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Protein

Bcl-2-like protein 1

Gene

BCL2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).1 Publication
Isoform Bcl-X(S) promotes apoptosis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Endocytosis

Enzyme and pathway databases

ReactomeiR-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-844455 The NLRP1 inflammasome
SIGNORiQ07817

Protein family/group databases

TCDBi1.A.21.1.1 the bcl-2 (bcl-2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 1
Short name:
Bcl2-L-1
Alternative name(s):
Apoptosis regulator Bcl-X
Gene namesi
Name:BCL2L1
Synonyms:BCL2L, BCLX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171552.12
HGNCiHGNC:992 BCL2L1
MIMi600039 gene
neXtProtiNX_Q07817

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei210 – 226HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Nucleus, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49S → A: Less stable at G2 checkpoint after DNA damage. 1 Publication1
Mutagenesisi61D → A: No cleavage by caspase-1 nor by caspase-3. 1 Publication1
Mutagenesisi131 – 133FRD → VRA: No heterodimerization with BAX. 1 Publication3
Mutagenesisi135 – 137VNW → AIL: Loss of anti-apoptotic activity. 1 Publication3
Mutagenesisi138 – 140GRI → ELN: Loss of anti-apoptotic activity. 1 Publication3
Mutagenesisi138G → A: No heterodimerization with BAX. 1 Publication1
Mutagenesisi145 – 147SFG → YCC: Decreases interaction with DNM1L, no effect on endocytosis enhancement. 1 Publication3
Mutagenesisi148G → E: No heterodimerization with BAX. 1 Publication1
Mutagenesisi156D → A: No effect on caspase-1 cleavage. 1 Publication1
Mutagenesisi176D → A: No effect on caspase-1 cleavage. 1 Publication1
Mutagenesisi188 – 191WDTF → SVTC: Abolishes interaction with DNM1L and endocytosis enhancement. 1 Publication4
Mutagenesisi188 – 189WD → GA: Reduces anti-apoptotic activity by about half. 1 Publication2
Mutagenesisi189D → A: No effect on caspase-1 cleavage. 1 Publication1

Organism-specific databases

DisGeNETi598
OpenTargetsiENSG00000171552
PharmGKBiPA76

Chemistry databases

ChEMBLiCHEMBL4625
GuidetoPHARMACOLOGYi2845

Polymorphism and mutation databases

BioMutaiBCL2L1
DMDMi728955

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430621 – 233Bcl-2-like protein 1Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Phosphoserine; by PLK31 Publication1
Modified residuei62Phosphoserine; by CDK11 Publication1

Post-translational modificationi

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.1 Publication
Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei61 – 62Cleavage; by caspase-12

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ07817
MaxQBiQ07817
PaxDbiQ07817
PeptideAtlasiQ07817
PRIDEiQ07817
ProteomicsDBi58537
58538 [Q07817-2]
58539 [Q07817-3]
TopDownProteomicsiQ07817-1 [Q07817-1]
Q07817-2 [Q07817-2]

PTM databases

iPTMnetiQ07817
PhosphoSitePlusiQ07817

Miscellaneous databases

PMAP-CutDBiQ07817

Expressioni

Tissue specificityi

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Gene expression databases

BgeeiENSG00000171552 Expressed in 223 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_BCL2L1
ExpressionAtlasiQ07817 baseline and differential
GenevisibleiQ07817 HS

Organism-specific databases

HPAiCAB072801
HPA035734

Interactioni

Subunit structurei

Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with RTL10/BOP. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5F1A and ATP5F1B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F1F0 ATP synthase. Interacts with VDAC1 (PubMed:25296756). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785). Interacts with BCL2L11 (via BH3) (PubMed:27013495).14 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107070, 105 interactors
ComplexPortaliCPX-1983 BAD:BCL-XL complex [Q07817-1]
CPX-1985 BIM:BCL-XL complex [Q07817-1]
CPX-1987 PUMA:BCL-XL complex [Q07817-1]
CPX-1991 BID:BCL-XL complex [Q07817-1]
CPX-298 BCL-XL complex [Q07817-1]
CORUMiQ07817
DIPiDIP-30916N
ELMiQ07817
IntActiQ07817, 98 interactors
MINTiQ07817
STRINGi9606.ENSP00000302564

Chemistry databases

BindingDBiQ07817

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00298
ProteinModelPortaliQ07817
SMRiQ07817
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07817

