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Protein

Induced myeloid leukemia cell differentiation protein Mcl-1

Gene

MCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • BH3 domain binding Source: BHF-UCL
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: GO_Central
  • protein transmembrane transporter activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q07820

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Alternative name(s):
Bcl-2-like protein 3
Short name:
Bcl2-L-3
Bcl-2-related protein EAT/mcl1
mcl1/EAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCL1
Synonyms:BCL2L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143384.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6943 MCL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
159552 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07820

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei328 – 348HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5K → R: Reduced ubiquitination. 1 Publication1
Mutagenesisi40K → R: Reduced ubiquitination. 1 Publication1
Mutagenesisi127D → A: Abolishes formation of 28 and 17 kDa cleavage products by CASP3. Abolishes cleavage by caspase-3; when associated with A-157. 1 Publication1
Mutagenesisi136K → R: Reduced ubiquitination. 1 Publication1
Mutagenesisi157D → A: Abolishes formation of 23 and 21 kDa cleavage products by CASP3. Abolishes cleavage by caspase-3; when associated with A-127. 1 Publication1
Mutagenesisi159S → A: Loss of phosphorylation by GSK3 and loss of ubiquitination increasing protein stability. 1 Publication1
Mutagenesisi162S → A: Abolishes mitochondrial localization and decreases stability. 2 Publications1
Mutagenesisi162S → A: No effect. 2 Publications1
Mutagenesisi163T → A or E: No effect on mitochondrial localization. 1 Publication1
Mutagenesisi163T → A: Abolishes phosphorylation by MAPK. No effect on phosphorylation induced by okadaic acid or taxol. 1 Publication1
Mutagenesisi194K → R: Reduced ubiquitination. 1 Publication1
Mutagenesisi197K → R: Reduced ubiquitination. 1 Publication1
Mutagenesisi208K → R: No effect on ubiquitination. 1 Publication1
Mutagenesisi234K → R: No effect on ubiquitination. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4170

Open Targets

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OpenTargetsi
ENSG00000143384

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30688

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4361

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2847

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MCL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
83304396

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001430801 – 350Induced myeloid leukemia cell differentiation protein Mcl-1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei121Phosphoserine1 Publication1
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residuei159Phosphoserine; by GSK3-alpha and GSK3-beta1 Publication1
Modified residuei162Phosphoserine1 Publication1
Modified residuei163Phosphothreonine; by MAPK3 Publications1
Cross-linki194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.3 Publications
Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.1 Publication
Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei127 – 128Cleavage; by caspase-32
Sitei157 – 158Cleavage; by caspase-32

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q07820

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q07820

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q07820

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07820

PeptideAtlas

More...
PeptideAtlasi
Q07820

PRoteomics IDEntifications database

More...
PRIDEi
Q07820

ProteomicsDB human proteome resource

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ProteomicsDBi
58540
58541 [Q07820-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07820

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07820

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q07820

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143384 Expressed in 233 organ(s), highest expression level in epithelium of mammary gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_MCL1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q07820 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q07820 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002781
CAB068195
HPA008455
HPA031125

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with RTL10/BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110338, 78 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-304 MCL1:PMAIP1 complex
CPX-481 MCL-1-BIM complex [Q07820-1]

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q07820

Database of interacting proteins

More...
DIPi
DIP-231N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q07820

Protein interaction database and analysis system

More...
IntActi
Q07820, 35 interactors

Molecular INTeraction database

More...
MINTi
Q07820

STRING: functional protein association networks

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STRINGi
9606.ENSP00000358022

