BAX

Functionⁱ

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7 Publications

GO - Molecular functionⁱ

BH3 domain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21199865
channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 9219694
chaperone binding Source: Ensembl
Hsp70 protein binding Source: Ensembl
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
lipid binding
Source: HGNC
Inferred from direct assayⁱ
- 14522999
protein heterodimerization activity
Source: HGNC
Inferred from physical interactionⁱ
- 9111042
protein homodimerization activity
Source: HGNC
Inferred from direct assayⁱ
- 16608847

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process
Source: HGNC
Inferred from direct assayⁱ
- 11912183
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
Source: HGNC
Inferred from direct assayⁱ
- 15214043
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
apoptotic mitochondrial changes
Source: HGNC
Inferred from direct assayⁱ
- 9843949
apoptotic process
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 9660918
apoptotic process involved in blood vessel morphogenesis Source: Ensembl
apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
apoptotic signaling pathway
Source: HGNC
Inferred from direct assayⁱ
- 16424160
B cell apoptotic process
Source: HGNC
Inferred from direct assayⁱ
- 15214043
- 16424160
B cell homeostasis Source: Ensembl
B cell homeostatic proliferation Source: Ensembl
B cell negative selection Source: Ensembl
B cell receptor apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 15214043
blood vessel remodeling Source: Ensembl
cellular response to unfolded protein
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22013210
cellular response to UV Source: Ensembl
cerebral cortex development Source: Ensembl
development of secondary sexual characteristics Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
ectopic germ cell programmed cell death Source: Ensembl
endoplasmic reticulum calcium ion homeostasis
Source: UniProtKB
Traceable author statementⁱ
- 18309324
establishment or maintenance of transmembrane electrochemical gradient
Source: HGNC
Inferred from direct assayⁱ
- 9843949
extrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 15214043
extrinsic apoptotic signaling pathway in absence of ligand
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
extrinsic apoptotic signaling pathway via death domain receptors
Source: BHF-UCL
Inferred by curatorⁱ
- 16199525
fertilization Source: Ensembl
germ cell development Source: Ensembl
glycosphingolipid metabolic process Source: Ensembl
homeostasis of number of cells within a tissue Source: Ensembl
hypothalamus development Source: Ensembl
intrinsic apoptotic signaling pathway
Source: HGNC
Inferred from direct assayⁱ
- 16462759
intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
intrinsic apoptotic signaling pathway in response to DNA damage
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16645094
kidney development Source: Ensembl
mitochondrial fragmentation involved in apoptotic process
Source: HGNC
Inferred from direct assayⁱ
- 12499352
mitochondrial fusion
Source: HGNC
Inferred from direct assayⁱ
- 14769861
mitochondrion morphogenesis Source: Ensembl
myeloid cell homeostasis Source: Ensembl
negative regulation of apoptotic signaling pathway Source: Ensembl
negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
negative regulation of fibroblast proliferation Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
negative regulation of peptidyl-serine phosphorylation Source: Ensembl
negative regulation of protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9388232
neuron apoptotic process Source: Ensembl
neuron migration Source: Ensembl
odontogenesis of dentin-containing tooth Source: Ensembl
ovarian follicle development Source: Ensembl
positive regulation of apoptotic DNA fragmentation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11350920
positive regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17464193
positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
positive regulation of B cell apoptotic process Source: Ensembl
positive regulation of developmental pigmentation Source: Ensembl
positive regulation of endoplasmic reticulum unfolded protein response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16645094
positive regulation of intrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
positive regulation of IRE1-mediated unfolded protein response
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22013210
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Reactome
positive regulation of neuron apoptotic process
Source: HGNC
Inferred from direct assayⁱ
- 15637643
positive regulation of protein oligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 19805544
positive regulation of release of cytochrome c from mitochondria
Source: UniProtKB
Inferred from direct assayⁱ
- 14963330
positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
post-embryonic camera-type eye morphogenesis Source: Ensembl
protein complex oligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 19074440
protein homooligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 19767770
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
regulation of apoptotic process Source: Reactome
regulation of mammary gland epithelial cell proliferation Source: Ensembl
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Source: Ensembl
regulation of mitochondrial membrane potential
Source: HGNC
Inferred from direct assayⁱ
- 9843949
regulation of nitrogen utilization Source: Ensembl
regulation of protein heterodimerization activity
Source: HGNC
Inferred from physical interactionⁱ
- 9111042
regulation of protein homodimerization activity
Source: HGNC
Inferred from direct assayⁱ
- 9111042
release of cytochrome c from mitochondria
Source: BHF-UCL
Inferred from direct assayⁱ
- 16199525
release of matrix enzymes from mitochondria
Source: HGNC
Inferred from direct assayⁱ
- 9843949
response to axon injury Source: Ensembl
response to gamma radiation Source: Ensembl
response to salt stress Source: Ensembl
response to toxic substance
Source: HGNC
Inferred from direct assayⁱ
- 16307838
retina development in camera-type eye Source: Ensembl
retinal cell programmed cell death Source: Ensembl
Sertoli cell proliferation Source: Ensembl
spermatid differentiation Source: Ensembl
T cell homeostatic proliferation Source: Ensembl
thymocyte apoptotic process Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome
vagina development Source: Ensembl
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Host-virus interaction

