UniProtKB - Q07968 (F13B_MOUSE)
Protein
Coagulation factor XIII B chain
Gene
F13b
Organism
Mus musculus (Mouse)
Status
Functioni
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.By similarity
GO - Molecular functioni
- enzyme inhibitor activity Source: MGI
GO - Biological processi
- blood coagulation Source: MGI
- negative regulation of cellular protein catabolic process Source: MGI
Keywordsi
Biological process | Blood coagulation, Hemostasis |
Enzyme and pathway databases
Reactomei | R-MMU-140875, Common Pathway of Fibrin Clot Formation |
Names & Taxonomyi
Protein namesi | Recommended name: Coagulation factor XIII B chainAlternative name(s): Protein-glutamine gamma-glutamyltransferase B chain Transglutaminase B chain |
Gene namesi | Name:F13b Synonyms:Cf13b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88379, F13b |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000021223 | 22 – 669 | Coagulation factor XIII B chainAdd BLAST | 648 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 77 | PROSITE-ProRule annotation | ||
Disulfide bondi | 60 ↔ 88 | PROSITE-ProRule annotation | ||
Disulfide bondi | 92 ↔ 136 | PROSITE-ProRule annotation | ||
Disulfide bondi | 119 ↔ 147 | PROSITE-ProRule annotation | ||
Disulfide bondi | 154 ↔ 198 | PROSITE-ProRule annotation | ||
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 181 ↔ 209 | PROSITE-ProRule annotation | ||
Disulfide bondi | 214 ↔ 256 | PROSITE-ProRule annotation | ||
Disulfide bondi | 242 ↔ 268 | PROSITE-ProRule annotation | ||
Disulfide bondi | 275 ↔ 317 | PROSITE-ProRule annotation | ||
Disulfide bondi | 303 ↔ 328 | PROSITE-ProRule annotation | ||
Disulfide bondi | 337 ↔ 379 | PROSITE-ProRule annotation | ||
Disulfide bondi | 365 ↔ 390 | PROSITE-ProRule annotation | ||
Disulfide bondi | 397 ↔ 440 | PROSITE-ProRule annotation | ||
Disulfide bondi | 426 ↔ 451 | PROSITE-ProRule annotation | ||
Disulfide bondi | 455 ↔ 506 | PROSITE-ProRule annotation | ||
Disulfide bondi | 487 ↔ 516 | PROSITE-ProRule annotation | ||
Disulfide bondi | 525 ↔ 568 | PROSITE-ProRule annotation | ||
Glycosylationi | 546 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 554 ↔ 579 | PROSITE-ProRule annotation | ||
Disulfide bondi | 583 ↔ 637 | PROSITE-ProRule annotation | ||
Disulfide bondi | 617 ↔ 647 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-3398 non-CPTAC-3537 |
MaxQBi | Q07968 |
PaxDbi | Q07968 |
PeptideAtlasi | Q07968 |
PRIDEi | Q07968 |
PTM databases
GlyGeni | Q07968, 2 sites |
iPTMneti | Q07968 |
PhosphoSitePlusi | Q07968 |
Expressioni
Tissue specificityi
Predominantly expressed in liver and kidney.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000026368, Expressed in liver and 66 other tissues |
Genevisiblei | Q07968, MM |
Interactioni
Subunit structurei
Tetramer of two A chains (F13A1) and two B (F13B) chains.
