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Protein

Activated CDC42 kinase 1

Gene

TNK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370).12 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation5 Publications
ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactori

Mg2+3 Publications

Activity regulationi

Inhibited by AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine), which suppresses activating phosphorylation at Tyr-284. Repressed by dasatinib.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158ATP1
Active sitei252Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi132 – 140ATP9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological processEndocytosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
SignaLinkiQ07912
SIGNORiQ07912

Names & Taxonomyi

Protein namesi
Recommended name:
Activated CDC42 kinase 1 (EC:2.7.10.25 Publications, EC:2.7.11.12 Publications)
Short name:
ACK-1
Alternative name(s):
Tyrosine kinase non-receptor protein 2
Gene namesi
Name:TNK2
Synonyms:ACK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000061938.16
HGNCiHGNC:19297 TNK2
MIMi606994 gene
neXtProtiNX_Q07912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Coated pit, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi120L → Q: No effect on autophosphorylation at Y-284. 1 Publication1
Mutagenesisi158K → R: Loss of autophosphorylation at Y-284. 2 Publications1
Mutagenesisi197L → Q: No effect on autophosphorylation at Y-284. 1 Publication1
Mutagenesisi365V → R: Increased autophosphorylation at Y-284. 1 Publication1
Mutagenesisi487L → F: Constantly active kinase. 1 Publication1

Organism-specific databases

DisGeNETi10188
MalaCardsiTNK2
OpenTargetsiENSG00000061938
Orphaneti391316 Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression
PharmGKBiPA134909759

Chemistry databases

ChEMBLiCHEMBL4599
DrugBankiDB00171 Adenosine triphosphate
DB04367 Debromohymenialdisine
GuidetoPHARMACOLOGYi2246

Polymorphism and mutation databases

BioMutaiTNK2
DMDMi229462980

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000880581 – 1038Activated CDC42 kinase 1Add BLAST1038

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284Phosphotyrosine; by SRC and autocatalysisCombined sources7 Publications1
Modified residuei518Phosphotyrosine1 Publication1
Modified residuei724PhosphoserineCombined sources1
Modified residuei827Phosphotyrosine1 Publication1
Modified residuei839Omega-N-methylarginineBy similarity1
Modified residuei859Phosphotyrosine1 Publication1
Modified residuei872Phosphotyrosine1 Publication1
Modified residuei881PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and is observed during association with clathrin-coated pits.7 Publications
Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ07912
MaxQBiQ07912
PaxDbiQ07912
PeptideAtlasiQ07912
PRIDEiQ07912
ProteomicsDBi58556
58557 [Q07912-2]
58558 [Q07912-3]

PTM databases

GlyConnecti989
iPTMnetiQ07912
PhosphoSitePlusiQ07912

Expressioni

Tissue specificityi

The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in prostate cancers during the progressive stages.3 Publications

Gene expression databases

BgeeiENSG00000061938 Expressed in 220 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_TNK2
ExpressionAtlasiQ07912 baseline and differential
GenevisibleiQ07912 HS

Organism-specific databases

HPAiHPA041954

Interactioni

Subunit structurei

Interacts with NEDD4 (via WW3 domain). NEDD4L and EGF promote association with NEDD4 (By similarity). Homodimer. Interacts with AR, CDC42, WWASL and WWOX. Interacts with CSPG4 (activated). Interacts with MERTK (activated); stimulates autophosphorylation. May interact (phosphorylated) with HSP90AB1; maintains kinase activity. Interacts with NPHP1. Interacts with SNX9 (via SH3 domain). Interacts with SRC (via SH2 and SH3 domain). Interacts with EGFR, and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with BCAR1/p130cas via SH3 domains. Forms complexes with GRB2 and numerous receptor tyrosine kinases (RTK) including LTK, AXL or PDGFRL, in which GRB2 promotes RTK recruitment by TNK2.By similarity15 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115485, 88 interactors
CORUMiQ07912
DIPiDIP-33858N
IntActiQ07912, 38 interactors
MINTiQ07912
STRINGi9606.ENSP00000371341

Chemistry databases

BindingDBiQ07912

Structurei

Secondary structure

11038
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ07912
SMRiQ07912
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07912

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 385Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini388 – 448SH3PROSITE-ProRule annotationAdd BLAST61
Domaini454 – 466CRIBAdd BLAST13
Domaini958 – 996UBAAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 110SAM-like domainAdd BLAST110
Regioni623 – 652Required for interaction with SRC1 PublicationAdd BLAST30
Regioni632 – 635Required for interaction with NEDD4By similarity4
Regioni733 – 876EBD domainBy similarityAdd BLAST144

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi577 – 958Pro-richAdd BLAST382

Domaini

The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR.By similarity
The SAM-like domain is necessary for NEDD4-mediated ubiquitination. Promotes membrane localization and dimerization to allow for autophosphorylation.1 Publication
The UBA domain binds both poly- and mono-ubiquitin.1 Publication

