UniProtKB - Q07869 (PPARA_HUMAN)
Peroxisome proliferator-activated receptor alpha
PPARA
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 280 | Synthetic agonist5 Publications | 1 | |
Binding sitei | 314 | Synthetic agonist5 Publications | 1 | |
Sitei | 433 | Essential for heterodimerization with RXRA | 1 | |
Binding sitei | 440 | Synthetic agonist5 Publications | 1 | |
Binding sitei | 464 | Synthetic agonist5 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 99 – 173 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 75 | |
Zinc fingeri | 102 – 122 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 139 – 161 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- drug binding Source: UniProtKB
- lipid binding Source: UniProtKB
- MDM2/MDM4 family protein binding Source: Ensembl
- NFAT protein binding Source: Ensembl
- nuclear receptor activity Source: UniProtKB
- phosphatase binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: BHF-UCL
- steroid hormone receptor activity Source: BHF-UCL
- transcription coactivator binding Source: Ensembl
- transcription factor binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: BHF-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- behavioral response to nicotine Source: Ensembl
- cell differentiation Source: GO_Central
- cellular response to starvation Source: ARUK-UCL
- circadian regulation of gene expression Source: UniProtKB
- enamel mineralization Source: Ensembl
- epidermis development Source: Ensembl
- fatty acid metabolic process Source: GO_Central
- heart development Source: Ensembl
- hormone-mediated signaling pathway Source: GO_Central
- lipid localization Source: Ensembl
- lipoprotein metabolic process Source: Ensembl
- negative regulation of appetite Source: UniProtKB
- negative regulation of blood pressure Source: Ensembl
- negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
- negative regulation of cholesterol storage Source: BHF-UCL
- negative regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
- negative regulation of glycolytic process Source: BHF-UCL
- negative regulation of hepatocyte apoptotic process Source: ARUK-UCL
- negative regulation of inflammatory response Source: BHF-UCL
- negative regulation of leukocyte cell-cell adhesion Source: BHF-UCL
- negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
- negative regulation of neuron death Source: Ensembl
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of protein binding Source: Ensembl
- negative regulation of protein kinase B signaling Source: ARUK-UCL
- negative regulation of reactive oxygen species biosynthetic process Source: ARUK-UCL
- negative regulation of sequestering of triglyceride Source: BHF-UCL
- negative regulation of signaling receptor activity Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of transforming growth factor beta receptor signaling pathway Source: ARUK-UCL
- positive regulation of ATP biosynthetic process Source: ARUK-UCL
- positive regulation of fatty acid beta-oxidation Source: UniProtKB
- positive regulation of fatty acid metabolic process Source: GO_Central
- positive regulation of fatty acid oxidation Source: BHF-UCL
- positive regulation of gluconeogenesis Source: Ensembl
- positive regulation of lipid biosynthetic process Source: ARUK-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of viral genome replication Source: ARUK-UCL
- regulation of cellular ketone metabolic process Source: BHF-UCL
- regulation of circadian rhythm Source: UniProtKB
- regulation of fatty acid metabolic process Source: BHF-UCL
- regulation of fatty acid transport Source: UniProtKB
- regulation of lipid metabolic process Source: GO_Central
- response to ethanol Source: Ensembl
- response to hypoxia Source: Ensembl
- response to insulin Source: Ensembl
- response to lipid Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: Reactome
- wound healing Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q07869 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781, PPARA activates gene expression R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-4090294, SUMOylation of intracellular receptors |
SignaLinki | Q07869 |
SIGNORi | Q07869 |
Chemistry databases
SwissLipidsi | SLP:000001644 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisome proliferator-activated receptor alphaShort name: PPAR-alpha Alternative name(s): Nuclear receptor subfamily 1 group C member 1 |
Gene namesi | Name:PPARA Synonyms:NR1C1, PPAR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9232, PPARA |
MIMi | 170998, gene+phenotype |
neXtProti | NX_Q07869 |
VEuPathDBi | HostDB:ENSG00000186951.16 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 122 | C → G: Prevents DNA binding but no effect on heterodimerization with RXRA. 1 Publication | 1 | |
Mutagenesisi | 304 | D → A: Reduced heterodimerization with RXRA. Reduced DNA binding. 1 Publication | 1 | |
Mutagenesisi | 370 | L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication | 1 | |
Mutagenesisi | 391 | L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication | 1 | |
Mutagenesisi | 422 | L → R: No effect on heterodimerization with RXRA nor on DNA binding and transactivation activity. 1 Publication | 1 | |
Mutagenesisi | 431 | A → T: No effect on heterodimerization with RXRA nor on DNA binding. 1 Publication | 1 | |
Mutagenesisi | 433 | L → R: Abolishes heterodimerization with RXRA, DNA binding and transactivation activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5465 |
MIMi | 170998, gene+phenotype |
OpenTargetsi | ENSG00000186951 |
PharmGKBi | PA280 |
Miscellaneous databases
Pharosi | Q07869, Tclin |
Chemistry databases
ChEMBLi | CHEMBL239 |
DrugBanki | DB08915, Aleglitazar DB00132, alpha-Linolenic acid DB01118, Amiodarone DB04557, Arachidonic Acid DB01393, Bezafibrate DB04519, Caprylic acid DB05416, Cardarine DB09064, Ciprofibrate DB09006, Clinofibrate DB00636, Clofibrate DB09213, Dexibuprofen DB03756, Doconexent DB05187, Elafibranor DB06521, Ertiprotafib DB01039, Fenofibrate DB13873, Fenofibric acid DB00573, Fenoprofen DB13961, Fish oil DB02266, Flufenamic acid DB01241, Gemfibrozil DB07215, GW-590735 DB01050, Ibuprofen DB00159, Icosapent DB07724, Indeglitazar DB00328, Indomethacin DB12007, Isoflavone DB03017, Lauric acid DB12961, Leukotriene B4 DB06510, Muraglitazar DB08231, Myristic acid DB11605, Myrrh DB01890, N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide DB04224, Oleic Acid DB11133, Omega-3 fatty acids DB03796, Palmitic Acid DB02746, Phthalic Acid DB01708, Prasterone DB06533, Ragaglitazar DB04971, Reglitazar DB02709, Resveratrol DB00412, Rosiglitazone DB09422, Soybean oil DB03193, Stearic acid DB06536, Tesaglitazar DB00197, Troglitazone DB00313, Valproic acid |
DrugCentrali | Q07869 |
GuidetoPHARMACOLOGYi | 593 |
Genetic variation databases
BioMutai | PPARA |
DMDMi | 3041727 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053481 | 1 – 468 | Peroxisome proliferator-activated receptor alphaAdd BLAST | 468 |
Proteomic databases
MassIVEi | Q07869 |
PaxDbi | Q07869 |
PeptideAtlasi | Q07869 |
PRIDEi | Q07869 |
ProteomicsDBi | 58553 [Q07869-1] |
PTM databases
iPTMneti | Q07869 |
PhosphoSitePlusi | Q07869 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000186951, Expressed in liver and 225 other tissues |
ExpressionAtlasi | Q07869, baseline and differential |
Genevisiblei | Q07869, HS |
Organism-specific databases
HPAi | ENSG00000186951, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity.
Interacts with NCOA3 coactivator.
Interacts with CITED2; the interaction stimulates its transcriptional activity.
Also interacts with PPARBP in vitro.
Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6.
Interacts with ASXL1 and ASXL2.
Interacts with PER2.
Interacts with SIRT1; the interaction seems to be modulated by NAD+ levels (PubMed:24043310).
Interacts with CRY1 and CRY2 (By similarity).
By similarity12 PublicationsBinary interactionsi
Hide detailsQ07869
Isoform 1 [Q07869-1]
With | #Exp. | IntAct |
---|---|---|
NR1H2 - isoform 1 [P55055-1] | 2 | EBI-21458428,EBI-21458417 |
NR1H3 [Q13133] | 2 | EBI-21458428,EBI-781356 |
GO - Molecular functioni
- MDM2/MDM4 family protein binding Source: Ensembl
- NFAT protein binding Source: Ensembl
- phosphatase binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- transcription coactivator binding Source: Ensembl
- transcription factor binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111461, 70 interactors |
DIPi | DIP-241N |
IntActi | Q07869, 37 interactors |
MINTi | Q07869 |
STRINGi | 9606.ENSP00000385523 |
Chemistry databases
BindingDBi | Q07869 |
Miscellaneous databases
RNActi | Q07869, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q07869 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q07869 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 239 – 466 | NR LBDPROSITE-ProRule annotationAdd BLAST | 228 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 304 – 433 | Required for heterodimerization with RXRAAdd BLAST | 130 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 102 – 122 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 139 – 161 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157097 |
HOGENOMi | CLU_007368_4_1_1 |
InParanoidi | Q07869 |
OMAi | FSFTEYQ |
PhylomeDBi | Q07869 |
TreeFami | TF316304 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00382 |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003076, PPAR-alpha IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01289, PROXISOMPAAR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG
60 70 80 90 100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI
110 120 130 140 150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR
160 170 180 190 200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET
210 220 230 240 250
ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA
260 270 280 290 300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL
310 320 330 340 350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP
360 370 380 390 400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM
410 420 430 440 450
QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT
460
ESDAALHPLL QEIYRDMY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0QYX1 | B0QYX1_HUMAN | Peroxisome proliferator-activated r... | PPARA SC22CB-5E3.5-003 | 133 | Annotation score: | ||
B0QYX2 | B0QYX2_HUMAN | Peroxisome proliferator-activated r... | PPARA SC22CB-5E3.5-009 | 69 | Annotation score: | ||
Q86SF0 | Q86SF0_HUMAN | Peroxisome proliferator-activated r... | PPARA SC22CB-5E3.5-002 | 9 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | T → M in CAA68898 (PubMed:8993548).Curated | 1 | |
Sequence conflicti | 123 | K → M in CAA68898 (PubMed:8993548).Curated | 1 | |
Sequence conflicti | 296 | G → A in AAA36468 (PubMed:7684926).Curated | 1 | |
Sequence conflicti | 444 | V → A in CAA68898 (PubMed:8993548).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016110 | 127 | R → Q. Corresponds to variant dbSNP:rs1800204Ensembl. | 1 | |
Natural variantiVAR_016111 | 162 | L → V1 PublicationCorresponds to variant dbSNP:rs1800206EnsemblClinVar. | 1 | |
Natural variantiVAR_016112 | 227 | V → A. Corresponds to variant dbSNP:rs1800234EnsemblClinVar. | 1 | |
Natural variantiVAR_016113 | 268 | A → V1 PublicationCorresponds to variant dbSNP:rs1042311Ensembl. | 1 | |
Natural variantiVAR_016114 | 304 | D → N. Corresponds to variant dbSNP:rs1800242Ensembl. | 1 | |
Natural variantiVAR_050578 | 395 | G → R. Corresponds to variant dbSNP:rs2229245Ensembl. | 1 | |
Natural variantiVAR_016115 | 409 | R → T. Corresponds to variant dbSNP:rs1800243Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047571 | 171 – 174 | IRFG → FCHT in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_047572 | 175 – 468 | Missing in isoform 2. 1 PublicationAdd BLAST | 294 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000262735; ENSP00000262735; ENSG00000186951 [Q07869-1] ENST00000402126; ENSP00000385246; ENSG00000186951 [Q07869-1] ENST00000407236; ENSP00000385523; ENSG00000186951 [Q07869-1] |
GeneIDi | 5465 |
KEGGi | hsa:5465 |
UCSCi | uc003bgx.1, human [Q07869-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Peroxisome proliferator-activated receptor entry |
SeattleSNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I7G | X-ray | 2.20 | A | 196-468 | [»] | |
1K7L | X-ray | 2.50 | A/C/E/G | 192-468 | [»] | |
1KKQ | X-ray | 3.00 | A/B/C/D | 200-468 | [»] | |
2NPA | X-ray | 2.30 | A/C | 199-468 | [»] | |
2P54 | X-ray | 1.79 | A | 202-468 | [»] | |
2REW | X-ray | 2.35 | A | 196-468 | [»] | |
2ZNN | X-ray | 2.01 | A | 200-468 | [»] | |
3ET1 | X-ray | 2.50 | A/B | 199-468 | [»] | |
3FEI | X-ray | 2.40 | A | 202-468 | [»] | |
3G8I | X-ray | 2.20 | A | 199-468 | [»] | |
3KDT | X-ray | 2.70 | A/B | 196-468 | [»] | |
3KDU | X-ray | 2.07 | A/B | 196-468 | [»] | |
3SP6 | X-ray | 2.21 | A | 196-468 | [»] | |
3VI8 | X-ray | 1.75 | A | 200-468 | [»] | |
4BCR | X-ray | 2.50 | A/B | 195-468 | [»] | |
4CI4 | X-ray | 2.30 | A | 195-468 | [»] | |
5AZT | X-ray | 3.45 | A/B | 201-468 | [»] | |
5HYK | X-ray | 1.83 | A | 200-468 | [»] | |
6KXX | X-ray | 1.95 | A | 200-468 | [»] | |
6KXY | X-ray | 2.00 | A | 200-468 | [»] | |
6L96 | X-ray | 3.20 | A/B | 194-468 | [»] | |
SMRi | Q07869 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111461, 70 interactors |
DIPi | DIP-241N |
IntActi | Q07869, 37 interactors |
MINTi | Q07869 |
STRINGi | 9606.ENSP00000385523 |
Chemistry databases
BindingDBi | Q07869 |
ChEMBLi | CHEMBL239 |
DrugBanki | DB08915, Aleglitazar DB00132, alpha-Linolenic acid DB01118, Amiodarone DB04557, Arachidonic Acid DB01393, Bezafibrate DB04519, Caprylic acid DB05416, Cardarine DB09064, Ciprofibrate DB09006, Clinofibrate DB00636, Clofibrate DB09213, Dexibuprofen DB03756, Doconexent DB05187, Elafibranor DB06521, Ertiprotafib DB01039, Fenofibrate DB13873, Fenofibric acid DB00573, Fenoprofen DB13961, Fish oil DB02266, Flufenamic acid DB01241, Gemfibrozil DB07215, GW-590735 DB01050, Ibuprofen DB00159, Icosapent DB07724, Indeglitazar DB00328, Indomethacin DB12007, Isoflavone DB03017, Lauric acid DB12961, Leukotriene B4 DB06510, Muraglitazar DB08231, Myristic acid DB11605, Myrrh DB01890, N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide DB04224, Oleic Acid DB11133, Omega-3 fatty acids DB03796, Palmitic Acid DB02746, Phthalic Acid DB01708, Prasterone DB06533, Ragaglitazar DB04971, Reglitazar DB02709, Resveratrol DB00412, Rosiglitazone DB09422, Soybean oil DB03193, Stearic acid DB06536, Tesaglitazar DB00197, Troglitazone DB00313, Valproic acid |
DrugCentrali | Q07869 |
GuidetoPHARMACOLOGYi | 593 |
SwissLipidsi | SLP:000001644 |
PTM databases
iPTMneti | Q07869 |
PhosphoSitePlusi | Q07869 |
Genetic variation databases
BioMutai | PPARA |
DMDMi | 3041727 |
Proteomic databases
MassIVEi | Q07869 |
PaxDbi | Q07869 |
PeptideAtlasi | Q07869 |
PRIDEi | Q07869 |
ProteomicsDBi | 58553 [Q07869-1] |
Protocols and materials databases
Antibodypediai | 13823, 763 antibodies |
DNASUi | 5465 |
Genome annotation databases
Ensembli | ENST00000262735; ENSP00000262735; ENSG00000186951 [Q07869-1] ENST00000402126; ENSP00000385246; ENSG00000186951 [Q07869-1] ENST00000407236; ENSP00000385523; ENSG00000186951 [Q07869-1] |
GeneIDi | 5465 |
KEGGi | hsa:5465 |
UCSCi | uc003bgx.1, human [Q07869-1] |
Organism-specific databases
CTDi | 5465 |
DisGeNETi | 5465 |
GeneCardsi | PPARA |
HGNCi | HGNC:9232, PPARA |
HPAi | ENSG00000186951, Low tissue specificity |
MIMi | 170998, gene+phenotype |
neXtProti | NX_Q07869 |
OpenTargetsi | ENSG00000186951 |
PharmGKBi | PA280 |
VEuPathDBi | HostDB:ENSG00000186951.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157097 |
HOGENOMi | CLU_007368_4_1_1 |
InParanoidi | Q07869 |
OMAi | FSFTEYQ |
PhylomeDBi | Q07869 |
TreeFami | TF316304 |
Enzyme and pathway databases
PathwayCommonsi | Q07869 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781, PPARA activates gene expression R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-4090294, SUMOylation of intracellular receptors |
SignaLinki | Q07869 |
SIGNORi | Q07869 |
Miscellaneous databases
BioGRID-ORCSi | 5465, 9 hits in 898 CRISPR screens |
ChiTaRSi | PPARA, human |
EvolutionaryTracei | Q07869 |
GeneWikii | Peroxisome_proliferator-activated_receptor_alpha |
GenomeRNAii | 5465 |
Pharosi | Q07869, Tclin |
PROi | PR:Q07869 |
RNActi | Q07869, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186951, Expressed in liver and 225 other tissues |
ExpressionAtlasi | Q07869, baseline and differential |
Genevisiblei | Q07869, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00382 |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003076, PPAR-alpha IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01289, PROXISOMPAAR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPARA_HUMAN | |
Accessioni | Q07869Primary (citable) accession number: Q07869 Secondary accession number(s): B0G0X3 Q9Y3N1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 236 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants