SRSF1

Functionⁱ

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.1 Publication

GO - Molecular functionⁱ

DNA topoisomerase binding
Source: CAFA
Inferred from physical interactionⁱ
- 9611241
mRNA binding
Source: MGI
Inferred from direct assayⁱ
- 21984414
protein kinase B binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19561594
RS domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

alternative mRNA splicing, via spliceosome
Source: GO_Central
Inferred from direct assayⁱ
- 8940107
cardiac muscle contraction Source: Ensembl
in utero embryonic development Source: Ensembl
liver regeneration Source: Ensembl
mRNA 3'-end processing Source: Reactome
mRNA 5'-splice site recognition
Source: UniProtKB
Inferred from direct assayⁱ
- 9885563
mRNA cis splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA export from nucleus Source: Reactome
mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 1830244
mRNA splice site selection
Source: ProtInc
Traceable author statementⁱ
- 1830244
mRNA splicing, via spliceosome Source: Reactome
oligodendrocyte differentiation Source: Ensembl
positive regulation of RNA splicing Source: Ensembl
regulation of alternative mRNA splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA export from nucleus Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	Q07955

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/arginine-rich splicing factor 1 Alternative name(s): Alternative-splicing factor 1 Short name: ASF-1 Splicing factor, arginine/serine-rich 1 pre-mRNA-splicing factor SF2, P33 subunit
Gene namesⁱ	Name:SRSF1 Synonyms:ASF, SF2, SF2P33, SFRS1 ORF Names:OK/SW-cl.3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136450.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10780 SRSF1
MIMⁱ	600812 gene
neXtProtⁱ	NX_Q07955

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	58 – 59	FV → SR in FV1; loss of ability to activate splicing. Slight reduction in splice site switching activity and no effect on RNA-binding. 1 Publication	2
Mutagenesisⁱ	93	R → A: Predominantly localizes to cytoplasm and fails to modulate splicing of endogenous pre-mRNAs; when associated with Ala-97 and Ala-109. 1 Publication	1
Mutagenesisⁱ	97	R → A: Predominantly localizes to cytoplasm and fails to modulate splicing of endogenous pre-mRNAs; when associated with Ala-93 and Ala-109. 1 Publication	1
Mutagenesisⁱ	109	R → A: Predominantly localizes to cytoplasm and fails to modulate splicing of endogenous pre-mRNAs; when associated with Ala-93 and Ala-97. 1 Publication	1
Mutagenesisⁱ	162 – 163	FV → SR in FV2; loss of ability to activate splicing. Great reduction in splice site switching activity and RNA-binding. 1 Publication	2
Mutagenesisⁱ	162	F → A in AV; loss of ability to activate splicing. Great reduction in splice site switching activity and no effect on RNA-binding. 1 Publication	1
Mutagenesisⁱ	162	F → D: Reduced nucleocytoplasmic shuttling; when associated with D-190. 1 Publication	1
Mutagenesisⁱ	180	F → D: Reduced nucleocytoplasmic shuttling; when associated with D-162. 1 Publication	1
Mutagenesisⁱ	182 – 248	Missing in MR-B; strongly inhibits splicing. 1 PublicationAdd BLAST	67
Mutagenesisⁱ	182 – 199	Missing in MR-E; loss of ability to activate splicing. 1 PublicationAdd BLAST	18
Mutagenesisⁱ	192 – 248	Missing in MR-A; loss of ability to activate splicing. 1 PublicationAdd BLAST	57
Mutagenesisⁱ	192 – 199	Missing in MR-D; loss of ability to activate splicing. 1 Publication	8
Mutagenesisⁱ	199 – 224	Missing in RS-A; loss of ability to activate splicing but retains splice site switching. 1 PublicationAdd BLAST	26
Mutagenesisⁱ	215 – 248	Missing in RS-C; loss of ability to activate splicing but retains splice site switching. 1 PublicationAdd BLAST	34
Mutagenesisⁱ	226 – 248	Missing in RS-B; retains both splice activation and splice site switching activity. 1 PublicationAdd BLAST	23

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6426
Open Targets More...OpenTargetsⁱ	ENSG00000136450
PharmGKBⁱ	PA35696

Polymorphism and mutation databases

BioMutaⁱ	SRSF1
DMDMⁱ	730773

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000081911	2 – 248	Serine/arginine-rich splicing factor 1Add BLAST		247

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	2	PhosphoserineCombined sources	1
Cross-linkⁱ	30	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	38	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	38	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	93	Asymmetric dimethylarginine; alternate1 Publication	1
Modified residueⁱ	93	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	97	Asymmetric dimethylarginine; alternate1 Publication	1
Modified residueⁱ	97	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	109	Asymmetric dimethylarginine; alternate1 Publication	1
Modified residueⁱ	109	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	111	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	133	PhosphoserineCombined sources	1
Modified residueⁱ	179	N6-acetyllysineCombined sources	1
Modified residueⁱ	199	PhosphoserineCombined sources	1
Modified residueⁱ	201	PhosphoserineCombined sources	1
Modified residueⁱ	202	PhosphotyrosineCombined sources	1
Modified residueⁱ	205	PhosphoserineCombined sources	1
Modified residueⁱ	231	PhosphoserineCombined sources	1
Modified residueⁱ	234	PhosphoserineCombined sources	1
Modified residueⁱ	238	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed.5 Publications

Asymmetrically dimethylated at arginines, probably by PRMT1, methylation promotes localization to nuclear speckles.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q07955
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q07955
PaxDbⁱ	Q07955
PeptideAtlas More...PeptideAtlasⁱ	Q07955
PRIDEⁱ	Q07955
ProteomicsDBⁱ	58560 58561 [Q07955-2] 58562 [Q07955-3]
TopDownProteomicsⁱ	Q07955-1 [Q07955-1] Q07955-2 [Q07955-2] Q07955-3 [Q07955-3]

PTM databases

iPTMnetⁱ	Q07955
PhosphoSitePlusⁱ	Q07955
SwissPalmⁱ	Q07955

Miscellaneous databases

PMAP-CutDBⁱ	Q07955

PMAP-CutDBⁱ

Q07955

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136450 Expressed in 241 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_SFRS1
ExpressionAtlasⁱ	Q07955 baseline and differential
Genevisibleⁱ	Q07955 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013073 HPA061301

HPAⁱ

CAB013073
HPA061301

Interactionⁱ

Subunit structureⁱ

Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1. Identified in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction is essential for its sequential and processive phosphorylation by SRPK1. Interacts with NXF1. Interacts with CCNL1, CCNL2 and CDK11B (PubMed:18216018). Interacts with RRP1B (PubMed:23604122).13 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CIR1	Q86X95	3	EBI-398920,EBI-627102
NFYA	P23511	5	EBI-398920,EBI-389739
NXF1	Q9UBU9	5	EBI-398920,EBI-398874
RRP1B	Q14684	6	EBI-398920,EBI-372051
SNRNP70	P08621	3	EBI-398920,EBI-1049228
SRPK1	Q96SB4	3	EBI-398920,EBI-539478
Srpk1	O70551	5	EBI-398920,EBI-593343	From Mus musculus.
Srpk2	O54781	3	EBI-398920,EBI-593325	From Mus musculus.
TRAF5	O00463	2	EBI-398920,EBI-523498
U2AF1	Q01081	4	EBI-398920,EBI-632461

GO - Molecular functionⁱ

DNA topoisomerase binding
Source: CAFA
Inferred from physical interactionⁱ
- 9611241
protein kinase B binding Source: Ensembl
RS domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112324, 184 interactors
CORUMⁱ	Q07955
Database of interacting proteins More...DIPⁱ	DIP-2155N
IntActⁱ	Q07955, 74 interactors
Molecular INTeraction database More...MINTⁱ	Q07955
STRINGⁱ	9606.ENSP00000258962

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	15 – 22	Combined sources	8
Helixⁱ	29 – 36	Combined sources	8
Helixⁱ	37 – 39	Combined sources	3
Beta strandⁱ	42 – 47	Combined sources	6
Beta strandⁱ	50 – 54	Combined sources	5
Beta strandⁱ	57 – 62	Combined sources	6
Helixⁱ	64 – 74	Combined sources	11
Beta strandⁱ	85 – 87	Combined sources	3
Beta strandⁱ	110 – 113	Combined sources	4
Beta strandⁱ	122 – 127	Combined sources	6
Helixⁱ	134 – 141	Combined sources	8
Helixⁱ	142 – 144	Combined sources	3
Beta strandⁱ	147 – 152	Combined sources	6
Beta strandⁱ	158 – 164	Combined sources	7
Helixⁱ	165 – 174	Combined sources	10
Turnⁱ	175 – 177	Combined sources	3
Beta strandⁱ	179 – 181	Combined sources	3
Beta strandⁱ	183 – 185	Combined sources	3
Beta strandⁱ	187 – 189	Combined sources	3
Beta strandⁱ	191 – 197	Combined sources	7
Beta strandⁱ	202 – 204	Combined sources	3
Beta strandⁱ	206 – 208	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q07955
SMRⁱ	Q07955
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q07955

EvolutionaryTraceⁱ

Q07955

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	16 – 91	RRM 1PROSITE-ProRule annotationAdd BLAST		76
Domainⁱ	121 – 195	RRM 2PROSITE-ProRule annotationAdd BLAST		75

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	198 – 247	Interaction with SAFB1Add BLAST		50

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	94 – 113	Gly-rich (hinge region)Add BLAST		20
Compositional biasⁱ	198 – 247	Arg/Ser-rich (RS domain)Add BLAST		50

Domainⁱ

The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation mechanism of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional (C-terminus to N-terminus) phosphorylation reaction in which the RS domain slides through an extended electronegative channel separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the periphery of the active site and guides the directional phosphorylation mechanism. Both the RS domain and an RRM domain are required for nucleocytoplasmic shuttling.1 Publication

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0105 Eukaryota COG0724 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144049
HOVERGENⁱ	HBG002295
InParanoidⁱ	Q07955
KEGG Orthology (KO) More...KOⁱ	K12890
PhylomeDBⁱ	Q07955
TreeFamⁱ	TF106261

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12597 RRM1_SRSF1, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR029538 SRSF1 IPR034520 SRSF1_RRM1
PANTHERⁱ	PTHR43933:SF2 PTHR43933:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform ASF-1 (identifier: Q07955-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR 
        60         70         80         90        100
RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG 
       110        120        130        140        150
GGGGGGAPRG RYGPPSRRSE NRVVVSGLPP SGSWQDLKDH MREAGDVCYA 
       160        170        180        190        200
DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF RSHEGETAYI RVKVDGPRSP 
       210        220        230        240 
SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR HSRSRSRT

Length:248

Mass (Da):27,745

Last modified:January 23, 2007 - v2

Checksum:ⁱC28A0B2F112EA713

GO

Isoform ASF-2 (identifier: Q07955-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
185-248: GETAYIRVKV...PRHSRSRSRT → FCLSNREKLP...NCFVQNGLKC

« Hide

        10         20         30         40         50
MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR 
        60         70         80         90        100
RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG 
       110        120        130        140        150
GGGGGGAPRG RYGPPSRRSE NRVVVSGLPP SGSWQDLKDH MREAGDVCYA 
       160        170        180        190        200
DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF RSHEFCLSNR EKLPTSGLKL 
       210        220        230        240        250
MGPEVQVMED LDLEAVVVAE AVAEATAGVA VTPQGEAEDH HAILPVIADL 
       260        270        280        290 
ALVHKMIGDT FCRTHVVYSF PLFSTIFSFF NSNCFVQNGL KC

Show »

Length:292

Mass (Da):31,999

Checksum:ⁱC9502AC70F373EAC

GO

Isoform ASF-3 (identifier: Q07955-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
185-201: GETAYIRVKVDGPRSPS → VGYTRILFFDQNWIQWS
202-248: Missing.

« Hide

        10         20         30         40         50
MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR 
        60         70         80         90        100
RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG 
       110        120        130        140        150
GGGGGGAPRG RYGPPSRRSE NRVVVSGLPP SGSWQDLKDH MREAGDVCYA 
       160        170        180        190        200
DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF RSHEVGYTRI LFFDQNWIQW 

S

Note: May be due to intron retention.

Show »

Length:201

Mass (Da):22,460

Checksum:ⁱB9AC6495A491613D

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KTL2	J3KTL2_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 1 (Splicing factor, arginine/serine-rich 1 (Splicing factor 2, alternate splicing factor), isoform CRA_g)	SRSF1 SFRS1, hCG_1774411	253	Annotation score:
J3QQV5	J3QQV5_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 1 (Splicing factor, arginine/serine-rich 1 (Splicing factor 2, alternate splicing factor), isoform CRA_f)	SRSF1 SFRS1, hCG_1774411	65	Annotation score:
J3KSR8	J3KSR8_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 1	SRSF1	143	Annotation score:
J3KSW7	J3KSW7_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 1	SRSF1	73	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035488	89	P → S in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_005856	185 – 248	GETAY…SRSRT → FCLSNREKLPTSGLKLMGPE VQVMEDLDLEAVVVAEAVAE ATAGVAVTPQGEAEDHHAIL PVIADLALVHKMIGDTFCRT HVVYSFPLFSTIFSFFNSNC FVQNGLKC in isoform ASF-2. 1 PublicationAdd BLAST	64
Alternative sequenceⁱVSP_005857	185 – 201	GETAY…PRSPS → VGYTRILFFDQNWIQWS in isoform ASF-3. 1 PublicationAdd BLAST	17
Alternative sequenceⁱVSP_005858	202 – 248	Missing in isoform ASF-3. 1 PublicationAdd BLAST	47

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M72709 mRNA Translation: AAA35565.1 M72709 mRNA Translation: AAA35564.1 M69040 mRNA Translation: AAA03476.1 AB062124 mRNA Translation: BAB93456.1 AK312781 mRNA Translation: BAG35644.1 CH471109 Genomic DNA Translation: EAW94485.1 CH471109 Genomic DNA Translation: EAW94486.1 BC010264 mRNA Translation: AAH10264.1 BC033785 mRNA Translation: AAH33785.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11600.1 [Q07955-1] CCDS58580.1 [Q07955-3]
PIRⁱ	A40040 B40040 C40040
NCBI Reference Sequences More...RefSeqⁱ	NP_001071634.1, NM_001078166.1 [Q07955-3] NP_008855.1, NM_006924.4 [Q07955-1]
UniGeneⁱ	Hs.68714 Hs.710026 Hs.744140

Genome annotation databases

Ensemblⁱ	ENST00000258962; ENSP00000258962; ENSG00000136450 [Q07955-1] ENST00000581979; ENSP00000463223; ENSG00000136450 [Q07955-3] ENST00000582730; ENSP00000462215; ENSG00000136450 [Q07955-3]
GeneIDⁱ	6426
KEGGⁱ	hsa:6426
UCSC genome browser More...UCSCⁱ	uc002ivi.4 human [Q07955-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07955	Serine/arginine-rich splicing factor 1		BOVIN		248	UniRef100_Q07955
Serine/arginine-rich splicing factor 1	)	MOUSE		248
Serine/arginine-rich splicing factor 1		PIG		248
SRSF1 isoform 1		PANTR		248
Serine/arginine-rich splicing factor 1 isoform 1		CALJA		248
+41
Q07955-3	SRSF1 isoform 4		PANTR		201	UniRef100_Q07955-3
Splicing factor, arginine/serine-rich 1 (Splicing factor 2, alternate splicing factor) variant (Fragment)		HUMAN		233
SRSF1 isoform 4		PONAB		201

Protein	Similar proteins		Species	Score	Length	Source
Q07955	Serine/arginine-rich splicing factor 1		BOVIN		248	UniRef90_Q07955
Serine/arginine-rich splicing factor 1	)	MOUSE		248
Serine/arginine-rich splicing factor 1		PIG		248
SRSF1 isoform 1		PANTR		248
Serine/arginine-rich splicing factor 1 isoform 1		CALJA		248
+45
Q07955-2	Uncharacterized protein		MACMU		292	UniRef90_Q07955-2
Serine and arginine rich splicing factor 1		MONDO		292
Splicing factor, arginine/serine-rich 1		HETGA		292
Q07955-3	SRSF1 isoform 4		PANTR		201	UniRef90_Q07955-3
Splicing factor, arginine/serine-rich 1 (Splicing factor 2, alternate splicing factor) variant (Fragment)		HUMAN		233
SRSF1 isoform 4		PONAB		201
Uncharacterized protein (Fragment)		MACMU		231
Serine/arginine-rich splicing factor 1 isoform 2		CALJA		201
+1

Protein	Similar proteins		Species	Score	Length	Source
Q07955	Serine/arginine-rich splicing factor 1		BOVIN		248	UniRef50_Q07955
Serine/arginine-rich splicing factor 1	)	MOUSE		248
Serine/arginine-rich splicing factor 1		PIG		248
SRSF1 isoform 1		PANTR		248
Serine/arginine-rich splicing factor 1 isoform 1		CALJA		248
+47
Q07955-2	Serine/arginine-rich splicing factor 1		XENTR		267	UniRef50_Q07955-2
Serine/arginine-rich splicing factor 1B		DANRE		245
Serine/arginine-rich splicing factor 1		PONAB		248
Uncharacterized protein		MACMU		292
Serine and arginine rich splicing factor 1		MONDO		292
+222
Q07955-3	SRSF1 isoform 4		PANTR		201	UniRef50_Q07955-3
Splicing factor, arginine/serine-rich 1 (Splicing factor 2, alternate splicing factor) variant (Fragment)		HUMAN		233
SRSF1 isoform 4		PONAB		201
Uncharacterized protein (Fragment)		MACMU		231
Serine/arginine-rich splicing factor 1 isoform 2		CALJA		201
+93

