UniProtKB - Q07817 (B2CL1_HUMAN)
Bcl-2-like protein 1
BCL2L1
Functioni
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
1 PublicationIsoform Bcl-X(S) promotes apoptosis.
GO - Molecular functioni
- BH3 domain binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: UniProtKB
GO - Biological processi
- apoptotic mitochondrial changes Source: ProtInc
- apoptotic process in bone marrow cell Source: Ensembl
- cell population proliferation Source: Ensembl
- cellular response to alkaloid Source: Ensembl
- cellular response to amino acid stimulus Source: Ensembl
- cellular response to gamma radiation Source: Ensembl
- defense response to virus Source: DIBU
- endocytosis Source: UniProtKB-KW
- extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
- fertilization Source: Ensembl
- germ cell development Source: Ensembl
- hepatocyte apoptotic process Source: Ensembl
- intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
- in utero embryonic development Source: Ensembl
- male gonad development Source: Ensembl
- mitochondrion morphogenesis Source: Ensembl
- negative regulation of anoikis Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of autophagy Source: UniProtKB
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: UniProtKB
- negative regulation of execution phase of apoptosis Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
- negative regulation of intrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: ComplexPortal
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of protein localization to plasma membrane Source: BHF-UCL
- negative regulation of release of cytochrome c from mitochondria Source: ComplexPortal
- neuron apoptotic process Source: Ensembl
- ovarian follicle development Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- regulation of cytokinesis Source: UniProtKB
- regulation of growth Source: Ensembl
- regulation of mitochondrial membrane permeability Source: HGNC-UCL
- regulation of mitochondrial membrane potential Source: HGNC-UCL
- release of cytochrome c from mitochondria Source: HGNC-UCL
- response to cycloheximide Source: Ensembl
- response to cytokine Source: MGI
- spermatogenesis Source: Ensembl
- suppression by virus of host apoptotic process Source: MGI
Keywordsi
Biological process | Apoptosis, Endocytosis |
Enzyme and pathway databases
PathwayCommonsi | Q07817 |
Reactomei | R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-844455, The NLRP1 inflammasome R-HSA-9648002, RAS processing R-HSA-9702518, STAT5 activation downstream of FLT3 ITD mutants |
SignaLinki | Q07817 |
SIGNORi | Q07817 |
Protein family/group databases
TCDBi | 1.A.21.1.1, the bcl-2 (bcl-2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-like protein 1Short name: Bcl2-L-1 Alternative name(s): Apoptosis regulator Bcl-X |
Gene namesi | Name:BCL2L1 Synonyms:BCL2L, BCLX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:992, BCL2L1 |
MIMi | 600039, gene |
neXtProti | NX_Q07817 |
VEuPathDBi | HostDB:ENSG00000171552 |
Subcellular locationi
Nucleus
- Nucleus membrane By similarity; Single-pass membrane protein By similarity; Cytoplasmic side By similarity
Mitochondrion
- Mitochondrion inner membrane By similarity
- Mitochondrion outer membrane By similarity
- Mitochondrion matrix By similarity
Cytoplasm and Cytosol
- cytosol By similarity
Cytoskeleton
Other locations
- synaptic vesicle membrane By similarity
Note: After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.By similarity
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: HGNC-UCL
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- Bcl-2 family protein complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- PUMA-BCL-xl complex Source: ComplexPortal
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 210 – 226 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Nucleus, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 49 | S → A: Less stable at G2 checkpoint after DNA damage. 1 Publication | 1 | |
Mutagenesisi | 61 | D → A: No cleavage by caspase-1 nor by caspase-3. 1 Publication | 1 | |
Mutagenesisi | 131 – 133 | FRD → VRA: No heterodimerization with BAX. 1 Publication | 3 | |
Mutagenesisi | 135 – 137 | VNW → AIL: Loss of anti-apoptotic activity. 1 Publication | 3 | |
Mutagenesisi | 138 – 140 | GRI → ELN: Loss of anti-apoptotic activity. 1 Publication | 3 | |
Mutagenesisi | 138 | G → A: No heterodimerization with BAX. 1 Publication | 1 | |
Mutagenesisi | 145 – 147 | SFG → YCC: Decreases interaction with DNM1L, no effect on endocytosis enhancement. 1 Publication | 3 | |
Mutagenesisi | 148 | G → E: No heterodimerization with BAX. 1 Publication | 1 | |
Mutagenesisi | 156 | D → A: No effect on caspase-1 cleavage. 1 Publication | 1 | |
Mutagenesisi | 176 | D → A: No effect on caspase-1 cleavage. 1 Publication | 1 | |
Mutagenesisi | 188 – 191 | WDTF → SVTC: Abolishes interaction with DNM1L and endocytosis enhancement. 1 Publication | 4 | |
Mutagenesisi | 188 – 189 | WD → GA: Reduces anti-apoptotic activity by about half. 1 Publication | 2 | |
Mutagenesisi | 189 | D → A: No effect on caspase-1 cleavage. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 598 |
OpenTargetsi | ENSG00000171552 |
PharmGKBi | PA76 |
Miscellaneous databases
Pharosi | Q07817, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4625 |
DrugBanki | DB07108, 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID DB13044, Gossypol DB09401, Isosorbide |
DrugCentrali | Q07817 |
GuidetoPHARMACOLOGYi | 2845 |
Genetic variation databases
BioMutai | BCL2L1 |
DMDMi | 728955 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143062 | 1 – 233 | Bcl-2-like protein 1Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | Phosphoserine; by PLK31 Publication | 1 | |
Modified residuei | 62 | Phosphoserine; by CDK11 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 61 – 62 | Cleavage; by caspase-1 | 2 |
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q07817 |
jPOSTi | Q07817 |
MassIVEi | Q07817 |
MaxQBi | Q07817 |
PaxDbi | Q07817 |
PeptideAtlasi | Q07817 |
PRIDEi | Q07817 |
ProteomicsDBi | 58537 [Q07817-1] 58538 [Q07817-2] 58539 [Q07817-3] |
TopDownProteomicsi | Q07817-1 [Q07817-1] Q07817-2 [Q07817-2] |
PTM databases
iPTMneti | Q07817 |
PhosphoSitePlusi | Q07817 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000171552, Expressed in upper lobe of left lung and 238 other tissues |
ExpressionAtlasi | Q07817, baseline and differential |
Genevisiblei | Q07817, HS |
Organism-specific databases
HPAi | ENSG00000171552, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity.
Interacts with BCL2L11.
Interacts with BAD.
Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity.
Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3.
Interacts with HEBP2. Isoform Bcl-X(L) interacts with RTL10/BOP.
Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF.
Interacts with ATP5F1A and ATP5F1B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F1F0 ATP synthase.
Interacts with VDAC1 (PubMed:25296756). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785).
Interacts with BCL2L11 (via BH3) (PubMed:27013495).
Interacts with RNF183 (PubMed:29507230).
Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771).
Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and BCL2L1 is impaired in the absence of GIMAP5 (By similarity).
Interacts with CLU (isoform 4); this interaction releases and activates BAX and promotes cell death (PubMed:21567405).
By similarity17 PublicationsBinary interactionsi
Q07817
BCL2L1 - isoform Bcl-X(L) [Q07817-1]
GO - Molecular functioni
- BH3 domain binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107070, 201 interactors |
ComplexPortali | CPX-1983, BAD:BCL-XL complex [Q07817-1] CPX-1985, BIM:BCL-XL complex [Q07817-1] CPX-1987, PUMA:BCL-XL complex [Q07817-1] CPX-1991, BID:BCL-XL complex [Q07817-1] CPX-298, BCL-XL complex [Q07817-1] |
CORUMi | Q07817 |
DIPi | DIP-30916N |
ELMi | Q07817 |
IntActi | Q07817, 105 interactors |
MINTi | Q07817 |
STRINGi | 9606.ENSP00000302564 |
Chemistry databases
BindingDBi | Q07817 |
Miscellaneous databases
RNActi | Q07817, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q07817 |
SMRi | Q07817 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q07817 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 71 | DisorderedSequence analysisAdd BLAST | 44 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 4 – 24 | BH4Add BLAST | 21 | |
Motifi | 86 – 100 | BH3Add BLAST | 15 | |
Motifi | 129 – 148 | BH1Add BLAST | 20 | |
Motifi | 180 – 195 | BH2Add BLAST | 16 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT01020000230347 |
InParanoidi | Q07817 |
OMAi | RIASWMT |
PhylomeDBi | Q07817 |
TreeFami | TF315834 |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
DisProti | DP00298 |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR004725, Bcl2/BclX IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF12, PTHR11256:SF12, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
TIGRFAMsi | TIGR00865, bcl-2, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180 190 200
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA
210 220 230
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK
The sequence of this isoform differs from the canonical sequence as follows:
126-188: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
189-233: DTFVELYGNN...VLLGSLFSRK → VRTKPLVCPF...CWVIVGDVDS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5TE64 | Q5TE64_HUMAN | Apoptosis regulator Bcl-X | BCL2L1 | 307 | Annotation score: | ||
Q5QP56 | Q5QP56_HUMAN | Apoptosis regulator Bcl-X | BCL2L1 | 181 | Annotation score: | ||
Q9H1R6 | Q9H1R6_HUMAN | Apoptosis regulator Bcl-X | BCL2L1 | 188 | Annotation score: | ||
A0A7I2V597 | A0A7I2V597_HUMAN | Apoptosis regulator Bcl-X | BCL2L1 | 200 | Annotation score: | ||
Q5QP59 | Q5QP59_HUMAN | Bcl-2-like protein 1 | BCL2L1 | 48 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | G → A in CAA80661 (PubMed:8358789).Curated | 1 | |
Sequence conflicti | 168 | A → V in CAI56777 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000515 | 126 – 188 | Missing in isoform Bcl-X(S). CuratedAdd BLAST | 63 | |
Alternative sequenceiVSP_000516 | 189 – 233 | DTFVE…LFSRK → VRTKPLVCPFSLASGQRSPT ALLLYLFLLCWVIVGDVDS in isoform Bcl-X(beta). CuratedAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23115 mRNA Translation: CAA80661.1 Z23116 mRNA Translation: CAA80662.1 U72398 Genomic DNA Translation: AAB17354.1 CR936637 mRNA Translation: CAI56777.1 BT007208 mRNA Translation: AAP35872.1 AL117381 Genomic DNA No translation available. AL160175 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76424.1 CH471077 Genomic DNA Translation: EAW76425.1 CH471077 Genomic DNA Translation: EAW76429.1 BC019307 mRNA Translation: AAH19307.1 |
CCDSi | CCDS13188.1 [Q07817-2] CCDS13189.1 [Q07817-1] |
PIRi | B47537 JE0203 |
RefSeqi | NP_001182.1, NM_001191.3 [Q07817-2] NP_001304848.1, NM_001317919.1 [Q07817-1] NP_001304849.1, NM_001317920.1 [Q07817-1] NP_001304850.1, NM_001317921.1 [Q07817-1] NP_001309168.1, NM_001322239.1 [Q07817-1] NP_001309169.1, NM_001322240.1 [Q07817-1] NP_001309171.1, NM_001322242.1 [Q07817-1] NP_612815.1, NM_138578.2 [Q07817-1] XP_011527266.1, XM_011528964.2 [Q07817-1] XP_016883482.1, XM_017027993.1 [Q07817-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23115 mRNA Translation: CAA80661.1 Z23116 mRNA Translation: CAA80662.1 U72398 Genomic DNA Translation: AAB17354.1 CR936637 mRNA Translation: CAI56777.1 BT007208 mRNA Translation: AAP35872.1 AL117381 Genomic DNA No translation available. AL160175 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76424.1 CH471077 Genomic DNA Translation: EAW76425.1 CH471077 Genomic DNA Translation: EAW76429.1 BC019307 mRNA Translation: AAH19307.1 |
CCDSi | CCDS13188.1 [Q07817-2] CCDS13189.1 [Q07817-1] |
PIRi | B47537 JE0203 |
RefSeqi | NP_001182.1, NM_001191.3 [Q07817-2] NP_001304848.1, NM_001317919.1 [Q07817-1] NP_001304849.1, NM_001317920.1 [Q07817-1] NP_001304850.1, NM_001317921.1 [Q07817-1] NP_001309168.1, NM_001322239.1 [Q07817-1] NP_001309169.1, NM_001322240.1 [Q07817-1] NP_001309171.1, NM_001322242.1 [Q07817-1] NP_612815.1, NM_138578.2 [Q07817-1] XP_011527266.1, XM_011528964.2 [Q07817-1] XP_016883482.1, XM_017027993.1 [Q07817-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BXL | NMR | - | A | 1-209 | [»] | |
1G5J | NMR | - | A | 1-209 | [»] | |
1LXL | NMR | - | A | 1-209 | [»] | |
1MAZ | X-ray | 2.20 | A | 1-209 | [»] | |
1R2D | X-ray | 1.95 | A | 1-211 | [»] | |
1R2E | X-ray | 2.10 | A | 1-211 | [»] | |
1R2G | X-ray | 2.70 | A | 1-211 | [»] | |
1R2H | X-ray | 2.20 | A | 1-211 | [»] | |
1R2I | X-ray | 2.00 | A | 1-211 | [»] | |
1YSG | NMR | - | A | 1-209 | [»] | |
1YSI | NMR | - | A | 1-209 | [»] | |
1YSN | NMR | - | A | 1-209 | [»] | |
2B48 | X-ray | 3.45 | A | 1-211 | [»] | |
2LP8 | NMR | - | A | 1-209 | [»] | |
2LPC | NMR | - | A | 1-209 | [»] | |
2M03 | NMR | - | A | 1-209 | [»] | |
2M04 | NMR | - | A | 1-209 | [»] | |
2ME8 | NMR | - | A | 1-209 | [»] | |
2ME9 | NMR | - | A | 1-209 | [»] | |
2MEJ | NMR | - | A | 1-209 | [»] | |
2O1Y | NMR | - | A | 1-209 | [»] | |
2O2M | NMR | - | A | 2-20 | [»] | |
A | 83-196 | [»] | ||||
2O2N | NMR | - | A | 2-20 | [»] | |
A | 83-196 | [»] | ||||
2P1L | X-ray | 2.50 | A/C/E/G | 1-209 | [»] | |
2PON | NMR | - | B | 1-196 | [»] | |
2YJ1 | X-ray | 2.24 | A/C | 1-209 | [»] | |
2YQ6 | X-ray | 1.80 | A | 1-209 | [»] | |
2YQ7 | X-ray | 1.90 | A | 1-209 | [»] | |
2YXJ | X-ray | 2.20 | A/B | 1-209 | [»] | |
3CVA | X-ray | 2.70 | X | 1-211 | [»] | |
3FDL | X-ray | 1.78 | A | 1-209 | [»] | |
3FDM | X-ray | 2.26 | A/B/C | 1-209 | [»] | |
