PPARA

Functionⁱ

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.5 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	280	Synthetic agonist5 Publications	1
Binding siteⁱ	314	Synthetic agonist5 Publications	1
Siteⁱ	433	Essential for heterodimerization with RXRA	1
Binding siteⁱ	440	Synthetic agonist5 Publications	1
Binding siteⁱ	464	Synthetic agonist5 Publications	1

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	99 – 173	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	75
Zinc fingerⁱ	102 – 122	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	139 – 161	NR C4-typePROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 10860941
DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19955185
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
drug binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12955147
fatty acid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12955147
MDM2/MDM4 family protein binding Source: Ensembl
NFAT protein binding Source: Ensembl
nuclear receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12955147
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatase binding Source: Ensembl
protein-containing complex binding Source: Ensembl
protein domain specific binding Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 9748239
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 9748239
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9748239
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19955185
sequence-specific DNA binding Source: BHF-UCL
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19955185
transcription coactivator binding Source: Ensembl
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26504087
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin conjugating enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19955185
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral response to nicotine Source: Ensembl
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
circadian regulation of gene expression Source: UniProtKB
enamel mineralization Source: Ensembl
epidermis development Source: Ensembl
fatty acid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fatty acid transport
Source: UniProtKB
Traceable author statementⁱ
- 16271724
heart development Source: Ensembl
hormone-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 7684926
- 9792666
lipoprotein metabolic process Source: Ensembl
multicellular organism development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of appetite Source: UniProtKB
negative regulation of blood pressure Source: Ensembl
negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
negative regulation of cholesterol storage
Source: BHF-UCL
Inferred from direct assayⁱ
- 19114110
negative regulation of glycolytic process
Source: BHF-UCL
Inferred by curatorⁱ
- 19955185
negative regulation of inflammatory response
Source: BHF-UCL
Inferred from direct assayⁱ
- 21636785
negative regulation of leukocyte cell-cell adhesion
Source: BHF-UCL
Inferred from direct assayⁱ
- 21636785
negative regulation of macrophage derived foam cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19114110
negative regulation of neuron death Source: Ensembl
negative regulation of pri-miRNA transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 21636785
negative regulation of protein binding Source: Ensembl
negative regulation of receptor biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 12700342
negative regulation of sequestering of triglyceride
Source: BHF-UCL
Inferred from direct assayⁱ
- 12700342
negative regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 12700342
positive regulation of fatty acid beta-oxidation
Source: UniProtKB
Traceable author statementⁱ
- 16271724
positive regulation of fatty acid oxidation Source: BHF-UCL
positive regulation of gluconeogenesis Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12955147
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 19955185
- 20837115
regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
Source: BHF-UCL
Inferred from direct assayⁱ
- 19955185
regulation of circadian rhythm Source: UniProtKB
regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
Source: BHF-UCL
Inferred from direct assayⁱ
- 19955185
regulation of lipid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
Source: BHF-UCL
Inferred from direct assayⁱ
- 19955185
response to hypoxia Source: Ensembl
response to insulin Source: Ensembl
response to lipid
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription initiation from RNA polymerase II promoter Source: Reactome
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Biological rhythms, Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368082 RORA activates gene expression R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400253 Circadian Clock R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkⁱ	Q07869
SIGNORⁱ	Q07869

Chemistry databases

SwissLipidsⁱ	SLP:000001644

SwissLipidsⁱ

SLP:000001644

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxisome proliferator-activated receptor alpha Short name: PPAR-alpha Alternative name(s): Nuclear receptor subfamily 1 group C member 1
Gene namesⁱ	Name:PPARA Synonyms:NR1C1, PPAR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186951.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9232 PPARA
MIMⁱ	170998 gene+phenotype
neXtProtⁱ	NX_Q07869

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	122	C → G: Prevents DNA binding but no effect on heterodimerization with RXRA. 1 Publication	1
Mutagenesisⁱ	304	D → A: Reduced heterodimerization with RXRA. Reduced DNA binding. 1 Publication	1
Mutagenesisⁱ	370	L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication	1
Mutagenesisⁱ	391	L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication	1
Mutagenesisⁱ	422	L → R: No effect on heterodimerization with RXRA nor on DNA binding and transactivation activity. 1 Publication	1
Mutagenesisⁱ	431	A → T: No effect on heterodimerization with RXRA nor on DNA binding. 1 Publication	1
Mutagenesisⁱ	433	L → R: Abolishes heterodimerization with RXRA, DNA binding and transactivation activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5465
MIMⁱ	170998 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000186951
PharmGKBⁱ	PA280

Chemistry databases

ChEMBLⁱ	CHEMBL239
Drug and drug target database More...DrugBankⁱ	DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid DB08915 Aleglitazar DB01393 Bezafibrate DB00636 Clofibrate DB01039 Fenofibrate DB01241 Gemfibrozil DB05187 GFT505 DB00328 Indomethacin DB01708 Prasterone DB04971 Reglixane
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	593

Polymorphism and mutation databases

BioMutaⁱ	PPARA
DMDMⁱ	3041727

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053481	1 – 468	Peroxisome proliferator-activated receptor alphaAdd BLAST		468

Proteomic databases

PaxDbⁱ	Q07869
PeptideAtlas More...PeptideAtlasⁱ	Q07869
PRIDEⁱ	Q07869
ProteomicsDBⁱ	58553

PTM databases

iPTMnetⁱ	Q07869
PhosphoSitePlusⁱ	Q07869

Expressionⁱ

Tissue specificityⁱ

Skeletal muscle, liver, heart and kidney.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000186951 Expressed in 211 organ(s), highest expression level in liver
CleanExⁱ	HS_PPARA
ExpressionAtlasⁱ	Q07869 baseline and differential
Genevisibleⁱ	Q07869 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB075701 HPA058901 HPA067049

HPAⁱ

CAB075701
HPA058901
HPA067049

Interactionⁱ

Subunit structureⁱ

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD⁺ levels (PubMed:24043310).By similarity12 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CHD9	Q3L8U1-3	2	EBI-78615,EBI-960730
GRB2	P62993	3	EBI-78615,EBI-401755
NCOR1	O75376	3	EBI-78615,EBI-347233

GO - Molecular functionⁱ

MDM2/MDM4 family protein binding Source: Ensembl
NFAT protein binding Source: Ensembl
phosphatase binding Source: Ensembl
protein domain specific binding Source: Ensembl
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19955185
transcription coactivator binding Source: Ensembl
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26504087
ubiquitin conjugating enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19955185

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111461, 44 interactors
Database of interacting proteins More...DIPⁱ	DIP-241N
IntActⁱ	Q07869, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q07869
STRINGⁱ	9606.ENSP00000262735

Chemistry databases

BindingDBⁱ

Q07869

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	203 – 217	Combined sources	15
Helixⁱ	222 – 229	Combined sources	8
Beta strandⁱ	233 – 235	Combined sources	3
Beta strandⁱ	239 – 241	Combined sources	3
Helixⁱ	244 – 254	Combined sources	11
Helixⁱ	256 – 259	Combined sources	4
Helixⁱ	263 – 265	Combined sources	3
Helixⁱ	268 – 290	Combined sources	23
Helixⁱ	291 – 293	Combined sources	3
Turnⁱ	295 – 299	Combined sources	5
Helixⁱ	302 – 321	Combined sources	20
Helixⁱ	322 – 324	Combined sources	3
Beta strandⁱ	329 – 332	Combined sources	4
Turnⁱ	333 – 336	Combined sources	4
Beta strandⁱ	337 – 340	Combined sources	4
Helixⁱ	341 – 346	Combined sources	6
Turnⁱ	349 – 351	Combined sources	3
Helixⁱ	352 – 366	Combined sources	15
Helixⁱ	372 – 383	Combined sources	12
Helixⁱ	394 – 415	Combined sources	22
Helixⁱ	422 – 450	Combined sources	29
Beta strandⁱ	453 – 456	Combined sources	4
Helixⁱ	458 – 464	Combined sources	7
Turnⁱ	465 – 467	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q07869
SMRⁱ	Q07869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q07869

EvolutionaryTraceⁱ

Q07869

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	239 – 466	NR LBDPROSITE-ProRule annotationAdd BLAST		228

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	304 – 433	Required for heterodimerization with RXRAAdd BLAST		130

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	102 – 122	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	139 – 161	NR C4-typePROSITE-ProRule annotationAdd BLAST		23

