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Protein

Bcl-2-like protein 1

Gene

BCL2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).1 Publication
Isoform Bcl-X(S) promotes apoptosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • BH3 domain binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: GO_Central
  • protein kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Endocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-844455 The NLRP1 inflammasome

SIGNOR Signaling Network Open Resource

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SIGNORi
Q07817

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.21.1.1 the bcl-2 (bcl-2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-like protein 1
Short name:
Bcl2-L-1
Alternative name(s):
Apoptosis regulator Bcl-X
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL2L1
Synonyms:BCL2L, BCLX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171552.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:992 BCL2L1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600039 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07817

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei210 – 226HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49S → A: Less stable at G2 checkpoint after DNA damage. 1 Publication1
Mutagenesisi61D → A: No cleavage by caspase-1 nor by caspase-3. 1 Publication1
Mutagenesisi131 – 133FRD → VRA: No heterodimerization with BAX. 1 Publication3
Mutagenesisi135 – 137VNW → AIL: Loss of anti-apoptotic activity. 1 Publication3
Mutagenesisi138 – 140GRI → ELN: Loss of anti-apoptotic activity. 1 Publication3
Mutagenesisi138G → A: No heterodimerization with BAX. 1 Publication1
Mutagenesisi145 – 147SFG → YCC: Decreases interaction with DNM1L, no effect on endocytosis enhancement. 1 Publication3
Mutagenesisi148G → E: No heterodimerization with BAX. 1 Publication1
Mutagenesisi156D → A: No effect on caspase-1 cleavage. 1 Publication1
Mutagenesisi176D → A: No effect on caspase-1 cleavage. 1 Publication1
Mutagenesisi188 – 191WDTF → SVTC: Abolishes interaction with DNM1L and endocytosis enhancement. 1 Publication4
Mutagenesisi188 – 189WD → GA: Reduces anti-apoptotic activity by about half. 1 Publication2
Mutagenesisi189D → A: No effect on caspase-1 cleavage. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
598

Open Targets

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OpenTargetsi
ENSG00000171552

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA76

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4625

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2845

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCL2L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
728955

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001430621 – 233Bcl-2-like protein 1Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49Phosphoserine; by PLK31 Publication1
Modified residuei62Phosphoserine; by CDK11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.1 Publication
Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.2 Publications
Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei61 – 62Cleavage; by caspase-12

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q07817

MaxQB - The MaxQuant DataBase

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MaxQBi
Q07817

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07817

PeptideAtlas

More...
PeptideAtlasi
Q07817

PRoteomics IDEntifications database

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PRIDEi
Q07817

ProteomicsDB human proteome resource

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ProteomicsDBi
58537
58538 [Q07817-2]
58539 [Q07817-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q07817-1 [Q07817-1]
Q07817-2 [Q07817-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07817

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q07817

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q07817

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171552 Expressed in 223 organ(s), highest expression level in upper lobe of left lung

CleanEx database of gene expression profiles

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CleanExi
HS_BCL2L1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q07817 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q07817 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB072801
HPA035734

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with RTL10/BOP. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5F1A and ATP5F1B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F1F0 ATP synthase. Interacts with VDAC1 (PubMed:25296756). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785). Interacts with BCL2L11 (via BH3) (PubMed:27013495). Interacts with RNF183 (PubMed:29507230).By similarity15 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107070, 106 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1983 BAD:BCL-XL complex [Q07817-1]
CPX-1985 BIM:BCL-XL complex [Q07817-1]
CPX-1987 PUMA:BCL-XL complex [Q07817-1]
CPX-1991 BID:BCL-XL complex [Q07817-1]
CPX-298 BCL-XL complex [Q07817-1]

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q07817

Database of interacting proteins

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DIPi
DIP-30916N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q07817

Protein interaction database and analysis system

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IntActi
Q07817, 98 interactors

Molecular INTeraction database

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MINTi
Q07817

STRING: functional protein association networks

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STRINGi
9606.ENSP00000302564

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q07817

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00298

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q07817

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07817

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q07817

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi4 – 24BH4Add BLAST21
Motifi86 – 100BH3Add BLAST15
Motifi129 – 148BH1Add BLAST20
Motifi180 – 195BH2Add BLAST16

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4728 Eukaryota
ENOG41123S0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000062935

