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Entry version 185 (26 Feb 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Protein enhancer of sevenless 2B

Gene

drk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109704 PI3K Cascade
R-DME-112412 SOS-mediated signalling
R-DME-1250347 SHC1 events in ERBB4 signaling
R-DME-1257604 PIP3 activates AKT signaling
R-DME-1295596 Spry regulation of FGF signaling
R-DME-1433557 Signaling by SCF-KIT
R-DME-1433559 Regulation of KIT signaling
R-DME-167044 Signalling to RAS
R-DME-179812 GRB2 events in EGFR signaling
R-DME-180292 GAB1 signalosome
R-DME-180336 SHC1 events in EGFR signaling
R-DME-182971 EGFR downregulation
R-DME-186763 Downstream signal transduction
R-DME-1963640 GRB2 events in ERBB2 signaling
R-DME-1963642 PI3K events in ERBB2 signaling
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-210993 Tie2 Signaling
R-DME-2179392 EGFR Transactivation by Gastrin
R-DME-2424491 DAP12 signaling
R-DME-2428933 SHC-related events triggered by IGF1R
R-DME-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-2871796 FCERI mediated MAPK activation
R-DME-2871809 FCERI mediated Ca+2 mobilization
R-DME-5654688 SHC-mediated cascade:FGFR1
R-DME-5654689 PI-3K cascade:FGFR1
R-DME-5654693 FRS-mediated FGFR1 signaling
R-DME-5654695 PI-3K cascade:FGFR2
R-DME-5654699 SHC-mediated cascade:FGFR2
R-DME-5654700 FRS-mediated FGFR2 signaling
R-DME-5654704 SHC-mediated cascade:FGFR3
R-DME-5654706 FRS-mediated FGFR3 signaling
R-DME-5654710 PI-3K cascade:FGFR3
R-DME-5654712 FRS-mediated FGFR4 signaling
R-DME-5654719 SHC-mediated cascade:FGFR4
R-DME-5654720 PI-3K cascade:FGFR4
R-DME-5654726 Negative regulation of FGFR1 signaling
R-DME-5654727 Negative regulation of FGFR2 signaling
R-DME-5654732 Negative regulation of FGFR3 signaling
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-5673001 RAF/MAP kinase cascade
R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-74749 Signal attenuation
R-DME-74751 Insulin receptor signalling cascade
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-912631 Regulation of signaling by CBL
R-DME-9607240 FLT3 Signaling
R-DME-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q08012

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein enhancer of sevenless 2BCurated
Short name:
Protein E(sev)2B
Alternative name(s):
Downstream of receptor kinase
GRB2-related adapter protein homologCurated
SH2-SH3 adapter protein drk
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:drk
Synonyms:E(sev)2B
ORF Names:CG6033
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004638 drk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonically lethal (PubMed:30610177). Loss in Johnston's organ causes scolopidium abnormalities (PubMed:30610177).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49P → L: Inactivates the SH3 domain. Abolishes binding to Dab; when associated with R-199. 1 Publication1
Mutagenesisi67R → H in Su(sevs11)R1 mutant; ommatidial cell development obstruction. 1 Publication1
Mutagenesisi85R → K: Disrupts the SH2 domain. Does not affect binding to Dab. 1 Publication1
Mutagenesisi106H → Y in E(sev)2B mutant; ommatidial cell development obstruction. 1 Publication1
Mutagenesisi199G → R: Disrupts the SH3 domain. Abolishes binding to Dab; when associated with L-49. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000882101 – 211Protein enhancer of sevenless 2BAdd BLAST211

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08012

PRoteomics IDEntifications database

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PRIDEi
Q08012

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found mainly in the developing eye and in the antennal disk. Also observed in other imaginal disks tested and in the embryo. Expressed in Johnston's organ, the hearing organ, neurons (at protein level) (PubMed:30610177).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004638 Expressed in antenna and 42 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q08012 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with autophosphorylated sev via SH2 domain and Sos, Dos and Dab via SH3 domains. Binds to tyrosine phosphorylated Dab via the SH2 domain. Required for functional and morphological integrities of the scolopidia, sensory neurons and the antennal mechanosensory and motor center (AMMC) brain neuropil (PubMed:30610177).

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62256, 76 interactors

Database of interacting proteins

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DIPi
DIP-21223N

Protein interaction database and analysis system

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IntActi
Q08012, 4 interactors

Molecular INTeraction database

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MINTi
Q08012

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086812

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08012

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q08012

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 151SH2PROSITE-ProRule annotationAdd BLAST92
Domaini152 – 211SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3601 Eukaryota
ENOG410XR1G LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_073617_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q08012

KEGG Orthology (KO)

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KOi
K04364

Identification of Orthologs from Complete Genome Data

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OMAi
YHRSASV

Database of Orthologous Groups

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OrthoDBi
1091250at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q08012

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030219 Grb2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR46037:SF4 PTHR46037:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q08012-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAIAKHDFS ATADDELSFR KTQILKILNM EDDSNWYRAE LDGKEGLIPS
60 70 80 90 100
NYIEMKNHDW YYGRITRADA EKLLSNKHEG AFLIRISESS PGDFSLSVKC
110 120 130 140 150
PDGVQHFKVL RDAQSKFFLW VVKFNSLNEL VEYHRTASVS RSQDVKLRDM
160 170 180 190 200
IPEEMLVQAL YDFVPQESGE LDFRRGDVIT VTDRSDENWW NGEIGNRKGI
210
FPATYVTPYH S
Length:211
Mass (Da):24,435
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1D0614AF358F3C0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L12446 mRNA Translation: AAA28898.1
L13173 mRNA No translation available.
AY135053 Genomic DNA Translation: AAN17564.1
AY135054 Genomic DNA Translation: AAN17565.1
AY135055 Genomic DNA Translation: AAN17566.1
AY135056 Genomic DNA Translation: AAN17567.1
AY135057 Genomic DNA Translation: AAN17568.1
AY135058 Genomic DNA Translation: AAN17569.1
AY135059 Genomic DNA Translation: AAN17570.1
AY135060 Genomic DNA Translation: AAN17571.1
AY135061 Genomic DNA Translation: AAN17572.1
AY135062 Genomic DNA Translation: AAN17573.1
AY135063 Genomic DNA Translation: AAN17574.1
AY135064 Genomic DNA Translation: AAN17575.1
AY135065 Genomic DNA Translation: AAN17576.1
AY135066 Genomic DNA Translation: AAN17577.1
AY135067 Genomic DNA Translation: AAN17578.1
AY135068 Genomic DNA Translation: AAN17579.1
AY135069 Genomic DNA Translation: AAN17580.1
AY135070 Genomic DNA Translation: AAN17581.1
AY135071 Genomic DNA Translation: AAN17582.1
AY135072 Genomic DNA Translation: AAN17583.1
AY135073 Genomic DNA Translation: AAN17584.1
AY135074 Genomic DNA Translation: AAN17585.1
AE013599 Genomic DNA Translation: AAF58368.1
AE013599 Genomic DNA Translation: AAM68582.1
AE013599 Genomic DNA Translation: AAM68583.1
AE013599 Genomic DNA Translation: AAM68584.1
AE013599 Genomic DNA Translation: AAM68585.1
AY061142 mRNA Translation: AAL28690.1

Protein sequence database of the Protein Information Resource

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PIRi
A46444

NCBI Reference Sequences

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RefSeqi
NP_476858.1, NM_057510.4
NP_725302.1, NM_165994.2
NP_725303.1, NM_165995.2
NP_725304.1, NM_165996.2
NP_725306.1, NM_165998.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087694; FBpp0086813; FBgn0004638
FBtr0087695; FBpp0086814; FBgn0004638
FBtr0087696; FBpp0086815; FBgn0004638
FBtr0087697; FBpp0086816; FBgn0004638
FBtr0087698; FBpp0086817; FBgn0004638

Database of genes from NCBI RefSeq genomes

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GeneIDi
36497

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6033

UCSC genome browser

More...
UCSCi
CG6033-RC d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12446 mRNA Translation: AAA28898.1
L13173 mRNA No translation available.
AY135053 Genomic DNA Translation: AAN17564.1
AY135054 Genomic DNA Translation: AAN17565.1
AY135055 Genomic DNA Translation: AAN17566.1
AY135056 Genomic DNA Translation: AAN17567.1
AY135057 Genomic DNA Translation: AAN17568.1
AY135058 Genomic DNA Translation: AAN17569.1
AY135059 Genomic DNA Translation: AAN17570.1
AY135060 Genomic DNA Translation: AAN17571.1
AY135061 Genomic DNA Translation: AAN17572.1
AY135062 Genomic DNA Translation: AAN17573.1
AY135063 Genomic DNA Translation: AAN17574.1
AY135064 Genomic DNA Translation: AAN17575.1
AY135065 Genomic DNA Translation: AAN17576.1
AY135066 Genomic DNA Translation: AAN17577.1
AY135067 Genomic DNA Translation: AAN17578.1
AY135068 Genomic DNA Translation: AAN17579.1
AY135069 Genomic DNA Translation: AAN17580.1
AY135070 Genomic DNA Translation: AAN17581.1
AY135071 Genomic DNA Translation: AAN17582.1
AY135072 Genomic DNA Translation: AAN17583.1
AY135073 Genomic DNA Translation: AAN17584.1
AY135074 Genomic DNA Translation: AAN17585.1
AE013599 Genomic DNA Translation: AAF58368.1
AE013599 Genomic DNA Translation: AAM68582.1
AE013599 Genomic DNA Translation: AAM68583.1
AE013599 Genomic DNA Translation: AAM68584.1
AE013599 Genomic DNA Translation: AAM68585.1
AY061142 mRNA Translation: AAL28690.1
PIRiA46444
RefSeqiNP_476858.1, NM_057510.4
NP_725302.1, NM_165994.2
NP_725303.1, NM_165995.2
NP_725304.1, NM_165996.2
NP_725306.1, NM_165998.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A36NMR-A1-59[»]
2A37NMR-A1-59[»]
2AZSNMR-A1-59[»]
2AZVNMR-A1-59[»]
SMRiQ08012
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi62256, 76 interactors
DIPiDIP-21223N
IntActiQ08012, 4 interactors
MINTiQ08012
STRINGi7227.FBpp0086812