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000261626
HOVERGENⁱ	HBG106004
InParanoidⁱ	Q07869
KEGG Orthology (KO) More...KOⁱ	K07294
OMAⁱ	FSFTEYQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05U8
PhylomeDBⁱ	Q07869
TreeFamⁱ	TF316304

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003074 1Cnucl_rcpt IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003076 PPAR-alpha IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01288 PROXISOMEPAR PR01289 PROXISOMPAAR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q07869-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG 
        60         70         80         90        100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI 
       110        120        130        140        150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR 
       160        170        180        190        200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET 
       210        220        230        240        250
ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA 
       260        270        280        290        300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL 
       310        320        330        340        350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP 
       360        370        380        390        400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM 
       410        420        430        440        450
QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT 
       460 
ESDAALHPLL QEIYRDMY

Length:468

Mass (Da):52,225

Last modified:July 15, 1998 - v2

Checksum:ⁱ850846FD51ADA883

GO

Isoform 2 (identifier: Q07869-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
171-174: IRFG → FCHT
175-468: Missing.

« Hide

        10         20         30         40         50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG 
        60         70         80         90        100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI 
       110        120        130        140        150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR 
       160        170 
NKCQYCRFHK CLSVGMSHNA FCHT

Show »

Length:174

Mass (Da):18,942

Checksum:ⁱ8587321146D06A03

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B0QYX1	B0QYX1_HUMAN	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor alpha	PPARA SC22CB-5E3.5-003	133	Annotation score:
B0QYX2	B0QYX2_HUMAN	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor alpha	PPARA SC22CB-5E3.5-009	69	Annotation score:
Q86SF0	Q86SF0_HUMAN	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor alpha	PPARA SC22CB-5E3.5-002	9	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	71	T → M in CAA68898 (PubMed:8993548).Curated	1
Sequence conflictⁱ	123	K → M in CAA68898 (PubMed:8993548).Curated	1
Sequence conflictⁱ	296	G → A in AAA36468 (PubMed:7684926).Curated	1
Sequence conflictⁱ	444	V → A in CAA68898 (PubMed:8993548).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_016110	127	R → Q. Corresponds to variant dbSNP:rs1800204Ensembl.	1
Natural variantⁱVAR_016111	162	L → V1 PublicationCorresponds to variant dbSNP:rs1800206EnsemblClinVar.	1
Natural variantⁱVAR_016112	227	V → A. Corresponds to variant dbSNP:rs1800234Ensembl.	1
Natural variantⁱVAR_016113	268	A → V1 PublicationCorresponds to variant dbSNP:rs1042311Ensembl.	1
Natural variantⁱVAR_016114	304	D → N. Corresponds to variant dbSNP:rs1800242Ensembl.	1
Natural variantⁱVAR_050578	395	G → R. Corresponds to variant dbSNP:rs2229245Ensembl.	1
Natural variantⁱVAR_016115	409	R → T. Corresponds to variant dbSNP:rs1800243Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047571	171 – 174	IRFG → FCHT in isoform 2. 1 Publication		4
Alternative sequenceⁱVSP_047572	175 – 468	Missing in isoform 2. 1 PublicationAdd BLAST		294

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L02932 mRNA Translation: AAA36468.1 S74349 mRNA Translation: AAB32649.1 Y07619 mRNA Translation: CAA68898.1 AB307690 mRNA Translation: BAH02281.1 EU650667 mRNA Translation: ACD12656.1 EU395809 mRNA Translation: ABY73535.1 CR456547 mRNA Translation: CAG30433.1 AK289821 mRNA Translation: BAF82510.1 CR457435 mRNA Translation: CAG33716.1 AY206718 Genomic DNA Translation: AAO13489.1 AL049856, AL078611 Genomic DNA Translation: CAI22450.1 Z94161 Genomic DNA No translation available. CH471138 Genomic DNA Translation: EAW73402.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33669.1 [Q07869-1]
PIRⁱ	A49289 I56603
NCBI Reference Sequences More...RefSeqⁱ	NP_001001928.1, NM_001001928.2 [Q07869-1] NP_005027.2, NM_005036.4 [Q07869-1] XP_005261712.1, XM_005261655.3 XP_005261713.1, XM_005261656.3 [Q07869-1] XP_006724332.1, XM_006724269.3 XP_006724333.1, XM_006724270.3 [Q07869-1] XP_011528541.1, XM_011530239.2 [Q07869-1] XP_011528542.1, XM_011530240.2 [Q07869-1] XP_011528543.1, XM_011530241.2 [Q07869-1] XP_011528544.1, XM_011530242.2 [Q07869-1] XP_011528545.1, XM_011530243.2 [Q07869-1]
UniGeneⁱ	Hs.103110 Hs.710044

Genome annotation databases

Ensemblⁱ	ENST00000262735; ENSP00000262735; ENSG00000186951 [Q07869-1] ENST00000402126; ENSP00000385246; ENSG00000186951 [Q07869-1] ENST00000407236; ENSP00000385523; ENSG00000186951 [Q07869-1]
GeneIDⁱ	5465
KEGGⁱ	hsa:5465
UCSC genome browser More...UCSCⁱ	uc003bgx.1 human [Q07869-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07869	Peroxisome proliferative activated receptor, alpha, isoform CRA_a		HUMAN		468	UniRef100_Q07869
Peroxisome proliferator activated receptor alpha		GORGO		468
UPI000332EA7F		HUMAN		274

Protein	Similar proteins		Species	Score	Length	Source
Q07869	Peroxisome proliferative activated receptor, alpha, isoform CRA_a		HUMAN		468	UniRef90_Q07869
Peroxisome proliferator activated receptor alpha		GORGO		468
Peroxisome proliferator activated receptor alpha		AILME		472
Peroxisome proliferator-activated receptor alpha		BUBBU		470
Uncharacterized protein		HORSE		470
+73

Protein	Similar proteins		Species	Score	Length	Source
Q07869	Peroxisome proliferator-activated receptor alpha		CANLF		468	UniRef50_Q07869
Peroxisome proliferator-activated receptor alpha		CAVPO		467
Peroxisome proliferator-activated receptor alpha		PHACI		468
Peroxisome proliferator-activated receptor alpha		MOUSE		468
Peroxisome proliferator-activated receptor alpha		RAT		468
+447
Q07869-2	Peroxisome proliferator-activated receptor alpha (Fragment)		ESCRO		197	UniRef50_Q07869-2
PPARA		blackstripe livebearer		204
UPI0008FA756A		CYPCA		186

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Peroxisome proliferator-activated receptor entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L02932 mRNA Translation: AAA36468.1 S74349 mRNA Translation: AAB32649.1 Y07619 mRNA Translation: CAA68898.1 AB307690 mRNA Translation: BAH02281.1 EU650667 mRNA Translation: ACD12656.1 EU395809 mRNA Translation: ABY73535.1 CR456547 mRNA Translation: CAG30433.1 AK289821 mRNA Translation: BAF82510.1 CR457435 mRNA Translation: CAG33716.1 AY206718 Genomic DNA Translation: AAO13489.1 AL049856, AL078611 Genomic DNA Translation: CAI22450.1 Z94161 Genomic DNA No translation available. CH471138 Genomic DNA Translation: EAW73402.1
CCDSⁱ	CCDS33669.1 [Q07869-1]
PIRⁱ	A49289 I56603
RefSeqⁱ	NP_001001928.1, NM_001001928.2 [Q07869-1] NP_005027.2, NM_005036.4 [Q07869-1] XP_005261712.1, XM_005261655.3 XP_005261713.1, XM_005261656.3 [Q07869-1] XP_006724332.1, XM_006724269.3 XP_006724333.1, XM_006724270.3 [Q07869-1] XP_011528541.1, XM_011530239.2 [Q07869-1] XP_011528542.1, XM_011530240.2 [Q07869-1] XP_011528543.1, XM_011530241.2 [Q07869-1] XP_011528544.1, XM_011530242.2 [Q07869-1] XP_011528545.1, XM_011530243.2 [Q07869-1]
UniGeneⁱ	Hs.103110 Hs.710044

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1I7G	X-ray	2.20	A	196-468	[»]
	1K7L	X-ray	2.50	A/C/E/G	192-468	[»]
	1KKQ	X-ray	3.00	A/B/C/D	200-468	[»]
	2NPA	X-ray	2.30	A/C	199-468	[»]
	2P54	X-ray	1.79	A	202-468	[»]
	2REW	X-ray	2.35	A	196-468	[»]
	2ZNN	X-ray	2.01	A	200-468	[»]
	3ET1	X-ray	2.50	A/B	199-468	[»]
	3FEI	X-ray	2.40	A	202-468	[»]
	3G8I	X-ray	2.20	A	199-468	[»]
	3KDT	X-ray	2.70	A/B	196-468	[»]
	3KDU	X-ray	2.07	A/B	196-468	[»]
	3SP6	X-ray	2.21	A	196-468	[»]
	3VI8	X-ray	1.75	A	200-468	[»]
	4BCR	X-ray	2.50	A/B	195-468	[»]
	4CI4	X-ray	2.30	A	195-468	[»]
	5AZT	X-ray	3.45	A/B	201-468	[»]
	5HYK	X-ray	1.83	A	200-468	[»]
ProteinModelPortalⁱ	Q07869
SMRⁱ	Q07869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111461, 44 interactors
DIPⁱ	DIP-241N
IntActⁱ	Q07869, 18 interactors
MINTⁱ	Q07869
STRINGⁱ	9606.ENSP00000262735

Chemistry databases

BindingDBⁱ	Q07869
ChEMBLⁱ	CHEMBL239
DrugBankⁱ	DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid DB08915 Aleglitazar DB01393 Bezafibrate DB00636 Clofibrate DB01039 Fenofibrate DB01241 Gemfibrozil DB05187 GFT505 DB00328 Indomethacin DB01708 Prasterone DB04971 Reglixane
GuidetoPHARMACOLOGYⁱ	593
SwissLipidsⁱ	SLP:000001644

PTM databases

iPTMnetⁱ	Q07869
PhosphoSitePlusⁱ	Q07869

Polymorphism and mutation databases

BioMutaⁱ	PPARA
DMDMⁱ	3041727

Proteomic databases

PaxDbⁱ	Q07869
PeptideAtlasⁱ	Q07869
PRIDEⁱ	Q07869
ProteomicsDBⁱ	58553

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5465
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262735; ENSP00000262735; ENSG00000186951 [Q07869-1] ENST00000402126; ENSP00000385246; ENSG00000186951 [Q07869-1] ENST00000407236; ENSP00000385523; ENSG00000186951 [Q07869-1]
GeneIDⁱ	5465
KEGGⁱ	hsa:5465
UCSCⁱ	uc003bgx.1 human [Q07869-1]

Organism-specific databases

CTDⁱ	5465
DisGeNETⁱ	5465
EuPathDBⁱ	HostDB:ENSG00000186951.16
GeneCardsⁱ	PPARA
HGNCⁱ	HGNC:9232 PPARA
HPAⁱ	CAB075701 HPA058901 HPA067049
MIMⁱ	170998 gene+phenotype
neXtProtⁱ	NX_Q07869
OpenTargetsⁱ	ENSG00000186951
PharmGKBⁱ	PA280
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000261626
HOVERGENⁱ	HBG106004
InParanoidⁱ	Q07869
KOⁱ	K07294
OMAⁱ	FSFTEYQ
OrthoDBⁱ	EOG091G05U8
PhylomeDBⁱ	Q07869
TreeFamⁱ	TF316304

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368082 RORA activates gene expression R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400253 Circadian Clock R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkⁱ	Q07869
SIGNORⁱ	Q07869

Miscellaneous databases

ChiTaRSⁱ	PPARA human
EvolutionaryTraceⁱ	Q07869
GeneWikiⁱ	Peroxisome_proliferator-activated_receptor_alpha
GenomeRNAiⁱ	5465
Protein Ontology More...PROⁱ	PR:Q07869
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186951 Expressed in 211 organ(s), highest expression level in liver
CleanExⁱ	HS_PPARA
ExpressionAtlasⁱ	Q07869 baseline and differential
Genevisibleⁱ	Q07869 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003074 1Cnucl_rcpt IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003076 PPAR-alpha IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01288 PROXISOMEPAR PR01289 PROXISOMPAAR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPARA_HUMAN
Accessionⁱ	Q07869Primary (citable) accession number: Q07869 Secondary accession number(s): B0G0X3 , Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	July 15, 1998
	Last modified:	November 7, 2018
	This is version 219 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q07869 (PPARA_HUMAN)

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Peroxisome proliferator-activated receptor alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