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000056452

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07817

KEGG Orthology (KO)

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KOi
K04570

Identification of Orthologs from Complete Genome Data

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OMAi
NGSPSWH

Database of Orthologous Groups

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OrthoDBi
EOG091G0OCU

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07817

TreeFam database of animal gene trees

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TreeFami
TF315834

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.437.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013279 Apop_reg_BclX
IPR002475 Bcl2-like
IPR004725 Bcl2/BclX
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS
IPR003093 Bcl2_BH4
IPR020731 Bcl2_BH4_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam

The PANTHER Classification System

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PANTHERi
PTHR11256 PTHR11256, 1 hit
PTHR11256:SF12 PTHR11256:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01864 APOPREGBCLX
PR01862 BCL2FAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00265 BH4, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56854 SSF56854, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00865 bcl-2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01259 BH3, 1 hit
PS01260 BH4_1, 1 hit
PS50063 BH4_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Bcl-X(L) (identifier: Q07817-1) [UniParc]FASTAAdd to basket
Also known as: Bcl-xL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180 190 200
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA
210 220 230
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK
Length:233
Mass (Da):26,049
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE09D3CDD851AE9BE
GO
Isoform Bcl-X(S) (identifier: Q07817-2) [UniParc]FASTAAdd to basket
Also known as: Bcl-xS

The sequence of this isoform differs from the canonical sequence as follows:
     126-188: Missing.

Show »
Length:170
Mass (Da):18,894
Checksum:i75D1FC01EC06AD47
GO
Isoform Bcl-X(beta) (identifier: Q07817-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-233: DTFVELYGNN...VLLGSLFSRK → VRTKPLVCPF...CWVIVGDVDS

Show »
Length:227
Mass (Da):25,290
Checksum:i1EF621E5D0744E4E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TE64Q5TE64_HUMAN
Bcl-2-like protein 1
BCL2L1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QP56Q5QP56_HUMAN
Bcl-2-like protein 1
BCL2L1
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9H1R6Q9H1R6_HUMAN
Bcl-2-like protein 1
BCL2L1
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QP59Q5QP59_HUMAN
Bcl-2-like protein 1
BCL2L1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70G → A in CAA80661 (PubMed:8358789).Curated1
Sequence conflicti168A → V in CAI56777 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000515126 – 188Missing in isoform Bcl-X(S). CuratedAdd BLAST63
Alternative sequenceiVSP_000516189 – 233DTFVE…LFSRK → VRTKPLVCPFSLASGQRSPT ALLLYLFLLCWVIVGDVDS in isoform Bcl-X(beta). CuratedAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z23115 mRNA Translation: CAA80661.1
Z23116 mRNA Translation: CAA80662.1
U72398 Genomic DNA Translation: AAB17354.1
CR936637 mRNA Translation: CAI56777.1
BT007208 mRNA Translation: AAP35872.1
AL117381 Genomic DNA No translation available.
AL160175 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76424.1
CH471077 Genomic DNA Translation: EAW76425.1
CH471077 Genomic DNA Translation: EAW76429.1
BC019307 mRNA Translation: AAH19307.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13188.1 [Q07817-2]
CCDS13189.1 [Q07817-1]

Protein sequence database of the Protein Information Resource

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PIRi
B47537
JE0203

NCBI Reference Sequences

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RefSeqi
NP_001182.1, NM_001191.3 [Q07817-2]
NP_001304848.1, NM_001317919.1 [Q07817-1]
NP_001304849.1, NM_001317920.1 [Q07817-1]
NP_001304850.1, NM_001317921.1 [Q07817-1]
NP_001309168.1, NM_001322239.1 [Q07817-1]
NP_001309169.1, NM_001322240.1 [Q07817-1]
NP_001309171.1, NM_001322242.1 [Q07817-1]
NP_612815.1, NM_138578.2 [Q07817-1]
XP_011527266.1, XM_011528964.2 [Q07817-1]
XP_016883482.1, XM_017027993.1 [Q07817-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.516966
Hs.732176

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307677; ENSP00000302564; ENSG00000171552 [Q07817-1]
ENST00000376055; ENSP00000365223; ENSG00000171552 [Q07817-2]
ENST00000376062; ENSP00000365230; ENSG00000171552 [Q07817-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
598

