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UniProtKB - Q07890 (SOS2_HUMAN)
Protein
Son of sevenless homolog 2
Gene
SOS2
Organism
Homo sapiens (Human)
Status
Functioni
Promotes the exchange of Ras-bound GDP by GTP.
By similarityGO - Molecular functioni
- DNA binding Source: InterPro
- guanyl-nucleotide exchange factor activity Source: GO_Central
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- B cell homeostasis Source: Ensembl
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of small GTPase mediated signal transduction Source: Ensembl
- Ras protein signal transduction Source: GO_Central
- regulation of pro-B cell differentiation Source: Ensembl
- regulation of T cell differentiation in thymus Source: Ensembl
- regulation of T cell proliferation Source: Ensembl
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | Q07890 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-416482, G alpha (12/13) signalling events R-HSA-428540, Activation of RAC1 R-HSA-8983432, Interleukin-15 signaling R-HSA-9013149, RAC1 GTPase cycle |
SignaLinki | Q07890 |
SIGNORi | Q07890 |
Names & Taxonomyi
Protein namesi | Recommended name: Son of sevenless homolog 2Short name: SOS-2 |
Gene namesi | Name:SOS2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11188, SOS2 |
MIMi | 601247, gene |
neXtProti | NX_Q07890 |
VEuPathDBi | HostDB:ENSG00000100485 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: GO_Central
Pathology & Biotechi
Involvement in diseasei
Noonan syndrome 9 (NS9)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075686 | 267 | M → K in NS9. 1 PublicationCorresponds to variant dbSNP:rs797045167EnsemblClinVar. | 1 | |
Natural variantiVAR_075687 | 310 | N → K in NS9; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_075688 | 334 | R → H in NS9; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373233749Ensembl. | 1 | |
Natural variantiVAR_075689 | 376 | T → S in NS9. 1 PublicationCorresponds to variant dbSNP:rs869320687EnsemblClinVar. | 1 | |
Natural variantiVAR_075692 | 1092 | P → L in NS9; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1442962879EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6655 |
GeneReviewsi | SOS2 |
MalaCardsi | SOS2 |
MIMi | 616559, phenotype |
OpenTargetsi | ENSG00000100485 |
Orphaneti | 648, Noonan syndrome |
PharmGKBi | PA36025 |
Miscellaneous databases
Pharosi | Q07890, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4524041 |
Genetic variation databases
BioMutai | SOS2 |
DMDMi | 223634694 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068896 | 1 – 1332 | Son of sevenless homolog 2Add BLAST | 1332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1321 | Asymmetric dimethylarginineBy similarity | 1 |
Keywords - PTMi
MethylationProteomic databases
CPTACi | CPTAC-1553 |
EPDi | Q07890 |
jPOSTi | Q07890 |
MassIVEi | Q07890 |
MaxQBi | Q07890 |
PaxDbi | Q07890 |
PeptideAtlasi | Q07890 |
PRIDEi | Q07890 |
ProteomicsDBi | 58555 [Q07890-1] 7192 |
PTM databases
iPTMneti | Q07890 |
PhosphoSitePlusi | Q07890 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100485, Expressed in biceps brachii and 256 other tissues |
ExpressionAtlasi | Q07890, baseline and differential |
Genevisiblei | Q07890, HS |
Organism-specific databases
HPAi | ENSG00000100485, Low tissue specificity |
Interactioni
Binary interactionsi
Q07890
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 112538, 42 interactors |
IntActi | Q07890, 33 interactors |
MINTi | Q07890 |
STRINGi | 9606.ENSP00000216373 |
Miscellaneous databases
RNActi | Q07890, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q07890 |
SMRi | Q07890 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 198 – 388 | DHPROSITE-ProRule annotationAdd BLAST | 191 | |
Domaini | 442 – 546 | PHPROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 595 – 739 | N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST | 145 | |
Domaini | 778 – 1017 | Ras-GEFPROSITE-ProRule annotationAdd BLAST | 240 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1018 – 1061 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 1076 – 1096 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1142 – 1332 | DisorderedSequence analysisAdd BLAST | 191 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1034 – 1054 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1151 – 1165 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1173 – 1189 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1197 – 1225 | Pro residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1286 – 1301 | Pro residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | KOG3417, Eukaryota |
GeneTreei | ENSGT00940000158324 |
HOGENOMi | CLU_002744_0_0_1 |
InParanoidi | Q07890 |
OMAi | PPPFEWH |
OrthoDBi | 576110at2759 |
PhylomeDBi | Q07890 |
TreeFami | TF317296 |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.20.10, 1 hit 1.10.840.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF00169, PH, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48065, SSF48065, 1 hit SSF48366, SSF48366, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q07890-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE
60 70 80 90 100
LIFQLLNKLC MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLLLPVDKI HPSLKEVLGY KVDYHVSLYI VAVLEYISAD ILKLAGNYVF
160 170 180 190 200
NIRHYEISQQ DIKVSMCADK VLMDMFDQDD IGLVSLCEDE PSSSGELNYY
210 220 230 240 250
DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI EKIFSNISDI
260 270 280 290 300
HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI
310 320 330 340 350
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH
360 370 380 390 400
YFELLKQLKA CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD
410 420 430 440 450
PVCPFYSHQL RSKHLAIKKM NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR
460 470 480 490 500
IGAKHERHIF LFDGLMISCK PNHGQTRLPG YSSAEYRLKE KFVMRKIQIC
510 520 530 540 550
DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI SLHYRSTLDR
560 570 580 590 600
MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK
610 620 630 640 650
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE
660 670 680 690 700
PEPTDADKLA IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY
710 720 730 740 750
DFERDLELLE RLESFISSVR GKAMKKWVES IAKIIRRKKQ AQANGVSHNI
760 770 780 790 800
TFESPPPPIE WHISKPGQFE TFDLMTLHPI EIARQLTLLE SDLYRKVQPS
810 820 830 840 850
ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA ENFEERVAVL
860 870 880 890 900
SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD
910 920 930 940 950
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG
960 970 980 990 1000
KDLINFSKRR KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE
1010 1020 1030 1040 1050
KEFTDYLFNK SLEIEPRNCK QPPRFPRKST FSLKSPGIRP NTGRHGSTSG
1060 1070 1080 1090 1100
TLRGHPTPLE REPCKISFSR IAETELESTV SAPTSPNTPS TPPVSASSDL
1110 1120 1130 1140 1150
SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS EEPLIPPPLP
1160 1170 1180 1190 1200
PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL
1210 1220 1230 1240 1250
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR
1260 1270 1280 1290 1300
DISTCPNSPS TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP
1310 1320 1330
HLPKLPPKTY KRELSHPPLY RLPLLENAET PQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X277 | A0A087X277_HUMAN | Son of sevenless homolog 2 | SOS2 | 419 | Annotation score: | ||
G3V5W3 | G3V5W3_HUMAN | Son of sevenless homolog 2 | SOS2 | 70 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | E → V in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 192 | S → C in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 239 – 240 | DI → VY in AAA35914 (PubMed:8493579).Curated | 2 | |
Sequence conflicti | 381 | L → H in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 482 | S → T in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 687 | I → V in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 696 | E → D in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 699 | F → Y in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 778 | H → D in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 861 | Q → R in AAA91852 (Ref. 5) Curated | 1 | |
Sequence conflicti | 948 | K → R in AAA35914 (PubMed:8493579).Curated | 1 | |
Sequence conflicti | 999 | S → C in AAA91852 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1032 | S → E in AAA91852 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1042 | T → A in AAA91852 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1112 – 1114 | CGS → LC in AAA91852 (Ref. 5) Curated | 3 | |
Sequence conflicti | 1159 | A → G in AAA91852 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1296 | Q → E in AAA91852 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075686 | 267 | M → K in NS9. 1 PublicationCorresponds to variant dbSNP:rs797045167EnsemblClinVar. | 1 | |
Natural variantiVAR_075687 | 310 | N → K in NS9; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_075688 | 334 | R → H in NS9; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373233749Ensembl. | 1 | |
Natural variantiVAR_075689 | 376 | T → S in NS9. 1 PublicationCorresponds to variant dbSNP:rs869320687EnsemblClinVar. | 1 | |
Natural variantiVAR_075690 | 449 | T → A1 PublicationCorresponds to variant dbSNP:rs768547025Ensembl. | 1 | |
Natural variantiVAR_054327 | 483 | S → N. Corresponds to variant dbSNP:rs17122201EnsemblClinVar. | 1 | |
Natural variantiVAR_054328 | 508 | H → Y. Corresponds to variant dbSNP:rs8010237Ensembl. | 1 | |
Natural variantiVAR_034441 | 672 | L → I. Corresponds to variant dbSNP:rs34139502EnsemblClinVar. | 1 | |
Natural variantiVAR_075691 | 952 | D → N1 PublicationCorresponds to variant dbSNP:rs200387871EnsemblClinVar. | 1 | |
Natural variantiVAR_075692 | 1092 | P → L in NS9; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1442962879EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054492 | 324 – 356 | Missing in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13858 mRNA Translation: AAA35914.1 AL109758 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65727.1 CH471078 Genomic DNA Translation: EAW65728.1 BC143367 mRNA Translation: AAI43368.1 BC117261 mRNA Translation: AAI17262.1 L20686 mRNA Translation: AAA91852.1 |
CCDSi | CCDS9697.1 [Q07890-1] |
RefSeqi | NP_008870.2, NM_006939.3 [Q07890-1] |
Genome annotation databases
Ensembli | ENST00000216373.10; ENSP00000216373.5; ENSG00000100485.12 ENST00000543680.5; ENSP00000445328.1; ENSG00000100485.12 [Q07890-2] |
GeneIDi | 6655 |
KEGGi | hsa:6655 |
MANE-Selecti | ENST00000216373.10; ENSP00000216373.5; NM_006939.4; NP_008870.2 |
UCSCi | uc001wxs.5, human [Q07890-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Son of sevenless entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13858 mRNA Translation: AAA35914.1 AL109758 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65727.1 CH471078 Genomic DNA Translation: EAW65728.1 BC143367 mRNA Translation: AAI43368.1 BC117261 mRNA Translation: AAI17262.1 L20686 mRNA Translation: AAA91852.1 |
CCDSi | CCDS9697.1 [Q07890-1] |
RefSeqi | NP_008870.2, NM_006939.3 [Q07890-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6EIE | X-ray | 2.72 | A | 562-1047 | [»] | |
AlphaFoldDBi | Q07890 | |||||
SMRi | Q07890 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112538, 42 interactors |
IntActi | Q07890, 33 interactors |
MINTi | Q07890 |
STRINGi | 9606.ENSP00000216373 |
Chemistry databases
ChEMBLi | CHEMBL4524041 |
PTM databases
iPTMneti | Q07890 |
PhosphoSitePlusi | Q07890 |
Genetic variation databases
BioMutai | SOS2 |
DMDMi | 223634694 |
Proteomic databases
CPTACi | CPTAC-1553 |
EPDi | Q07890 |
jPOSTi | Q07890 |
MassIVEi | Q07890 |
MaxQBi | Q07890 |
PaxDbi | Q07890 |
PeptideAtlasi | Q07890 |
PRIDEi | Q07890 |
ProteomicsDBi | 58555 [Q07890-1] 7192 |
Protocols and materials databases
Antibodypediai | 3885, 162 antibodies from 28 providers |
DNASUi | 6655 |
Genome annotation databases
Ensembli | ENST00000216373.10; ENSP00000216373.5; ENSG00000100485.12 ENST00000543680.5; ENSP00000445328.1; ENSG00000100485.12 [Q07890-2] |
GeneIDi | 6655 |
KEGGi | hsa:6655 |
MANE-Selecti | ENST00000216373.10; ENSP00000216373.5; NM_006939.4; NP_008870.2 |
UCSCi | uc001wxs.5, human [Q07890-1] |
Organism-specific databases
CTDi | 6655 |
DisGeNETi | 6655 |
GeneCardsi | SOS2 |
GeneReviewsi | SOS2 |
HGNCi | HGNC:11188, SOS2 |
HPAi | ENSG00000100485, Low tissue specificity |
MalaCardsi | SOS2 |
MIMi | 601247, gene 616559, phenotype |
neXtProti | NX_Q07890 |
OpenTargetsi | ENSG00000100485 |
Orphaneti | 648, Noonan syndrome |
PharmGKBi | PA36025 |
VEuPathDBi | HostDB:ENSG00000100485 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3417, Eukaryota |
GeneTreei | ENSGT00940000158324 |
HOGENOMi | CLU_002744_0_0_1 |
InParanoidi | Q07890 |
OMAi | PPPFEWH |
OrthoDBi | 576110at2759 |
PhylomeDBi | Q07890 |
TreeFami | TF317296 |
Enzyme and pathway databases
PathwayCommonsi | Q07890 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-416482, G alpha (12/13) signalling events R-HSA-428540, Activation of RAC1 R-HSA-8983432, Interleukin-15 signaling R-HSA-9013149, RAC1 GTPase cycle |
SignaLinki | Q07890 |
SIGNORi | Q07890 |
Miscellaneous databases
BioGRID-ORCSi | 6655, 8 hits in 1077 CRISPR screens |
ChiTaRSi | SOS2, human |
GenomeRNAii | 6655 |
Pharosi | Q07890, Tbio |
PROi | PR:Q07890 |
RNActi | Q07890, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100485, Expressed in biceps brachii and 256 other tissues |
ExpressionAtlasi | Q07890, baseline and differential |
Genevisiblei | Q07890, HS |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.20.10, 1 hit 1.10.840.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF00169, PH, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48065, SSF48065, 1 hit SSF48366, SSF48366, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SOS2_HUMAN | |
Accessioni | Q07890Primary (citable) accession number: Q07890 Secondary accession number(s): B7ZKT6 Q17RN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 25, 2022 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references