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG0199 Eukaryota
ENOG410XPRC LUCA
GeneTreeiENSGT00760000118799
HOGENOMiHOG000168225
HOVERGENiHBG100429
InParanoidiQ07912
KOiK08886
OMAiPQRGCPG
OrthoDBiEOG091G03HT
PhylomeDBiQ07912
TreeFamiTF316643

Family and domain databases

Gene3Di4.10.680.10, 1 hit
InterProiView protein in InterPro
IPR030220 Ack1
IPR037085 Cdc42-bd-like_dom_sf
IPR015116 Cdc42_binding_dom-like
IPR011009 Kinase-like_dom_sf
IPR021619 Mig-6
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR14254:SF4 PTHR14254:SF4, 1 hit
PfamiView protein in Pfam
PF09027 GTPase_binding, 1 hit
PF11555 Inhibitor_Mig-6, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50002 SH3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG
60 70 80 90 100
MGRPGQRRLW EAVKRRKALC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK
110 120 130 140 150
TSPAPGGPAG EGPLQSLTCL IGEKDLRLLE KLGDGSFGVV RRGEWDAPSG
160 170 180 190 200
KTVSVAVKCL KPDVLSQPEA MDDFIREVNA MHSLDHRNLI RLYGVVLTPP
210 220 230 240 250
MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM GYLESKRFIH
260 270 280 290 300
RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE
310 320 330 340 350
SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL
360 370 380 390 400
PRPEDCPQDI YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE
410 420 430 440 450
EPDKLHIQMN DVITVIEGRA ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS
460 470 480 490 500
AQDISQPLQN SFIHTGHGDS DPRHCWGFPD RIDELYLGNP MDPPDLLSVE
510 520 530 540 550
LSTSRPPQHL GGVKKPTYDP VSEDQDPLSS DFKRLGLRKP GLPRGLWLAK
560 570 580 590 600
PSARVPGTKA SRGSGAEVTL IDFGEEPVVP ALRPCAPSLA QLAMDACSLL
610 620 630 640 650
DETPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEICSI
660 670 680 690 700
NSTLVGAGVP AGPSQGQTNY AFVPEQARPP PPLEDNLFLP PQGGGKPPSS
710 720 730 740 750
AQTAEIFQAL QQECMRQLQA PAGSPAPSPS PGGDDKPQVP PRVPIPPRPT
760 770 780 790 800
RPHVQLSPAP PGEEETSQWP GPASPPRVPP REPLSPQGSR TPSPLVPPGS
810 820 830 840 850
SPLPPRLSSS PGKTMPTTQS FASDPKYATP QVIQAPGPRA GPCILPIVRD
860 870 880 890 900
GKKVSSTHYY LLPERPSYLE RYQRFLREAQ SPEEPTPLPV PLLLPPPSTP
910 920 930 940 950
APAAPTATVR PMPQAALDPK ANFSTNNSNP GARPPPPRAT ARLPQRGCPG
960 970 980 990 1000
DGPEAGRPAD KIQMAMVHGV TTEECQAALQ CHGWSVQRAA QYLKVEQLFG
1010 1020 1030
LGLRPRGECH KVLEMFDWNL EQAGCHLLGS WGPAHHKR
Length:1,038
Mass (Da):114,569
Last modified:May 5, 2009 - v3
Checksum:i74A1980665BC3E6B
GO
Isoform 2 (identifier: Q07912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     485-528: LYLGNPMDPP...DPVSEDQDPL → CPFSAFSPGH...HPVSSRTKGL
     529-1038: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:528
Mass (Da):60,062
Checksum:i6CE378AE9D186C20
GO
Isoform 3 (identifier: Q07912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLEARPPRTQGSDAAGAAAGRGLRALLLSLTAAAGIWGSMGERSAYQRLAGGEEGPQRLGGGRM
     514-514: K → KREPPPRPPQPAFFTQ
     965-994: Missing.

Note: No experimental confirmation available.
Show »
Length:1,086
Mass (Da):119,349
Checksum:i6FC37F9EFDF69D5E
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1X3C9J1X3_HUMAN
Activated CDC42 kinase 1
TNK2
1,040Annotation score:
H7BZZ3H7BZZ3_HUMAN
Activated CDC42 kinase 1
TNK2
290Annotation score:
H0Y5H7H0Y5H7_HUMAN
Activated CDC42 kinase 1
TNK2
607Annotation score:
H7C412H7C412_HUMAN
Activated CDC42 kinase 1
TNK2
200Annotation score:
H7C343H7C343_HUMAN
Activated CDC42 kinase 1
TNK2
143Annotation score:
H7BZM8H7BZM8_HUMAN
Activated CDC42 kinase 1
TNK2
242Annotation score:
C9JDG3C9JDG3_HUMAN
Activated CDC42 kinase 1
TNK2
97Annotation score:
F8WER3F8WER3_HUMAN
Activated CDC42 kinase 1
TNK2
86Annotation score:
C9JIR5C9JIR5_HUMAN
Activated CDC42 kinase 1
TNK2
143Annotation score:

