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Protein

Protein Wnt-2

Gene

WNT2

Organism
Aotus nancymaae (Ma's night monkey)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Gene namesi
Name:WNT2
OrganismiAotus nancymaae (Ma's night monkey)
Taxonomic identifieri37293 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniAotidaeAotus
Proteomesi
  • UP000233020 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000026033826 – 360Protein Wnt-2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 87By similarity
Disulfide bondi127 ↔ 135By similarity
Disulfide bondi137 ↔ 157By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
Lipidationi212O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PRIDEiQ07DV4

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ07DV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000118943
HOVERGENiHBG001595
OrthoDBiEOG091G0OFF

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009140 Wnt2
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01842 WNT2PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07DV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSPLRGIWL WLPLLLTWLT PEVSSSWWYM GATGGSARVM CDNVPGLVSS
60 70 80 90 100
QRQLCHRHPD VMRAIGLGVT EWTSECQYQF RQHRWNCNTL DRDHSLFGRV
110 120 130 140 150
LLRSSRESAF VYAISSAGVV FAITRACSQG EVKSCSCDPK KMGSGKDSKG
160 170 180 190 200
VFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKSVKR
210 220 230 240 250
FLKQECKCHG VSGSCSLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG
260 270 280 290 300
TGFTVANERF KKPTKNDLVY FENSPDYCIR DRETGSLGTA GRVCNLTSRG
310 320 330 340 350
MDSCEVMCCG RGYDTSHVTR MIKCGCKFHW CCAVRCQDCL EALDVHTCKA
360
PKNADWTSPT
Length:360
Mass (Da):40,446
Last modified:October 31, 2006 - v1
Checksum:iB4CCD0E3B779DD25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000197 Genomic DNA Translation: ABJ08888.1
RefSeqiXP_012312394.1, XM_012456971.1

Genome annotation databases

EnsembliENSANAT00000037728; ENSANAP00000019854; ENSANAG00000027702
GeneIDi105720427

Similar proteinsi

Entry informationi

Entry nameiWNT2_AOTNA
AccessioniPrimary (citable) accession number: Q07DV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 31, 2006
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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