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Protein

Chromatin structure-remodeling complex protein RSC58

Gene

RSC58

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.6 Publications

Miscellaneous

Present with 4460 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32192-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin structure-remodeling complex protein RSC58
Alternative name(s):
Remodel the structure of chromatin complex subunit 58
Gene namesi
Name:RSC58
Ordered Locus Names:YLR033W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

SGDiS000004023 RSC58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974731 – 502Chromatin structure-remodeling complex protein RSC58Add BLAST502

Proteomic databases

MaxQBiQ07979
PaxDbiQ07979
PRIDEiQ07979

Interactioni

Subunit structurei

Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi31307, 239 interactors
ComplexPortaliCPX-1888 RSC complex variant RSC2
CPX-1889 RSC complex variant RSC1
DIPiDIP-6656N
IntActiQ07979, 104 interactors
MINTiQ07979
STRINGi4932.YLR033W

Structurei

3D structure databases

ProteinModelPortaliQ07979
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000066118
InParanoidiQ07979
KOiK11766
OMAiSIRGPYK
OrthoDBiEOG092C4G07

Family and domain databases

InterProiView protein in InterPro
IPR001487 Bromodomain
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit

Sequencei

Sequence statusi: Complete.

Q07979-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTESVGGNKL VDFLVNVQSI LNAASVKCHV VDESFPAKFF EKNPDKIYES
60 70 80 90 100
YCKFIKNRSN SEGLIRNEDK LVLTTINKRF ENGEYEPIQG GFYKLYHDIK
110 120 130 140 150
LVCTILIHFY PQGTRNYQLV DKFYKFSSEL LLRECCRIGI ALTQTNNIKS
160 170 180 190 200
RSGKLLSGNE MDEYDDDDAT ELDKIISYDF IKISMNYTVP ISQTYQIRTK
210 220 230 240 250
DMDLFSSIIS KSNLDKRPHE LPNTNFKINN VLPQTDIENE APRLGFVGAN
260 270 280 290 300
TSNIPDPTLP PTEMMTRFLH PNWYALPTTV WLKYGNYNSW APSFNENGTV
310 320 330 340 350
VDSTTRGLIW LERIGYMDLY EKNEKKVKQE ELLNTNEEGI NRKQNDENNK
360 370 380 390 400
NVDGKSNGVQ DDGGDNDNDA TIASANSEST ENKEQFIIKL QNLYNWTPSN
410 420 430 440 450
YIGDDEIENF RNGTPDKLVS DSLLKLKRLR KERILNKVLK PTTEERELYF
460 470 480 490 500
KVKRILKEVI LAKKVSKVPI NNVRAFPVLQ TNYNGSIPVV RAQPGRKRKH

KK
Length:502
Mass (Da):57,794
Last modified:November 1, 1996 - v1
Checksum:i8F8D01184DAE1F6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73205 Genomic DNA Translation: CAA97557.1
BK006945 Genomic DNA Translation: DAA09351.1
PIRiS64860
RefSeqiNP_013133.1, NM_001181920.1

Genome annotation databases

EnsemblFungiiYLR033W; YLR033W; YLR033W
GeneIDi850720
KEGGisce:YLR033W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73205 Genomic DNA Translation: CAA97557.1
BK006945 Genomic DNA Translation: DAA09351.1
PIRiS64860
RefSeqiNP_013133.1, NM_001181920.1

3D structure databases

ProteinModelPortaliQ07979
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31307, 239 interactors
ComplexPortaliCPX-1888 RSC complex variant RSC2
CPX-1889 RSC complex variant RSC1
DIPiDIP-6656N
IntActiQ07979, 104 interactors
MINTiQ07979
STRINGi4932.YLR033W

Proteomic databases

MaxQBiQ07979
PaxDbiQ07979
PRIDEiQ07979

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR033W; YLR033W; YLR033W
GeneIDi850720
KEGGisce:YLR033W

Organism-specific databases

SGDiS000004023 RSC58

Phylogenomic databases

HOGENOMiHOG000066118
InParanoidiQ07979
KOiK11766
OMAiSIRGPYK
OrthoDBiEOG092C4G07

Enzyme and pathway databases

BioCyciYEAST:G3O-32192-MONOMER

Miscellaneous databases

PROiPR:Q07979

Family and domain databases

InterProiView protein in InterPro
IPR001487 Bromodomain
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSC58_YEAST
AccessioniPrimary (citable) accession number: Q07979
Secondary accession number(s): D6VY35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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