UniProtKB - Q07973 (CP24A_HUMAN)
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
CYP24A1
Functioni
A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D3) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D3) (PubMed:24893882, PubMed:15574355, PubMed:8679605, PubMed:11012668, PubMed:16617161, PubMed:29461981).
With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:24893882, PubMed:15574355).
With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605).
Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742).
Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605).
7 PublicationsCatalytic activityi
- calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]5 PublicationsEC:1.14.15.165 PublicationsThis reaction proceeds in the forward1 Publication direction.
- calcitetrol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]3 PublicationsEC:1.14.15.163 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (1S)-1,25-dihydroxy-24-oxocalciol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]3 PublicationsEC:1.14.15.163 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]2 PublicationsEC:1.14.15.162 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H+ + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]2 PublicationsEC:1.14.15.162 PublicationsThis reaction proceeds in the forward1 Publication direction.
- calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1α,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol4 PublicationsEC:1.14.15.164 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 2 H+ + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]3 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 25-hydroxy-24-oxocalciol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]3 PublicationsThis reaction proceeds in the forward1 Publication direction.
- calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]3 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 20S-hydroxycholecalciferol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 20S-hydroxycholecalciferol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 20S,23-dihydroxycholecalciferol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Kineticsi
- KM=0.16 µM for calcidiol1 Publication
- KM=0.072 µM for calcitriol1 Publication
- KM=0.35 µM for calcitriol1 Publication
- Vmax=0.088 mol/min/mol enzyme toward calcidiol1 Publication
- Vmax=0.066 mol/min/mol enzyme toward calcitriol1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 462 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity Source: UniProtKB
- 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Source: UniProtKB
- 25-hydroxycholecalciferol-23-hydroxylase activity Source: UniProtKB
- 25-hydroxycholecalciferol-24-hydroxylase activity Source: UniProtKB
- heme binding Source: UniProtKB
- iron ion binding Source: InterPro
- vitamin D 25-hydroxylase activity Source: UniProtKB
GO - Biological processi
- fatty acid omega-oxidation Source: GO_Central
- osteoblast differentiation Source: BHF-UCL
- response to vitamin D Source: BHF-UCL
- vitamin D catabolic process Source: UniProtKB
- vitamin D metabolic process Source: Reactome
- vitamin D receptor signaling pathway Source: BHF-UCL
- vitamin metabolic process Source: Reactome
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Lipid metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.14.24, 2681 1.14.15.16, 2681 |
PathwayCommonsi | Q07973 |
Reactomei | R-HSA-196791, Vitamin D (calciferol) metabolism R-HSA-211916, Vitamins R-HSA-5579010, Defective CYP24A1 causes HCAI |
SABIO-RKi | Q07973 |
SignaLinki | Q07973 |
SIGNORi | Q07973 |
Chemistry databases
SwissLipidsi | SLP:000001269 |
Names & Taxonomyi
Protein namesi | Recommended name: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial1 Publication (EC:1.14.15.165 Publications)Short name: 24-OHase Short name: Vitamin D(3) 24-hydroxylase Alternative name(s): Cytochrome P450 24A1 Cytochrome P450-CC24 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2602, CYP24A1 |
MIMi | 126065, gene |
neXtProti | NX_Q07973 |
VEuPathDBi | HostDB:ENSG00000019186 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrial inner membrane Source: Reactome
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Hypercalcemia, infantile, 1 (HCINF1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066408 | 143 | Missing in HCINF1; complete loss of function. 1 Publication | 1 | |
Natural variantiVAR_066409 | 159 | R → Q in HCINF1; complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs387907322EnsemblClinVar. | 1 | |
Natural variantiVAR_066410 | 322 | E → K in HCINF1; complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs387907324EnsemblClinVar. | 1 | |
Natural variantiVAR_066411 | 396 | R → W in HCINF1; complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs114368325EnsemblClinVar. | 1 | |
Natural variantiVAR_048466 | 409 | L → S in HCINF1; retains small but measurable levels of activity. 1 PublicationCorresponds to variant dbSNP:rs6068812EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1591 |
MalaCardsi | CYP24A1 |
MIMi | 143880, phenotype |
OpenTargetsi | ENSG00000019186 |
Orphaneti | 300547, Autosomal recessive infantile hypercalcemia |
PharmGKBi | PA27097 |
Miscellaneous databases
Pharosi | Q07973, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4521 |
DrugBanki | DB00146, Calcifediol DB02300, Calcipotriol DB00136, Calcitriol DB01285, Corticotropin DB05024, CTA018 DB00153, Ergocalciferol DB00910, Paricalcitol |
DrugCentrali | Q07973 |
GuidetoPHARMACOLOGYi | 1365 |
Genetic variation databases
BioMutai | CYP24A1 |
DMDMi | 19862747 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 35 | MitochondrionBy similarityAdd BLAST | 35 | |
ChainiPRO_0000003615 | 36 – 514 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialAdd BLAST | 479 |
Proteomic databases
jPOSTi | Q07973 |
MassIVEi | Q07973 |
MaxQBi | Q07973 |
PaxDbi | Q07973 |
PeptideAtlasi | Q07973 |
PRIDEi | Q07973 |
ProteomicsDBi | 58564 [Q07973-1] 58565 [Q07973-2] 62973 |
PTM databases
iPTMneti | Q07973 |
PhosphoSitePlusi | Q07973 |
Expressioni
Gene expression databases
Bgeei | ENSG00000019186, Expressed in urinary bladder and 120 other tissues |
Genevisiblei | Q07973, HS |
Organism-specific databases
HPAi | ENSG00000019186, Group enriched (endometrium, kidney, lymphoid tissue, placenta, urinary bladder) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107963, 102 interactors |
IntActi | Q07973, 6 interactors |
MINTi | Q07973 |
STRINGi | 9606.ENSP00000216862 |
Chemistry databases
BindingDBi | Q07973 |
Miscellaneous databases
RNActi | Q07973, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0159, Eukaryota |
GeneTreei | ENSGT00950000182905 |
HOGENOMi | CLU_001570_28_1_1 |
InParanoidi | Q07973 |
OMAi | MQHRNVA |
OrthoDBi | 1273535at2759 |
PhylomeDBi | Q07973 |
TreeFami | TF105094 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG
60 70 80 90 100
ETQNAAALPG PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK
110 120 130 140 150
LGSFESVHLG SPCLLEALYR TESAYPQRLE IKPWKAYRDY RKEGYGLLIL
160 170 180 190 200
EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN EVLADFMGRI DELCDERGHV
210 220 230 240 250
EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM AIKTMMSTFG
260 270 280 290 300
RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD
310 320 330 340 350
FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ
360 370 380 390 400
KLLKEIQSVL PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK
410 420 430 440 450
ATVLGEYALP KGTVLMLNTQ VLGSSEDNFE DSSQFRPERW LQEKEKINPF
460 470 480 490 500
AHLPFGVGKR MCIGRRLAEL QLHLALCWIV RKYDIQATDN EPVEMLHSGT
510
LVPSRELPIA FCQR
The sequence of this isoform differs from the canonical sequence as follows:
1-8: MSSPISKS → MYSCFSHR
9-150: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | G → A in AAA62379 (PubMed:8506296).Curated | 1 | |
Sequence conflicti | 68 | G → A in AAB03776 (PubMed:8506296).Curated | 1 | |
Sequence conflicti | 124 – 125 | AY → V in AAA62379 (PubMed:8506296).Curated | 2 | |
Sequence conflicti | 270 | D → G in AAA62379 (PubMed:8506296).Curated | 1 | |
Sequence conflicti | 365 | V → R in AAA62379 (PubMed:8506296).Curated | 1 | |
Sequence conflicti | 368 | A → E in AAA62379 (PubMed:8506296).Curated | 1 | |
Sequence conflicti | 390 | S → G in AAA62379 (PubMed:8506296).Curated | 1 | |
Sequence conflicti | 511 | F → S in AAB29308 (PubMed:8266831).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066408 | 143 | Missing in HCINF1; complete loss of function. 1 Publication | 1 | |
Natural variantiVAR_048464 | 157 | R → Q. Corresponds to variant dbSNP:rs35051736EnsemblClinVar. | 1 | |
Natural variantiVAR_066409 | 159 | R → Q in HCINF1; complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs387907322EnsemblClinVar. | 1 | |
Natural variantiVAR_066410 | 322 | E → K in HCINF1; complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs387907324EnsemblClinVar. | 1 | |
Natural variantiVAR_048465 | 374 | M → T. Corresponds to variant dbSNP:rs6022990EnsemblClinVar. | 1 | |
Natural variantiVAR_066411 | 396 | R → W in HCINF1; complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs114368325EnsemblClinVar. | 1 | |
Natural variantiVAR_048466 | 409 | L → S in HCINF1; retains small but measurable levels of activity. 1 PublicationCorresponds to variant dbSNP:rs6068812EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053367 | 1 – 8 | MSSPISKS → MYSCFSHR in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_053368 | 9 – 150 | Missing in isoform 3. 1 PublicationAdd BLAST | 142 | |
Alternative sequenceiVSP_043101 | 413 – 478 | Missing in isoform 2. 1 PublicationAdd BLAST | 66 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13286 mRNA Translation: AAA62379.1 AY858838 mRNA Translation: AAW50795.1 AL138805 Genomic DNA No translation available. BC109083 mRNA Translation: AAI09084.1 BC109084 mRNA Translation: AAI09085.1 U60669 Genomic DNA Translation: AAB03776.1 Sequence problems. S67623 mRNA Translation: AAB29308.1 |
CCDSi | CCDS33491.1 [Q07973-1] CCDS46616.1 [Q07973-2] |
PIRi | A47436 I55488 |
RefSeqi | NP_000773.2, NM_000782.4 [Q07973-1] NP_001122387.1, NM_001128915.1 [Q07973-2] XP_005260361.1, XM_005260304.4 [Q07973-1] XP_016883180.1, XM_017027691.1 [Q07973-1] XP_016883181.1, XM_017027692.1 [Q07973-1] XP_016883182.1, XM_017027693.1 [Q07973-2] |
Genome annotation databases
Ensembli | ENST00000216862.8; ENSP00000216862.3; ENSG00000019186.10 ENST00000395954.3; ENSP00000379284.3; ENSG00000019186.10 [Q07973-3] ENST00000395955.7; ENSP00000379285.3; ENSG00000019186.10 [Q07973-2] |
GeneIDi | 1591 |
KEGGi | hsa:1591 |
MANE-Selecti | ENST00000216862.8; ENSP00000216862.3; NM_000782.5; NP_000773.2 |
UCSCi | uc002xwu.2, human [Q07973-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13286 mRNA Translation: AAA62379.1 AY858838 mRNA Translation: AAW50795.1 AL138805 Genomic DNA No translation available. BC109083 mRNA Translation: AAI09084.1 BC109084 mRNA Translation: AAI09085.1 U60669 Genomic DNA Translation: AAB03776.1 Sequence problems. S67623 mRNA Translation: AAB29308.1 |
CCDSi | CCDS33491.1 [Q07973-1] CCDS46616.1 [Q07973-2] |
PIRi | A47436 I55488 |
RefSeqi | NP_000773.2, NM_000782.4 [Q07973-1] NP_001122387.1, NM_001128915.1 [Q07973-2] XP_005260361.1, XM_005260304.4 [Q07973-1] XP_016883180.1, XM_017027691.1 [Q07973-1] XP_016883181.1, XM_017027692.1 [Q07973-1] XP_016883182.1, XM_017027693.1 [Q07973-2] |
3D structure databases
AlphaFoldDBi | Q07973 |
SMRi | Q07973 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107963, 102 interactors |
IntActi | Q07973, 6 interactors |
MINTi | Q07973 |
STRINGi | 9606.ENSP00000216862 |
Chemistry databases
BindingDBi | Q07973 |
ChEMBLi | CHEMBL4521 |
DrugBanki | DB00146, Calcifediol DB02300, Calcipotriol DB00136, Calcitriol DB01285, Corticotropin DB05024, CTA018 DB00153, Ergocalciferol DB00910, Paricalcitol |
DrugCentrali | Q07973 |
GuidetoPHARMACOLOGYi | 1365 |
SwissLipidsi | SLP:000001269 |
PTM databases
iPTMneti | Q07973 |
PhosphoSitePlusi | Q07973 |
Genetic variation databases
BioMutai | CYP24A1 |
DMDMi | 19862747 |
Proteomic databases
jPOSTi | Q07973 |
MassIVEi | Q07973 |
MaxQBi | Q07973 |
PaxDbi | Q07973 |
PeptideAtlasi | Q07973 |
PRIDEi | Q07973 |
ProteomicsDBi | 58564 [Q07973-1] 58565 [Q07973-2] 62973 |
Protocols and materials databases
Antibodypediai | 13944, 320 antibodies from 36 providers |
DNASUi | 1591 |
Genome annotation databases
Ensembli | ENST00000216862.8; ENSP00000216862.3; ENSG00000019186.10 ENST00000395954.3; ENSP00000379284.3; ENSG00000019186.10 [Q07973-3] ENST00000395955.7; ENSP00000379285.3; ENSG00000019186.10 [Q07973-2] |
GeneIDi | 1591 |
KEGGi | hsa:1591 |
MANE-Selecti | ENST00000216862.8; ENSP00000216862.3; NM_000782.5; NP_000773.2 |
UCSCi | uc002xwu.2, human [Q07973-1] |
Organism-specific databases
CTDi | 1591 |
DisGeNETi | 1591 |
GeneCardsi | CYP24A1 |
HGNCi | HGNC:2602, CYP24A1 |
HPAi | ENSG00000019186, Group enriched (endometrium, kidney, lymphoid tissue, placenta, urinary bladder) |
MalaCardsi | CYP24A1 |
MIMi | 126065, gene 143880, phenotype |
neXtProti | NX_Q07973 |
OpenTargetsi | ENSG00000019186 |
Orphaneti | 300547, Autosomal recessive infantile hypercalcemia |
PharmGKBi | PA27097 |
VEuPathDBi | HostDB:ENSG00000019186 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0159, Eukaryota |
GeneTreei | ENSGT00950000182905 |
HOGENOMi | CLU_001570_28_1_1 |
InParanoidi | Q07973 |
OMAi | MQHRNVA |
OrthoDBi | 1273535at2759 |
PhylomeDBi | Q07973 |
TreeFami | TF105094 |
Enzyme and pathway databases
BRENDAi | 1.14.14.24, 2681 1.14.15.16, 2681 |
PathwayCommonsi | Q07973 |
Reactomei | R-HSA-196791, Vitamin D (calciferol) metabolism R-HSA-211916, Vitamins R-HSA-5579010, Defective CYP24A1 causes HCAI |
SABIO-RKi | Q07973 |
SignaLinki | Q07973 |
SIGNORi | Q07973 |
Miscellaneous databases
BioGRID-ORCSi | 1591, 16 hits in 1070 CRISPR screens |
ChiTaRSi | CYP24A1, human |
GeneWikii | CYP24A1 |
GenomeRNAii | 1591 |
Pharosi | Q07973, Tchem |
PROi | PR:Q07973 |
RNActi | Q07973, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000019186, Expressed in urinary bladder and 120 other tissues |
Genevisiblei | Q07973, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP24A_HUMAN | |
Accessioni | Q07973Primary (citable) accession number: Q07973 Secondary accession number(s): Q15807, Q32ML3, Q5I2W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 18, 2001 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families