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q07820

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KBWNMR-A163-326[»]
2MHSNMR-A171-327[»]
2NL9X-ray1.55A209-327[»]
2NLAX-ray2.80A209-327[»]
2PQKX-ray2.00A172-327[»]
3D7VX-ray2.03A209-327[»]
3IO9X-ray2.40A209-327[»]
3KJ0X-ray1.70A172-327[»]
3KJ1X-ray1.94A172-327[»]
3KJ2X-ray2.35A172-327[»]
3KZ0X-ray2.35A/B172-327[»]
3MK8X-ray2.32A172-327[»]
B208-228[»]
3PK1X-ray2.49A/C174-326[»]
3TWUX-ray1.80B73-88[»]
3WIXX-ray1.90A/B/C/D172-327[»]
3WIYX-ray2.15A/B/C/D/E/F172-327[»]
4BPIX-ray1.98A209-327[»]
4BPJX-ray1.60A209-327[»]
4HW2X-ray2.80A/B/C/D/E/F172-323[»]
4HW3X-ray2.40A/B/C/D/E/F/G/H/I/J/K/L172-323[»]
4HW4X-ray1.53A/B172-327[»]
4OQ5X-ray2.86A/B/C/D/E/F174-326[»]
4OQ6X-ray1.81A/B174-326[»]
4WGIX-ray1.85A173-321[»]
4WMRX-ray1.70A173-321[»]
4WMSX-ray1.90A174-321[»]
4WMTX-ray2.35A174-321[»]
4WMUX-ray1.55A174-321[»]
4WMVX-ray2.40A174-321[»]
4WMWX-ray1.90A174-321[»]
4WMXX-ray2.00A174-321[»]
4ZBFX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L172-327[»]
4ZBIX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L172-327[»]
5C3FX-ray1.43A173-327[»]
5C6HX-ray2.05A/C/E/G/I/K/M/O/Q/S/U/W171-327[»]
5FC4X-ray1.50A172-320[»]
5FDOX-ray2.80A/B/C/D172-320[»]
5FDRX-ray2.60A/B/C/D172-327[»]
5IEZX-ray2.60A/B/C/D172-327[»]
5IF4X-ray2.39A/B172-327[»]
5JSBX-ray2.74A/C/E/G/I/K172-350[»]
5KU9X-ray2.20A/B174-219[»]
A/B258-327[»]
5LOFX-ray2.20A173-321[»]
5MESX-ray2.24A241-327[»]
5MEVX-ray2.94A241-327[»]
5UUMX-ray2.35A/B172-325[»]
5VKCX-ray2.31A/B174-326[»]
5VX2X-ray1.85A/C241-327[»]
5W89X-ray1.42A172-321[»]
5W8FX-ray1.85A172-320[»]
6B4LX-ray2.25A/B174-326[»]
6B4UX-ray1.95A174-326[»]
6BW2X-ray2.75A/B/C/D172-327[»]
6BW8X-ray2.90A/B/C/D172-327[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q07820

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07820

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q07820

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 175PEST-likeAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi209 – 223BH3Add BLAST15
Motifi252 – 272BH1Add BLAST21
Motifi304 – 319BH2Add BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4728 Eukaryota
ENOG41123S0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048923

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003527

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07820

KEGG Orthology (KO)

More...
KOi
K02539

Identification of Orthologs from Complete Genome Data

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OMAi
KDAKPMG

Database of Orthologous Groups

More...
OrthoDBi
1218929at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07820

TreeFam database of animal gene trees

More...
TreeFami
TF315834

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.437.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013281 Apop_reg_Mc1
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam

The PANTHER Classification System

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PANTHERi
PTHR11256 PTHR11256, 1 hit
PTHR11256:SF46 PTHR11256:SF46, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00452 Bcl-2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01866 APOPREGMCL1
PR01862 BCL2FAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56854 SSF56854, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01259 BH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07820-1) [UniParc]FASTAAdd to basket
Also known as: MCL1L, MCL-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG
60 70 80 90 100
GEAGAVIGGS AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA
110 120 130 140 150
PTRRAAPLEE MEAPAADAIM SPEEELDGYE PEPLGKRPAV LPLLELVGES
160 170 180 190 200
GNNTSTDGSL PSTPPPAEEE EDELYRQSLE IISRYLREQA TGAKDTKPMG
210 220 230 240 250
RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE DDVKSLSRVM
260 270 280 290 300
IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR
310 320 330 340 350
TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR
Length:350
Mass (Da):37,337
Last modified:December 6, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD85821AC59275F1F
GO
Isoform 2 (identifier: Q07820-2) [UniParc]FASTAAdd to basket
Also known as: Delta S, MCL-1S, TM

The sequence of this isoform differs from the canonical sequence as follows:
     231-271: MLRKLDIKNE...GRIVTLISFG → WVCGVLPCRG...FGISNKIALL
     272-350: Missing.

Show »
Length:271
Mass (Da):28,662
Checksum:iFAE0BF9E126523EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT64A0A087WT64_HUMAN
Induced myeloid leukemia cell diffe...
MCL1
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024021173E → D2 PublicationsCorresponds to variant dbSNP:rs2737820Ensembl.1
Natural variantiVAR_024022227A → V3 PublicationsCorresponds to variant dbSNP:rs11580946Ensembl.1
Natural variantiVAR_054157231M → L1 PublicationCorresponds to variant dbSNP:rs140449444Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000532231 – 271MLRKL…LISFG → WVCGVLPCRGPRRWHQECAA GFCRCCWSRSWFGISNKIAL L in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_000533272 – 350Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L08246 mRNA No translation available.
AF118124 mRNA Translation: AAD13299.1
AF147742 Genomic DNA Translation: AAF74821.1
AF198614 Genomic DNA Translation: AAF64255.1
AF198614 Genomic DNA Translation: AAF64256.1
AF162677, AF162676 Genomic DNA Translation: AAG00896.1
AF203373 mRNA Translation: AAG00904.1
BT006640 mRNA Translation: AAP35286.1
AK312508 mRNA Translation: BAG35409.1
DQ088966 Genomic DNA Translation: AAY68220.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53538.1
CH471121 Genomic DNA Translation: EAW53539.1
CH471121 Genomic DNA Translation: EAW53540.1
CH471121 Genomic DNA Translation: EAW53541.1
BC017197 mRNA Translation: AAH17197.1
BC071897 mRNA Translation: AAH71897.1
BC107735 mRNA Translation: AAI07736.1
AF118276 mRNA Translation: AAF15309.1
AF118277 mRNA Translation: AAF15310.1
AF118278 mRNA Translation: AAF15311.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS956.1 [Q07820-2]
CCDS957.1 [Q07820-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A47476

NCBI Reference Sequences

More...
RefSeqi
NP_001184249.1, NM_001197320.1
NP_068779.1, NM_021960.4 [Q07820-1]
NP_877495.1, NM_182763.2 [Q07820-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632486

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307940; ENSP00000309973; ENSG00000143384 [Q07820-2]
ENST00000369026; ENSP00000358022; ENSG00000143384 [Q07820-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4170

UCSC genome browser

More...
UCSCi
uc001euz.4 human [Q07820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08246 mRNA No translation available.
AF118124 mRNA Translation: AAD13299.1
AF147742 Genomic DNA Translation: AAF74821.1
AF198614 Genomic DNA Translation: AAF64255.1
AF198614 Genomic DNA Translation: AAF64256.1
AF162677, AF162676 Genomic DNA Translation: AAG00896.1
AF203373 mRNA Translation: AAG00904.1
BT006640 mRNA Translation: AAP35286.1
AK312508 mRNA Translation: BAG35409.1
DQ088966 Genomic DNA Translation: AAY68220.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53538.1
CH471121 Genomic DNA Translation: EAW53539.1
CH471121 Genomic DNA Translation: EAW53540.1
CH471121 Genomic DNA Translation: EAW53541.1
BC017197 mRNA Translation: AAH17197.1
BC071897 mRNA Translation: AAH71897.1
BC107735 mRNA Translation: AAI07736.1
AF118276 mRNA Translation: AAF15309.1
AF118277 mRNA Translation: AAF15310.1
AF118278 mRNA Translation: AAF15311.1
CCDSiCCDS956.1 [Q07820-2]
CCDS957.1 [Q07820-1]
PIRiA47476
RefSeqiNP_001184249.1, NM_001197320.1
NP_068779.1, NM_021960.4 [Q07820-1]
NP_877495.1, NM_182763.2 [Q07820-2]
UniGeneiHs.632486

