UniProtKB - Q07951 (POC3_YEAST)
Protein
Proteasome chaperone 3
Gene
IRC25
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in 20S proteasome assembly, facilitating the alpha-ring formation.2 Publications
Miscellaneous
Present with 1820 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- chaperone-mediated protein complex assembly Source: SGD
- nuclear-transcribed mRNA catabolic process, non-stop decay Source: SGD
- proteasome assembly Source: SGD
Keywordsi
Molecular function | Chaperone |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome chaperone 3Alternative name(s): Increased recombination centers protein 25 |
Gene namesi | Name:IRC25 Synonyms:DMP2, POC3 Ordered Locus Names:YLR021W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YLR021W |
SGDi | S000004011, IRC25 |
Subcellular locationi
Nucleus
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
- protein-containing complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247202 | 1 – 179 | Proteasome chaperone 3Add BLAST | 179 |
Proteomic databases
MaxQBi | Q07951 |
PaxDbi | Q07951 |
PRIDEi | Q07951 |
Interactioni
Subunit structurei
Component of the 20S proteasome chaperone.
Forms a heterodimer with POC4 that binds to proteasome precursors.
Interacts with POP2.
2 PublicationsBinary interactionsi
Q07951
With | #Exp. | IntAct |
---|---|---|
POC4 [Q12245] | 12 | EBI-31959,EBI-2343020 |
Protein-protein interaction databases
BioGRIDi | 31295, 273 interactors |
DIPi | DIP-4747N |
IntActi | Q07951, 4 interactors |
MINTi | Q07951 |
STRINGi | 4932.YLR021W |
Miscellaneous databases
RNActi | Q07951, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q07951 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q07951 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PSMG3 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S42X, Eukaryota |
HOGENOMi | CLU_133914_0_0_1 |
InParanoidi | Q07951 |
OMAi | SNDMKLP |
Family and domain databases
InterProi | View protein in InterPro IPR018854, Psome_chaperone_3/4 |
Pfami | View protein in Pfam PF10448, POC3_POC4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q07951-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISYEFQTHL PKGKDSSLNA SSENKELYVQ ATHFNNTILL QIRLNGEMDS
60 70 80 90 100
TYEVSSKGLN PILDINVPLA GNLGNTGGDY DDEEEEFVRD HLSDYQVVTK
110 120 130 140 150
LGDSADPKVP VVCVQIAELY RRVILPEVSG TMAQDNMQFS LLISMSSKIW
160 170
RATKEQSADD NDFGKLVFVL KCIKDMYAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73193 Genomic DNA Translation: CAA97544.1 AY558201 Genomic DNA Translation: AAS56527.1 BK006945 Genomic DNA Translation: DAA09339.1 |
PIRi | S64843 |
RefSeqi | NP_013121.1, NM_001181908.1 |
Genome annotation databases
EnsemblFungii | YLR021W_mRNA; YLR021W; YLR021W |
GeneIDi | 850708 |
KEGGi | sce:YLR021W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73193 Genomic DNA Translation: CAA97544.1 AY558201 Genomic DNA Translation: AAS56527.1 BK006945 Genomic DNA Translation: DAA09339.1 |
PIRi | S64843 |
RefSeqi | NP_013121.1, NM_001181908.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Z5B | X-ray | 1.96 | B | 1-179 | [»] | |
2Z5C | X-ray | 2.90 | B/E | 1-179 | [»] | |
SMRi | Q07951 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 31295, 273 interactors |
DIPi | DIP-4747N |
IntActi | Q07951, 4 interactors |
MINTi | Q07951 |
STRINGi | 4932.YLR021W |
Proteomic databases
MaxQBi | Q07951 |
PaxDbi | Q07951 |
PRIDEi | Q07951 |
Genome annotation databases
EnsemblFungii | YLR021W_mRNA; YLR021W; YLR021W |
GeneIDi | 850708 |
KEGGi | sce:YLR021W |
Organism-specific databases
EuPathDBi | FungiDB:YLR021W |
SGDi | S000004011, IRC25 |
Phylogenomic databases
eggNOGi | ENOG502S42X, Eukaryota |
HOGENOMi | CLU_133914_0_0_1 |
InParanoidi | Q07951 |
OMAi | SNDMKLP |
Miscellaneous databases
EvolutionaryTracei | Q07951 |
PROi | PR:Q07951 |
RNActi | Q07951, protein |
Family and domain databases
InterProi | View protein in InterPro IPR018854, Psome_chaperone_3/4 |
Pfami | View protein in Pfam PF10448, POC3_POC4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | POC3_YEAST | |
Accessioni | Q07951Primary (citable) accession number: Q07951 Secondary accession number(s): D6VY23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD