BCL2L1

Functionⁱ

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F₁F₀ activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).1 Publication

Isoform Bcl-X(S) promotes apoptosis.

GO - Molecular functionⁱ

BH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21639858
- 15901672
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21856303
- 15131699
protein heterodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21840391

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic mitochondrial changes
Source: ProtInc
Traceable author statementⁱ
- 9393856
apoptotic process in bone marrow Source: Ensembl
cell proliferation Source: Ensembl
cellular process regulating host cell cycle in response to virus Source: Ensembl
cellular response to alkaloid Source: Ensembl
cellular response to amino acid stimulus Source: Ensembl
cellular response to gamma radiation Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
endocytosis Source: UniProtKB-KW
extrinsic apoptotic signaling pathway in absence of ligand
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fertilization Source: Ensembl
germ cell development Source: Ensembl
hepatocyte apoptotic process Source: Ensembl
intrinsic apoptotic signaling pathway in response to DNA damage
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
in utero embryonic development Source: Ensembl
male gonad development Source: Ensembl
mitochondrion morphogenesis Source: Ensembl
mitotic cell cycle checkpoint
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21840391
negative regulation of anoikis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15006356
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 9388232
- 21567405
negative regulation of autophagy
Source: UniProtKB
Traceable author statementⁱ
- 18309324
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 29507230
negative regulation of execution phase of apoptosis
Source: UniProtKB
Inferred from direct assayⁱ
- 20673843
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Source: BHF-UCL
Traceable author statementⁱ
- 8358789
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Source: MGI
Inferred from direct assayⁱ
- 26582200
negative regulation of intrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 12011449
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Source: BHF-UCL
Inferred from direct assayⁱ
- 16608847
negative regulation of neuron apoptotic process Source: Ensembl
negative regulation of protein localization to plasma membrane
Source: BHF-UCL
Inferred from direct assayⁱ
- 21041309
negative regulation of release of cytochrome c from mitochondria
Source: UniProtKB
Inferred from direct assayⁱ
- 12667443
neuron apoptotic process Source: Ensembl
ovarian follicle development Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of intrinsic apoptotic signaling pathway Source: Reactome
regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21840391
regulation of growth Source: Ensembl
regulation of mitochondrial membrane permeability
Source: HGNC
Inferred from direct assayⁱ
- 9843949
regulation of mitochondrial membrane potential
Source: HGNC
Inferred from direct assayⁱ
- 9843949
release of cytochrome c from mitochondria
Source: HGNC
Inferred from direct assayⁱ
- 9843949
response to cycloheximide Source: Ensembl
response to cytokine
Source: MGI
Inferred from direct assayⁱ
- 9184696
spermatogenesis Source: Ensembl
suppression by virus of host apoptotic process
Source: MGI
Inferred from direct assayⁱ
- 15231831

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Endocytosis

Biological process

Apoptosis, Endocytosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-844455 The NLRP1 inflammasome
SIGNORⁱ	Q07817

Protein family/group databases

TCDBⁱ	1.A.21.1.1 the bcl-2 (bcl-2) family

TCDBⁱ

1.A.21.1.1 the bcl-2 (bcl-2) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bcl-2-like protein 1 Short name: Bcl2-L-1 Alternative name(s): Apoptosis regulator Bcl-X
Gene namesⁱ	Name:BCL2L1 Synonyms:BCL2L, BCLX
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171552.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:992 BCL2L1
MIMⁱ	600039 gene
neXtProtⁱ	NX_Q07817

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	210 – 226	HelicalSequence analysisAdd BLAST		17

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Nucleus, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	49	S → A: Less stable at G2 checkpoint after DNA damage. 1 Publication	1
Mutagenesisⁱ	61	D → A: No cleavage by caspase-1 nor by caspase-3. 1 Publication	1
Mutagenesisⁱ	131 – 133	FRD → VRA: No heterodimerization with BAX. 1 Publication	3
Mutagenesisⁱ	135 – 137	VNW → AIL: Loss of anti-apoptotic activity. 1 Publication	3
Mutagenesisⁱ	138 – 140	GRI → ELN: Loss of anti-apoptotic activity. 1 Publication	3
Mutagenesisⁱ	138	G → A: No heterodimerization with BAX. 1 Publication	1
Mutagenesisⁱ	145 – 147	SFG → YCC: Decreases interaction with DNM1L, no effect on endocytosis enhancement. 1 Publication	3
Mutagenesisⁱ	148	G → E: No heterodimerization with BAX. 1 Publication	1
Mutagenesisⁱ	156	D → A: No effect on caspase-1 cleavage. 1 Publication	1
Mutagenesisⁱ	176	D → A: No effect on caspase-1 cleavage. 1 Publication	1
Mutagenesisⁱ	188 – 191	WDTF → SVTC: Abolishes interaction with DNM1L and endocytosis enhancement. 1 Publication	4
Mutagenesisⁱ	188 – 189	WD → GA: Reduces anti-apoptotic activity by about half. 1 Publication	2
Mutagenesisⁱ	189	D → A: No effect on caspase-1 cleavage. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	598
Open Targets More...OpenTargetsⁱ	ENSG00000171552
PharmGKBⁱ	PA76

Chemistry databases

ChEMBLⁱ	CHEMBL4625
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2845

Polymorphism and mutation databases

BioMutaⁱ	BCL2L1
DMDMⁱ	728955

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000143062	1 – 233	Bcl-2-like protein 1Add BLAST		233

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	49	Phosphoserine; by PLK31 Publication		1
Modified residueⁱ	62	Phosphoserine; by CDK11 Publication		1

Post-translational modificationⁱ

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.1 Publication

Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.2 Publications

Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	61 – 62	Cleavage; by caspase-1		2

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q07817
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q07817
PaxDbⁱ	Q07817
PeptideAtlas More...PeptideAtlasⁱ	Q07817
PRIDEⁱ	Q07817
ProteomicsDBⁱ	58537 58538 [Q07817-2] 58539 [Q07817-3]
TopDownProteomicsⁱ	Q07817-1 [Q07817-1] Q07817-2 [Q07817-2]

PTM databases

iPTMnetⁱ	Q07817
PhosphoSitePlusⁱ	Q07817

Miscellaneous databases

PMAP-CutDBⁱ	Q07817

PMAP-CutDBⁱ

Q07817

Expressionⁱ

Tissue specificityⁱ

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Gene expression databases

Bgeeⁱ	ENSG00000171552 Expressed in 223 organ(s), highest expression level in upper lobe of left lung
CleanExⁱ	HS_BCL2L1
ExpressionAtlasⁱ	Q07817 baseline and differential
Genevisibleⁱ	Q07817 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB072801 HPA035734

HPAⁱ

CAB072801
HPA035734

Interactionⁱ

Subunit structureⁱ

Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with RTL10/BOP. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5F1A and ATP5F1B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F₁F₀ ATP synthase. Interacts with VDAC1 (PubMed:25296756). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785). Interacts with BCL2L11 (via BH3) (PubMed:27013495). Interacts with RNF183 (PubMed:29507230).By similarity15 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-78035,EBI-78035
BAD	Q92934	12	EBI-78035,EBI-700771
Bad	Q61337	3	EBI-287195,EBI-400328	From Mus musculus.
BAK1	Q16611	13	EBI-287195,EBI-519866
BAX	Q07812	20	EBI-287195,EBI-516580
BBC3	Q9BXH1	9	EBI-287195,EBI-519884
Bbc3	Q99ML1	3	EBI-287195,EBI-727801	From Mus musculus.
BCL2L11	O43521	10	EBI-287195,EBI-526406
BCL2L11	O43521-1	2	EBI-287195,EBI-526416
Bcl2l11	O54918-3	3	EBI-287195,EBI-526084	From a different organism.
BECN1	Q14457	5	EBI-287195,EBI-949378
BID	P55957	7	EBI-287195,EBI-519672
BIK	Q13323	12	EBI-78035,EBI-700794
BMF	Q96LC9	10	EBI-78035,EBI-3919268
ced-4	P30429-2	2	EBI-287195,EBI-536271	From a different organism.
CLU	P10909-4	6	EBI-287195,EBI-4322678
CYCS	P99999	2	EBI-78035,EBI-446479
Gimap3	Q99MI6	3	EBI-287195,EBI-15572304	From Mus musculus.
Gimap5	Q8BWF2	3	EBI-287195,EBI-15572348	From Mus musculus.
HRK	O00198	3	EBI-287195,EBI-701322
MTOR	P42345	4	EBI-287195,EBI-359260
NLRP1	Q9C000	9	EBI-78035,EBI-1220518
RTL10	Q7L3V2	3	EBI-287195,EBI-10697720
SIVA1	O15304	2	EBI-78035,EBI-520756
SIVA1	O15304-1	5	EBI-287195,EBI-520766
SPNS1	Q9H2V7	3	EBI-78035,EBI-1386527
TP53	P04637	26	EBI-287195,EBI-366083
Tp53	P02340	3	EBI-287195,EBI-474016	From Mus musculus.
TP53BP2	Q13625	3	EBI-287195,EBI-77642
VRK2	Q86Y07-1	2	EBI-287195,EBI-1207633