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KBWNMR-A163-326[»]
2MHSNMR-A171-327[»]
2NL9X-ray1.55A209-327[»]
2NLAX-ray2.80A209-327[»]
2PQKX-ray2.00A172-327[»]
3D7VX-ray2.03A209-327[»]
3IO9X-ray2.40A209-327[»]
3KJ0X-ray1.70A172-327[»]
3KJ1X-ray1.94A172-327[»]
3KJ2X-ray2.35A172-327[»]
3KZ0X-ray2.35A/B172-327[»]
3MK8X-ray2.32A172-327[»]
B208-228[»]
3PK1X-ray2.49A/C174-326[»]
3TWUX-ray1.80B73-88[»]
3WIXX-ray1.90A/B/C/D172-327[»]
3WIYX-ray2.15A/B/C/D/E/F172-327[»]
4BPIX-ray1.98A209-327[»]
4BPJX-ray1.60A209-327[»]
4HW2X-ray2.80A/B/C/D/E/F172-323[»]
4HW3X-ray2.40A/B/C/D/E/F/G/H/I/J/K/L172-323[»]
4HW4X-ray1.53A/B172-327[»]
4OQ5X-ray2.86A/B/C/D/E/F174-326[»]
4OQ6X-ray1.81A/B174-326[»]
4WGIX-ray1.85A173-321[»]
4WMRX-ray1.70A173-321[»]
4WMSX-ray1.90A174-321[»]
4WMTX-ray2.35A174-321[»]
4WMUX-ray1.55A174-321[»]
4WMVX-ray2.40A174-321[»]
4WMWX-ray1.90A174-321[»]
4WMXX-ray2.00A174-321[»]
4ZBFX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L172-327[»]
4ZBIX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L172-327[»]
5C3FX-ray1.43A173-327[»]
5C6HX-ray2.05A/C/E/G/I/K/M/O/Q/S/U/W171-327[»]
5FC4X-ray1.50A172-320[»]
5FDOX-ray2.80A/B/C/D172-320[»]
5FDRX-ray2.60A/B/C/D172-327[»]
5IEZX-ray2.60A/B/C/D172-327[»]
5IF4X-ray2.39A/B172-327[»]
5JSBX-ray2.74A/C/E/G/I/K172-350[»]
5KU9X-ray2.20A/B174-219[»]
A/B258-327[»]
5LOFX-ray2.20A173-321[»]
5MESX-ray2.24A241-327[»]
5MEVX-ray2.94A241-327[»]
5UUMX-ray2.35A/B172-325[»]
5VKCX-ray2.31A/B174-326[»]
5VX2X-ray1.85A/C241-327[»]
5W89X-ray1.42A172-321[»]
5W8FX-ray1.85A172-320[»]
6B4LX-ray2.25A/B174-326[»]
6B4UX-ray1.95A174-326[»]
6BW2X-ray2.75A/B/C/D172-327[»]
6BW8X-ray2.90A/B/C/D172-327[»]
ProteinModelPortaliQ07820
SMRiQ07820
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110338, 78 interactors
ComplexPortaliCPX-304 MCL1:PMAIP1 complex
CPX-481 MCL-1-BIM complex [Q07820-1]
CORUMiQ07820
DIPiDIP-231N
ELMiQ07820
IntActiQ07820, 35 interactors
MINTiQ07820
STRINGi9606.ENSP00000358022

Chemistry databases

BindingDBiQ07820
ChEMBLiCHEMBL4361
GuidetoPHARMACOLOGYi2847

PTM databases

iPTMnetiQ07820
PhosphoSitePlusiQ07820

Polymorphism and mutation databases

BioMutaiMCL1
DMDMi83304396

Proteomic databases

EPDiQ07820
jPOSTiQ07820
MaxQBiQ07820
PaxDbiQ07820
PeptideAtlasiQ07820
PRIDEiQ07820
ProteomicsDBi58540
58541 [Q07820-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4170
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307940; ENSP00000309973; ENSG00000143384 [Q07820-2]
ENST00000369026; ENSP00000358022; ENSG00000143384 [Q07820-1]
GeneIDi4170
KEGGihsa:4170
UCSCiuc001euz.4 human [Q07820-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4170
DisGeNETi4170
EuPathDBiHostDB:ENSG00000143384.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MCL1
HGNCiHGNC:6943 MCL1
HPAiCAB002781
CAB068195
HPA008455
HPA031125
MIMi159552 gene
neXtProtiNX_Q07820
OpenTargetsiENSG00000143384
PharmGKBiPA30688

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00510000048923
HOVERGENiHBG003527
InParanoidiQ07820
KOiK02539
OMAiKDAKPMG
OrthoDBi1218929at2759
PhylomeDBiQ07820
TreeFamiTF315834

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORiQ07820

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MCL1 human
EvolutionaryTraceiQ07820

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MCL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4170
PMAP-CutDBiQ07820

Protein Ontology

More...
PROi
PR:Q07820

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143384 Expressed in 233 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_MCL1
ExpressionAtlasiQ07820 baseline and differential
GenevisibleiQ07820 HS

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR013281 Apop_reg_Mc1
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF46 PTHR11256:SF46, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PRINTSiPR01866 APOPREGMCL1
PR01862 BCL2FAMILY
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01259 BH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07820
Secondary accession number(s): B2R6B2
, D3DV03, D3DV04, Q9HD91, Q9NRQ3, Q9NRQ4, Q9UHR7, Q9UHR8, Q9UHR9, Q9UNJ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 6, 2005
Last modified: January 16, 2019
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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