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:598

UCSC genome browser

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UCSCi
uc002wwl.4 human [Q07817-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23115 mRNA Translation: CAA80661.1
Z23116 mRNA Translation: CAA80662.1
U72398 Genomic DNA Translation: AAB17354.1
CR936637 mRNA Translation: CAI56777.1
BT007208 mRNA Translation: AAP35872.1
AL117381 Genomic DNA No translation available.
AL160175 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76424.1
CH471077 Genomic DNA Translation: EAW76425.1
CH471077 Genomic DNA Translation: EAW76429.1
BC019307 mRNA Translation: AAH19307.1
CCDSiCCDS13188.1 [Q07817-2]
CCDS13189.1 [Q07817-1]
PIRiB47537
JE0203
RefSeqiNP_001182.1, NM_001191.3 [Q07817-2]
NP_001304848.1, NM_001317919.1 [Q07817-1]
NP_001304849.1, NM_001317920.1 [Q07817-1]
NP_001304850.1, NM_001317921.1 [Q07817-1]
NP_001309168.1, NM_001322239.1 [Q07817-1]
NP_001309169.1, NM_001322240.1 [Q07817-1]
NP_001309171.1, NM_001322242.1 [Q07817-1]
NP_612815.1, NM_138578.2 [Q07817-1]
XP_011527266.1, XM_011528964.2 [Q07817-1]
XP_016883482.1, XM_017027993.1 [Q07817-1]
UniGeneiHs.516966
Hs.732176

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXLNMR-A1-209[»]
1G5JNMR-A1-209[»]
1LXLNMR-A1-209[»]
1MAZX-ray2.20A1-209[»]
1R2DX-ray1.95A1-211[»]
1R2EX-ray2.10A1-211[»]
1R2GX-ray2.70A1-211[»]
1R2HX-ray2.20A1-211[»]
1R2IX-ray2.00A1-211[»]
1YSGNMR-A1-209[»]
1YSINMR-A1-209[»]
1YSNNMR-A1-209[»]
2B48X-ray3.45A1-211[»]
2LP8NMR-A1-209[»]
2LPCNMR-A1-209[»]
2M03NMR-A1-209[»]
2M04NMR-A1-209[»]
2ME8NMR-A1-209[»]
2ME9NMR-A1-209[»]
2MEJNMR-A1-209[»]
2O1YNMR-A1-209[»]
2O2MNMR-A2-20[»]
A83-196[»]
2O2NNMR-A2-20[»]
A83-196[»]
2P1LX-ray2.50A/C/E/G1-209[»]
2PONNMR-B1-196[»]
2YJ1X-ray2.24A/C1-209[»]
2YQ6X-ray1.80A1-209[»]
2YQ7X-ray1.90A1-209[»]
2YXJX-ray2.20A/B1-209[»]
3CVAX-ray2.70X1-211[»]
3FDLX-ray1.78A1-209[»]
3FDMX-ray2.26A/B/C1-209[»]
3INQX-ray2.00A/B1-209[»]
3IO8X-ray2.30A/C1-209[»]
3PL7X-ray2.61A/B1-209[»]
3QKDX-ray2.02A/B1-209[»]
3R85X-ray1.95A/B/C/D1-197[»]
3SP7X-ray1.40A1-209[»]
3SPFX-ray1.70A1-209[»]
3WIZX-ray2.45A/B1-209[»]
3ZK6X-ray2.48A/B1-209[»]
3ZLNX-ray2.29A1-209[»]
3ZLOX-ray2.60A1-209[»]
3ZLRX-ray2.03A/B1-209[»]
4A1UX-ray1.54A1-209[»]
4A1WX-ray2.50A/B/C/D1-209[»]
4AQ3X-ray2.40A/B/C/D/E/F29-44[»]
4BPKX-ray1.76A/B1-209[»]
4C52X-ray2.05A/B1-209[»]
4C5DX-ray2.30A/B1-209[»]
4CINX-ray2.69A/B1-209[»]
C/D79-102[»]
4EHRX-ray2.09A1-209[»]
4HNJX-ray2.90A/B1-209[»]
4IEHX-ray2.10A29-44[»]
4PPIX-ray2.85A1-209[»]
4QVEX-ray2.05A1-209[»]
4QVFX-ray1.53A1-209[»]
4QVXX-ray2.10A/B1-23[»]
A/B83-209[»]
4TUHX-ray1.80A/B/C/D/E/F/G/H1-209[»]
4Z9VX-ray2.10A/B1-208[»]
5AGWX-ray2.69A/B29-44[»]
5AGXX-ray2.24A/B29-44[»]
5B1ZX-ray2.15A/B1-209[»]
5C3GX-ray2.45A83-209[»]
5FMJX-ray2.43A1-209[»]
5FMKX-ray1.73A1-209[»]
5VAYX-ray1.80A/B/C/D29-44[»]
5VX3X-ray1.95A/C/E/G1-209[»]
6BF2NMR-A1-209[»]
6DCNX-ray2.44A/B1-26[»]
A/B83-208[»]
6DCOX-ray2.20A/B1-26[»]
A/B83-208[»]
6F46NMR-A202-233[»]
DisProtiDP00298
ProteinModelPortaliQ07817
SMRiQ07817
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107070, 106 interactors
ComplexPortaliCPX-1983 BAD:BCL-XL complex [Q07817-1]
CPX-1985 BIM:BCL-XL complex [Q07817-1]
CPX-1987 PUMA:BCL-XL complex [Q07817-1]
CPX-1991 BID:BCL-XL complex [Q07817-1]
CPX-298 BCL-XL complex [Q07817-1]
CORUMiQ07817
DIPiDIP-30916N
ELMiQ07817
IntActiQ07817, 98 interactors
MINTiQ07817
STRINGi9606.ENSP00000302564

