Apoptosis regulator BAX

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BH3 domain binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 21199865
• channel activity Source: BHF-UCLInferred from direct assayⁱ
  • 9219694
• chaperone binding Source: Ensembl
• Hsp70 protein binding Source: Ensembl
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 10620504
  • 14963330
  • 17289999
  • 17668322
  • 18547146
  • 18835031
  • 19062087
  • 19074440
  • 19767770
  • 20360684
  • 20850011
  • 22198199
  • 23374347
• lipid binding Source: HGNCInferred from direct assayⁱ
  • 14522999
• protein heterodimerization activity Source: HGNCInferred from physical interactionⁱ
  • 9111042
• protein homodimerization activity Source: HGNCInferred from direct assayⁱ
  • 16608847

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNCInferred from direct assayⁱ
  • 11912183
• activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: HGNCInferred from direct assayⁱ
  • 15214043
• activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
• apoptotic mitochondrial changes Source: HGNCInferred from direct assayⁱ
  • 9843949
• apoptotic process Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • 9660918
• apoptotic process involved in blood vessel morphogenesis Source: Ensembl
• apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
• apoptotic signaling pathway Source: HGNCInferred from direct assayⁱ
  • 16424160
• B cell apoptotic process Source: HGNCInferred from direct assayⁱ
  • 15214043
  • 16424160
• B cell homeostasis Source: Ensembl
• B cell homeostatic proliferation Source: Ensembl
• B cell negative selection Source: Ensembl
• B cell receptor apoptotic signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 15214043
• blood vessel remodeling Source: Ensembl
• cellular response to unfolded protein Source: ParkinsonsUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 22013210
• cellular response to UV Source: Ensembl
• cerebral cortex development Source: Ensembl
• development of secondary sexual characteristics Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
• ectopic germ cell programmed cell death Source: Ensembl
• endoplasmic reticulum calcium ion homeostasis Source: UniProtKBTraceable author statementⁱ
  • 18309324
• establishment or maintenance of transmembrane electrochemical gradient Source: HGNCInferred from direct assayⁱ
  • 9843949
• extrinsic apoptotic signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 15214043
• extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
• extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 16199525
• fertilization Source: Ensembl
• germ cell development Source: Ensembl
• glycosphingolipid metabolic process Source: Ensembl
• homeostasis of number of cells within a tissue Source: Ensembl
• hypothalamus development Source: Ensembl
• intrinsic apoptotic signaling pathway Source: HGNCInferred from direct assayⁱ
  • 16462759
• intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
• intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
• intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16645094
• kidney development Source: Ensembl
• mitochondrial fragmentation involved in apoptotic process Source: HGNCInferred from direct assayⁱ
  • 12499352
• mitochondrial fusion Source: HGNCInferred from direct assayⁱ
  • 14769861
• mitochondrion morphogenesis Source: Ensembl
• myeloid cell homeostasis Source: Ensembl
• negative regulation of apoptotic signaling pathway Source: Ensembl
• negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
• negative regulation of fibroblast proliferation Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of peptidyl-serine phosphorylation Source: Ensembl
• negative regulation of protein binding Source: UniProtKBInferred from direct assayⁱ
  • 9388232
• neuron apoptotic process Source: Ensembl
• neuron migration Source: Ensembl
• odontogenesis of dentin-containing tooth Source: Ensembl
• ovarian follicle development Source: Ensembl
• positive regulation of apoptotic DNA fragmentation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 11350920
• positive regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • 17464193
• positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
• positive regulation of B cell apoptotic process Source: Ensembl
• positive regulation of developmental pigmentation Source: Ensembl
• positive regulation of endoplasmic reticulum unfolded protein response Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16645094
• positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
• positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • 14963330
  • 21199865
  • 21262771
• positive regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 22013210
• positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Reactome
• positive regulation of neuron apoptotic process Source: HGNCInferred from direct assayⁱ
  • 15637643
• positive regulation of protein oligomerization Source: UniProtKBInferred from direct assayⁱ
  • 19805544
• positive regulation of release of cytochrome c from mitochondria Source: UniProtKBInferred from direct assayⁱ
  • 14963330
• positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
• post-embryonic camera-type eye morphogenesis Source: Ensembl
• protein complex oligomerization Source: UniProtKBInferred from direct assayⁱ
  • 19074440
• protein homooligomerization Source: UniProtKBInferred from direct assayⁱ
  • 19767770
• protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
• regulation of apoptotic process Source: Reactome
• regulation of mammary gland epithelial cell proliferation Source: Ensembl
• regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Source: Ensembl
• regulation of mitochondrial membrane potential Source: HGNCInferred from direct assayⁱ
  • 9843949
• regulation of nitrogen utilization Source: Ensembl
• regulation of protein heterodimerization activity Source: HGNCInferred from physical interactionⁱ
  • 9111042
• regulation of protein homodimerization activity Source: HGNCInferred from direct assayⁱ
  • 9111042
• release of cytochrome c from mitochondria Source: BHF-UCLInferred from direct assayⁱ
  • 16199525
• release of matrix enzymes from mitochondria Source: HGNCInferred from direct assayⁱ
  • 9843949
• response to axon injury Source: Ensembl
• response to gamma radiation Source: Ensembl
• response to salt stress Source: Ensembl
• response to toxic substance Source: HGNCInferred from direct assayⁱ
  • 16307838
• retina development in camera-type eye Source: Ensembl
• retinal cell programmed cell death Source: Ensembl
• Sertoli cell proliferation Source: Ensembl
• spermatid differentiation Source: Ensembl
• T cell homeostatic proliferation Source: Ensembl
• thymocyte apoptotic process Source: Ensembl
• transcription initiation from RNA polymerase II promoter Source: Reactome
• vagina development Source: Ensembl
• viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• BH3 domain binding Source: UniProtKBInferred from direct assayⁱ
  • 21199865
• chaperone binding Source: Ensembl
• Hsp70 protein binding Source: Ensembl
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 10620504
  • 14963330
  • 17289999
  • 17668322
  • 18547146
  • 18835031
  • 19062087
  • 19074440
  • 19767770
  • 20360684
  • 20850011
  • 22198199
  • 23374347
• protein heterodimerization activity Source: HGNCInferred from physical interactionⁱ
  • 9111042
• protein homodimerization activity Source: HGNCInferred from direct assayⁱ
  • 16608847

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 
       160        170        180        190 
WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG         

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 
       160        170        180        190        200
WIQDQGGWVR LLKPPHPHHR ALTTAPAPPS LPPATPLGPW AFWSRSQWCP 
       210 
LPIFRSSDVV YNAFSLRV                                    

        10         20         30         40 
MDGSGEQPRG GVSSRIEQGE WGGRHPSWPW TRCLRMRPPR S          

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGM IAAVDTDSPR EVFFRVAADM 
        60         70         80         90        100
FSDGNFNWGR VVALFYFASK LVLKALCTKV PELIRTIMGW TLDFLRERLL 
       110        120        130        140 
GWIQDQGGWD GLLSYFGTPT WQTVTIFVAG VLTASLTIWK KMG        

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKAGVKWRD LGSLQPLPPG FKRFTCLSIP 
       160 
RSWDYRPCAP RCRN                                        

        10         20         30         40         50
MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK 
        60         70         80         90        100
VPELIRTIMG WTLDFLRERL LGWIQDQGGW DGLLSYFGTP TWQTVTIFVA 
       110 
GVLTASLTIW KKMG                                        

        10         20         30         40         50
MKTGALLLQG FIQDRAGRMG GEAPELALDP VPQDASTKKL SECLKRIGDE 
        60         70         80         90        100
LDSNMELQRM IAAVDTDSPR EVFFRVAADM FSDGNFNWGR VVALFYFASK 
       110        120        130        140        150
LVLKALCTKV PELIRTIMGW TLDFLRERLL GWIQDQGGWD GLLSYFGTPT 
       160        170 
WQTVTIFVAG VLTASLTIWK KMG                              

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 
       160        170 
WIQDQGGWTV TIFVAGVLTA SLTIWKKMG                        

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases