UniProtKB - Q07994 (NCPR_MUSDO)
Protein
NADPH--cytochrome P450 reductase
Gene
N/A
Organism
Musca domestica (House fly)
Status
Functioni
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.UniRule annotation
Catalytic activityi
- EC:1.6.2.4UniRule annotation
Cofactori
Protein has several cofactor binding sites:- FADUniRule annotationNote: Binds 1 FAD per monomer.UniRule annotation
- FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 205 | FMNUniRule annotation | 1 | |
Binding sitei | 295 | NADPUniRule annotation | 1 | |
Binding sitei | 475 | FADUniRule annotation | 1 | |
Binding sitei | 529 | NADPUniRule annotation | 1 | |
Binding sitei | 632 | NADPUniRule annotation | 1 | |
Binding sitei | 670 | FADUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 83 – 88 | FMNUniRule annotation | 6 | |
Nucleotide bindingi | 135 – 138 | FMNUniRule annotation | 4 | |
Nucleotide bindingi | 170 – 179 | FMNUniRule annotation | 10 | |
Nucleotide bindingi | 451 – 454 | FADUniRule annotation | 4 | |
Nucleotide bindingi | 469 – 471 | FADUniRule annotation | 3 | |
Nucleotide bindingi | 485 – 488 | FADUniRule annotation | 4 | |
Nucleotide bindingi | 589 – 590 | NADPUniRule annotation | 2 | |
Nucleotide bindingi | 595 – 599 | NADPUniRule annotation | 5 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: UniProtKB-UniRule
- FMN binding Source: UniProtKB-UniRule
- NADP binding Source: UniProtKB-UniRule
- NADPH-hemoprotein reductase activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, FMN, NADP |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-18499 |
Names & Taxonomyi
Protein namesi | Recommended name: NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)Short name: CPRUniRule annotation Short name: P450RUniRule annotation |
Organismi | Musca domestica (House fly) |
Taxonomic identifieri | 7370 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Muscoidea › Muscidae › Musca › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | VectorBase:MDOA011246 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation; Single-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 14 | LumenalUniRule annotationAdd BLAST | 14 | |
Transmembranei | 15 – 35 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 36 – 671 | CytoplasmicUniRule annotationAdd BLAST | 636 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000167603 | 1 – 671 | NADPH--cytochrome P450 reductaseAdd BLAST | 671 |
Expressioni
Developmental stagei
Expressed throughout development, with high levels before metamorphosis and low levels in pupae.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 221 | Flavodoxin-likeUniRule annotationAdd BLAST | 145 | |
Domaini | 276 – 515 | FAD-binding FR-typeUniRule annotationAdd BLAST | 240 |
Sequence similaritiesi
Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1158, Eukaryota |
Family and domain databases
Gene3Di | 1.20.990.10, 2 hits 3.40.50.360, 1 hit 3.40.50.80, 1 hit |
HAMAPi | MF_03212, NCPR, 1 hit |
InterProi | View protein in InterPro IPR003097, CysJ-like_FAD-binding IPR017927, FAD-bd_FR_type IPR001094, Flavdoxin-like IPR008254, Flavodoxin/NO_synth IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR029039, Flavoprotein-like_sf IPR039261, FNR_nucleotide-bd IPR023173, NADPH_Cyt_P450_Rdtase_alpha IPR001433, OxRdtase_FAD/NAD-bd IPR023208, P450R IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00667, FAD_binding_1, 1 hit PF00258, Flavodoxin_1, 1 hit PF00175, NAD_binding_1, 1 hit |
PIRSFi | PIRSF000208, P450R, 1 hit |
PRINTSi | PR00369, FLAVODOXIN PR00371, FPNCR |
SUPFAMi | SSF52218, SSF52218, 1 hit SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit PS50902, FLAVODOXIN_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q07994-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAEHVEEVV SEEPFLGTLD IALLVVLLVG ATWYFMRSRK KEEAPIRSYS
60 70 80 90 100
IQPTTVSTVS TTENSFIKKL KASGRSLVVF YGSQTGTAEE FAGRLAKEGL
110 120 130 140 150
RYRMKGMVAD PEECDMEELL QMKDIPNSLA VFCLATYGEG DPTDNAMEFY
160 170 180 190 200
EWITNGEVDL TGLNYAVFGL GNKTYEHYNK VAIYVDKRLE ELGATRVFEL
210 220 230 240 250
GLGDDDANIE DDFITWKDRF WPSVCDFFGI EGSGEEVLMR QFRLLEQPDV
260 270 280 290 300
QPDRIYTGEI ARLHSMQNQR PPFDAKNPFL ASVIVNRELH KGGGRSCMHI
310 320 330 340 350
ELDIDGSKMR YDAGDHIAMY PINDKILVEK LGKLCDANLD TVFSLINTDT
360 370 380 390 400
DSSKKHPFPC PTTYRTALTH YLEITAIPRT HILKELAEYC SDEKDKEFLR
410 420 430 440 450
NMASITPEGK EKYQNWIQNS SRNIVHILED IKSCRPPIDH ICELLPRLQP
460 470 480 490 500
RYYSISSSSK LYPTNVHITA VLVQYETPTG RVNKGVATSY MKEKNPSVGE
510 520 530 540 550
VKVPVFIRKS QFRLPTKSEI PIIMVGPGTG LAPFRGFIQE RQFLRDGGKV
560 570 580 590 600
VGDTILYFGC RKKDEDFIYR EELEQYVQNG TLTLKTAFSR DQQEKIYVTH
610 620 630 640 650
LIEQDADLIW KVIGEQKGHF YICGDAKNMA VDVRNILVKI LSTKGNMNES
660 670
DAVQYIKKME AQKRYSADVW S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19897 mRNA Translation: AAA29295.1 |
PIRi | A56592 |
RefSeqi | NP_001273818.1, NM_001286889.1 XP_011294253.1, XM_011295951.2 |
Genome annotation databases
EnsemblMetazoai | MDOA011246-RC; MDOA011246-PC; MDOA011246 MDOA011246-RD; MDOA011246-PD; MDOA011246 |
GeneIDi | 101890161 |
KEGGi | mde:101890161 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19897 mRNA Translation: AAA29295.1 |
PIRi | A56592 |
RefSeqi | NP_001273818.1, NM_001286889.1 XP_011294253.1, XM_011295951.2 |
3D structure databases
SMRi | Q07994 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7370.XP_005187795.1 |
Genome annotation databases
EnsemblMetazoai | MDOA011246-RC; MDOA011246-PC; MDOA011246 MDOA011246-RD; MDOA011246-PD; MDOA011246 |
GeneIDi | 101890161 |
KEGGi | mde:101890161 |
Organism-specific databases
CTDi | 33883 |
VEuPathDBi | VectorBase:MDOA011246 |
Phylogenomic databases
eggNOGi | KOG1158, Eukaryota |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-18499 |
Family and domain databases
Gene3Di | 1.20.990.10, 2 hits 3.40.50.360, 1 hit 3.40.50.80, 1 hit |
HAMAPi | MF_03212, NCPR, 1 hit |
InterProi | View protein in InterPro IPR003097, CysJ-like_FAD-binding IPR017927, FAD-bd_FR_type IPR001094, Flavdoxin-like IPR008254, Flavodoxin/NO_synth IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR029039, Flavoprotein-like_sf IPR039261, FNR_nucleotide-bd IPR023173, NADPH_Cyt_P450_Rdtase_alpha IPR001433, OxRdtase_FAD/NAD-bd IPR023208, P450R IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00667, FAD_binding_1, 1 hit PF00258, Flavodoxin_1, 1 hit PF00175, NAD_binding_1, 1 hit |
PIRSFi | PIRSF000208, P450R, 1 hit |
PRINTSi | PR00369, FLAVODOXIN PR00371, FPNCR |
SUPFAMi | SSF52218, SSF52218, 1 hit SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit PS50902, FLAVODOXIN_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCPR_MUSDO | |
Accessioni | Q07994Primary (citable) accession number: Q07994 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |