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UniProtKB - Q07869 (PPARA_HUMAN)

Entry version 240 (23 Feb 2022)
Sequence version 2 (15 Jul 1998)
Previous versions | rss
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Protein

Peroxisome proliferator-activated receptor alpha

Gene

PPARA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei280Indeglitazar; agonistCombined sources1 Publication1
Binding sitei314Indeglitazar; agonistCombined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei433Essential for heterodimerization with RXRA1
Binding sitei464Indeglitazar; agonistCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi99 – 173Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q07869

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-383280, Nuclear Receptor transcription pathway
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-4090294, SUMOylation of intracellular receptors
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707616, Heme signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q07869

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q07869

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.208.1.6, the vitamin d3 receptor (vdr) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001644

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor alpha
Short name:
PPAR-alpha
Alternative name(s):
Nuclear receptor subfamily 1 group C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPARA
Synonyms:NR1C1, PPAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9232, PPARA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		170998, gene+phenotype

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q07869

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi122C → G: Prevents DNA binding but no effect on heterodimerization with RXRA. 1 Publication1
Mutagenesisi304D → A: Reduced heterodimerization with RXRA. Reduced DNA binding. 1 Publication1
Mutagenesisi370L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication1
Mutagenesisi391L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication1
Mutagenesisi422L → R: No effect on heterodimerization with RXRA nor on DNA binding and transactivation activity. 1 Publication1
Mutagenesisi431A → T: No effect on heterodimerization with RXRA nor on DNA binding. 1 Publication1
Mutagenesisi433L → R: Abolishes heterodimerization with RXRA, DNA binding and transactivation activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5465
MIMi170998, gene+phenotype

Open Targets

More...OpenTargetsi		ENSG00000186951

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA280

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q07869, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL239

Drug and drug target database

More...DrugBanki		DB08915, Aleglitazar
DB00132, alpha-Linolenic acid
DB01118, Amiodarone
DB04557, Arachidonic Acid
DB01393, Bezafibrate
DB04519, Caprylic acid
DB05416, Cardarine
DB09064, Ciprofibrate
DB09006, Clinofibrate
DB00636, Clofibrate
DB09213, Dexibuprofen
DB03756, Doconexent
DB05187, Elafibranor
DB06521, Ertiprotafib
DB01039, Fenofibrate
DB13873, Fenofibric acid
DB00573, Fenoprofen
DB13961, Fish oil
DB02266, Flufenamic acid
DB01241, Gemfibrozil
DB07215, GW-590735
DB01050, Ibuprofen
DB00159, Icosapent
DB07724, Indeglitazar
DB00328, Indomethacin
DB12007, Isoflavone
DB03017, Lauric acid
DB12961, Leukotriene B4
DB06510, Muraglitazar
DB08231, Myristic acid
DB11605, Myrrh
DB01890, N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
DB04224, Oleic Acid
DB11133, Omega-3 fatty acids
DB03796, Palmitic Acid
DB02746, Phthalic Acid
DB01708, Prasterone
DB06533, Ragaglitazar
DB04971, Reglitazar
DB02709, Resveratrol
DB00412, Rosiglitazone
DB09422, Soybean oil
DB03193, Stearic acid
DB06536, Tesaglitazar
DB00197, Troglitazone
DB00313, Valproic acid

DrugCentral

More...DrugCentrali		Q07869

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		593

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPARA

Domain mapping of disease mutations (DMDM)

More...DMDMi		3041727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000534811 – 468Peroxisome proliferator-activated receptor alphaAdd BLAST468

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q07869

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q07869

PeptideAtlas

More...PeptideAtlasi		Q07869

PRoteomics IDEntifications database

More...PRIDEi		Q07869

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q07869

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q07869

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by aging.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186951, Expressed in liver and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q07869, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q07869, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186951, Tissue enhanced (tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity.

Interacts with NCOA3 coactivator.

Interacts with CITED2; the interaction stimulates its transcriptional activity.

Also interacts with PPARBP in vitro.

Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6.

Interacts with ASXL1 and ASXL2.

Interacts with PER2.

Interacts with SIRT1; the interaction seems to be modulated by NAD+ levels (PubMed:24043310).

Interacts with CRY1 and CRY2 (By similarity).

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111461, 76 interactors

Database of interacting proteins

More...DIPi		DIP-241N

Protein interaction database and analysis system

More...IntActi		Q07869, 38 interactors

Molecular INTeraction database

More...MINTi		Q07869

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385523

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q07869

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q07869, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q07869

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q07869

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini239 – 466NR LBDPROSITE-ProRule annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni304 – 433Required for heterodimerization with RXRAAdd BLAST130

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3575, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007368_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q07869

Identification of Orthologs from Complete Genome Data

More...OMAi		EMGSIQE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q07869

TreeFam database of animal gene trees

More...TreeFami		TF316304

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.565.10, 1 hit
3.30.50.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00382

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003074, 1Cnucl_rcpt
IPR035500, NHR-like_dom_sf
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR003076, PPAR-alpha
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01288, PROXISOMEPAR
PR01289, PROXISOMPAAR
PR00398, STRDHORMONER
PR00047, STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48508, SSF48508, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG 
        60         70         80         90        100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI 
       110        120        130        140        150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR 
       160        170        180        190        200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET 
       210        220        230        240        250
ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA 
       260        270        280        290        300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL 
       310        320        330        340        350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP 
       360        370        380        390        400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM 
       410        420        430        440        450
QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT 
       460 
ESDAALHPLL QEIYRDMY
Length:468
Mass (Da):52,225
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i850846FD51ADA883
GO
Isoform 2 (identifier: Q07869-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-174: IRFG → FCHT
     175-468: Missing.

Show »
Length:174
Mass (Da):18,942
Checksum:i8587321146D06A03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYX1B0QYX1_HUMAN
Peroxisome proliferator-activated r...
PPARA SC22CB-5E3.5-003
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYX2B0QYX2_HUMAN
Peroxisome proliferator-activated r...
PPARA SC22CB-5E3.5-009
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86SF0Q86SF0_HUMAN
Peroxisome proliferator-activated r...
PPARA SC22CB-5E3.5-002
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71T → M in CAA68898 (PubMed:8993548).Curated1
Sequence conflicti123K → M in CAA68898 (PubMed:8993548).Curated1
Sequence conflicti296G → A in AAA36468 (PubMed:7684926).Curated1
Sequence conflicti444V → A in CAA68898 (PubMed:8993548).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016110127R → Q. Corresponds to variant dbSNP:rs1800204Ensembl.1
Natural variantiVAR_016111162L → V1 PublicationCorresponds to variant dbSNP:rs1800206EnsemblClinVar.1
Natural variantiVAR_016112227V → A. Corresponds to variant dbSNP:rs1800234EnsemblClinVar.1
Natural variantiVAR_016113268A → V1 PublicationCorresponds to variant dbSNP:rs1042311Ensembl.1
Natural variantiVAR_016114304D → N. Corresponds to variant dbSNP:rs1800242Ensembl.1
Natural variantiVAR_050578395G → R. Corresponds to variant dbSNP:rs2229245Ensembl.1
Natural variantiVAR_016115409R → T. Corresponds to variant dbSNP:rs1800243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047571171 – 174IRFG → FCHT in isoform 2. 1 Publication4
Alternative sequenceiVSP_047572175 – 468Missing in isoform 2. 1 PublicationAdd BLAST294

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L02932 mRNA Translation: AAA36468.1
S74349 mRNA Translation: AAB32649.1
Y07619 mRNA Translation: CAA68898.1
AB307690 mRNA Translation: BAH02281.1
EU650667 mRNA Translation: ACD12656.1
EU395809 mRNA Translation: ABY73535.1
CR456547 mRNA Translation: CAG30433.1
AK289821 mRNA Translation: BAF82510.1
CR457435 mRNA Translation: CAG33716.1
AY206718 Genomic DNA Translation: AAO13489.1
AL049856, AL078611 Genomic DNA Translation: CAI22450.1
Z94161 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73402.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33669.1 [Q07869-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A49289
I56603

NCBI Reference Sequences

More...RefSeqi		NP_001001928.1, NM_001001928.2 [Q07869-1]
NP_005027.2, NM_005036.4 [Q07869-1]
XP_005261712.1, XM_005261655.3
XP_005261713.1, XM_005261656.3 [Q07869-1]
XP_006724332.1, XM_006724269.3
XP_006724333.1, XM_006724270.3 [Q07869-1]
XP_011528541.1, XM_011530239.2 [Q07869-1]
XP_011528542.1, XM_011530240.2 [Q07869-1]
XP_011528543.1, XM_011530241.2 [Q07869-1]
XP_011528544.1, XM_011530242.2 [Q07869-1]
XP_011528545.1, XM_011530243.2 [Q07869-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262735; ENSP00000262735; ENSG00000186951
ENST00000402126; ENSP00000385246; ENSG00000186951
ENST00000407236; ENSP00000385523; ENSG00000186951

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5465

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5465

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000407236.6; ENSP00000385523.1; NM_005036.6; NP_005027.2

UCSC genome browser

More...UCSCi		uc003bgx.1, human [Q07869-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Peroxisome proliferator-activated receptor entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02932 mRNA Translation: AAA36468.1
S74349 mRNA Translation: AAB32649.1
Y07619 mRNA Translation: CAA68898.1
AB307690 mRNA Translation: BAH02281.1
EU650667 mRNA Translation: ACD12656.1
EU395809 mRNA Translation: ABY73535.1
CR456547 mRNA Translation: CAG30433.1
AK289821 mRNA Translation: BAF82510.1
CR457435 mRNA Translation: CAG33716.1
AY206718 Genomic DNA Translation: AAO13489.1
AL049856, AL078611 Genomic DNA Translation: CAI22450.1
Z94161 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73402.1
CCDSiCCDS33669.1 [Q07869-1]
PIRiA49289
I56603
RefSeqiNP_001001928.1, NM_001001928.2 [Q07869-1]
NP_005027.2, NM_005036.4 [Q07869-1]
XP_005261712.1, XM_005261655.3
XP_005261713.1, XM_005261656.3 [Q07869-1]
XP_006724332.1, XM_006724269.3
XP_006724333.1, XM_006724270.3 [Q07869-1]
XP_011528541.1, XM_011530239.2 [Q07869-1]
XP_011528542.1, XM_011530240.2 [Q07869-1]
XP_011528543.1, XM_011530241.2 [Q07869-1]
XP_011528544.1, XM_011530242.2 [Q07869-1]
XP_011528545.1, XM_011530243.2 [Q07869-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I7GX-ray2.20A196-468[»]
1K7LX-ray2.50A/C/E/G192-468[»]
1KKQX-ray3.00A/B/C/D200-468[»]
2NPAX-ray2.30A/C199-468[»]
2P54X-ray1.79A202-468[»]
2REWX-ray2.35A196-468[»]
2ZNNX-ray2.01A200-468[»]
3ET1X-ray2.50A/B199-468[»]
3FEIX-ray2.40A202-468[»]
3G8IX-ray2.20A199-468[»]
3KDTX-ray2.70A/B196-468[»]
3KDUX-ray2.07A/B196-468[»]
3SP6X-ray2.21A196-468[»]
3VI8X-ray1.75A200-468[»]
4BCRX-ray2.50A/B195-468[»]
4CI4X-ray2.30A195-468[»]
5AZTX-ray3.45A/B201-468[»]
5HYKX-ray1.83A200-468[»]
6KAXX-ray1.23A200-468[»]
6KAYX-ray1.74A200-468[»]
6KAZX-ray1.48A200-468[»]
6KB0X-ray1.35A200-468[»]
6KB1X-ray1.25A200-468[»]
6KB2X-ray1.95A200-468[»]
6KB3X-ray1.45A200-468[»]
6KB4X-ray1.42A200-468[»]
6KB5X-ray1.95A200-468[»]
6KB6X-ray1.43A200-468[»]
6KB7X-ray2.14A200-468[»]
6KB8X-ray1.47A200-468[»]
6KB9X-ray1.55A200-468[»]
6KBAX-ray1.82A200-468[»]
6KXXX-ray1.95A200-468[»]
6KXYX-ray2.00A200-468[»]
6KYPX-ray2.86A/B200-468[»]
6L36X-ray3.30A/B200-468[»]
6L37X-ray2.91A/B200-468[»]
6L38X-ray2.76A/B200-468[»]
6L96X-ray3.20A/B194-468[»]
6LX4X-ray2.13A/B200-468[»]
6LX5X-ray1.87A/B200-468[»]
6LX6X-ray1.30A200-468[»]
6LX7X-ray1.41A200-468[»]
6LX8X-ray1.54A200-468[»]
6LX9X-ray1.40A200-468[»]
6LXAX-ray1.23A200-468[»]
6LXBX-ray2.36A200-468[»]
6LXCX-ray2.03A200-468[»]
7BPYX-ray2.09A/C200-468[»]
7BPZX-ray2.43A/C200-468[»]
7BQ0X-ray1.77A/C200-468[»]
7BQ1X-ray1.52A200-468[»]
7BQ2X-ray1.52A200-468[»]
7BQ3X-ray1.98A200-468[»]
7BQ4X-ray1.62A200-468[»]
7C6QX-ray2.76A196-468[»]
7E5FX-ray1.79A200-468[»]
7E5GX-ray1.66A200-468[»]
7E5HX-ray1.66A200-468[»]
7E5IX-ray1.58A200-468[»]
SMRiQ07869
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111461, 76 interactors
DIPiDIP-241N
IntActiQ07869, 38 interactors
MINTiQ07869
STRINGi9606.ENSP00000385523