By similarityProtein-protein interaction databases
BioGRIDi | 199567, 4 interactors |
IntActi | Q07968, 1 interactor |
STRINGi | 10090.ENSMUSP00000027615 |
Miscellaneous databases
RNActi | Q07968, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 89 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 90 – 149 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 152 – 211 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 212 – 270 | Sushi 4PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 273 – 330 | Sushi 5PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 335 – 392 | Sushi 6PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 395 – 453 | Sushi 7PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 454 – 517 | Sushi 8PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 523 – 581 | Sushi 9PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 582 – 648 | Sushi 10PROSITE-ProRule annotationAdd BLAST | 67 |
Keywords - Domaini
Repeat, Signal, SushiPhylogenomic databases
eggNOGi | ENOG502RDCS, Eukaryota |
GeneTreei | ENSGT00940000154967 |
HOGENOMi | CLU_020107_6_0_1 |
InParanoidi | Q07968 |
OMAi | IFHGEYI |
OrthoDBi | 296899at2759 |
PhylomeDBi | Q07968 |
TreeFami | TF326157 |
Family and domain databases
CDDi | cd00033, CCP, 7 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 8 hits |
SMARTi | View protein in SMART SM00032, CCP, 8 hits |
SUPFAMi | SSF57535, SSF57535, 10 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 7 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q07968-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTLRHLPFI LLLILSGELY AEEKQCDFPT VENGRIAQYY YTFKSFYFPM
60 70 80 90 100
SVDKKLSFFC LAGYATESGK QEEQIRCTAE GWSPNPRCYK KCLKPDLRNG
110 120 130 140 150
YVSNDKVLYK LQERMSYGCS SGYKTTGGKD EEVVHCLSAG WSSQPSCRKE
160 170 180 190 200
QETCLAPELE HGNYSTTQRT FKVKDIVAYT CTAGYYTTTG KQTGEAECQA
210 220 230 240 250
NGWSLTPQCN KLMCSSLRLI ENGYFHPVKQ TYEEGDVVQF FCHENYYLSG
260 270 280 290 300
SDLIQCYNFG WYPESPICEG RRNRCPPPPV PLNSKIQPHS TTYRHGERVH
310 320 330 340 350
IECELNFVIQ GSEELLCENG KWTEPPKCIE EKEKVACEQP PSVENGVAHP
360 370 380 390 400
HSEIYYSGDK VTYRCGGGYS LRGSSTITCN RGRWTLPPEC VENIENCKPP
410 420 430 440 450
PDIANGVVVD GLLASYTTGS SVEYRCNEYY LLKGSETSRC EQGAWSSPPV
460 470 480 490 500
CLEPCTIDVD HMNRNNIQLK WKYEGKILHG DLIDFVCKQG YNLSPSIPLS
510 520 530 540 550
EISAQCNRGD VRYPMCIRKE SKGMCASPPV IRNGDIVSSA ARTYENGSSV
560 570 580 590 600
EYRCFDNHFL QGSQNVYCVD GVWTTPPSCL EPCTLSFVEM DKNYLQLKWN
610 620 630 640 650
FDNRPLILHG EYIEFMCKRD AYISETSIAG SVLRVQCDRG RLKYPKCTPR
660
DRRLSFQEAL RTRRQMEKR
Sequence cautioni
The sequence BAA00963 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 237 | V → L in BAA00963 (PubMed:8468048).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10071 mRNA Translation: BAA00963.1 Different initiation. AC158946 Genomic DNA No translation available. AL837518 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39526.1 |
CCDSi | CCDS48386.1 |
PIRi | A46013 |
RefSeqi | NP_112441.2, NM_031164.2 |
Genome annotation databases
Ensembli | ENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368 |
GeneIDi | 14060 |
KEGGi | mmu:14060 |
UCSCi | uc007cwk.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10071 mRNA Translation: BAA00963.1 Different initiation. AC158946 Genomic DNA No translation available. AL837518 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39526.1 |
CCDSi | CCDS48386.1 |
PIRi | A46013 |
RefSeqi | NP_112441.2, NM_031164.2 |
3D structure databases
SMRi | Q07968 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199567, 4 interactors |
IntActi | Q07968, 1 interactor |
STRINGi | 10090.ENSMUSP00000027615 |
PTM databases
GlyGeni | Q07968, 2 sites |
iPTMneti | Q07968 |
PhosphoSitePlusi | Q07968 |
Proteomic databases
CPTACi | non-CPTAC-3398 non-CPTAC-3537 |
MaxQBi | Q07968 |
PaxDbi | Q07968 |
PeptideAtlasi | Q07968 |
PRIDEi | Q07968 |
Protocols and materials databases
Antibodypediai | 868, 224 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368 |
GeneIDi | 14060 |
KEGGi | mmu:14060 |
UCSCi | uc007cwk.2, mouse |
Organism-specific databases
CTDi | 2165 |
MGIi | MGI:88379, F13b |
Phylogenomic databases
eggNOGi | ENOG502RDCS, Eukaryota |
GeneTreei | ENSGT00940000154967 |
HOGENOMi | CLU_020107_6_0_1 |
InParanoidi | Q07968 |
OMAi | IFHGEYI |
OrthoDBi | 296899at2759 |
PhylomeDBi | Q07968 |
TreeFami | TF326157 |
Enzyme and pathway databases
Reactomei | R-MMU-140875, Common Pathway of Fibrin Clot Formation |
Miscellaneous databases
BioGRID-ORCSi | 14060, 0 hits in 17 CRISPR screens |
PROi | PR:Q07968 |
RNActi | Q07968, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026368, Expressed in liver and 66 other tissues |
Genevisiblei | Q07968, MM |
Family and domain databases
CDDi | cd00033, CCP, 7 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 8 hits |
SMARTi | View protein in SMART SM00032, CCP, 8 hits |
SUPFAMi | SSF57535, SSF57535, 10 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F13B_MOUSE | |
Accessioni | Q07968Primary (citable) accession number: Q07968 Secondary accession number(s): B1AY02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot