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UniProtKB - Q08092 (CNN1_PIG)
Protein
Calponin-1
Gene
CNN1
Organism
Sus scrofa (Pig)
Status
Functioni
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
GO - Molecular functioni
- actin binding Source: GO_Central
- calmodulin binding Source: UniProtKB-KW
GO - Biological processi
- actomyosin structure organization Source: InterPro
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calponin-1Alternative name(s): Basic calponin Calponin H1, smooth muscle |
Gene namesi | Name:CNN1 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204769 | 1 – 297 | Calponin-1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 170 | Phosphothreonine; by ROCK2By similarity | 1 | |
Modified residuei | 175 | Phosphoserine; by ROCK2By similarity | 1 | |
Modified residuei | 180 | Phosphothreonine; by ROCK2By similarity | 1 | |
Modified residuei | 184 | Phosphothreonine; by ROCK2By similarity | 1 | |
Modified residuei | 259 | Phosphothreonine; by ROCK2By similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q08092 |
PeptideAtlasi | Q08092 |
PRIDEi | Q08092 |
PTM databases
iPTMneti | Q08092 |
Expressioni
Tissue specificityi
Smooth muscle, and tissues containing significant amounts of smooth muscle.
Gene expression databases
Bgeei | ENSSSCG00000013614, Expressed in stomach and 42 other tissues |
Genevisiblei | Q08092, SS |
Interactioni
Subunit structurei
Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.
By similarityGO - Molecular functioni
- actin binding Source: GO_Central
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000014468 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 131 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 104 | |
Repeati | 164 – 189 | Calponin-like 1Add BLAST | 26 | |
Repeati | 204 – 229 | Calponin-like 2Add BLAST | 26 | |
Repeati | 243 – 268 | Calponin-like 3Add BLAST | 26 |
Sequence similaritiesi
Belongs to the calponin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2046, Eukaryota |
HOGENOMi | CLU_055232_0_0_1 |
InParanoidi | Q08092 |
OrthoDBi | 861989at2759 |
TreeFami | TF313921 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 3 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08092-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQQ EQELREWIEG VTGRRIGNNF
60 70 80 90 100
MDGLKDGIIL CEFINKLQPG SVKKVNESTQ NWHQLENIGN FIKAITKYGV
110 120 130 140 150
KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER
160 170 180 190 200
KFEPEKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD
210 220 230 240 250
QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN
260 270 280 290
KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHP HNYYNSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19538 mRNA Translation: CAA79598.1 |
PIRi | S36146, S31484 |
RefSeqi | NP_999043.1, NM_213878.1 |
Genome annotation databases
Ensembli | ENSSSCT00005072861; ENSSSCP00005045603; ENSSSCG00005045130 |
GeneIDi | 396911 |
KEGGi | ssc:396911 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19538 mRNA Translation: CAA79598.1 |
PIRi | S36146, S31484 |
RefSeqi | NP_999043.1, NM_213878.1 |
3D structure databases
AlphaFoldDBi | Q08092 |
SMRi | Q08092 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000014468 |
PTM databases
iPTMneti | Q08092 |
Proteomic databases
PaxDbi | Q08092 |
PeptideAtlasi | Q08092 |
PRIDEi | Q08092 |
Genome annotation databases
Ensembli | ENSSSCT00005072861; ENSSSCP00005045603; ENSSSCG00005045130 |
GeneIDi | 396911 |
KEGGi | ssc:396911 |
Organism-specific databases
CTDi | 1264 |
Phylogenomic databases
eggNOGi | KOG2046, Eukaryota |
HOGENOMi | CLU_055232_0_0_1 |
InParanoidi | Q08092 |
OrthoDBi | 861989at2759 |
TreeFami | TF313921 |
Gene expression databases
Bgeei | ENSSSCG00000013614, Expressed in stomach and 42 other tissues |
Genevisiblei | Q08092, SS |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 3 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CNN1_PIG | |
Accessioni | Q08092Primary (citable) accession number: Q08092 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families