Peroxisome proliferator-activated receptor alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Differences in the formation of PPARalpha-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration."
    Rodriguez C., Noe V., Cabrero A., Ciudad C.J., Laguna J.C.
    Mol Pharmacol 58:185-193(2000) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates."
    Vu-Dac N., Chopin-Delannoy S., Gervois P., Bonnelye E., Martin G., Fruchart J.C., Laudet V., Staels B.
    J Biol Chem 273:25713-25720(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates."
    Vu-Dac N., Chopin-Delannoy S., Gervois P., Bonnelye E., Martin G., Fruchart J.C., Laudet V., Staels B.
    J Biol Chem 273:25713-25720(1998) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.19

    "Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha."
    Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez De Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D.
    Nature 425:90-93(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION AS RECEPTOR FOR OLEYLETHANOLAMIDE.
• lipid binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.19

    "Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha."
    Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez De Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D.
    Nature 425:90-93(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION AS RECEPTOR FOR OLEYLETHANOLAMIDE.
• MDM2/MDM4 family protein binding Source: Ensembl
• NFAT protein binding Source: Ensembl
• nuclear receptor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.19

    "Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha."
    Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez De Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D.
    Nature 425:90-93(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION AS RECEPTOR FOR OLEYLETHANOLAMIDE.
• phosphatase binding Source: Ensembl
• protein-containing complex binding Source: Ensembl
• protein domain specific binding Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates."
    Vu-Dac N., Chopin-Delannoy S., Gervois P., Bonnelye E., Martin G., Fruchart J.C., Laudet V., Staels B.
    J Biol Chem 273:25713-25720(1998) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II repressing transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: BHF-UCL
• steroid hormone receptor activity Source: BHF-UCLInferred from direct assayⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator binding Source: Ensembl
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-gamma in CD36 Protein Expression and Foam Cell Formation."
    Kotla S., Rao G.N.
    J Biol Chem 290:30306-30320(2015) [PubMed] [Europe PMC] [Abstract]
• ubiquitin conjugating enzyme binding Source: BHF-UCLInferred from physical interactionⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• behavioral response to nicotine Source: Ensembl
• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to starvation Source: ARUK-UCL
• circadian regulation of gene expression Source: UniProtKB
• enamel mineralization Source: Ensembl
• epidermis development Source: Ensembl
• fatty acid metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• heart development Source: Ensembl
• hormone-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• lipid localization Source: Ensembl
• lipoprotein metabolic process Source: Ensembl
• negative regulation of appetite Source: UniProtKB
• negative regulation of blood pressure Source: Ensembl
• negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
• negative regulation of cholesterol storage Source: BHF-UCLInferred from direct assayⁱ
  • "Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways."
    Mei C.L., He P., Cheng B., Liu W., Wang Y.F., Wan J.J.
    Cell Biol Int 33:301-308(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cytokine production involved in inflammatory response Source: ARUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "LncRNA H19/microRNA-675/PPARalpha axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling."
    Liu Y., Xu L., Lu B., Zhao M., Li L., Sun W., Qiu Z., Zhang B.
    Mol Immunol 116:18-28(2019) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glycolytic process Source: BHF-UCLInferred from direct assayⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of hepatocyte apoptotic process Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "LncRNA H19/microRNA-675/PPARalpha axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling."
    Liu Y., Xu L., Lu B., Zhao M., Li L., Sun W., Qiu Z., Zhang B.
    Mol Immunol 116:18-28(2019) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: BHF-UCLInferred from direct assayⁱ
  • "MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation."
    Zhou J., Wang K.C., Wu W., Subramaniam S., Shyy J.Y., Chiu J.J., Li J.Y., Chien S.
    Proc Natl Acad Sci U S A 108:10355-10360(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of leukocyte cell-cell adhesion Source: BHF-UCLInferred from direct assayⁱ
  • "MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation."
    Zhou J., Wang K.C., Wu W., Subramaniam S., Shyy J.Y., Chiu J.J., Li J.Y., Chien S.
    Proc Natl Acad Sci U S A 108:10355-10360(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of macrophage derived foam cell differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways."
    Mei C.L., He P., Cheng B., Liu W., Wang Y.F., Wan J.J.
    Cell Biol Int 33:301-308(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron death Source: Ensembl
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation."
    Zhou J., Wang K.C., Wu W., Subramaniam S., Shyy J.Y., Chiu J.J., Li J.Y., Chien S.
    Proc Natl Acad Sci U S A 108:10355-10360(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein binding Source: Ensembl
• negative regulation of protein kinase B signaling Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "LncRNA H19/microRNA-675/PPARalpha axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling."
    Liu Y., Xu L., Lu B., Zhao M., Li L., Sun W., Qiu Z., Zhang B.
    Mol Immunol 116:18-28(2019) [PubMed] [Europe PMC] [Abstract]
• negative regulation of reactive oxygen species biosynthetic process Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "LncRNA H19/microRNA-675/PPARalpha axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling."
    Liu Y., Xu L., Lu B., Zhao M., Li L., Sun W., Qiu Z., Zhang B.
    Mol Immunol 116:18-28(2019) [PubMed] [Europe PMC] [Abstract]
• negative regulation of sequestering of triglyceride Source: BHF-UCLInferred from direct assayⁱ
  • "PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor."
    Haraguchi G., Kobayashi Y., Brown M.L., Tanaka A., Isobe M., Gianturco S.H., Bradley W.A.
    J. Lipid Res. 44:1224-1231(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of signaling receptor activity Source: BHF-UCLInferred from direct assayⁱ
  • "PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor."
    Haraguchi G., Kobayashi Y., Brown M.L., Tanaka A., Isobe M., Gianturco S.H., Bradley W.A.
    J. Lipid Res. 44:1224-1231(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor."
    Haraguchi G., Kobayashi Y., Brown M.L., Tanaka A., Isobe M., Gianturco S.H., Bradley W.A.
    J. Lipid Res. 44:1224-1231(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transforming growth factor beta receptor signaling pathway Source: ARUK-UCLInferred from direct assayⁱ
  • "Overexpression of microRNA-21 mediates Ang II-induced renal fibrosis by activating the TGF-beta1/Smad3 pathway via suppressing PPARalpha."
    Lyu H., Li X., Wu Q., Hao L.
    J Pharmacol Sci 141:70-78(2019) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ATP biosynthetic process Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "LncRNA H19/microRNA-675/PPARalpha axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling."
    Liu Y., Xu L., Lu B., Zhao M., Li L., Sun W., Qiu Z., Zhang B.
    Mol Immunol 116:18-28(2019) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid beta-oxidation Source: UniProtKBTraceable author statementⁱ
  • "An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A."
    Napal L., Marrero P.F., Haro D.
    J. Mol. Biol. 354:751-759(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid oxidation Source: BHF-UCL
• positive regulation of gluconeogenesis Source: Ensembl
• positive regulation of lipid biosynthetic process Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway."
    Cui M., Xiao Z., Wang Y., Zheng M., Song T., Cai X., Sun B., Ye L., Zhang X.
    Cancer Res 75:846-857(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.19