Biological process

Apoptosis, Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111457 Release of apoptotic factors from the mitochondria R-HSA-114294 Activation, translocation and oligomerization of BAX R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-9603505 NTRK3 as a dependence receptor
SIGNORⁱ	Q07812

Protein family/group databases

TCDBⁱ	1.A.21.1.2 the bcl-2 (bcl-2) family

TCDBⁱ

1.A.21.1.2 the bcl-2 (bcl-2) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apoptosis regulator BAX Alternative name(s): Bcl-2-like protein 4 Short name: Bcl2-L-4
Gene namesⁱ	Name:BAX Synonyms:BCL2L4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000087088.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:959 BAX
MIMⁱ	600040 gene
neXtProtⁱ	NX_Q07812

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	172 – 192	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	21	K → E: Reduces interaction with BCL2L11, homooligomerization and triggering of apoptosis. 1 Publication	1
Mutagenesisⁱ	74	M → D or E: Strongly reduced interaction with MCL1, BCL2, BCL2L1 and BCL2L2. No effect on cytochrome c release and subsequent apoptosis triggered by etoposide. 1 Publication	1
Mutagenesisⁱ	184	S → D, E, H or K: Constitutive cytoplasmic location. 1 Publication	1
Mutagenesisⁱ	184	S → V: Constitutive mitochondrial location. 1 Publication	1

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	581
MalaCards human disease database More...MalaCardsⁱ	BAX
Open Targets More...OpenTargetsⁱ	ENSG00000087088
PharmGKBⁱ	PA25269

Chemistry databases

ChEMBLⁱ	CHEMBL5318

ChEMBLⁱ

CHEMBL5318

Polymorphism and mutation databases

BioMutaⁱ	BAX
DMDMⁱ	728945

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000143053	1 – 192	Apoptosis regulator BAXAdd BLAST		192

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q07812
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q07812
PaxDbⁱ	Q07812
PeptideAtlas More...PeptideAtlasⁱ	Q07812
PRIDEⁱ	Q07812
ProteomicsDBⁱ	58529 58530 [Q07812-2] 58531 [Q07812-3] 58532 [Q07812-4] 58533 [Q07812-5] 58534 [Q07812-6] 58535 [Q07812-7] 58536 [Q07812-8]
TopDownProteomicsⁱ	Q07812-1 [Q07812-1] Q07812-2 [Q07812-2] Q07812-5 [Q07812-5] Q07812-6 [Q07812-6] Q07812-8 [Q07812-8]

PTM databases

iPTMnetⁱ	Q07812
PhosphoSitePlusⁱ	Q07812
SwissPalmⁱ	Q07812

Miscellaneous databases

PMAP-CutDBⁱ	Q07812

PMAP-CutDBⁱ

Q07812

Expressionⁱ

Tissue specificityⁱ

Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000087088 Expressed in 197 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_BAX
ExpressionAtlasⁱ	Q07812 baseline and differential
Genevisibleⁱ	Q07812 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004206 HPA027878

HPAⁱ

CAB004206
HPA027878

Interactionⁱ

Subunit structureⁱ

Homodimer. Forms higher oligomers under stress conditions. Forms heterooligomers with BAK (PubMed:29531808). Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with RTL10/BOP. Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria.16 Publications

(Microbial infection) Interacts with adenovirus E1B 19K protein; this interaction blocks BAX oligomerization (PubMed:11462023).1 Publication

(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37.1 Publication

(Microbial infection) Interacts with enterovirus protein 2B; this interaction activates BAX-induced apoptosis.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		28	EBI-516580,EBI-516580
	P26662	3	EBI-516580,EBI-9099462	From Hepatitis C virus genotype 1b (isolate Japanese).
BAK1	Q16611	5	EBI-516580,EBI-519866
BCL2	P10415	13	EBI-516580,EBI-77694
BCL2L1	Q07817	3	EBI-516580,EBI-78035
BCL2L1	Q07817-1	20	EBI-516580,EBI-287195
BCL2L10	Q9HD36	2	EBI-516580,EBI-2126349
BCL2L11	O43521	22	EBI-516580,EBI-526406
BCL2L2	Q92843	5	EBI-516580,EBI-707714
BID	P55957	17	EBI-516580,EBI-519672
Bid	P70444	2	EBI-516580,EBI-783400	From Mus musculus.
ERN1	O75460	2	EBI-516580,EBI-371750
Gimap3	Q99MI6	2	EBI-516580,EBI-15572304	From Mus musculus.
Gimap5	Q8BWF2	2	EBI-516580,EBI-15572348	From Mus musculus.
KCNA3	P22001	2	EBI-516580,EBI-8627664
MCL1	Q07820	8	EBI-516580,EBI-1003422
Mcl1	P97287	2	EBI-516580,EBI-707292	From Mus musculus.
Mfn1	Q811U4	2	EBI-516580,EBI-9029118	From Mus musculus.
Mfn2	Q80U63	2	EBI-516580,EBI-8437663	From Mus musculus.
PYCARD	Q9ULZ3	7	EBI-516580,EBI-751215
RNF144B	Q7Z419	5	EBI-516580,EBI-2129982
RTL10	Q7L3V2	2	EBI-516580,EBI-10697720
SH3GLB1	Q9Y371-1	2	EBI-516580,EBI-5291808
TOM22	P49334	3	EBI-516580,EBI-12527	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TOM40	P23644	2	EBI-516580,EBI-12539	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
tom40	P24391	2	EBI-516580,EBI-1791540	From Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987).
TOM70	P07213	2	EBI-516580,EBI-12551	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
UL37	P16778	2	EBI-516580,EBI-16026491	From Human cytomegalovirus (strain AD169).
UVRAG	Q9P2Y5	6	EBI-516580,EBI-2952704
VACWR028	P17361	3	EBI-516580,EBI-7115640	From Vaccinia virus (strain Western Reserve).
XRCC6	P12956	2	EBI-516580,EBI-353208

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107057, 83 interactors
ComplexPortalⁱ	CPX-1988 BAX oligomer
CORUMⁱ	Q07812
Database of interacting proteins More...DIPⁱ	DIP-232N
IntActⁱ	Q07812, 71 interactors
Molecular INTeraction database More...MINTⁱ	Q07812
STRINGⁱ	9606.ENSP00000293288

