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Protein

Coagulation factor XIII B chain

Gene

F13b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.By similarity

GO - Molecular functioni

  • enzyme inhibitor activity Source: MGI

GO - Biological processi

  • blood coagulation Source: MGI
  • blood coagulation, fibrin clot formation Source: MGI
  • negative regulation of cellular protein catabolic process Source: MGI

Keywordsi

Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140875 Common Pathway of Fibrin Clot Formation

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII B chain
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
Gene namesi
Name:F13b
Synonyms:Cf13b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88379 F13b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000002122322 – 669Coagulation factor XIII B chainAdd BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 77PROSITE-ProRule annotation
Disulfide bondi60 ↔ 88PROSITE-ProRule annotation
Disulfide bondi92 ↔ 136PROSITE-ProRule annotation
Disulfide bondi119 ↔ 147PROSITE-ProRule annotation
Disulfide bondi154 ↔ 198PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 209PROSITE-ProRule annotation
Disulfide bondi214 ↔ 256PROSITE-ProRule annotation
Disulfide bondi242 ↔ 268PROSITE-ProRule annotation
Disulfide bondi275 ↔ 317PROSITE-ProRule annotation
Disulfide bondi303 ↔ 328PROSITE-ProRule annotation
Disulfide bondi337 ↔ 379PROSITE-ProRule annotation
Disulfide bondi365 ↔ 390PROSITE-ProRule annotation
Disulfide bondi397 ↔ 440PROSITE-ProRule annotation
Disulfide bondi426 ↔ 451PROSITE-ProRule annotation
Disulfide bondi455 ↔ 506PROSITE-ProRule annotation
Disulfide bondi487 ↔ 516PROSITE-ProRule annotation
Disulfide bondi525 ↔ 568PROSITE-ProRule annotation
Glycosylationi546N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi554 ↔ 579PROSITE-ProRule annotation
Disulfide bondi583 ↔ 637PROSITE-ProRule annotation
Disulfide bondi617 ↔ 647PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ07968
PaxDbiQ07968
PeptideAtlasiQ07968
PRIDEiQ07968

PTM databases

iPTMnetiQ07968
PhosphoSitePlusiQ07968

Expressioni

Tissue specificityi

Predominantly expressed in liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000026368 Expressed in 48 organ(s), highest expression level in liver
CleanExiMM_F13B
GenevisibleiQ07968 MM

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.By similarity

Protein-protein interaction databases

BioGridi199567, 1 interactor
IntActiQ07968, 1 interactor
STRINGi10090.ENSMUSP00000027615

Structurei

3D structure databases

ProteinModelPortaliQ07968
SMRiQ07968
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 89Sushi 1PROSITE-ProRule annotationAdd BLAST65
Domaini90 – 149Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini152 – 211Sushi 3PROSITE-ProRule annotationAdd BLAST60
Domaini212 – 270Sushi 4PROSITE-ProRule annotationAdd BLAST59
Domaini273 – 330Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini335 – 392Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini395 – 453Sushi 7PROSITE-ProRule annotationAdd BLAST59
Domaini454 – 517Sushi 8PROSITE-ProRule annotationAdd BLAST64
Domaini523 – 581Sushi 9PROSITE-ProRule annotationAdd BLAST59
Domaini582 – 648Sushi 10PROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IE82 Eukaryota
ENOG410YE48 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000049250
HOVERGENiHBG005626
InParanoidiQ07968
KOiK03906
OMAiCYNFGWY
OrthoDBiEOG091G03MW
PhylomeDBiQ07968
TreeFamiTF326157

Family and domain databases

CDDicd00033 CCP, 7 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 8 hits
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SUPFAMiSSF57535 SSF57535, 10 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07968-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTLRHLPFI LLLILSGELY AEEKQCDFPT VENGRIAQYY YTFKSFYFPM
60 70 80 90 100
SVDKKLSFFC LAGYATESGK QEEQIRCTAE GWSPNPRCYK KCLKPDLRNG
110 120 130 140 150
YVSNDKVLYK LQERMSYGCS SGYKTTGGKD EEVVHCLSAG WSSQPSCRKE
160 170 180 190 200
QETCLAPELE HGNYSTTQRT FKVKDIVAYT CTAGYYTTTG KQTGEAECQA
210 220 230 240 250
NGWSLTPQCN KLMCSSLRLI ENGYFHPVKQ TYEEGDVVQF FCHENYYLSG
260 270 280 290 300
SDLIQCYNFG WYPESPICEG RRNRCPPPPV PLNSKIQPHS TTYRHGERVH
310 320 330 340 350
IECELNFVIQ GSEELLCENG KWTEPPKCIE EKEKVACEQP PSVENGVAHP
360 370 380 390 400
HSEIYYSGDK VTYRCGGGYS LRGSSTITCN RGRWTLPPEC VENIENCKPP
410 420 430 440 450
PDIANGVVVD GLLASYTTGS SVEYRCNEYY LLKGSETSRC EQGAWSSPPV
460 470 480 490 500
CLEPCTIDVD HMNRNNIQLK WKYEGKILHG DLIDFVCKQG YNLSPSIPLS
510 520 530 540 550
EISAQCNRGD VRYPMCIRKE SKGMCASPPV IRNGDIVSSA ARTYENGSSV
560 570 580 590 600
EYRCFDNHFL QGSQNVYCVD GVWTTPPSCL EPCTLSFVEM DKNYLQLKWN
610 620 630 640 650
FDNRPLILHG EYIEFMCKRD AYISETSIAG SVLRVQCDRG RLKYPKCTPR
660
DRRLSFQEAL RTRRQMEKR
Length:669
Mass (Da):76,195
Last modified:October 3, 2012 - v2
Checksum:i1ADB8DCCDE1050E0
GO

Sequence cautioni

The sequence BAA00963 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237V → L in BAA00963 (PubMed:8468048).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10071 mRNA Translation: BAA00963.1 Different initiation.
AL837518, AC158946 Genomic DNA Translation: CAM20501.1
CH466520 Genomic DNA Translation: EDL39526.1
CCDSiCCDS48386.1
PIRiA46013
RefSeqiNP_112441.2, NM_031164.2
UniGeneiMm.30105

Genome annotation databases

EnsembliENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368
GeneIDi14060
KEGGimmu:14060
UCSCiuc007cwk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10071 mRNA Translation: BAA00963.1 Different initiation.
AL837518, AC158946 Genomic DNA Translation: CAM20501.1
CH466520 Genomic DNA Translation: EDL39526.1
CCDSiCCDS48386.1
PIRiA46013
RefSeqiNP_112441.2, NM_031164.2
UniGeneiMm.30105

3D structure databases

ProteinModelPortaliQ07968
SMRiQ07968
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199567, 1 interactor
IntActiQ07968, 1 interactor
STRINGi10090.ENSMUSP00000027615

PTM databases

iPTMnetiQ07968
PhosphoSitePlusiQ07968

Proteomic databases

MaxQBiQ07968
PaxDbiQ07968
PeptideAtlasiQ07968
PRIDEiQ07968

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368
GeneIDi14060
KEGGimmu:14060
UCSCiuc007cwk.2 mouse

Organism-specific databases

CTDi2165
MGIiMGI:88379 F13b

Phylogenomic databases

eggNOGiENOG410IE82 Eukaryota
ENOG410YE48 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000049250
HOVERGENiHBG005626
InParanoidiQ07968
KOiK03906
OMAiCYNFGWY
OrthoDBiEOG091G03MW
PhylomeDBiQ07968
TreeFamiTF326157

Enzyme and pathway databases

ReactomeiR-MMU-140875 Common Pathway of Fibrin Clot Formation

Miscellaneous databases

PROiPR:Q07968
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026368 Expressed in 48 organ(s), highest expression level in liver
CleanExiMM_F13B
GenevisibleiQ07968 MM

Family and domain databases

CDDicd00033 CCP, 7 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 8 hits
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SUPFAMiSSF57535 SSF57535, 10 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF13B_MOUSE
AccessioniPrimary (citable) accession number: Q07968
Secondary accession number(s): B1AY02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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