    "Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha."
    Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez De Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D.
    Nature 425:90-93(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION AS RECEPTOR FOR OLEYLETHANOLAMIDE.
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of LPCAT3 by LXR."
    Demeure O., Lecerf F., Duby C., Desert C., Ducheix S., Guillou H., Lagarrigue S.
    Gene 470:7-11(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of viral genome replication Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "MicroRNA-141 represses HBV replication by targeting PPARA."
    Hu W., Wang X., Ding X., Li Y., Zhang X., Xie P., Yang J., Wang S.
    PLoS One 7:e34165-e34165(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of cellular ketone metabolic process Source: BHF-UCLInferred from direct assayⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian rhythm Source: UniProtKB
• regulation of fatty acid metabolic process Source: BHF-UCLInferred from direct assayⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of fatty acid transport Source: UniProtKBTraceable author statementⁱ
  • "An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A."
    Napal L., Marrero P.F., Haro D.
    J. Mol. Biol. 354:751-759(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of lipid metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: Ensembl
• response to hypoxia Source: Ensembl
• response to insulin Source: Ensembl
• response to lipid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription initiation from RNA polymerase II promoter Source: Reactome
• wound healing Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• MDM2/MDM4 family protein binding Source: Ensembl
• NFAT protein binding Source: Ensembl
• phosphatase binding Source: Ensembl
• protein domain specific binding Source: Ensembl
• RNA polymerase II repressing transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator binding Source: Ensembl
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-gamma in CD36 Protein Expression and Foam Cell Formation."
    Kotla S., Rao G.N.
    J Biol Chem 290:30306-30320(2015) [PubMed] [Europe PMC] [Abstract]
• ubiquitin conjugating enzyme binding Source: BHF-UCLInferred from physical interactionⁱ
  • "SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR."
    Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
    J Biol Chem 285:5983-5992(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG 
        60         70         80         90        100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI 
       110        120        130        140        150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR 
       160        170        180        190        200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET 
       210        220        230        240        250
ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA 
       260        270        280        290        300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL 
       310        320        330        340        350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP 
       360        370        380        390        400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM 
       410        420        430        440        450
QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT 
       460 
ESDAALHPLL QEIYRDMY                                    

        10         20         30         40         50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG 
        60         70         80         90        100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI 
       110        120        130        140        150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR 
       160        170 
NKCQYCRFHK CLSVGMSHNA FCHT                             

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human variants curated from literature reports
   Index of human variants curated from literature reports
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families
5. Human chromosome 22
   Human chromosome 22: entries, gene names and cross-references to MIM
6. Human entries with genetic variants
   List of human entries with genetic variants