Chemistry databases

BindingDBⁱ

Q07812

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	2 – 4	Combined sources	3
Beta strandⁱ	10 – 14	Combined sources	5
Helixⁱ	16 – 34	Combined sources	19
Helixⁱ	36 – 38	Combined sources	3
Beta strandⁱ	39 – 41	Combined sources	3
Helixⁱ	43 – 45	Combined sources	3
Helixⁱ	54 – 71	Combined sources	18
Helixⁱ	74 – 82	Combined sources	9
Beta strandⁱ	85 – 87	Combined sources	3
Helixⁱ	88 – 99	Combined sources	12
Turnⁱ	100 – 102	Combined sources	3
Helixⁱ	107 – 147	Combined sources	41
Helixⁱ	149 – 154	Combined sources	6
Turnⁱ	155 – 158	Combined sources	4
Helixⁱ	159 – 164	Combined sources	6
Turnⁱ	167 – 169	Combined sources	3
Helixⁱ	170 – 187	Combined sources	18

Show more details

3D structure databases

ProteinModelPortalⁱ	Q07812
SMRⁱ	Q07812
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q07812

EvolutionaryTraceⁱ

Q07812

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	59 – 73	BH3Add BLAST	15
Motifⁱ	98 – 118	BH1Add BLAST	21
Motifⁱ	150 – 165	BH2Add BLAST	16

Domainⁱ

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.By similarity

Sequence similaritiesⁱ

Belongs to the Bcl-2 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWQJ Eukaryota ENOG4112738 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111112
HOVERGENⁱ	HBG003606
InParanoidⁱ	Q07812
KEGG Orthology (KO) More...KOⁱ	K02159
OMAⁱ	EQGGWEG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YWR
PhylomeDBⁱ	Q07812
TreeFamⁱ	TF315834

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR026304 BAX IPR002475 Bcl2-like IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR020728 Bcl2_BH3_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF42 PTHR11256:SF42, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit
PRINTSⁱ	PR01862 BCL2FAMILY
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01259 BH3, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform Alpha (identifier: Q07812-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 
       160        170        180        190 
WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG

Length:192

Mass (Da):21,184

Last modified:February 1, 1995 - v1

Checksum:ⁱ6C0CDB0A7DEE4994

GO

Isoform Beta (identifier: Q07812-2) [UniParc] [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
159-192: DGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG → VRLLKPPHPH...VVYNAFSLRV

« Hide

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 
       160        170        180        190        200
WIQDQGGWVR LLKPPHPHHR ALTTAPAPPS LPPATPLGPW AFWSRSQWCP 
       210 
LPIFRSSDVV YNAFSLRV

Show »

Length:218

Mass (Da):24,220

Checksum:ⁱF69DCD70F960192F

GO

Isoform Gamma (identifier: Q07812-3) [UniParc] [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
12-41: GPTSSEQIMKTGALLLQGFIQDRAGRMGGE → VSSRIEQGEWGGRHPSWPWTRCLRMRPPRS
42-192: Missing.

« Hide

        10         20         30         40 
MDGSGEQPRG GVSSRIEQGE WGGRHPSWPW TRCLRMRPPR S

Show »

Length:41

Mass (Da):4,678

Checksum:ⁱD94639AABB927859

GO

Isoform Delta (identifier: Q07812-4) [UniParc] [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
30-78: Missing.

« Hide

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGM IAAVDTDSPR EVFFRVAADM 
        60         70         80         90        100
FSDGNFNWGR VVALFYFASK LVLKALCTKV PELIRTIMGW TLDFLRERLL 
       110        120        130        140 
GWIQDQGGWD GLLSYFGTPT WQTVTIFVAG VLTASLTIWK KMG

Show »

Length:143

Mass (Da):15,772

Checksum:ⁱBADE4D71D06A75AB

GO

Isoform Epsilon (identifier: Q07812-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
125-192: LCTKVPELIR...ASLTIWKKMG → GVKWRDLGSL...YRPCAPRCRN

« Hide

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKAGVKWRD LGSLQPLPPG FKRFTCLSIP 
       160 
RSWDYRPCAP RCRN

Show »

Length:164

Mass (Da):18,129

Checksum:ⁱ12CCDB8073EF4C9E

GO

Isoform Zeta (identifier: Q07812-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-78: Missing.