GO - Molecular functionⁱ

BH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21639858
- 15901672
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21856303
- 15131699
protein heterodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21840391

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107070, 106 interactors
ComplexPortalⁱ	CPX-1983 BAD:BCL-XL complex [Q07817-1] CPX-1985 BIM:BCL-XL complex [Q07817-1] CPX-1987 PUMA:BCL-XL complex [Q07817-1] CPX-1991 BID:BCL-XL complex [Q07817-1] CPX-298 BCL-XL complex [Q07817-1]
CORUMⁱ	Q07817
Database of interacting proteins More...DIPⁱ	DIP-30916N
ELMⁱ	Q07817
IntActⁱ	Q07817, 98 interactors
Molecular INTeraction database More...MINTⁱ	Q07817
STRINGⁱ	9606.ENSP00000302564

Chemistry databases

BindingDBⁱ

Q07817

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 18	Combined sources	16
Turnⁱ	19 – 21	Combined sources	3
Helixⁱ	24 – 26	Combined sources	3
Beta strandⁱ	29 – 36	Combined sources	8
Beta strandⁱ	38 – 41	Combined sources	4
Turnⁱ	42 – 44	Combined sources	3
Beta strandⁱ	50 – 53	Combined sources	4
Beta strandⁱ	56 – 59	Combined sources	4
Beta strandⁱ	60 – 64	Combined sources	5
Turnⁱ	65 – 68	Combined sources	4
Turnⁱ	70 – 73	Combined sources	4
Beta strandⁱ	82 – 84	Combined sources	3
Helixⁱ	85 – 101	Combined sources	17
Helixⁱ	102 – 104	Combined sources	3
Helixⁱ	108 – 111	Combined sources	4
Turnⁱ	112 – 114	Combined sources	3
Turnⁱ	116 – 118	Combined sources	3
Helixⁱ	120 – 130	Combined sources	11
Turnⁱ	131 – 133	Combined sources	3
Helixⁱ	137 – 156	Combined sources	20
Helixⁱ	162 – 177	Combined sources	16
Helixⁱ	179 – 184	Combined sources	6
Turnⁱ	185 – 187	Combined sources	3
Helixⁱ	188 – 198	Combined sources	11
Helixⁱ	199 – 205	Combined sources	7
Beta strandⁱ	206 – 208	Combined sources	3
Helixⁱ	213 – 229	Combined sources	17

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00298
ProteinModelPortalⁱ	Q07817
SMRⁱ	Q07817
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q07817

EvolutionaryTraceⁱ

Q07817

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	4 – 24	BH4Add BLAST	21
Motifⁱ	86 – 100	BH3Add BLAST	15
Motifⁱ	129 – 148	BH1Add BLAST	20
Motifⁱ	180 – 195	BH2Add BLAST	16

Domainⁱ

The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.

The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.1 Publication

Sequence similaritiesⁱ

Belongs to the Bcl-2 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4728 Eukaryota ENOG41123S0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062935
HOGENOMⁱ	HOG000056452
InParanoidⁱ	Q07817
KEGG Orthology (KO) More...KOⁱ	K04570
OMAⁱ	NGSPSWH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OCU
PhylomeDBⁱ	Q07817
TreeFamⁱ	TF315834

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR013279 Apop_reg_BclX IPR002475 Bcl2-like IPR004725 Bcl2/BclX IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR020728 Bcl2_BH3_motif_CS IPR003093 Bcl2_BH4 IPR020731 Bcl2_BH4_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF12 PTHR11256:SF12, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit PF02180 BH4, 1 hit
PRINTSⁱ	PR01864 APOPREGBCLX PR01862 BCL2FAMILY
SMARTⁱ	View protein in SMART SM00265 BH4, 1 hit
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
TIGRFAMsⁱ	TIGR00865 bcl-2, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01259 BH3, 1 hit PS01260 BH4_1, 1 hit PS50063 BH4_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform Bcl-X(L) (identifier: Q07817-1) [UniParc]FASTA Add to basket

Also known as: Bcl-xL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA 
        60         70         80         90        100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 
       110        120        130        140        150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL 
       160        170        180        190        200
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA 
       210        220        230 
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

Length:233

Mass (Da):26,049

Last modified:February 1, 1995 - v1

Checksum:ⁱE09D3CDD851AE9BE

GO

Isoform Bcl-X(S) (identifier: Q07817-2) [UniParc]FASTA Add to basket

Also known as: Bcl-xS

The sequence of this isoform differs from the canonical sequence as follows:
126-188: Missing.

« Hide

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA 
        60         70         80         90        100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 
       110        120        130        140        150
YRRAFSDLTS QLHITPGTAY QSFEQDTFVE LYGNNAAAES RKGQERFNRW 
       160        170
FLTGMTVAGV VLLGSLFSRK

Show »

Length:170

Mass (Da):18,894

Checksum:ⁱ75D1FC01EC06AD47

GO

Isoform Bcl-X(beta) (identifier: Q07817-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
189-233: DTFVELYGNN...VLLGSLFSRK → VRTKPLVCPF...CWVIVGDVDS

« Hide

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA 
        60         70         80         90        100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 
       110        120        130        140        150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL 
       160        170        180        190        200
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWVR TKPLVCPFSL 
       210        220 
ASGQRSPTAL LLYLFLLCWV IVGDVDS

Show »

Length:227

Mass (Da):25,290

Checksum:ⁱ1EF621E5D0744E4E

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5TE64	Q5TE64_HUMAN	Bcl-2-like protein 1 Bcl-2-like protein 1	BCL2L1	205	Annotation score:
Q5QP56	Q5QP56_HUMAN	Bcl-2-like protein 1 Bcl-2-like protein 1	BCL2L1	181	Annotation score:
Q9H1R6	Q9H1R6_HUMAN	Bcl-2-like protein 1 Bcl-2-like protein 1	BCL2L1	188	Annotation score:
Q5QP59	Q5QP59_HUMAN	Bcl-2-like protein 1 Bcl-2-like protein 1	BCL2L1	48	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	70	G → A in CAA80661 (PubMed:8358789).Curated		1
Sequence conflictⁱ	168	A → V in CAI56777 (PubMed:17974005).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_000515	126 – 188	Missing in isoform Bcl-X(S). CuratedAdd BLAST		63
Alternative sequenceⁱVSP_000516	189 – 233	DTFVE…LFSRK → VRTKPLVCPFSLASGQRSPT ALLLYLFLLCWVIVGDVDS in isoform Bcl-X(beta). CuratedAdd BLAST		45

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z23115 mRNA Translation: CAA80661.1 Z23116 mRNA Translation: CAA80662.1 U72398 Genomic DNA Translation: AAB17354.1 CR936637 mRNA Translation: CAI56777.1 BT007208 mRNA Translation: AAP35872.1 AL117381 Genomic DNA No translation available. AL160175 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76424.1 CH471077 Genomic DNA Translation: EAW76425.1 CH471077 Genomic DNA Translation: EAW76429.1 BC019307 mRNA Translation: AAH19307.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13188.1 [Q07817-2] CCDS13189.1 [Q07817-1]
PIRⁱ	B47537 JE0203
NCBI Reference Sequences More...RefSeqⁱ	NP_001182.1, NM_001191.3 [Q07817-2] NP_001304848.1, NM_001317919.1 [Q07817-1] NP_001304849.1, NM_001317920.1 [Q07817-1] NP_001304850.1, NM_001317921.1 [Q07817-1] NP_001309168.1, NM_001322239.1 [Q07817-1] NP_001309169.1, NM_001322240.1 [Q07817-1] NP_001309171.1, NM_001322242.1 [Q07817-1] NP_612815.1, NM_138578.2 [Q07817-1] XP_011527266.1, XM_011528964.2 [Q07817-1] XP_016883482.1, XM_017027993.1 [Q07817-1]
UniGeneⁱ	Hs.516966 Hs.732176

Genome annotation databases

Ensemblⁱ	ENST00000307677; ENSP00000302564; ENSG00000171552 [Q07817-1] ENST00000376055; ENSP00000365223; ENSG00000171552 [Q07817-2] ENST00000376062; ENSP00000365230; ENSG00000171552 [Q07817-1]
GeneIDⁱ	598
KEGGⁱ	hsa:598
UCSC genome browser More...UCSCⁱ	uc002wwl.4 human [Q07817-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07817	BCL2-like 1 isoform 1 (Fragment)		HUMAN		233	UniRef100_Q07817
BCL2 like 1		CANLF		233
BCL2-like 1		PANTR		233
BCL2 like 1		PONAB		233
Uncharacterized protein		PANPA		233
+1
Q07817-2	BCL2-like 1 isoform 2		HUMAN		170	UniRef100_Q5TE63
BCL2-like 1		PANTR		170
BCL2L1 isoform 1		PONAB		170
bcl-2-like protein 1 isoform X2		URSMA		170

Protein	Similar proteins		Species	Score	Length	Source
Q07817	Bcl-2-like protein 1	)	MOUSE		233	UniRef90_Q07817
Bcl-2-like protein 1		PIG		233
Bcl-2-like protein 1	)	RAT		233
BCL2-like 1 isoform 1 (Fragment)		HUMAN		233
BCL2 like 1		CANLF		233
+120
Q07817-2	Isoform Bcl-X(S) of Bcl-2-like protein 1		MOUSE		170	UniRef90_Q64373-2
Bcl-2-like protein 1		PIG		175
bcl-2-like protein 1 isoform X2		DIPOR		171
BCL2-like protein 1 (Fragment)		SHEEP		59
BCL2-like 1 isoform 2		HUMAN		170
+41
Q07817-3	BCL2-like protein 1 (Fragment)		BOVIN		212	UniRef90_Q07817-3

Protein	Similar proteins		Species	Score	Length	Source
Q07817	Bcl-2-like protein 1		PIG		233	UniRef50_Q07817
Bcl-2-like protein 1	)	MOUSE		233
Bcl-2-like protein 1	)	RAT		233
Bcl-2-like protein 1		CHICK		229
BCL2-like 1 isoform 1 (Fragment)		HUMAN		233
+237
Q07817-2	Isoform Bcl-X(S) of Bcl-2-like protein 1		MOUSE		170	UniRef50_Q64373-2
Bcl-2-like protein 1		PIG		175
bcl-2-like protein 1 isoform X2		DIPOR		171
BCL2-like protein 1 (Fragment)		SHEEP		59
bcl-2-like protein 1 isoform X2		DELLE		170
+65

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z23115 mRNA Translation: CAA80661.1 Z23116 mRNA Translation: CAA80662.1 U72398 Genomic DNA Translation: AAB17354.1 CR936637 mRNA Translation: CAI56777.1 BT007208 mRNA Translation: AAP35872.1 AL117381 Genomic DNA No translation available. AL160175 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76424.1 CH471077 Genomic DNA Translation: EAW76425.1 CH471077 Genomic DNA Translation: EAW76429.1 BC019307 mRNA Translation: AAH19307.1
CCDSⁱ	CCDS13188.1 [Q07817-2] CCDS13189.1 [Q07817-1]
PIRⁱ	B47537 JE0203
RefSeqⁱ	NP_001182.1, NM_001191.3 [Q07817-2] NP_001304848.1, NM_001317919.1 [Q07817-1] NP_001304849.1, NM_001317920.1 [Q07817-1] NP_001304850.1, NM_001317921.1 [Q07817-1] NP_001309168.1, NM_001322239.1 [Q07817-1] NP_001309169.1, NM_001322240.1 [Q07817-1] NP_001309171.1, NM_001322242.1 [Q07817-1] NP_612815.1, NM_138578.2 [Q07817-1] XP_011527266.1, XM_011528964.2 [Q07817-1] XP_016883482.1, XM_017027993.1 [Q07817-1]
UniGeneⁱ	Hs.516966 Hs.732176