Sequence cautioni

The sequence AAH08884 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138G → V in AAH08884 (PubMed:15489334).Curated1
Sequence conflicti304 – 352TRTFS…ERLPR → PPWRDISASSSTQFPHAVPC FPTSLLAKLLLRHSVPASSR EIKLVSILC in AAH08884 (PubMed:15489334).CuratedAdd BLAST49
Sequence conflicti353 – 1038Missing in AAH08884 (PubMed:15489334).CuratedAdd BLAST686
Sequence conflicti586A → P in AAA53570 (PubMed:8497321).Curated1
Sequence conflicti722Missing in AAA53570 (PubMed:8497321).Curated1
Sequence conflicti838 – 840PRA → AG in AAA53570 (PubMed:8497321).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03279234R → L in a lung adenocarcinoma sample; somatic mutation; increased autophosphorylation at Y-284; increased function in phosphorylation of peptide substrates; no effect on subcellular localization to perinuclear region. 2 Publications1
Natural variantiVAR_03279371K → R1 PublicationCorresponds to variant dbSNP:rs56036945Ensembl.1
Natural variantiVAR_03279499R → Q in an ovarian mucinous carcinoma sample; somatic mutation; increased autophosphorylation at Y-284; increased function in phosphorylation of peptide substrates and WASP; no effect on subcellular localization to perinuclear region. 2 PublicationsCorresponds to variant dbSNP:rs113498671Ensembl.1
Natural variantiVAR_03279599R → W1 PublicationCorresponds to variant dbSNP:rs3747673Ensembl.1
Natural variantiVAR_032796152T → M1 PublicationCorresponds to variant dbSNP:rs56161912Ensembl.1
Natural variantiVAR_032797346E → K in an ovarian endometrioid cancer sample; somatic mutation; undergoes autoactivation and causes phosphorylation on Y-284 leading to activation of AKT1; increased autophosphorylation at Y-284; increased function in phosphorylation of peptide substrates and WASP; no effect on catalytic activity itself as the purified kinase domain has activity in vitro comparable to wild-type protein; no effect on subcellular localization to perinuclear region. 3 PublicationsCorresponds to variant dbSNP:rs970946035Ensembl.1
Natural variantiVAR_032798409M → I in a gastric adenocarcinoma sample; somatic mutation; increased autophosphorylation at Y-284; increased function in phosphorylation of peptide substrates and WASP; no effect on subcellular localization to perinuclear region. 2 Publications1
Natural variantiVAR_032799507P → S1 PublicationCorresponds to variant dbSNP:rs35759128Ensembl.1
Natural variantiVAR_076966638V → M Found in patients with childhood-onset epilepsy; unknown pathological significance; loss of interaction with NEDD4 and NEDD4L; increased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs201407161EnsemblClinVar.1
Natural variantiVAR_032800725P → L2 PublicationsCorresponds to variant dbSNP:rs56260729EnsemblClinVar.1
Natural variantiVAR_032801748R → Q1 PublicationCorresponds to variant dbSNP:rs57872314Ensembl.1
Natural variantiVAR_057115802P → L. Corresponds to variant dbSNP:rs3749333Ensembl.1
Natural variantiVAR_0328021038R → H1 PublicationCorresponds to variant dbSNP:rs13433937EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0372841M → MLEARPPRTQGSDAAGAAAG RGLRALLLSLTAAAGIWGSM GERSAYQRLAGGEEGPQRLG GGRM in isoform 3. 1 Publication1
Alternative sequenceiVSP_008655485 – 528LYLGN…DQDPL → CPFSAFSPGHPPAETCGQVL WTGRREACASDPRLHPVSSR TKGL in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_037285514K → KREPPPRPPQPAFFTQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_008656529 – 1038Missing in isoform 2. 1 PublicationAdd BLAST510
Alternative sequenceiVSP_037286965 – 994Missing in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13738 mRNA Translation: AAA53570.2
AK131539 mRNA Translation: BAD18675.1
AC124944 Genomic DNA No translation available.
BC008884 mRNA Translation: AAH08884.1 Sequence problems.
BC028164 mRNA Translation: AAH28164.1
CCDSiCCDS33927.1 [Q07912-3]
CCDS33928.1 [Q07912-1]
PIRiS33596
RefSeqiNP_001010938.1, NM_001010938.1 [Q07912-3]
NP_001294975.1, NM_001308046.1
NP_005772.3, NM_005781.4 [Q07912-1]
UniGeneiHs.518513

Genome annotation databases

EnsembliENST00000333602; ENSP00000329425; ENSG00000061938 [Q07912-1]
ENST00000381916; ENSP00000371341; ENSG00000061938 [Q07912-3]
ENST00000439230; ENSP00000395588; ENSG00000061938 [Q07912-2]
GeneIDi10188
KEGGihsa:10188
UCSCiuc003fvt.2 human [Q07912-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13738 mRNA Translation: AAA53570.2
AK131539 mRNA Translation: BAD18675.1
AC124944 Genomic DNA No translation available.
BC008884 mRNA Translation: AAH08884.1 Sequence problems.
BC028164 mRNA Translation: AAH28164.1
CCDSiCCDS33927.1 [Q07912-3]
CCDS33928.1 [Q07912-1]
PIRiS33596
RefSeqiNP_001010938.1, NM_001010938.1 [Q07912-3]
NP_001294975.1, NM_001308046.1
NP_005772.3, NM_005781.4 [Q07912-1]
UniGeneiHs.518513

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CF4NMR-B448-489[»]
1U46X-ray2.00A/B109-395[»]
1U4DX-ray2.10A/B109-395[»]
1U54X-ray2.80A/B109-395[»]
3EQPX-ray2.30A/B117-392[»]
3EQRX-ray2.00A/B117-392[»]
4EWHX-ray2.50A/B117-391[»]
4HZRX-ray1.31A/B115-389[»]
4HZSX-ray3.23A/B/C/D115-453[»]
4ID7X-ray3.00A117-389[»]
ProteinModelPortaliQ07912
SMRiQ07912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115485, 88 interactors
CORUMiQ07912
DIPiDIP-33858N
IntActiQ07912, 38 interactors
MINTiQ07912
STRINGi9606.ENSP00000371341

Chemistry databases

BindingDBiQ07912
ChEMBLiCHEMBL4599
DrugBankiDB00171 Adenosine triphosphate
DB04367 Debromohymenialdisine
GuidetoPHARMACOLOGYi2246

PTM databases

GlyConnecti989
iPTMnetiQ07912
PhosphoSitePlusiQ07912

Polymorphism and mutation databases

BioMutaiTNK2
DMDMi229462980

Proteomic databases

EPDiQ07912
MaxQBiQ07912
PaxDbiQ07912
PeptideAtlasiQ07912
PRIDEiQ07912
ProteomicsDBi58556
58557 [Q07912-2]
58558 [Q07912-3]

Protocols and materials databases

DNASUi10188
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333602; ENSP00000329425; ENSG00000061938 [Q07912-1]
ENST00000381916; ENSP00000371341; ENSG00000061938 [Q07912-3]
ENST00000439230; ENSP00000395588; ENSG00000061938 [Q07912-2]
GeneIDi10188
KEGGihsa:10188
UCSCiuc003fvt.2 human [Q07912-1]

Organism-specific databases

CTDi10188
DisGeNETi10188
EuPathDBiHostDB:ENSG00000061938.16
GeneCardsiTNK2
H-InvDBiHIX0003961
HGNCiHGNC:19297 TNK2
HPAiHPA041954
MalaCardsiTNK2
MIMi606994 gene
neXtProtiNX_Q07912
OpenTargetsiENSG00000061938
Orphaneti391316 Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression
PharmGKBiPA134909759
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0199 Eukaryota
ENOG410XPRC LUCA
GeneTreeiENSGT00760000118799
HOGENOMiHOG000168225
HOVERGENiHBG100429
InParanoidiQ07912
KOiK08886
OMAiPQRGCPG
OrthoDBiEOG091G03HT
PhylomeDBiQ07912
TreeFamiTF316643

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
SignaLinkiQ07912
SIGNORiQ07912

Miscellaneous databases

ChiTaRSiTNK2 human
EvolutionaryTraceiQ07912
GeneWikiiTNK2
GenomeRNAii10188
PROiPR:Q07912
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000061938 Expressed in 220 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_TNK2
ExpressionAtlasiQ07912 baseline and differential
GenevisibleiQ07912 HS

Family and domain databases

Gene3Di4.10.680.10, 1 hit
InterProiView protein in InterPro
IPR030220 Ack1
IPR037085 Cdc42-bd-like_dom_sf
IPR015116 Cdc42_binding_dom-like
IPR011009 Kinase-like_dom_sf
IPR021619 Mig-6
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR14254:SF4 PTHR14254:SF4, 1 hit
PfamiView protein in Pfam
PF09027 GTPase_binding, 1 hit
PF11555 Inhibitor_Mig-6, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACK1_HUMAN
AccessioniPrimary (citable) accession number: Q07912
Secondary accession number(s): Q6ZMQ0, Q8N6U7, Q96H59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 5, 2009
Last modified: October 10, 2018
This is version 198 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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