« Hide

        10         20         30         40         50
MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK 
        60         70         80         90        100
VPELIRTIMG WTLDFLRERL LGWIQDQGGW DGLLSYFGTP TWQTVTIFVA 
       110 
GVLTASLTIW KKMG

Show »

Length:114

Mass (Da):12,887

Checksum:ⁱA9DAFC5C06E36F4A

GO

Isoform Psi (identifier: Q07812-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-19: Missing.

« Hide

        10         20         30         40         50
MKTGALLLQG FIQDRAGRMG GEAPELALDP VPQDASTKKL SECLKRIGDE 
        60         70         80         90        100
LDSNMELQRM IAAVDTDSPR EVFFRVAADM FSDGNFNWGR VVALFYFASK 
       110        120        130        140        150
LVLKALCTKV PELIRTIMGW TLDFLRERLL GWIQDQGGWD GLLSYFGTPT 
       160        170 
WQTVTIFVAG VLTASLTIWK KMG

Show »

Length:173

Mass (Da):19,312

Checksum:ⁱ266F3151438B6201

GO

Isoform Sigma (identifier: Q07812-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
159-171: Missing.

« Hide

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 
       160        170 
WIQDQGGWTV TIFVAGVLTA SLTIWKKMG

Show »

Length:179

Mass (Da):19,718

Checksum:ⁱ5802B0AC73B2E4CE

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YA56	H0YA56_HUMAN	Apoptosis regulator BAX Apoptosis regulator BAX	BAX	126	Annotation score:
K4JQN1	K4JQN1_HUMAN	Apoptosis regulator BAX Apoptosis regulator BAX (BCL2-associated X protein transcript variant delta2)	BAX	175	Annotation score:
I6LPK7	I6LPK7_HUMAN	Apoptosis regulator BAX Apoptosis regulator BAX (BCL2-associated X protein theta)	BAX	140	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013575	11	G → E in a plasmacytoma cell line. 1 PublicationCorresponds to variant dbSNP:rs555248599Ensembl.	1
Natural variantⁱVAR_047053	39	G → R. Corresponds to variant dbSNP:rs36017265Ensembl.	1
Natural variantⁱVAR_007809	67	G → R in a T-cell acute lymphoblastic leukemia cell line; loss of heterodimerization with Bcl-2 or Bcl-X(L). 2 PublicationsCorresponds to variant dbSNP:rs398122513EnsemblClinVar.	1
Natural variantⁱVAR_013576	108	G → V in a Burkitt lymphoma; loss of homodimerization. 2 Publications	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_031239	1 – 78	Missing in isoform Zeta. 1 PublicationAdd BLAST	78
Alternative sequenceⁱVSP_031238	1 – 19	Missing in isoform Psi. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_031234	12 – 41	GPTSS…RMGGE → VSSRIEQGEWGGRHPSWPWT RCLRMRPPRS in isoform Gamma. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_031235	30 – 78	Missing in isoform Delta. 1 PublicationAdd BLAST	49
Alternative sequenceⁱVSP_031236	42 – 192	Missing in isoform Gamma. 1 PublicationAdd BLAST	151
Alternative sequenceⁱVSP_031240	125 – 192	LCTKV…WKKMG → GVKWRDLGSLQPLPPGFKRF TCLSIPRSWDYRPCAPRCRN in isoform Epsilon. 1 PublicationAdd BLAST	68
Alternative sequenceⁱVSP_031237	159 – 192	DGLLS…WKKMG → VRLLKPPHPHHRALTTAPAP PSLPPATPLGPWAFWSRSQW CPLPIFRSSDVVYNAFSLRV in isoform Beta. 1 PublicationAdd BLAST	34
Alternative sequenceⁱVSP_037475	159 – 171	Missing in isoform Sigma. 1 PublicationAdd BLAST	13

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22473 mRNA Translation: AAA03619.1 L22474 mRNA Translation: AAA03620.1 L22475 mRNA Translation: AAA03621.1 U19599 mRNA Translation: AAC50142.1 AF007826 mRNA Translation: AAD22706.1 AF247393 mRNA Translation: AAF71267.1 AJ417988 mRNA Translation: CAD10744.1 AF250190 mRNA Translation: AAF82094.1 AK291076 mRNA Translation: BAF83765.1 AY217036 Genomic DNA Translation: AAO22992.1 CH471177 Genomic DNA Translation: EAW52418.1 CH471177 Genomic DNA Translation: EAW52417.1 BC014175 mRNA Translation: AAH14175.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12742.1 [Q07812-1] CCDS12743.1 [Q07812-4] CCDS12744.1 [Q07812-2] CCDS12745.2 [Q07812-8]
PIRⁱ	A47538 B47538 C47538 I38921 JC7255
NCBI Reference Sequences More...RefSeqⁱ	NP_001278357.1, NM_001291428.1 NP_001278360.1, NM_001291431.1 [Q07812-6] NP_004315.1, NM_004324.3 [Q07812-2] NP_620116.1, NM_138761.3 [Q07812-1] NP_620118.1, NM_138763.3 [Q07812-4] NP_620119.2, NM_138764.4 [Q07812-8] XP_016882566.1, XM_017027077.1 [Q07812-7]
UniGeneⁱ	Hs.624291

Genome annotation databases

Ensemblⁱ	ENST00000293288; ENSP00000293288; ENSG00000087088 [Q07812-2] ENST00000345358; ENSP00000263262; ENSG00000087088 [Q07812-1] ENST00000354470; ENSP00000346461; ENSG00000087088 [Q07812-4] ENST00000356483; ENSP00000348871; ENSG00000087088 [Q07812-5] ENST00000415969; ENSP00000389971; ENSG00000087088 [Q07812-8] ENST00000515540; ENSP00000426328; ENSG00000087088 [Q07812-3]
GeneIDⁱ	581
KEGGⁱ	hsa:581
UCSC genome browser More...UCSCⁱ	uc002plf.2 human [Q07812-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07812	BAX isoform 2		PONAB		192	UniRef100_Q07812
BCL2 associated X, apoptosis regulator		PANPA		192
BCL2 associated X, apoptosis regulator		GORGO		192
Isoform Psi of Apoptosis regulator BAX		HUMAN		173
BAX isoform 5		PONAB		173
Q07812-2	Apoptosis regulator BAX		HUMAN		140	UniRef100_Q07812-2
UPI00044313D0		HUMAN		181
Q07812-3	BAX isoform 8		PONAB		41	UniRef100_Q07812-3
Bax protein (Fragment)		HUMAN		36
Q07812-4	BAX isoform 6		PONAB		143	UniRef100_Q07812-4
apoptosis regulator BAX isoform X4		ODORO		143
apoptosis regulator BAX isoform X4		Enhydra lutris kenyoni		143
BAX isoform 4		PANTR		143
BCL2 associated X, apoptosis regulator		PANPA		143
+1
Q07812-5	BAX isoform 10		PONAB		142	UniRef100_Q07812-5
Q07812-6	apoptosis regulator BAX		URSMA		205	UniRef100_Q07812-6
apoptosis regulator BAX isoform X3		ODORO		155
apoptosis regulator BAX isoform X5		ODORO		114
Q07812-8	BAX isoform 7		PONAB		179	UniRef100_Q07812-8

Protein	Similar proteins		Species	Score	Length	Source
Q07812	Apoptosis regulator BAX		BOVIN		192	UniRef90_Q07812
BAX isoform 2		PONAB		192
BCL2 associated X, apoptosis regulator		PANPA		192
BCL2 associated X, apoptosis regulator		GORGO		192
Isoform Psi of Apoptosis regulator BAX		HUMAN		173
+96
Q07812-2	Apoptosis regulator BAX		HUMAN		140	UniRef90_Q07812-2
BAX isoform 7		PANTR		218
BCL2 associated X, apoptosis regulator		PANPA		218
BCL2 associated X, apoptosis regulator		GORGO		217
BCL2 associated X, apoptosis regulator		PAPAN		203
+7
Q07812-3	BAX isoform 8		PONAB		41	UniRef90_Q07812-3
Bax protein (Fragment)		HUMAN		36
Q07812-4	BAX isoform 6		PONAB		143	UniRef90_Q07812-4
apoptosis regulator BAX isoform X4		ODORO		143
apoptosis regulator BAX isoform X4		Enhydra lutris kenyoni		143
BAX isoform 4		PANTR		143
BCL2 associated X, apoptosis regulator		PANPA		143
+21
Q07812-5	BAX isoform 10		PONAB		142	UniRef90_Q07812-5
BAX isoform 11		PANTR		164
Bax epsilon (Fragment)		HUMAN		40
Q07812-6	apoptosis regulator BAX		URSMA		205	UniRef90_Q07812-6
apoptosis regulator BAX isoform X3		ODORO		155
Bax (Fragment)		FELCA		78
BCL2-associated X protein (Fragment)		LYNPA		169
Bax (Fragment)		CEREL		95
+12

Protein	Similar proteins		Species	Score	Length	Source
Q07812	Apoptosis regulator BAX	)	MOUSE		192	UniRef50_Q07813
Apoptosis regulator BAX		RAT		192
Apoptosis regulator BAX		BOVIN		192
apoptosis regulator BAX		MESAU		193
Bax		CRIGR		192
+194
Q07812-3	BAX isoform 8		PONAB		41	UniRef50_Q07812-3
Bax protein (Fragment)		HUMAN		36
BCL2-associated X protein, isoform CRA_a (Fragment)		HUMAN		38
Q07812-4	BAX isoform 6		PONAB		143	UniRef50_Q07812-4
apoptosis regulator BAX isoform X4		ODORO		143
apoptosis regulator BAX isoform X4		Enhydra lutris kenyoni		143
BAX isoform 4		PANTR		143
BCL2 associated X, apoptosis regulator		PANPA		143
+24
Q07812-5	BAX isoform 10		PONAB		142	UniRef50_Q07812-5
BAX isoform 11		PANTR		164
Bax epsilon (Fragment)		HUMAN		40
BCL2 associated X, apoptosis regulator		CALJA		192
Uncharacterized protein (Fragment)		AILME		154
+13
Q07812-6	apoptosis regulator BAX		URSMA		205	UniRef50_Q07812-6
apoptosis regulator BAX isoform X3		ODORO		155
Bax (Fragment)		FELCA		78
BCL2-associated X protein (Fragment)		LYNPA		169
Bax (Fragment)		CEREL		95
+54

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22473 mRNA Translation: AAA03619.1 L22474 mRNA Translation: AAA03620.1 L22475 mRNA Translation: AAA03621.1 U19599 mRNA Translation: AAC50142.1 AF007826 mRNA Translation: AAD22706.1 AF247393 mRNA Translation: AAF71267.1 AJ417988 mRNA Translation: CAD10744.1 AF250190 mRNA Translation: AAF82094.1 AK291076 mRNA Translation: BAF83765.1 AY217036 Genomic DNA Translation: AAO22992.1 CH471177 Genomic DNA Translation: EAW52418.1 CH471177 Genomic DNA Translation: EAW52417.1 BC014175 mRNA Translation: AAH14175.1
CCDSⁱ	CCDS12742.1 [Q07812-1] CCDS12743.1 [Q07812-4] CCDS12744.1 [Q07812-2] CCDS12745.2 [Q07812-8]
PIRⁱ	A47538 B47538 C47538 I38921 JC7255
RefSeqⁱ	NP_001278357.1, NM_001291428.1 NP_001278360.1, NM_001291431.1 [Q07812-6] NP_004315.1, NM_004324.3 [Q07812-2] NP_620116.1, NM_138761.3 [Q07812-1] NP_620118.1, NM_138763.3 [Q07812-4] NP_620119.2, NM_138764.4 [Q07812-8] XP_016882566.1, XM_017027077.1 [Q07812-7]
UniGeneⁱ	Hs.624291