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M72709 mRNA Translation: AAA35565.1 M72709 mRNA Translation: AAA35564.1 M69040 mRNA Translation: AAA03476.1 AB062124 mRNA Translation: BAB93456.1 AK312781 mRNA Translation: BAG35644.1 CH471109 Genomic DNA Translation: EAW94485.1 CH471109 Genomic DNA Translation: EAW94486.1 BC010264 mRNA Translation: AAH10264.1 BC033785 mRNA Translation: AAH33785.1
CCDSⁱ	CCDS11600.1 [Q07955-1] CCDS58580.1 [Q07955-3]
PIRⁱ	A40040 B40040 C40040
RefSeqⁱ	NP_001071634.1, NM_001078166.1 [Q07955-3] NP_008855.1, NM_006924.4 [Q07955-1]
UniGeneⁱ	Hs.68714 Hs.710026 Hs.744140

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X4A	NMR	-	A	1-96	[»]
	2M7S	NMR	-	A	106-195	[»]
	2M8D	NMR	-	B	107-196	[»]
	2O3D	NMR	-	A	107-215	[»]
	3BEG	X-ray	2.90	B	105-219	[»]
	4C0O	X-ray	2.56	C/D	106-230	[»]
ProteinModelPortalⁱ	Q07955
SMRⁱ	Q07955
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112324, 184 interactors
CORUMⁱ	Q07955
DIPⁱ	DIP-2155N
IntActⁱ	Q07955, 74 interactors
MINTⁱ	Q07955
STRINGⁱ	9606.ENSP00000258962

PTM databases

iPTMnetⁱ	Q07955
PhosphoSitePlusⁱ	Q07955
SwissPalmⁱ	Q07955

Polymorphism and mutation databases

BioMutaⁱ	SRSF1
DMDMⁱ	730773

Proteomic databases

EPDⁱ	Q07955
MaxQBⁱ	Q07955
PaxDbⁱ	Q07955
PeptideAtlasⁱ	Q07955
PRIDEⁱ	Q07955
ProteomicsDBⁱ	58560 58561 [Q07955-2] 58562 [Q07955-3]
TopDownProteomicsⁱ	Q07955-1 [Q07955-1] Q07955-2 [Q07955-2] Q07955-3 [Q07955-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6426
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000258962; ENSP00000258962; ENSG00000136450 [Q07955-1] ENST00000581979; ENSP00000463223; ENSG00000136450 [Q07955-3] ENST00000582730; ENSP00000462215; ENSG00000136450 [Q07955-3]
GeneIDⁱ	6426
KEGGⁱ	hsa:6426
UCSCⁱ	uc002ivi.4 human [Q07955-1]

Organism-specific databases

CTDⁱ	6426
DisGeNETⁱ	6426
EuPathDBⁱ	HostDB:ENSG00000136450.12
GeneCardsⁱ	SRSF1
H-InvDBⁱ	HIX0173551
HGNCⁱ	HGNC:10780 SRSF1
HPAⁱ	CAB013073 HPA061301
MIMⁱ	600812 gene
neXtProtⁱ	NX_Q07955
OpenTargetsⁱ	ENSG00000136450
PharmGKBⁱ	PA35696
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0105 Eukaryota COG0724 LUCA
GeneTreeⁱ	ENSGT00910000144049
HOVERGENⁱ	HBG002295
InParanoidⁱ	Q07955
KOⁱ	K12890
PhylomeDBⁱ	Q07955
TreeFamⁱ	TF106261

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	Q07955

Miscellaneous databases

ChiTaRSⁱ	SRSF1 human
EvolutionaryTraceⁱ	Q07955
GeneWikiⁱ	ASF/SF2
GenomeRNAiⁱ	6426
PMAP-CutDBⁱ	Q07955
Protein Ontology More...PROⁱ	PR:Q07955
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136450 Expressed in 241 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_SFRS1
ExpressionAtlasⁱ	Q07955 baseline and differential
Genevisibleⁱ	Q07955 HS

Family and domain databases

CDDⁱ	cd12597 RRM1_SRSF1, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR029538 SRSF1 IPR034520 SRSF1_RRM1
PANTHERⁱ	PTHR43933:SF2 PTHR43933:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRSF1_HUMAN
Accessionⁱ	Q07955Primary (citable) accession number: Q07955 Secondary accession number(s): B2R6Z7, D3DTZ3, Q13809
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 223 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q07955 (SRSF1_HUMAN)

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Serine/arginine-rich splicing factor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Nucleus

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Keywords - Cellular componenti

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Phylogenomic databases

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Natural variant

Alternative sequence

Sequence databases

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Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