F13b

Functionⁱ

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.By similarity

GO - Molecular functionⁱ

enzyme inhibitor activity
Source: MGI
Traceable author statementⁱ
- 18224415

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation
Source: MGI
Inferred from mutant phenotypeⁱ
- 18224415
blood coagulation, fibrin clot formation
Source: MGI
Inferred from mutant phenotypeⁱ
- 18224415
negative regulation of cellular protein catabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 18224415

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Blood coagulation, Hemostasis

Biological process

Blood coagulation, Hemostasis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140875 Common Pathway of Fibrin Clot Formation

Reactomeⁱ

R-MMU-140875 Common Pathway of Fibrin Clot Formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coagulation factor XIII B chain Alternative name(s): Protein-glutamine gamma-glutamyltransferase B chain Transglutaminase B chain
Gene namesⁱ	Name:F13b Synonyms:Cf13b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:88379 F13b

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	By similarityAdd BLAST		21
ChainⁱPRO_0000021223	22 – 669	Coagulation factor XIII B chainAdd BLAST		648

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	26 ↔ 77	PROSITE-ProRule annotation
Disulfide bondⁱ	60 ↔ 88	PROSITE-ProRule annotation
Disulfide bondⁱ	92 ↔ 136	PROSITE-ProRule annotation
Disulfide bondⁱ	119 ↔ 147	PROSITE-ProRule annotation
Disulfide bondⁱ	154 ↔ 198	PROSITE-ProRule annotation
Glycosylationⁱ	163	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	181 ↔ 209	PROSITE-ProRule annotation
Disulfide bondⁱ	214 ↔ 256	PROSITE-ProRule annotation
Disulfide bondⁱ	242 ↔ 268	PROSITE-ProRule annotation
Disulfide bondⁱ	275 ↔ 317	PROSITE-ProRule annotation
Disulfide bondⁱ	303 ↔ 328	PROSITE-ProRule annotation
Disulfide bondⁱ	337 ↔ 379	PROSITE-ProRule annotation
Disulfide bondⁱ	365 ↔ 390	PROSITE-ProRule annotation
Disulfide bondⁱ	397 ↔ 440	PROSITE-ProRule annotation
Disulfide bondⁱ	426 ↔ 451	PROSITE-ProRule annotation
Disulfide bondⁱ	455 ↔ 506	PROSITE-ProRule annotation
Disulfide bondⁱ	487 ↔ 516	PROSITE-ProRule annotation
Disulfide bondⁱ	525 ↔ 568	PROSITE-ProRule annotation
Glycosylationⁱ	546	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	554 ↔ 579	PROSITE-ProRule annotation
Disulfide bondⁱ	583 ↔ 637	PROSITE-ProRule annotation
Disulfide bondⁱ	617 ↔ 647	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q07968
PaxDbⁱ	Q07968
PeptideAtlas More...PeptideAtlasⁱ	Q07968
PRIDEⁱ	Q07968

PTM databases

iPTMnetⁱ	Q07968
PhosphoSitePlusⁱ	Q07968

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in liver and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000026368 Expressed in 48 organ(s), highest expression level in liver
CleanExⁱ	MM_F13B
Genevisibleⁱ	Q07968 MM

Interactionⁱ

Subunit structureⁱ

Tetramer of two A chains (F13A1) and two B (F13B) chains.By similarity

Protein-protein interaction databases

BioGridⁱ	199567, 1 interactor
IntActⁱ	Q07968, 1 interactor
STRINGⁱ	10090.ENSMUSP00000027615

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q07968
SMRⁱ	Q07968
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 89	Sushi 1PROSITE-ProRule annotationAdd BLAST	65
Domainⁱ	90 – 149	Sushi 2PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	152 – 211	Sushi 3PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	212 – 270	Sushi 4PROSITE-ProRule annotationAdd BLAST	59
Domainⁱ	273 – 330	Sushi 5PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	335 – 392	Sushi 6PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	395 – 453	Sushi 7PROSITE-ProRule annotationAdd BLAST	59
Domainⁱ	454 – 517	Sushi 8PROSITE-ProRule annotationAdd BLAST	64
Domainⁱ	523 – 581	Sushi 9PROSITE-ProRule annotationAdd BLAST	59
Domainⁱ	582 – 648	Sushi 10PROSITE-ProRule annotationAdd BLAST	67

Keywords - Domainⁱ

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGⁱ	ENOG410IE82 Eukaryota ENOG410YE48 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143999
HOGENOMⁱ	HOG000049250
HOVERGENⁱ	HBG005626
InParanoidⁱ	Q07968
KEGG Orthology (KO) More...KOⁱ	K03906
OMAⁱ	CYNFGWY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03MW
PhylomeDBⁱ	Q07968
TreeFamⁱ	TF326157

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00033 CCP, 7 hits
InterProⁱ	View protein in InterPro IPR035976 Sushi/SCR/CCP_sf IPR000436 Sushi_SCR_CCP_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00084 Sushi, 8 hits
SMARTⁱ	View protein in SMART SM00032 CCP, 8 hits
SUPFAMⁱ	SSF57535 SSF57535, 10 hits
PROSITEⁱ	View protein in PROSITE PS50923 SUSHI, 7 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q07968-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMTLRHLPFI LLLILSGELY AEEKQCDFPT VENGRIAQYY YTFKSFYFPM 
        60         70         80         90        100
SVDKKLSFFC LAGYATESGK QEEQIRCTAE GWSPNPRCYK KCLKPDLRNG 
       110        120        130        140        150
YVSNDKVLYK LQERMSYGCS SGYKTTGGKD EEVVHCLSAG WSSQPSCRKE 
       160        170        180        190        200
QETCLAPELE HGNYSTTQRT FKVKDIVAYT CTAGYYTTTG KQTGEAECQA 
       210        220        230        240        250
NGWSLTPQCN KLMCSSLRLI ENGYFHPVKQ TYEEGDVVQF FCHENYYLSG 
       260        270        280        290        300
SDLIQCYNFG WYPESPICEG RRNRCPPPPV PLNSKIQPHS TTYRHGERVH 
       310        320        330        340        350
IECELNFVIQ GSEELLCENG KWTEPPKCIE EKEKVACEQP PSVENGVAHP 
       360        370        380        390        400
HSEIYYSGDK VTYRCGGGYS LRGSSTITCN RGRWTLPPEC VENIENCKPP 
       410        420        430        440        450
PDIANGVVVD GLLASYTTGS SVEYRCNEYY LLKGSETSRC EQGAWSSPPV 
       460        470        480        490        500
CLEPCTIDVD HMNRNNIQLK WKYEGKILHG DLIDFVCKQG YNLSPSIPLS 
       510        520        530        540        550
EISAQCNRGD VRYPMCIRKE SKGMCASPPV IRNGDIVSSA ARTYENGSSV 
       560        570        580        590        600
EYRCFDNHFL QGSQNVYCVD GVWTTPPSCL EPCTLSFVEM DKNYLQLKWN 
       610        620        630        640        650
FDNRPLILHG EYIEFMCKRD AYISETSIAG SVLRVQCDRG RLKYPKCTPR 
       660 
DRRLSFQEAL RTRRQMEKR

Length:669

Mass (Da):76,195

Last modified:October 3, 2012 - v2

Checksum:ⁱ1ADB8DCCDE1050E0

GO

Sequence cautionⁱ

The sequence BAA00963 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	237	V → L in BAA00963 (PubMed:8468048).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10071 mRNA Translation: BAA00963.1 Different initiation. AL837518, AC158946 Genomic DNA Translation: CAM20501.1 CH466520 Genomic DNA Translation: EDL39526.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48386.1
PIRⁱ	A46013
NCBI Reference Sequences More...RefSeqⁱ	NP_112441.2, NM_031164.2
UniGeneⁱ	Mm.30105

Genome annotation databases

Ensemblⁱ	ENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368
GeneIDⁱ	14060
KEGGⁱ	mmu:14060
UCSC genome browser More...UCSCⁱ	uc007cwk.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07968	Uncharacterized protein		MOUSE		669	UniRef90_Q07968
UPI000A30823D		MUSPA		669
UPI000A3197CB		MUSCR		669
Coagulation factor XIII, beta subunit		MOUSE		668
UPI0003D74553		MOUSE		620
+1

Protein	Similar proteins		Species	Score	Length	Source
Q07968	Coagulation factor XIII B chain		HUMAN		661	UniRef50_P05160
Coagulation factor XIII B chain		GORGO		661
Uncharacterized protein		MACNE		661
Coagulation factor XIII B chain		PANTR		661
Uncharacterized protein		PANPA		661
+199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10071 mRNA Translation: BAA00963.1 Different initiation. AL837518, AC158946 Genomic DNA Translation: CAM20501.1 CH466520 Genomic DNA Translation: EDL39526.1
CCDSⁱ	CCDS48386.1
PIRⁱ	A46013
RefSeqⁱ	NP_112441.2, NM_031164.2
UniGeneⁱ	Mm.30105

3D structure databases

ProteinModelPortalⁱ	Q07968
SMRⁱ	Q07968
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199567, 1 interactor
IntActⁱ	Q07968, 1 interactor
STRINGⁱ	10090.ENSMUSP00000027615

PTM databases

iPTMnetⁱ	Q07968
PhosphoSitePlusⁱ	Q07968

Proteomic databases

MaxQBⁱ	Q07968
PaxDbⁱ	Q07968
PeptideAtlasⁱ	Q07968
PRIDEⁱ	Q07968

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368
GeneIDⁱ	14060
KEGGⁱ	mmu:14060
UCSCⁱ	uc007cwk.2 mouse

Organism-specific databases

CTDⁱ	2165
MGIⁱ	MGI:88379 F13b

Phylogenomic databases

eggNOGⁱ	ENOG410IE82 Eukaryota ENOG410YE48 LUCA
GeneTreeⁱ	ENSGT00910000143999
HOGENOMⁱ	HOG000049250
HOVERGENⁱ	HBG005626
InParanoidⁱ	Q07968
KOⁱ	K03906
OMAⁱ	CYNFGWY
OrthoDBⁱ	EOG091G03MW
PhylomeDBⁱ	Q07968
TreeFamⁱ	TF326157

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140875 Common Pathway of Fibrin Clot Formation

Reactomeⁱ

R-MMU-140875 Common Pathway of Fibrin Clot Formation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q07968
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026368 Expressed in 48 organ(s), highest expression level in liver
CleanExⁱ	MM_F13B
Genevisibleⁱ	Q07968 MM

Family and domain databases

CDDⁱ	cd00033 CCP, 7 hits
InterProⁱ	View protein in InterPro IPR035976 Sushi/SCR/CCP_sf IPR000436 Sushi_SCR_CCP_dom
Pfamⁱ	View protein in Pfam PF00084 Sushi, 8 hits
SMARTⁱ	View protein in SMART SM00032 CCP, 8 hits
SUPFAMⁱ	SSF57535 SSF57535, 10 hits
PROSITEⁱ	View protein in PROSITE PS50923 SUSHI, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F13B_MOUSE
Accessionⁱ	Q07968Primary (citable) accession number: Q07968 Secondary accession number(s): B1AY02
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	October 3, 2012
	Last modified:	September 12, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q07968 (F13B_MOUSE)

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Coagulation factor XIII B chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