We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q08093 (CNN2_MOUSE)
Protein
Calponin-2
Gene
Cnn2
Organism
Mus musculus (Mouse)
Status
Functioni
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
GO - Biological processi
- actomyosin structure organization Source: InterPro
- cellular response to mechanical stimulus Source: MGI
- hemopoiesis Source: MGI
- negative regulation of cell migration Source: MGI
- negative regulation of phagocytosis Source: MGI
- positive regulation of gene expression Source: MGI
- regulation of actin filament-based process Source: MGI
- regulation of cell population proliferation Source: MGI
- wound healing Source: MGI
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Calponin-2Alternative name(s): Calponin H2, smooth muscle Neutral calponin |
Gene namesi | Name:Cnn2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105093, Cnn2 |
VEuPathDBi | HostDB:ENSMUSG00000004665 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000204774 | 2 – 305 | Calponin-2Add BLAST | 304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 8 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 25 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 138 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q08093 |
jPOSTi | Q08093 |
PaxDbi | Q08093 |
PeptideAtlasi | Q08093 |
PRIDEi | Q08093 |
ProteomicsDBi | 283453 |
PTM databases
iPTMneti | Q08093 |
PhosphoSitePlusi | Q08093 |
Expressioni
Tissue specificityi
Smooth muscle, and tissues containing significant amounts of smooth muscle.
Gene expression databases
Bgeei | ENSMUSG00000004665, Expressed in blood and 308 other tissues |
Genevisiblei | Q08093, MM |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 198791, 5 interactors |
IntActi | Q08093, 1 interactor |
MINTi | Q08093 |
STRINGi | 10090.ENSMUSP00000004784 |
Miscellaneous databases
RNActi | Q08093, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 132 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 105 | |
Repeati | 166 – 191 | Calponin-like 1Add BLAST | 26 | |
Repeati | 206 – 231 | Calponin-like 2Add BLAST | 26 | |
Repeati | 245 – 269 | Calponin-like 3Add BLAST | 25 |
Sequence similaritiesi
Belongs to the calponin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2046, Eukaryota |
GeneTreei | ENSGT00940000154355 |
HOGENOMi | CLU_055232_0_2_1 |
InParanoidi | Q08093 |
OMAi | GKQIGPD |
OrthoDBi | 861989at2759 |
PhylomeDBi | Q08093 |
TreeFami | TF313921 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR029974, CNN2 IPR003096, SM22_calponin |
PANTHERi | PTHR46756:SF2, PTHR46756:SF2, 1 hit |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 3 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q08093-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRSWIEG LTGLSIGPDF
60 70 80 90 100
QKGLKDGVIL CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM
110 120 130 140 150
NPVDLFEAND LFESGNMTQV QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ
160 170 180 190 200
ERNFDDATMK AGQCVIGLQM GTNKCASQSG MTAYGTRRHL YDPKNHILPP
210 220 230 240 250
MDHCTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC DNSSMSLQMG
260 270 280 290 300
YTQGANQSGQ VFGLGRQIYD PKYCPQGSAA DGAPAGDGQG EAPEYLAYCQ
EEAGY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z7R6 | D3Z7R6_MOUSE | Calponin | Cnn2 | 266 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19543 mRNA Translation: CAA79603.1 BC009144 mRNA Translation: AAH09144.1 BC018482 mRNA Translation: AAH18482.1 |
CCDSi | CCDS24003.1 |
PIRi | S36147, S31485 |
RefSeqi | NP_031751.1, NM_007725.2 |
Genome annotation databases
Ensembli | ENSMUST00000004784; ENSMUSP00000004784; ENSMUSG00000004665 |
GeneIDi | 12798 |
KEGGi | mmu:12798 |
UCSCi | uc007gaz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19543 mRNA Translation: CAA79603.1 BC009144 mRNA Translation: AAH09144.1 BC018482 mRNA Translation: AAH18482.1 |
CCDSi | CCDS24003.1 |
PIRi | S36147, S31485 |
RefSeqi | NP_031751.1, NM_007725.2 |
3D structure databases
AlphaFoldDBi | Q08093 |
SMRi | Q08093 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198791, 5 interactors |
IntActi | Q08093, 1 interactor |
MINTi | Q08093 |
STRINGi | 10090.ENSMUSP00000004784 |
PTM databases
iPTMneti | Q08093 |
PhosphoSitePlusi | Q08093 |
Proteomic databases
EPDi | Q08093 |
jPOSTi | Q08093 |
PaxDbi | Q08093 |
PeptideAtlasi | Q08093 |
PRIDEi | Q08093 |
ProteomicsDBi | 283453 |
Protocols and materials databases
Antibodypediai | 22499, 412 antibodies from 38 providers |
DNASUi | 12798 |
Genome annotation databases
Ensembli | ENSMUST00000004784; ENSMUSP00000004784; ENSMUSG00000004665 |
GeneIDi | 12798 |
KEGGi | mmu:12798 |
UCSCi | uc007gaz.1, mouse |
Organism-specific databases
CTDi | 1265 |
MGIi | MGI:105093, Cnn2 |
VEuPathDBi | HostDB:ENSMUSG00000004665 |
Phylogenomic databases
eggNOGi | KOG2046, Eukaryota |
GeneTreei | ENSGT00940000154355 |
HOGENOMi | CLU_055232_0_2_1 |
InParanoidi | Q08093 |
OMAi | GKQIGPD |
OrthoDBi | 861989at2759 |
PhylomeDBi | Q08093 |
TreeFami | TF313921 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 12798, 1 hit in 72 CRISPR screens |
ChiTaRSi | Cnn2, mouse |
PROi | PR:Q08093 |
RNActi | Q08093, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004665, Expressed in blood and 308 other tissues |
Genevisiblei | Q08093, MM |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR029974, CNN2 IPR003096, SM22_calponin |
PANTHERi | PTHR46756:SF2, PTHR46756:SF2, 1 hit |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 3 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CNN2_MOUSE | |
Accessioni | Q08093Primary (citable) accession number: Q08093 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families