Chemistry databases

BindingDBiQ07817
ChEMBLiCHEMBL4625
GuidetoPHARMACOLOGYi2845

Protein family/group databases

TCDBi1.A.21.1.1 the bcl-2 (bcl-2) family

PTM databases

iPTMnetiQ07817
PhosphoSitePlusiQ07817

Polymorphism and mutation databases

BioMutaiBCL2L1
DMDMi728955

Proteomic databases

EPDiQ07817
MaxQBiQ07817
PaxDbiQ07817
PeptideAtlasiQ07817
PRIDEiQ07817
ProteomicsDBi58537
58538 [Q07817-2]
58539 [Q07817-3]
TopDownProteomicsiQ07817-1 [Q07817-1]
Q07817-2 [Q07817-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
598
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307677; ENSP00000302564; ENSG00000171552 [Q07817-1]
ENST00000376055; ENSP00000365223; ENSG00000171552 [Q07817-2]
ENST00000376062; ENSP00000365230; ENSG00000171552 [Q07817-1]
GeneIDi598
KEGGihsa:598
UCSCiuc002wwl.4 human [Q07817-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
598
DisGeNETi598
EuPathDBiHostDB:ENSG00000171552.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCL2L1
HGNCiHGNC:992 BCL2L1
HPAiCAB072801
HPA035734
MIMi600039 gene
neXtProtiNX_Q07817
OpenTargetsiENSG00000171552
PharmGKBiPA76

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00530000062935
HOGENOMiHOG000056452
InParanoidiQ07817
KOiK04570
OMAiNGSPSWH
OrthoDBiEOG091G0OCU
PhylomeDBiQ07817
TreeFamiTF315834

Enzyme and pathway databases

ReactomeiR-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-844455 The NLRP1 inflammasome
SIGNORiQ07817

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BCL2L1 human
EvolutionaryTraceiQ07817

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BCL2-like_1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
598
PMAP-CutDBiQ07817

Protein Ontology

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PROi
PR:Q07817

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171552 Expressed in 223 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_BCL2L1
ExpressionAtlasiQ07817 baseline and differential
GenevisibleiQ07817 HS

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR013279 Apop_reg_BclX
IPR002475 Bcl2-like
IPR004725 Bcl2/BclX
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS
IPR003093 Bcl2_BH4
IPR020731 Bcl2_BH4_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF12 PTHR11256:SF12, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
PRINTSiPR01864 APOPREGBCLX
PR01862 BCL2FAMILY
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
TIGRFAMsiTIGR00865 bcl-2, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01259 BH3, 1 hit
PS01260 BH4_1, 1 hit
PS50063 BH4_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2CL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07817
Secondary accession number(s): E1P5L6
, Q5CZ89, Q5TE65, Q92976
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 5, 2018
This is version 222 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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