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Entry version 177 (13 Feb 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Hepatocyte growth factor

Gene

Hgf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.1 Publication

Caution

Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Serine protease homolog

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114608 Platelet degranulation
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6806942 MET Receptor Activation
R-MMU-6807004 Negative regulation of MET activity
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8851805 MET activates RAS signaling
R-MMU-8851907 MET activates PI3K/AKT signaling
R-MMU-8865999 MET activates PTPN11
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8875513 MET interacts with TNS proteins
R-MMU-8875555 MET activates RAP1 and RAC1
R-MMU-8875656 MET receptor recycling
R-MMU-8875791 MET activates STAT3

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.982

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatocyte growth factor
Alternative name(s):
Hepatopoietin-A
Scatter factor
Short name:
SF
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hgf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96079 Hgf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32By similarityAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002809333 – 495Hepatocyte growth factor alpha chainAdd BLAST463
ChainiPRO_0000028094496 – 728Hepatocyte growth factor beta chainAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33Pyrrolidone carboxylic acidBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi71 ↔ 97
Disulfide bondi75 ↔ 85
Disulfide bondi129 ↔ 207
Disulfide bondi150 ↔ 190
Disulfide bondi178 ↔ 202
Disulfide bondi212 ↔ 289By similarity
Disulfide bondi233 ↔ 272By similarity
Disulfide bondi261 ↔ 284By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi306 ↔ 384By similarity
Disulfide bondi327 ↔ 366By similarity
Disulfide bondi355 ↔ 378By similarity
Disulfide bondi392 ↔ 470By similarity
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi413 ↔ 453By similarity
Disulfide bondi441 ↔ 465By similarity
Disulfide bondi488 ↔ 607Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi520 ↔ 536By similarity
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi615 ↔ 682By similarity
Disulfide bondi645 ↔ 661By similarity
Glycosylationi656N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi672 ↔ 700By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08048

PRoteomics IDEntifications database

More...
PRIDEi
Q08048

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08048

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08048

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028864 Expressed in 115 organ(s), highest expression level in spinal cord

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q08048 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
METP085813EBI-15655650,EBI-1039152From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-46456N

Protein interaction database and analysis system

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IntActi
Q08048, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000030683

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QJ4X-ray2.50A/B29-210[»]
3HMRX-ray2.00A31-127[»]
4IUAX-ray3.05A/B/C/D/E/F/G/H31-290[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q08048

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08048

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q08048

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 124PANPROSITE-ProRule annotationAdd BLAST87
Domaini129 – 207Kringle 1PROSITE-ProRule annotationAdd BLAST79
Domaini212 – 289Kringle 2PROSITE-ProRule annotationAdd BLAST78
Domaini306 – 384Kringle 3PROSITE-ProRule annotationAdd BLAST79
Domaini392 – 470Kringle 4PROSITE-ProRule annotationAdd BLAST79
Domaini496 – 724Peptidase S1PROSITE-ProRule annotationAdd BLAST229

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDXR Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156019

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112892

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004381

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08048

KEGG Orthology (KO)

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KOi
K05460

Identification of Orthologs from Complete Genome Data

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OMAi
YCAIKMC

Database of Orthologous Groups

More...
OrthoDBi
164039at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q08048

TreeFam database of animal gene trees

More...
TreeFami
TF329901

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.20.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027284 Hepatocyte_GF
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF500183 Hepatocyte_GF, 1 hit
PIRSF001152 HGF_MST1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: Q08048-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT
60 70 80 90 100
LTKEDPLLKI KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY
110 120 130 140 150
PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC
160 170 180 190 200
QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE
210 220 230 240 250
VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER
260 270 280 290 300
YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKTCA HSAVNETDVP
310 320 330 340 350
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL
360 370 380 390 400
RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY
410 420 430 440 450
MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLNKNY CRNPDDDAHG
460 470 480 490 500
PWCYTGNPLI PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI
510 520 530 540 550
PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR NKDLKDYEAW
560 570 580 590 600
LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI
610 620 630 640 650
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ
660 670 680 690 700
GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC
710 720
AIPNRPGIFV RVAYYAKWIH KVILTYKL
Length:728
Mass (Da):82,945
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0381FC497534328
GO
Isoform Short (identifier: Q08048-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-167: Missing.

Show »
Length:723
Mass (Da):82,413
Checksum:i7BC19A16C399EDD2
GO
Isoform NK1 (identifier: Q08048-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: VE → GK
     212-728: Missing.

Show »
Length:211
Mass (Da):24,308
Checksum:i758BD0687A835F48
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA51054 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti189W → K AA sequence (PubMed:2144630).Curated1
Sequence conflicti344N → K in AAB31855 (PubMed:8081873).Curated1
Sequence conflicti378C → E AA sequence (PubMed:2144630).Curated1
Sequence conflicti380Q → E AA sequence (PubMed:2144630).Curated1
Sequence conflicti479V → L in AAB31855 (PubMed:8081873).Curated1
Sequence conflicti513K → L AA sequence (PubMed:2142751).Curated1
Sequence conflicti518H → T AA sequence (PubMed:1831975).Curated1
Sequence conflicti564R → H in CAA51054 (PubMed:8241272).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005408163 – 167Missing in isoform Short. 1 Publication5
Alternative sequenceiVSP_044345210 – 211VE → GK in isoform NK1. 1 Publication2
Alternative sequenceiVSP_044346212 – 728Missing in isoform NK1. 1 PublicationAdd BLAST517

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D10212 mRNA Translation: BAA01064.1
D10213 mRNA Translation: BAA01065.1
S71816 mRNA Translation: AAB31855.1
X72307 mRNA Translation: CAA51054.1 Different initiation.
AF042856 mRNA Translation: AAC40051.1
X84046 mRNA Translation: CAA58865.1
CH466586 Genomic DNA Translation: EDL03238.1
BC119228 mRNA Translation: AAI19229.1
X81630 Genomic DNA Translation: CAA57286.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS19097.1 [Q08048-1]
CCDS80213.1 [Q08048-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC2117 A60185

NCBI Reference Sequences

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RefSeqi
NP_001276387.1, NM_001289458.1 [Q08048-1]
NP_001276388.1, NM_001289459.1 [Q08048-1]
NP_001276389.1, NM_001289460.2 [Q08048-3]
NP_001276390.1, NM_001289461.1 [Q08048-2]
NP_034557.3, NM_010427.5 [Q08048-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.267078

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000030683; ENSMUSP00000030683; ENSMUSG00000028864 [Q08048-1]
ENSMUST00000196645; ENSMUSP00000142517; ENSMUSG00000028864 [Q08048-2]
ENSMUST00000199581; ENSMUSP00000143424; ENSMUSG00000028864 [Q08048-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
15234

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:15234

UCSC genome browser

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UCSCi
uc008wne.2 mouse [Q08048-3]
uc008wnf.2 mouse [Q08048-1]
uc008wnj.1 mouse [Q08048-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10212 mRNA Translation: BAA01064.1
D10213 mRNA Translation: BAA01065.1
S71816 mRNA Translation: AAB31855.1
X72307 mRNA Translation: CAA51054.1 Different initiation.
AF042856 mRNA Translation: AAC40051.1
X84046 mRNA Translation: CAA58865.1
CH466586 Genomic DNA Translation: EDL03238.1
BC119228 mRNA Translation: AAI19229.1
X81630 Genomic DNA Translation: CAA57286.1
CCDSiCCDS19097.1 [Q08048-1]
CCDS80213.1 [Q08048-2]
PIRiJC2117 A60185
RefSeqiNP_001276387.1, NM_001289458.1 [Q08048-1]
NP_001276388.1, NM_001289459.1 [Q08048-1]
NP_001276389.1, NM_001289460.2 [Q08048-3]
NP_001276390.1, NM_001289461.1 [Q08048-2]
NP_034557.3, NM_010427.5 [Q08048-1]
UniGeneiMm.267078

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QJ4X-ray2.50A/B29-210[»]
3HMRX-ray2.00A31-127[»]
4IUAX-ray3.05A/B/C/D/E/F/G/H31-290[»]
ProteinModelPortaliQ08048
SMRiQ08048
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46456N
IntActiQ08048, 1 interactor
STRINGi10090.ENSMUSP00000030683

Protein family/group databases

MEROPSiS01.982

PTM databases

iPTMnetiQ08048
PhosphoSitePlusiQ08048

Proteomic databases

PaxDbiQ08048
PRIDEiQ08048

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030683; ENSMUSP00000030683; ENSMUSG00000028864 [Q08048-1]
ENSMUST00000196645; ENSMUSP00000142517; ENSMUSG00000028864 [Q08048-2]
ENSMUST00000199581; ENSMUSP00000143424; ENSMUSG00000028864 [Q08048-1]
GeneIDi15234
KEGGimmu:15234
UCSCiuc008wne.2 mouse [Q08048-3]
uc008wnf.2 mouse [Q08048-1]
uc008wnj.1 mouse [Q08048-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3082
MGIiMGI:96079 Hgf

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000156019
HOGENOMiHOG000112892
HOVERGENiHBG004381
InParanoidiQ08048
KOiK05460
OMAiYCAIKMC
OrthoDBi164039at2759
PhylomeDBiQ08048
TreeFamiTF329901

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6806942 MET Receptor Activation
R-MMU-6807004 Negative regulation of MET activity
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8851805 MET activates RAS signaling
R-MMU-8851907 MET activates PI3K/AKT signaling
R-MMU-8865999 MET activates PTPN11
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8875513 MET interacts with TNS proteins
R-MMU-8875555 MET activates RAP1 and RAC1
R-MMU-8875656 MET receptor recycling
R-MMU-8875791 MET activates STAT3

Miscellaneous databases

EvolutionaryTraceiQ08048

Protein Ontology

More...
PROi
PR:Q08048

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028864 Expressed in 115 organ(s), highest expression level in spinal cord
GenevisibleiQ08048 MM

Family and domain databases

CDDicd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR027284 Hepatocyte_GF
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF500183 Hepatocyte_GF, 1 hit
PIRSF001152 HGF_MST1, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHGF_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08048
Secondary accession number(s): O55027
, Q53WS5, Q61662, Q64007, Q6LBE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 13, 2019
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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