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Entry version 162 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Core-binding factor subunit beta

Gene

Cbfb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917).3 Publications1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-MMU-8878166, Transcriptional regulation by RUNX2
R-MMU-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-MMU-8934593, Regulation of RUNX1 Expression and Activity
R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-MMU-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-MMU-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-MMU-8941326, RUNX2 regulates bone development
R-MMU-8941858, Regulation of RUNX3 expression and activity
R-MMU-8951936, RUNX3 regulates p14-ARF
R-MMU-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Core-binding factor subunit beta
Short name:
CBF-beta
Alternative name(s):
Polyomavirus enhancer-binding protein 2 beta subunit
Short name:
PEA2-beta
Short name:
PEBP2-beta
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cbfb
Synonyms:Pebp2b, Pebpb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99851, Cbfb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5V → A: Interferes with heterodimerization. 1 Publication1
Mutagenesisi63N → A: Interferes with heterodimerization. 1 Publication1
Mutagenesisi104N → A: Interferes with heterodimerization. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000583021 – 187Core-binding factor subunit betaAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Phosphoserine; by CK2Sequence analysis1
Modified residuei159Phosphoserine; by PKCSequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q08024

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q08024

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08024

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08024

PeptideAtlas

More...
PeptideAtlasi
Q08024

PRoteomics IDEntifications database

More...
PRIDEi
Q08024

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08024

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08024

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested. Highest level in thymus, but also abundantly expressed in muscle, lung and brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031885, Expressed in trigeminal ganglion and 331 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08024, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with RUNX1, RUNX2 and RUNX3 (Probable).

Interacts with COPRS.

Found in a complex with PRMT5 and RUNX1 (PubMed:22193545).

1 Publication1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
198525, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q08024, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000059382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q08024, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q08024

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08024

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q08024

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CBF-beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4785, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018132

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_074992_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08024

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGKVHIK

Database of Orthologous Groups

More...
OrthoDBi
1254153at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08024

TreeFam database of animal gene trees

More...
TreeFami
TF314675

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.250.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003417, CBF_beta
IPR036552, CBF_bsu_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10276, PTHR10276, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02312, CBF_beta, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50723, SSF50723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q08024-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QTRFQNACRD
60 70 80 90 100
GRSEIAFVAT GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP
110 120 130 140 150
MILNGVCVIW KGWIDLHRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT
160 170 180
REFEDRDRSH REEMEARRQQ DPSPGSNLGG GDDLKLR
Length:187
Mass (Da):22,030
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B2E6101A35D0FD8
GO
Isoform 2 (identifier: Q08024-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-187: ARRQQDPSPGSNLGGGDDLKLR → VRVSQLLAVTGKKTARP

Note: Major isoform.Curated
Show »
Length:182
Mass (Da):21,517
Checksum:i20EC3C81F39874FA
GO
Isoform 3 (identifier: Q08024-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-165: Missing.

Note: Does not dimerize with the alpha subunit.Curated
Show »
Length:155
Mass (Da):18,026
Checksum:i1E4C0F13B9B25697
GO
Isoform 4 (identifier: Q08024-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-94: Missing.

Note: Does not dimerize with the alpha subunit.Curated
Show »
Length:148
Mass (Da):17,633
Checksum:i4265D3ADB61D1352
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2P → S in BAC40748 (PubMed:16141072).Curated1
Sequence conflicti40R → P in BAC40748 (PubMed:16141072).Curated1
Sequence conflicti171D → N in L03279 (PubMed:8497254).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00435856 – 94Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_004359134 – 165Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_004360166 – 187ARRQQ…DLKLR → VRVSQLLAVTGKKTARP in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D14572 mRNA Translation: BAA03426.1
D14571 mRNA Translation: BAA03425.1
D14570 mRNA Translation: BAA03424.1
D14569 Genomic DNA Translation: BAA03423.1
L03305 mRNA No translation available.
L03306 mRNA No translation available.
L03279 mRNA No translation available.
AK089094 mRNA Translation: BAC40748.1
BC006763 mRNA Translation: AAH06763.1
BC026749 mRNA Translation: AAH26749.1
BC040752 mRNA Translation: AAH40752.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22592.1 [Q08024-1]
CCDS52654.1 [Q08024-2]
CCDS52655.1 [Q08024-3]
CCDS52656.1 [Q08024-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A46107
B48124

NCBI Reference Sequences

More...
RefSeqi
NP_001154928.1, NM_001161456.1 [Q08024-4]
NP_001154929.1, NM_001161457.1 [Q08024-3]
NP_001154930.1, NM_001161458.1 [Q08024-2]
NP_071704.3, NM_022309.4 [Q08024-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000052209; ENSMUSP00000059382; ENSMUSG00000031885 [Q08024-1]
ENSMUST00000109392; ENSMUSP00000105019; ENSMUSG00000031885 [Q08024-2]
ENSMUST00000109394; ENSMUSP00000105021; ENSMUSG00000031885 [Q08024-4]
ENSMUST00000109395; ENSMUSP00000105022; ENSMUSG00000031885 [Q08024-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
12400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12400

