protein 1R20
Gene namesi
Name:RGS1
Synonyms:1R20, BL34, IER1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000090104.11
HGNCiHGNC:9991 RGS1
MIMi600323 gene
neXtProtiNX_Q08116

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5996
OpenTargetsiENSG00000090104
PharmGKBiPA34361

Polymorphism and mutation databases

BioMutaiRGS1
DMDMi229470360

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041751 – 209Regulator of G-protein signaling 1Add BLAST209

Proteomic databases

PaxDbiQ08116
PeptideAtlasiQ08116
PRIDEiQ08116
ProteomicsDBi58570
58571 [Q08116-2]

PTM databases

iPTMnetiQ08116
PhosphoSitePlusiQ08116

Expressioni

Tissue specificityi

Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).2 Publications

Inductioni

In response to several B-cell activation signals.1 Publication

Gene expression databases

BgeeiENSG00000090104 Expressed in 197 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_RGS1
ExpressionAtlasiQ08116 baseline and differential
GenevisibleiQ08116 HS

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAQ.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111928, 7 interactors
DIPiDIP-59091N
IntActiQ08116, 6 interactors
STRINGi9606.ENSP00000356429

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ08116
SMRiQ08116
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08116

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 200RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ08116
KOiK16449
OMAiKIYKAFV
OrthoDBiEOG091G0BDG
PhylomeDBiQ08116
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR030409 RGS1
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF34 PTHR10845:SF34, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q08116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAAAISTPK LDKMPGMFFS ANPKELKGTT HSLLDDKMQK RRPKTFGMDM
60 70 80 90 100
KAYLRSMIPH LESGMKSSKS KDVLSAAEVM QWSQSLEKLL ANQTGQNVFG
110 120 130 140 150
SFLKSEFSEE NIEFWLACED YKKTESDLLP CKAEEIYKAF VHSDAAKQIN
160 170 180 190 200
IDFRTRESTA KKIKAPTPTC FDEAQKVIYT LMEKDSYPRF LKSDIYLNLL

NDLQANSLK
Length:209
Mass (Da):23,858
Last modified:March 24, 2009 - v3
Checksum:iD8D7D8E80819496A
GO
Isoform 2 (identifier: Q08116-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-209: INIDFRTRES...LNDLQANSLK → VSIKLIIISFSIKDPICRNNI

Show »
Length:169
Mass (Da):19,134
Checksum:i96E56F3B53747867
GO

Sequence cautioni

The sequence AAB26289 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH15510 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37976 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG64242 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA51826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177V → A in BAG37976 (PubMed:14702039).Curated1
Sequence conflicti194D → H in CAA51826 (PubMed:8241276).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036422149 – 209INIDF…ANSLK → VSIKLIIISFSIKDPICRNN I in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303138 mRNA Translation: BAG64242.1 Different initiation.
AK315607 mRNA Translation: BAG37976.1 Different initiation.
AL136987 Genomic DNA No translation available.
BC015510 mRNA Translation: AAH15510.1 Different initiation.
S59049 mRNA Translation: AAB26289.1 Different initiation.
X73427 mRNA Translation: CAA51826.1 Different initiation.
AF493925 mRNA Translation: AAM12639.1
BT006668 mRNA Translation: AAP35314.1
CCDSiCCDS1375.2 [Q08116-1]
PIRiS43436
RefSeqiNP_002913.3, NM_002922.3 [Q08116-1]
UniGeneiHs.75256

Genome annotation databases

EnsembliENST00000367459; ENSP00000356429; ENSG00000090104 [Q08116-1]
ENST00000469578; ENSP00000464323; ENSG00000090104 [Q08116-2]
GeneIDi5996
KEGGihsa:5996
UCSCiuc001gsi.2 human [Q08116-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303138 mRNA Translation: BAG64242.1 Different initiation.
AK315607 mRNA Translation: BAG37976.1 Different initiation.
AL136987 Genomic DNA No translation available.
BC015510 mRNA Translation: AAH15510.1 Different initiation.
S59049 mRNA Translation: AAB26289.1 Different initiation.
X73427 mRNA Translation: CAA51826.1 Different initiation.
AF493925 mRNA Translation: AAM12639.1
BT006668 mRNA Translation: AAP35314.1
CCDSiCCDS1375.2 [Q08116-1]
PIRiS43436
RefSeqiNP_002913.3, NM_002922.3 [Q08116-1]
UniGeneiHs.75256

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BV1X-ray2.00A/B63-205[»]
2GTPX-ray2.55C/D63-205[»]
ProteinModelPortaliQ08116
SMRiQ08116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111928, 7 interactors
DIPiDIP-59091N
IntActiQ08116, 6 interactors
STRINGi9606.ENSP00000356429

PTM databases

iPTMnetiQ08116
PhosphoSitePlusiQ08116

Polymorphism and mutation databases

BioMutaiRGS1
DMDMi229470360

Proteomic databases

PaxDbiQ08116
PeptideAtlasiQ08116
PRIDEiQ08116
ProteomicsDBi58570
58571 [Q08116-2]

Protocols and materials databases

DNASUi5996
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367459; ENSP00000356429; ENSG00000090104 [Q08116-1]
ENST00000469578; ENSP00000464323; ENSG00000090104 [Q08116-2]
GeneIDi5996
KEGGihsa:5996
UCSCiuc001gsi.2 human [Q08116-1]

Organism-specific databases

CTDi5996
DisGeNETi5996
EuPathDBiHostDB:ENSG00000090104.11
GeneCardsiRGS1
H-InvDBiHIX0001431
HGNCiHGNC:9991 RGS1
MIMi600323 gene
neXtProtiNX_Q08116
OpenTargetsiENSG00000090104
PharmGKBiPA34361
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ08116
KOiK16449
OMAiKIYKAFV
OrthoDBiEOG091G0BDG
PhylomeDBiQ08116
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiRGS1 human
EvolutionaryTraceiQ08116
GeneWikiiRGS1
GenomeRNAii5996
PROiPR:Q08116
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090104 Expressed in 197 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_RGS1
ExpressionAtlasiQ08116 baseline and differential
GenevisibleiQ08116 HS

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR030409 RGS1
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF34 PTHR10845:SF34, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS1_HUMAN
AccessioniPrimary (citable) accession number: Q08116
Secondary accession number(s): B2RDM9
, B4DZY0, Q07918, Q9H1W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: March 24, 2009
Last modified: October 10, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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