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi4 – 24BH4Add BLAST21
Motifi86 – 100BH3Add BLAST15
Motifi129 – 148BH1Add BLAST20
Motifi180 – 195BH2Add BLAST16

Domaini

The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.1 Publication

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00530000062935
HOGENOMiHOG000056452
InParanoidiQ07817
KOiK04570
OMAiNGSPSWH
OrthoDBiEOG091G0OCU
PhylomeDBiQ07817
TreeFamiTF315834

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR013279 Apop_reg_BclX
IPR002475 Bcl2-like
IPR004725 Bcl2/BclX
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS
IPR003093 Bcl2_BH4
IPR020731 Bcl2_BH4_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF12 PTHR11256:SF12, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
PRINTSiPR01864 APOPREGBCLX
PR01862 BCL2FAMILY
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
TIGRFAMsiTIGR00865 bcl-2, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01259 BH3, 1 hit
PS01260 BH4_1, 1 hit
PS50063 BH4_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Bcl-X(L) (identifier: Q07817-1) [UniParc]FASTAAdd to basket
Also known as: Bcl-xL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180 190 200
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA
210 220 230
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK
Length:233
Mass (Da):26,049
Last modified:February 1, 1995 - v1
Checksum:iE09D3CDD851AE9BE
GO
Isoform Bcl-X(S) (identifier: Q07817-2) [UniParc]FASTAAdd to basket
Also known as: Bcl-xS

The sequence of this isoform differs from the canonical sequence as follows:
     126-188: Missing.

Show »
Length:170
Mass (Da):18,894
Checksum:i75D1FC01EC06AD47
GO
Isoform Bcl-X(beta) (identifier: Q07817-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-233: DTFVELYGNN...VLLGSLFSRK → VRTKPLVCPF...CWVIVGDVDS

Show »
Length:227
Mass (Da):25,290
Checksum:i1EF621E5D0744E4E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TE64Q5TE64_HUMAN
Bcl-2-like protein 1
BCL2L1
205Annotation score:
Q5QP56Q5QP56_HUMAN
Bcl-2-like protein 1
BCL2L1
181Annotation score:
Q9H1R6Q9H1R6_HUMAN
Bcl-2-like protein 1
BCL2L1
188Annotation score:
Q5QP59Q5QP59_HUMAN
Bcl-2-like protein 1
BCL2L1
48Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70G → A in CAA80661 (PubMed:8358789).Curated1
Sequence conflicti168A → V in CAI56777 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000515126 – 188Missing in isoform Bcl-X(S). CuratedAdd BLAST63
Alternative sequenceiVSP_000516189 – 233DTFVE…LFSRK → VRTKPLVCPFSLASGQRSPT ALLLYLFLLCWVIVGDVDS in isoform Bcl-X(beta). CuratedAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23115 mRNA Translation: CAA80661.1
Z23116 mRNA Translation: CAA80662.1
U72398 Genomic DNA Translation: AAB17354.1
CR936637 mRNA Translation: CAI56777.1
BT007208 mRNA Translation: AAP35872.1
AL117381 Genomic DNA No translation available.
AL160175 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76424.1
CH471077 Genomic DNA Translation: EAW76425.1
CH471077 Genomic DNA Translation: EAW76429.1
BC019307 mRNA Translation: AAH19307.1
CCDSiCCDS13188.1 [Q07817-2]
CCDS13189.1 [Q07817-1]
PIRiB47537
JE0203
RefSeqiNP_001182.1, NM_001191.3 [Q07817-2]
NP_001304848.1, NM_001317919.1 [Q07817-1]
NP_001304849.1, NM_001317920.1 [Q07817-1]
NP_001304850.1, NM_001317921.1 [Q07817-1]
NP_001309168.1, NM_001322239.1 [Q07817-1]
NP_001309169.1, NM_001322240.1 [Q07817-1]
NP_001309171.1, NM_001322242.1 [Q07817-1]
NP_612815.1, NM_138578.2 [Q07817-1]
XP_011527266.1, XM_011528964.2 [Q07817-1]
XP_016883482.1, XM_017027993.1 [Q07817-1]
UniGeneiHs.516966
Hs.732176

Genome annotation databases

EnsembliENST00000307677; ENSP00000302564; ENSG00000171552 [Q07817-1]
ENST00000376055; ENSP00000365223; ENSG00000171552 [Q07817-2]
ENST00000376062; ENSP00000365230; ENSG00000171552 [Q07817-1]
GeneIDi598
KEGGihsa:598
UCSCiuc002wwl.4 human [Q07817-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23115 mRNA Translation: CAA80661.1
Z23116 mRNA Translation: CAA80662.1
U72398 Genomic DNA Translation: AAB17354.1
CR936637 mRNA Translation: CAI56777.1
BT007208 mRNA Translation: AAP35872.1
AL117381 Genomic DNA No translation available.
AL160175 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76424.1
CH471077 Genomic DNA Translation: EAW76425.1
CH471077 Genomic DNA Translation: EAW76429.1
BC019307 mRNA Translation: AAH19307.1
CCDSiCCDS13188.1 [Q07817-2]
CCDS13189.1 [Q07817-1]
PIRiB47537
JE0203
RefSeqiNP_001182.1, NM_001191.3 [Q07817-2]
NP_001304848.1, NM_001317919.1 [Q07817-1]
NP_001304849.1, NM_001317920.1 [Q07817-1]
NP_001304850.1, NM_001317921.1 [Q07817-1]
NP_001309168.1, NM_001322239.1 [Q07817-1]
NP_001309169.1, NM_001322240.1 [Q07817-1]
NP_001309171.1, NM_001322242.1 [Q07817-1]
NP_612815.1, NM_138578.2 [Q07817-1]
XP_011527266.1, XM_011528964.2 [Q07817-1]
XP_016883482.1, XM_017027993.1 [Q07817-1]
UniGeneiHs.516966
Hs.732176

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXLNMR-A1-209[»]
1G5JNMR-A1-209[»]
1LXLNMR-A1-209[»]
1MAZX-ray2.20A1-209[»]
1R2DX-ray1.95A1-211[»]
1R2EX-ray2.10A1-211[»]
1R2GX-ray2.70A1-211[»]
1R2HX-ray2.20A1-211[»]
1R2IX-ray2.00A1-211[»]
1YSGNMR-A1-209[»]
1YSINMR-A1-209[»]
1YSNNMR-A1-209[»]
2B48X-ray3.45A1-211[»]
2LP8NMR-A1-209[»]
2LPCNMR-A1-209[»]
2M03NMR-A1-209[»]
2M04NMR-A1-209[»]
2ME8NMR-A1-209[»]
2ME9NMR-A1-209[»]
2MEJNMR-A1-209[»]
2O1YNMR-A1-209[»]
2O2MNMR-A2-20[»]
A83-196[»]
2O2NNMR-A2-20[»]
A83-196[»]
2P1LX-ray2.50A/C/E/G1-209[»]
2PONNMR-B1-196[»]
2YJ1X-ray2.24A/C1-209[»]
2YQ6X-ray1.80A1-209[»]
2YQ7X-ray1.90A1-209[»]
2YXJX-ray2.20A/B1-209[»]
3CVAX-ray2.70X1-211[»]
3FDLX-ray1.78A1-209[»]
3FDMX-ray2.26A/B/C1-209[»]
3INQX-ray2.00A/B1-209[»]
3IO8X-ray2.30A/C1-209[»]
3PL7X-ray2.61A/B1-209[»]
3QKDX-ray2.02A/B1-209[»]
3R85X-ray1.95A/B/C/D1-197[»]
3SP7X-ray1.40A1-209[»]
3SPFX-ray1.70A1-209[»]
3WIZX-ray2.45A/B1-209[»]
3ZK6X-ray2.48A/B1-209[»]
3ZLNX-ray2.29A1-209[»]
3ZLOX-ray2.60A1-209[»]
3ZLRX-ray2.03A/B1-209[»]
4A1UX-ray1.54A1-209[»]
4A1WX-ray2.50A/B/C/D1-209[»]
4AQ3X-ray2.40A/B/C/D/E/F29-44[»]
4BPKX-ray1.76A/B1-209[»]
4C52X-ray2.05A/B1-209[»]
4C5DX-ray2.30A/B1-209[»]
4CINX-ray2.69A/B1-209[»]
C/D79-102[»]
4EHRX-ray2.09A1-209[»]
4HNJX-ray2.90A/B1-209[»]
4IEHX-ray2.10A29-44[»]
4PPIX-ray2.85A1-209[»]
4QVEX-ray2.05A1-209[»]
4QVFX-ray1.53A1-209[»]
4QVXX-ray2.10A/B1-23[»]
A/B83-209[»]
4TUHX-ray1.80A/B/C/D/E/F/G/H1-209[»]
4Z9VX-ray2.10A/B1-208[»]
5AGWX-ray2.69A/B29-44[»]
5AGXX-ray2.24A/B29-44[»]
5B1ZX-ray2.15A/B1-209[»]
5C3GX-ray2.45A83-209[»]
5FMJX-ray2.43A1-209[»]
5FMKX-ray1.73A1-209[»]
5VAYX-ray1.80A/B/C/D29-44[»]
5VX3X-ray1.95A/C/E/G1-209[»]
6BF2NMR-A1-209[»]
6DCNX-ray2.44A/B1-26[»]
A/B83-208[»]
6DCOX-ray2.20A/B1-26[»]
A/B83-208[»]
6F46NMR-A202-233[»]
DisProtiDP00298
ProteinModelPortaliQ07817
SMRiQ07817
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107070, 105 interactors
ComplexPortaliCPX-1983 BAD:BCL-XL complex [Q07817-1]
CPX-1985 BIM:BCL-XL complex [Q07817-1]
CPX-1987 PUMA:BCL-XL complex [Q07817-1]
CPX-1991 BID:BCL-XL complex [Q07817-1]
CPX-298 BCL-XL complex [Q07817-1]
CORUMiQ07817
DIPiDIP-30916N
ELMiQ07817
IntActiQ07817, 98 interactors
MINTiQ07817
STRINGi9606.ENSP00000302564