Proteomic databases

PaxDbiQ08012
PRIDEiQ08012

Genome annotation databases

EnsemblMetazoaiFBtr0087694; FBpp0086813; FBgn0004638
FBtr0087695; FBpp0086814; FBgn0004638
FBtr0087696; FBpp0086815; FBgn0004638
FBtr0087697; FBpp0086816; FBgn0004638
FBtr0087698; FBpp0086817; FBgn0004638
GeneIDi36497
KEGGidme:Dmel_CG6033
UCSCiCG6033-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36497
FlyBaseiFBgn0004638 drk

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00940000155738
HOGENOMiCLU_073617_1_0_1
InParanoidiQ08012
KOiK04364
OMAiYHRSASV
OrthoDBi1091250at2759
PhylomeDBiQ08012

Enzyme and pathway databases

ReactomeiR-DME-109704 PI3K Cascade
R-DME-112412 SOS-mediated signalling
R-DME-1250347 SHC1 events in ERBB4 signaling
R-DME-1257604 PIP3 activates AKT signaling
R-DME-1295596 Spry regulation of FGF signaling
R-DME-1433557 Signaling by SCF-KIT
R-DME-1433559 Regulation of KIT signaling
R-DME-167044 Signalling to RAS
R-DME-179812 GRB2 events in EGFR signaling
R-DME-180292 GAB1 signalosome
R-DME-180336 SHC1 events in EGFR signaling
R-DME-182971 EGFR downregulation
R-DME-186763 Downstream signal transduction
R-DME-1963640 GRB2 events in ERBB2 signaling
R-DME-1963642 PI3K events in ERBB2 signaling
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-210993 Tie2 Signaling
R-DME-2179392 EGFR Transactivation by Gastrin
R-DME-2424491 DAP12 signaling
R-DME-2428933 SHC-related events triggered by IGF1R
R-DME-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-2871796 FCERI mediated MAPK activation
R-DME-2871809 FCERI mediated Ca+2 mobilization
R-DME-5654688 SHC-mediated cascade:FGFR1
R-DME-5654689 PI-3K cascade:FGFR1
R-DME-5654693 FRS-mediated FGFR1 signaling
R-DME-5654695 PI-3K cascade:FGFR2
R-DME-5654699 SHC-mediated cascade:FGFR2
R-DME-5654700 FRS-mediated FGFR2 signaling
R-DME-5654704 SHC-mediated cascade:FGFR3
R-DME-5654706 FRS-mediated FGFR3 signaling
R-DME-5654710 PI-3K cascade:FGFR3
R-DME-5654712 FRS-mediated FGFR4 signaling
R-DME-5654719 SHC-mediated cascade:FGFR4
R-DME-5654720 PI-3K cascade:FGFR4
R-DME-5654726 Negative regulation of FGFR1 signaling
R-DME-5654727 Negative regulation of FGFR2 signaling
R-DME-5654732 Negative regulation of FGFR3 signaling
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-5673001 RAF/MAP kinase cascade
R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-74749 Signal attenuation
R-DME-74751 Insulin receptor signalling cascade
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-912631 Regulation of signaling by CBL
R-DME-9607240 FLT3 Signaling
R-DME-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiQ08012

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
drk fly
EvolutionaryTraceiQ08012

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36497

Protein Ontology

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PROi
PR:Q08012

Gene expression databases

BgeeiFBgn0004638 Expressed in antenna and 42 other tissues
GenevisibleiQ08012 DM

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR030219 Grb2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR46037:SF4 PTHR46037:SF4, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRAP_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08012
Secondary accession number(s): A4UZF9, Q0E989, Q9V6Q5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 26, 2020
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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