3INQ | X-ray | 2.00 | A/B | 1-209 | [»] | |
3IO8 | X-ray | 2.30 | A/C | 1-209 | [»] | |
3PL7 | X-ray | 2.61 | A/B | 1-209 | [»] | |
3QKD | X-ray | 2.02 | A/B | 1-209 | [»] | |
3R85 | X-ray | 1.95 | A/B/C/D | 1-197 | [»] | |
3SP7 | X-ray | 1.40 | A | 1-209 | [»] | |
3SPF | X-ray | 1.70 | A | 1-209 | [»] | |
3WIZ | X-ray | 2.45 | A/B | 1-209 | [»] | |
3ZK6 | X-ray | 2.48 | A/B | 1-209 | [»] | |
3ZLN | X-ray | 2.29 | A | 1-209 | [»] | |
3ZLO | X-ray | 2.60 | A | 1-209 | [»] | |
3ZLR | X-ray | 2.03 | A/B | 1-209 | [»] | |
4A1U | X-ray | 1.54 | A | 1-209 | [»] | |
4A1W | X-ray | 2.50 | A/B/C/D | 1-209 | [»] | |
4AQ3 | X-ray | 2.40 | A/B/C/D/E/F | 29-44 | [»] | |
4BPK | X-ray | 1.76 | A/B | 1-209 | [»] | |
4C52 | X-ray | 2.05 | A/B | 1-209 | [»] | |
4C5D | X-ray | 2.30 | A/B | 1-209 | [»] | |
4CIN | X-ray | 2.69 | A/B | 1-209 | [»] | |
C/D | 79-102 | [»] | ||||
4EHR | X-ray | 2.09 | A | 1-209 | [»] | |
4HNJ | X-ray | 2.90 | A/B | 1-209 | [»] | |
4IEH | X-ray | 2.10 | A | 29-44 | [»] | |
4PPI | X-ray | 2.85 | A | 1-209 | [»] | |
4QVE | X-ray | 2.05 | A | 1-209 | [»] | |
4QVF | X-ray | 1.53 | A | 1-209 | [»] | |
4QVX | X-ray | 2.10 | A/B | 1-23 | [»] | |
A/B | 83-209 | [»] | ||||
4TUH | X-ray | 1.80 | A/B/C/D/E/F/G/H | 1-209 | [»] | |
4Z9V | X-ray | 2.10 | A/B | 1-208 | [»] | |
5AGW | X-ray | 2.69 | A/B | 29-44 | [»] | |
5AGX | X-ray | 2.24 | A/B | 29-44 | [»] | |
5B1Z | X-ray | 2.15 | A/B | 1-209 | [»] | |
5C3G | X-ray | 2.45 | A | 83-209 | [»] | |
5FMJ | X-ray | 2.43 | A | 1-209 | [»] | |
5FMK | X-ray | 1.73 | A | 1-209 | [»] | |
5VAY | X-ray | 1.80 | A/B/C/D | 29-44 | [»] | |
5VX3 | X-ray | 1.95 | A/C/E/G | 1-209 | [»] | |
6BF2 | NMR | - | A | 1-209 | [»] | |
6DCN | X-ray | 2.44 | A/B | 1-26 | [»] | |
A/B | 83-208 | [»] | ||||
6DCO | X-ray | 2.20 | A/B | 1-26 | [»] | |
A/B | 83-208 | [»] | ||||
6F46 | NMR | - | A | 202-233 | [»] | |
6HJL | X-ray | 2.20 | A | 83-197 | [»] | |
B/E/F | 83-195 | [»] | ||||
6IJQ | NMR | - | B | 1-209 | [»] | |
6LHD | X-ray | 2.50 | A/B | 2-201 | [»] | |
6O0K | X-ray | 1.62 | A | 29-44 | [»] | |
6O0L | X-ray | 2.20 | A/C | 29-44 | [»] | |
6O0M | X-ray | 1.75 | A | 29-44 | [»] | |
6O0O | X-ray | 2.00 | A/C | 29-44 | [»] | |
6O0P | X-ray | 1.80 | A | 29-44 | [»] | |
6RNU | X-ray | 2.40 | A/B | 1-209 | [»] | |
6ST2 | X-ray | 1.79 | A/B | 1-209 | [»] | |
6UVC | X-ray | 1.90 | A/B | 1-209 | [»] | |
6UVD | X-ray | 2.15 | A/B | 1-209 | [»] | |
6UVE | X-ray | 2.87 | A/B/C | 1-209 | [»] | |
6UVF | X-ray | 2.24 | A/B/C/D/E/F/G/H/I/J/K/L | 1-209 | [»] | |
6UVG | X-ray | 2.10 | A/B/C/D/E/F/G/H/I/J/K/L | 1-209 | [»] | |
6UVH | X-ray | 2.19 | A/B/C/D | 1-209 | [»] | |
6VWC | X-ray | 1.60 | A/B | 1-25 | [»] | |
A/B | 83-209 | [»] | ||||
6X7I | Other | - | A | 206-233 | [»] | |
6YLI | X-ray | 1.90 | A/C | 1-209 | [»] | |
6ZHC | X-ray | 1.92 | DDD | 1-209 | [»] | |
7CA4 | X-ray | 2.70 | A | 1-211 | [»] | |
7JGV | X-ray | 2.05 | A/B | 1-209 | [»] | |
7JGW | X-ray | 1.30 | A | 1-209 | [»] | |
7LH7 | X-ray | 1.41 | A/B | 1-25 | [»] | |
A/B | 83-209 | [»] | ||||
BMRBi | Q07817 | |||||
SMRi | Q07817 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107070, 201 interactors |
ComplexPortali | CPX-1983, BAD:BCL-XL complex [Q07817-1] CPX-1985, BIM:BCL-XL complex [Q07817-1] CPX-1987, PUMA:BCL-XL complex [Q07817-1] CPX-1991, BID:BCL-XL complex [Q07817-1] CPX-298, BCL-XL complex [Q07817-1] |
CORUMi | Q07817 |
DIPi | DIP-30916N |
ELMi | Q07817 |
IntActi | Q07817, 105 interactors |
MINTi | Q07817 |
STRINGi | 9606.ENSP00000302564 |
Chemistry databases
BindingDBi | Q07817 |
ChEMBLi | CHEMBL4625 |
DrugBanki | DB07108, 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID DB13044, Gossypol DB09401, Isosorbide |
DrugCentrali | Q07817 |
GuidetoPHARMACOLOGYi | 2845 |
Protein family/group databases
TCDBi | 1.A.21.1.1, the bcl-2 (bcl-2) family |
PTM databases
iPTMneti | Q07817 |
PhosphoSitePlusi | Q07817 |
Genetic variation databases
BioMutai | BCL2L1 |
DMDMi | 728955 |
Proteomic databases
EPDi | Q07817 |
jPOSTi | Q07817 |
MassIVEi | Q07817 |
MaxQBi | Q07817 |
PaxDbi | Q07817 |
PeptideAtlasi | Q07817 |
PRIDEi | Q07817 |
ProteomicsDBi | 58537 [Q07817-1] 58538 [Q07817-2] 58539 [Q07817-3] |
TopDownProteomicsi | Q07817-1 [Q07817-1] Q07817-2 [Q07817-2] |
Protocols and materials databases
Antibodypediai | 3430, 2000 antibodies from 52 providers |
CPTCi | Q07817, 3 antibodies |
DNASUi | 598 |
Genome annotation databases
Organism-specific databases
CTDi | 598 |
DisGeNETi | 598 |
GeneCardsi | BCL2L1 |
HGNCi | HGNC:992, BCL2L1 |
HPAi | ENSG00000171552, Low tissue specificity |
MIMi | 600039, gene |
neXtProti | NX_Q07817 |
OpenTargetsi | ENSG00000171552 |
PharmGKBi | PA76 |
VEuPathDBi | HostDB:ENSG00000171552 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT01020000230347 |
InParanoidi | Q07817 |
OMAi | RIASWMT |
PhylomeDBi | Q07817 |
TreeFami | TF315834 |
Enzyme and pathway databases
PathwayCommonsi | Q07817 |
Reactomei | R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-844455, The NLRP1 inflammasome R-HSA-9648002, RAS processing R-HSA-9702518, STAT5 activation downstream of FLT3 ITD mutants |
SignaLinki | Q07817 |
SIGNORi | Q07817 |
Miscellaneous databases
BioGRID-ORCSi | 598, 526 hits in 1063 CRISPR screens |
ChiTaRSi | BCL2L1, human |
EvolutionaryTracei | Q07817 |
GeneWikii | BCL2-like_1_(gene) |
GenomeRNAii | 598 |
Pharosi | Q07817, Tchem |
PROi | PR:Q07817 |
RNActi | Q07817, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171552, Expressed in upper lobe of left lung and 238 other tissues |
ExpressionAtlasi | Q07817, baseline and differential |
Genevisiblei | Q07817, HS |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
DisProti | DP00298 |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR004725, Bcl2/BclX IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF12, PTHR11256:SF12, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
TIGRFAMsi | TIGR00865, bcl-2, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2CL1_HUMAN | |
Accessioni | Q07817Primary (citable) accession number: Q07817 Secondary accession number(s): E1P5L6 Q92976 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 244 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families