Chemistry databases

BindingDBiQ07817
ChEMBLiCHEMBL4625
GuidetoPHARMACOLOGYi2845

Protein family/group databases

TCDBi1.A.21.1.1 the bcl-2 (bcl-2) family

PTM databases

iPTMnetiQ07817
PhosphoSitePlusiQ07817

Polymorphism and mutation databases

BioMutaiBCL2L1
DMDMi728955

Proteomic databases

EPDiQ07817
MaxQBiQ07817
PaxDbiQ07817
PeptideAtlasiQ07817
PRIDEiQ07817
ProteomicsDBi58537
58538 [Q07817-2]
58539 [Q07817-3]
TopDownProteomicsiQ07817-1 [Q07817-1]
Q07817-2 [Q07817-2]

Protocols and materials databases

DNASUi598
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307677; ENSP00000302564; ENSG00000171552 [Q07817-1]
ENST00000376055; ENSP00000365223; ENSG00000171552 [Q07817-2]
ENST00000376062; ENSP00000365230; ENSG00000171552 [Q07817-1]
GeneIDi598
KEGGihsa:598
UCSCiuc002wwl.4 human [Q07817-1]

Organism-specific databases

CTDi598
DisGeNETi598
EuPathDBiHostDB:ENSG00000171552.12
GeneCardsiBCL2L1
HGNCiHGNC:992 BCL2L1
HPAiCAB072801
HPA035734
MIMi600039 gene
neXtProtiNX_Q07817
OpenTargetsiENSG00000171552
PharmGKBiPA76
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00530000062935
HOGENOMiHOG000056452
InParanoidiQ07817
KOiK04570
OMAiNGSPSWH
OrthoDBiEOG091G0OCU
PhylomeDBiQ07817
TreeFamiTF315834

Enzyme and pathway databases

ReactomeiR-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-844455 The NLRP1 inflammasome
SIGNORiQ07817

Miscellaneous databases

ChiTaRSiBCL2L1 human
EvolutionaryTraceiQ07817
GeneWikiiBCL2-like_1_(gene)
GenomeRNAii598
PMAP-CutDBiQ07817
PROiPR:Q07817
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171552 Expressed in 223 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_BCL2L1
ExpressionAtlasiQ07817 baseline and differential
GenevisibleiQ07817 HS

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR013279 Apop_reg_BclX
IPR002475 Bcl2-like
IPR004725 Bcl2/BclX
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS
IPR003093 Bcl2_BH4
IPR020731 Bcl2_BH4_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF12 PTHR11256:SF12, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
PRINTSiPR01864 APOPREGBCLX
PR01862 BCL2FAMILY
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
TIGRFAMsiTIGR00865 bcl-2, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit
PS01259 BH3, 1 hit
PS01260 BH4_1, 1 hit
PS50063 BH4_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2CL1_HUMAN
AccessioniPrimary (citable) accession number: Q07817
Secondary accession number(s): E1P5L6
, Q5CZ89, Q5TE65, Q92976
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 10, 2018
This is version 220 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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