UCSC genome browser

More...
UCSCi
uc009nbp.2, mouse [Q08024-1]
uc009nbq.2, mouse [Q08024-2]
uc009nbr.2, mouse [Q08024-4]
uc012gjd.1, mouse [Q08024-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14572 mRNA Translation: BAA03426.1
D14571 mRNA Translation: BAA03425.1
D14570 mRNA Translation: BAA03424.1
D14569 Genomic DNA Translation: BAA03423.1
L03305 mRNA No translation available.
L03306 mRNA No translation available.
L03279 mRNA No translation available.
AK089094 mRNA Translation: BAC40748.1
BC006763 mRNA Translation: AAH06763.1
BC026749 mRNA Translation: AAH26749.1
BC040752 mRNA Translation: AAH40752.2
CCDSiCCDS22592.1 [Q08024-1]
CCDS52654.1 [Q08024-2]
CCDS52655.1 [Q08024-3]
CCDS52656.1 [Q08024-4]
PIRiA46107
B48124
RefSeqiNP_001154928.1, NM_001161456.1 [Q08024-4]
NP_001154929.1, NM_001161457.1 [Q08024-3]
NP_001154930.1, NM_001161458.1 [Q08024-2]
NP_071704.3, NM_022309.4 [Q08024-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILFNMR-A1-141[»]
1IO4X-ray3.00D1-141[»]
2JHBNMR-A1-141[»]
3WTSX-ray2.35B/G1-142[»]
3WTTX-ray2.35B/G1-142[»]
3WTUX-ray2.70B/G1-142[»]
3WTVX-ray2.70B/G1-142[»]
3WTWX-ray2.90B/G1-142[»]
3WTXX-ray2.80B/G1-142[»]
3WTYX-ray2.70B/G1-142[»]
BMRBiQ08024
SMRiQ08024
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi198525, 9 interactors
IntActiQ08024, 3 interactors
STRINGi10090.ENSMUSP00000059382

PTM databases

iPTMnetiQ08024
PhosphoSitePlusiQ08024

Proteomic databases

EPDiQ08024
jPOSTiQ08024
MaxQBiQ08024
PaxDbiQ08024
PeptideAtlasiQ08024
PRIDEiQ08024

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15619, 396 antibodies

Genome annotation databases

EnsembliENSMUST00000052209; ENSMUSP00000059382; ENSMUSG00000031885 [Q08024-1]
ENSMUST00000109392; ENSMUSP00000105019; ENSMUSG00000031885 [Q08024-2]
ENSMUST00000109394; ENSMUSP00000105021; ENSMUSG00000031885 [Q08024-4]
ENSMUST00000109395; ENSMUSP00000105022; ENSMUSG00000031885 [Q08024-3]
GeneIDi12400
KEGGimmu:12400
UCSCiuc009nbp.2, mouse [Q08024-1]
uc009nbq.2, mouse [Q08024-2]
uc009nbr.2, mouse [Q08024-4]
uc012gjd.1, mouse [Q08024-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
865
MGIiMGI:99851, Cbfb

Phylogenomic databases

eggNOGiKOG4785, Eukaryota
GeneTreeiENSGT00390000018132
HOGENOMiCLU_074992_1_0_1
InParanoidiQ08024
OMAiPGKVHIK
OrthoDBi1254153at2759
PhylomeDBiQ08024
TreeFamiTF314675

Enzyme and pathway databases

ReactomeiR-MMU-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-MMU-8878166, Transcriptional regulation by RUNX2
R-MMU-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-MMU-8934593, Regulation of RUNX1 Expression and Activity
R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-MMU-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-MMU-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-MMU-8941326, RUNX2 regulates bone development
R-MMU-8941858, Regulation of RUNX3 expression and activity
R-MMU-8951936, RUNX3 regulates p14-ARF
R-MMU-9018519, Estrogen-dependent gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
12400, 8 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cbfb, mouse
EvolutionaryTraceiQ08024

Protein Ontology

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PROi
PR:Q08024
RNActiQ08024, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031885, Expressed in trigeminal ganglion and 331 other tissues
GenevisibleiQ08024, MM

Family and domain databases

Gene3Di2.40.250.10, 1 hit
InterProiView protein in InterPro
IPR003417, CBF_beta
IPR036552, CBF_bsu_sf
PANTHERiPTHR10276, PTHR10276, 1 hit
PfamiView protein in Pfam
PF02312, CBF_beta, 1 hit
SUPFAMiSSF50723, SSF50723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEBB_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08024
Secondary accession number(s): Q08025
, Q62050, Q62051, Q8C282, Q8CGD5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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