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Protein

Calponin-2

Gene

Cnn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-2
Alternative name(s):
Calponin H2, smooth muscle
Neutral calponin
Gene namesi
Name:Cnn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:105093 Cnn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002047742 – 305Calponin-2Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei8N6-acetyllysineCombined sources1
Modified residuei25N6-acetyllysineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ08093
PaxDbiQ08093
PeptideAtlasiQ08093
PRIDEiQ08093

PTM databases

iPTMnetiQ08093
PhosphoSitePlusiQ08093

Expressioni

Tissue specificityi

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Gene expression databases

BgeeiENSMUSG00000004665 Expressed in 285 organ(s), highest expression level in blood
CleanExiMM_CNN2
ExpressionAtlasiQ08093 baseline and differential
GenevisibleiQ08093 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198791, 3 interactors
IntActiQ08093, 2 interactors
MINTiQ08093
STRINGi10090.ENSMUSP00000004784

Structurei

3D structure databases

ProteinModelPortaliQ08093
SMRiQ08093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 132Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105
Repeati166 – 191Calponin-like 1Add BLAST26
Repeati206 – 231Calponin-like 2Add BLAST26
Repeati245 – 269Calponin-like 3Add BLAST25

Sequence similaritiesi

Belongs to the calponin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiQ08093
OMAiIPDYQDE
OrthoDBiEOG091G0LY2
PhylomeDBiQ08093
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997 Calponin/LIMCH1
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR029974 CNN2
IPR003096 SM22_calponin
PANTHERiPTHR18959:SF47 PTHR18959:SF47, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 3 hits
PF00307 CH, 1 hit
PRINTSiPR00889 CALPONIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 3 hits
PS51122 CALPONIN_2, 3 hits
PS50021 CH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q08093-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRSWIEG LTGLSIGPDF
60 70 80 90 100
QKGLKDGVIL CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM
110 120 130 140 150
NPVDLFEAND LFESGNMTQV QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ
160 170 180 190 200
ERNFDDATMK AGQCVIGLQM GTNKCASQSG MTAYGTRRHL YDPKNHILPP
210 220 230 240 250
MDHCTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC DNSSMSLQMG
260 270 280 290 300
YTQGANQSGQ VFGLGRQIYD PKYCPQGSAA DGAPAGDGQG EAPEYLAYCQ

EEAGY
Length:305
Mass (Da):33,156
Last modified:October 1, 1994 - v1
Checksum:i91DCDB47BEED53F8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7R6D3Z7R6_MOUSE
Calponin
Cnn2
266Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19543 mRNA Translation: CAA79603.1
BC009144 mRNA Translation: AAH09144.1
BC018482 mRNA Translation: AAH18482.1
CCDSiCCDS24003.1
PIRiS36147 S31485
RefSeqiNP_031751.1, NM_007725.2
UniGeneiMm.157770

Genome annotation databases

EnsembliENSMUST00000004784; ENSMUSP00000004784; ENSMUSG00000004665
GeneIDi12798
KEGGimmu:12798
UCSCiuc007gaz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19543 mRNA Translation: CAA79603.1
BC009144 mRNA Translation: AAH09144.1
BC018482 mRNA Translation: AAH18482.1
CCDSiCCDS24003.1
PIRiS36147 S31485
RefSeqiNP_031751.1, NM_007725.2
UniGeneiMm.157770

3D structure databases

ProteinModelPortaliQ08093
SMRiQ08093
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198791, 3 interactors
IntActiQ08093, 2 interactors
MINTiQ08093
STRINGi10090.ENSMUSP00000004784

PTM databases

iPTMnetiQ08093
PhosphoSitePlusiQ08093

Proteomic databases

EPDiQ08093
PaxDbiQ08093
PeptideAtlasiQ08093
PRIDEiQ08093

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004784; ENSMUSP00000004784; ENSMUSG00000004665
GeneIDi12798
KEGGimmu:12798
UCSCiuc007gaz.1 mouse

Organism-specific databases

CTDi1265
MGIiMGI:105093 Cnn2

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiQ08093
OMAiIPDYQDE
OrthoDBiEOG091G0LY2
PhylomeDBiQ08093
TreeFamiTF313921

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiCnn2 mouse
PROiPR:Q08093
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004665 Expressed in 285 organ(s), highest expression level in blood
CleanExiMM_CNN2
ExpressionAtlasiQ08093 baseline and differential
GenevisibleiQ08093 MM

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997 Calponin/LIMCH1
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR029974 CNN2
IPR003096 SM22_calponin
PANTHERiPTHR18959:SF47 PTHR18959:SF47, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 3 hits
PF00307 CH, 1 hit
PRINTSiPR00889 CALPONIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 3 hits
PS51122 CALPONIN_2, 3 hits
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNN2_MOUSE
AccessioniPrimary (citable) accession number: Q08093
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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