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BXL	NMR	-	A	1-209	[»]
	1G5J	NMR	-	A	1-209	[»]
	1LXL	NMR	-	A	1-209	[»]
	1MAZ	X-ray	2.20	A	1-209	[»]
	1R2D	X-ray	1.95	A	1-211	[»]
	1R2E	X-ray	2.10	A	1-211	[»]
	1R2G	X-ray	2.70	A	1-211	[»]
	1R2H	X-ray	2.20	A	1-211	[»]
	1R2I	X-ray	2.00	A	1-211	[»]
	1YSG	NMR	-	A	1-209	[»]
	1YSI	NMR	-	A	1-209	[»]
	1YSN	NMR	-	A	1-209	[»]
	2B48	X-ray	3.45	A	1-211	[»]
	2LP8	NMR	-	A	1-209	[»]
	2LPC	NMR	-	A	1-209	[»]
	2M03	NMR	-	A	1-209	[»]
	2M04	NMR	-	A	1-209	[»]
	2ME8	NMR	-	A	1-209	[»]
	2ME9	NMR	-	A	1-209	[»]
	2MEJ	NMR	-	A	1-209	[»]
	2O1Y	NMR	-	A	1-209	[»]
	2O2M	NMR	-	A	2-20	[»]
				A	83-196	[»]
	2O2N	NMR	-	A	2-20	[»]
				A	83-196	[»]
	2P1L	X-ray	2.50	A/C/E/G	1-209	[»]
	2PON	NMR	-	B	1-196	[»]
	2YJ1	X-ray	2.24	A/C	1-209	[»]
	2YQ6	X-ray	1.80	A	1-209	[»]
	2YQ7	X-ray	1.90	A	1-209	[»]
	2YXJ	X-ray	2.20	A/B	1-209	[»]
	3CVA	X-ray	2.70	X	1-211	[»]
	3FDL	X-ray	1.78	A	1-209	[»]
	3FDM	X-ray	2.26	A/B/C	1-209	[»]
	3INQ	X-ray	2.00	A/B	1-209	[»]
	3IO8	X-ray	2.30	A/C	1-209	[»]
	3PL7	X-ray	2.61	A/B	1-209	[»]
	3QKD	X-ray	2.02	A/B	1-209	[»]
	3R85	X-ray	1.95	A/B/C/D	1-197	[»]
	3SP7	X-ray	1.40	A	1-209	[»]
	3SPF	X-ray	1.70	A	1-209	[»]
	3WIZ	X-ray	2.45	A/B	1-209	[»]
	3ZK6	X-ray	2.48	A/B	1-209	[»]
	3ZLN	X-ray	2.29	A	1-209	[»]
	3ZLO	X-ray	2.60	A	1-209	[»]
	3ZLR	X-ray	2.03	A/B	1-209	[»]
	4A1U	X-ray	1.54	A	1-209	[»]
	4A1W	X-ray	2.50	A/B/C/D	1-209	[»]
	4AQ3	X-ray	2.40	A/B/C/D/E/F	29-44	[»]
	4BPK	X-ray	1.76	A/B	1-209	[»]
	4C52	X-ray	2.05	A/B	1-209	[»]
	4C5D	X-ray	2.30	A/B	1-209	[»]
	4CIN	X-ray	2.69	A/B	1-209	[»]
				C/D	79-102	[»]
	4EHR	X-ray	2.09	A	1-209	[»]
	4HNJ	X-ray	2.90	A/B	1-209	[»]
	4IEH	X-ray	2.10	A	29-44	[»]
	4PPI	X-ray	2.85	A	1-209	[»]
	4QVE	X-ray	2.05	A	1-209	[»]
	4QVF	X-ray	1.53	A	1-209	[»]
	4QVX	X-ray	2.10	A/B	1-23	[»]
				A/B	83-209	[»]
	4TUH	X-ray	1.80	A/B/C/D/E/F/G/H	1-209	[»]
4Z9V	X-ray	2.10	A/B	1-208	[»]
5AGW	X-ray	2.69	A/B	29-44	[»]
5AGX	X-ray	2.24	A/B	29-44	[»]
5B1Z	X-ray	2.15	A/B	1-209	[»]
5C3G	X-ray	2.45	A	83-209	[»]
5FMJ	X-ray	2.43	A	1-209	[»]
5FMK	X-ray	1.73	A	1-209	[»]
5VAY	X-ray	1.80	A/B/C/D	29-44	[»]
5VX3	X-ray	1.95	A/C/E/G	1-209	[»]
6BF2	NMR	-	A	1-209	[»]
6DCN	X-ray	2.44	A/B	1-26	[»]
			A/B	83-208	[»]
6DCO	X-ray	2.20	A/B	1-26	[»]
			A/B	83-208	[»]
6F46	NMR	-	A	202-233	[»]
DisProtⁱ	DP00298
ProteinModelPortalⁱ	Q07817
SMRⁱ	Q07817
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107070, 106 interactors
ComplexPortalⁱ	CPX-1983 BAD:BCL-XL complex [Q07817-1] CPX-1985 BIM:BCL-XL complex [Q07817-1] CPX-1987 PUMA:BCL-XL complex [Q07817-1] CPX-1991 BID:BCL-XL complex [Q07817-1] CPX-298 BCL-XL complex [Q07817-1]
CORUMⁱ	Q07817
DIPⁱ	DIP-30916N
ELMⁱ	Q07817
IntActⁱ	Q07817, 98 interactors
MINTⁱ	Q07817
STRINGⁱ	9606.ENSP00000302564

Chemistry databases

BindingDBⁱ	Q07817
ChEMBLⁱ	CHEMBL4625
GuidetoPHARMACOLOGYⁱ	2845

Protein family/group databases

TCDBⁱ	1.A.21.1.1 the bcl-2 (bcl-2) family

TCDBⁱ

1.A.21.1.1 the bcl-2 (bcl-2) family

PTM databases

iPTMnetⁱ	Q07817
PhosphoSitePlusⁱ	Q07817

Polymorphism and mutation databases

BioMutaⁱ	BCL2L1
DMDMⁱ	728955

Proteomic databases

EPDⁱ	Q07817
MaxQBⁱ	Q07817
PaxDbⁱ	Q07817
PeptideAtlasⁱ	Q07817
PRIDEⁱ	Q07817
ProteomicsDBⁱ	58537 58538 [Q07817-2] 58539 [Q07817-3]
TopDownProteomicsⁱ	Q07817-1 [Q07817-1] Q07817-2 [Q07817-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	598
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000307677; ENSP00000302564; ENSG00000171552 [Q07817-1] ENST00000376055; ENSP00000365223; ENSG00000171552 [Q07817-2] ENST00000376062; ENSP00000365230; ENSG00000171552 [Q07817-1]
GeneIDⁱ	598
KEGGⁱ	hsa:598
UCSCⁱ	uc002wwl.4 human [Q07817-1]

Organism-specific databases

CTDⁱ	598
DisGeNETⁱ	598
EuPathDBⁱ	HostDB:ENSG00000171552.12
GeneCardsⁱ	BCL2L1
HGNCⁱ	HGNC:992 BCL2L1
HPAⁱ	CAB072801 HPA035734
MIMⁱ	600039 gene
neXtProtⁱ	NX_Q07817
OpenTargetsⁱ	ENSG00000171552
PharmGKBⁱ	PA76
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4728 Eukaryota ENOG41123S0 LUCA
GeneTreeⁱ	ENSGT00530000062935
HOGENOMⁱ	HOG000056452
InParanoidⁱ	Q07817
KOⁱ	K04570
OMAⁱ	NGSPSWH
OrthoDBⁱ	EOG091G0OCU
PhylomeDBⁱ	Q07817
TreeFamⁱ	TF315834

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-844455 The NLRP1 inflammasome
SIGNORⁱ	Q07817

Miscellaneous databases

ChiTaRSⁱ	BCL2L1 human
EvolutionaryTraceⁱ	Q07817
GeneWikiⁱ	BCL2-like_1_(gene)
GenomeRNAiⁱ	598
PMAP-CutDBⁱ	Q07817
Protein Ontology More...PROⁱ	PR:Q07817
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171552 Expressed in 223 organ(s), highest expression level in upper lobe of left lung
CleanExⁱ	HS_BCL2L1
ExpressionAtlasⁱ	Q07817 baseline and differential
Genevisibleⁱ	Q07817 HS

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR013279 Apop_reg_BclX IPR002475 Bcl2-like IPR004725 Bcl2/BclX IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR020728 Bcl2_BH3_motif_CS IPR003093 Bcl2_BH4 IPR020731 Bcl2_BH4_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF12 PTHR11256:SF12, 1 hit
Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit PF02180 BH4, 1 hit
PRINTSⁱ	PR01864 APOPREGBCLX PR01862 BCL2FAMILY
SMARTⁱ	View protein in SMART SM00265 BH4, 1 hit
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
TIGRFAMsⁱ	TIGR00865 bcl-2, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01259 BH3, 1 hit PS01260 BH4_1, 1 hit PS50063 BH4_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2CL1_HUMAN
Accessionⁱ	Q07817Primary (citable) accession number: Q07817 Secondary accession number(s): E1P5L6 , Q5CZ89, Q5TE65, Q92976
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	November 7, 2018
	This is version 221 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q07817 (B2CL1_HUMAN)

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Bcl-2-like protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Nucleus

Mitochondrion

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