Chemistry databases

BindingDBiQ07869
ChEMBLiCHEMBL239
DrugBankiDB08915, Aleglitazar
DB00132, alpha-Linolenic acid
DB01118, Amiodarone
DB04557, Arachidonic Acid
DB01393, Bezafibrate
DB04519, Caprylic acid
DB05416, Cardarine
DB09064, Ciprofibrate
DB09006, Clinofibrate
DB00636, Clofibrate
DB09213, Dexibuprofen
DB03756, Doconexent
DB05187, Elafibranor
DB06521, Ertiprotafib
DB01039, Fenofibrate
DB13873, Fenofibric acid
DB00573, Fenoprofen
DB13961, Fish oil
DB02266, Flufenamic acid
DB01241, Gemfibrozil
DB07215, GW-590735
DB01050, Ibuprofen
DB00159, Icosapent
DB07724, Indeglitazar
DB00328, Indomethacin
DB12007, Isoflavone
DB03017, Lauric acid
DB12961, Leukotriene B4
DB06510, Muraglitazar
DB08231, Myristic acid
DB11605, Myrrh
DB01890, N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
DB04224, Oleic Acid
DB11133, Omega-3 fatty acids
DB03796, Palmitic Acid
DB02746, Phthalic Acid
DB01708, Prasterone
DB06533, Ragaglitazar
DB04971, Reglitazar
DB02709, Resveratrol
DB00412, Rosiglitazone
DB09422, Soybean oil
DB03193, Stearic acid
DB06536, Tesaglitazar
DB00197, Troglitazone
DB00313, Valproic acid
DrugCentraliQ07869
GuidetoPHARMACOLOGYi593
SwissLipidsiSLP:000001644

Protein family/group databases

TCDBi9.B.208.1.6, the vitamin d3 receptor (vdr) family

PTM databases

iPTMnetiQ07869
PhosphoSitePlusiQ07869

Genetic variation databases

BioMutaiPPARA
DMDMi3041727

Proteomic databases

MassIVEiQ07869
PaxDbiQ07869
PeptideAtlasiQ07869
PRIDEiQ07869

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13823, 789 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		5465

Genome annotation databases

EnsembliENST00000262735; ENSP00000262735; ENSG00000186951
ENST00000402126; ENSP00000385246; ENSG00000186951
ENST00000407236; ENSP00000385523; ENSG00000186951
GeneIDi5465
KEGGihsa:5465
MANE-SelectiENST00000407236.6; ENSP00000385523.1; NM_005036.6; NP_005027.2
UCSCiuc003bgx.1, human [Q07869-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5465
DisGeNETi5465

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPARA
HGNCiHGNC:9232, PPARA
HPAiENSG00000186951, Tissue enhanced (tongue)
MIMi170998, gene+phenotype
neXtProtiNX_Q07869
OpenTargetsiENSG00000186951
PharmGKBiPA280
VEuPathDBiHostDB:ENSG00000186951

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3575, Eukaryota
GeneTreeiENSGT00940000157097
HOGENOMiCLU_007368_4_1_1
InParanoidiQ07869
OMAiEMGSIQE
PhylomeDBiQ07869
TreeFamiTF316304

Enzyme and pathway databases

PathwayCommonsiQ07869
ReactomeiR-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-383280, Nuclear Receptor transcription pathway
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-4090294, SUMOylation of intracellular receptors
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707616, Heme signaling
SignaLinkiQ07869
SIGNORiQ07869

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5465, 9 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPARA, human
EvolutionaryTraceiQ07869

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Peroxisome_proliferator-activated_receptor_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5465
PharosiQ07869, Tclin

Protein Ontology

More...PROi		PR:Q07869
RNActiQ07869, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186951, Expressed in liver and 225 other tissues
ExpressionAtlasiQ07869, baseline and differential
GenevisibleiQ07869, HS

Family and domain databases

Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
IDEALiIID00382
InterProiView protein in InterPro
IPR003074, 1Cnucl_rcpt
IPR035500, NHR-like_dom_sf
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR003076, PPAR-alpha
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA
PfamiView protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit
PRINTSiPR01288, PROXISOMEPAR
PR01289, PROXISOMPAAR
PR00398, STRDHORMONER
PR00047, STROIDFINGER
SMARTiView protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit
SUPFAMiSSF48508, SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPARA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07869
Secondary accession number(s): B0G0X3
, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1998
Last modified: February 23, 2022
This is version 240 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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