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1F16	NMR	-	A	1-192	[»]
	2G5B	X-ray	2.30	I/J/K/L	13-19	[»]
	2K7W	NMR	-	A	1-192	[»]
	2LR1	NMR	-	A	1-192	[»]
	3PK1	X-ray	2.49	B/D	48-81	[»]
	3PL7	X-ray	2.61	C	48-81	[»]
	4BD2	X-ray	2.21	A	1-171	[»]
	4BD6	X-ray	2.49	A	1-171	[»]
				C	48-81	[»]
	4BD7	X-ray	2.80	A/B/C/D	1-171	[»]
	4BD8	X-ray	2.22	A/B/C/D	1-171	[»]
	4BDU	X-ray	3.00	A/B/C/D	53-128	[»]
	4S0O	X-ray	1.90	A/B	1-192	[»]
	4S0P	X-ray	3.25	A/B	1-192	[»]
	4UF2	X-ray	3.00	B	50-77	[»]
	4ZIE	X-ray	1.80	A	1-166	[»]
	4ZIF	X-ray	2.40	A	1-166	[»]
	4ZIG	X-ray	2.20	A	1-166	[»]
	4ZIH	X-ray	2.50	A	1-164	[»]
	4ZII	X-ray	2.19	A	1-170	[»]
	5W5X	X-ray	2.50	A	1-192	[»]
	5W5Z	X-ray	2.00	A	32-192	[»]
	5W60	X-ray	1.80	A	1-192	[»]
	5W61	X-ray	2.30	A	1-192	[»]
ProteinModelPortalⁱ	Q07812
SMRⁱ	Q07812
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107057, 83 interactors
ComplexPortalⁱ	CPX-1988 BAX oligomer
CORUMⁱ	Q07812
DIPⁱ	DIP-232N
IntActⁱ	Q07812, 71 interactors
MINTⁱ	Q07812
STRINGⁱ	9606.ENSP00000293288

Chemistry databases

BindingDBⁱ	Q07812
ChEMBLⁱ	CHEMBL5318

Protein family/group databases

TCDBⁱ	1.A.21.1.2 the bcl-2 (bcl-2) family

TCDBⁱ

1.A.21.1.2 the bcl-2 (bcl-2) family

PTM databases

iPTMnetⁱ	Q07812
PhosphoSitePlusⁱ	Q07812
SwissPalmⁱ	Q07812

Polymorphism and mutation databases

BioMutaⁱ	BAX
DMDMⁱ	728945

Proteomic databases

EPDⁱ	Q07812
MaxQBⁱ	Q07812
PaxDbⁱ	Q07812
PeptideAtlasⁱ	Q07812
PRIDEⁱ	Q07812
ProteomicsDBⁱ	58529 58530 [Q07812-2] 58531 [Q07812-3] 58532 [Q07812-4] 58533 [Q07812-5] 58534 [Q07812-6] 58535 [Q07812-7] 58536 [Q07812-8]
TopDownProteomicsⁱ	Q07812-1 [Q07812-1] Q07812-2 [Q07812-2] Q07812-5 [Q07812-5] Q07812-6 [Q07812-6] Q07812-8 [Q07812-8]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	581
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000293288; ENSP00000293288; ENSG00000087088 [Q07812-2] ENST00000345358; ENSP00000263262; ENSG00000087088 [Q07812-1] ENST00000354470; ENSP00000346461; ENSG00000087088 [Q07812-4] ENST00000356483; ENSP00000348871; ENSG00000087088 [Q07812-5] ENST00000415969; ENSP00000389971; ENSG00000087088 [Q07812-8] ENST00000515540; ENSP00000426328; ENSG00000087088 [Q07812-3]
GeneIDⁱ	581
KEGGⁱ	hsa:581
UCSCⁱ	uc002plf.2 human [Q07812-1]

Organism-specific databases

CTDⁱ	581
DisGeNETⁱ	581
EuPathDBⁱ	HostDB:ENSG00000087088.19
GeneCardsⁱ	BAX
HGNCⁱ	HGNC:959 BAX
HPAⁱ	CAB004206 HPA027878
MalaCardsⁱ	BAX
MIMⁱ	600040 gene
neXtProtⁱ	NX_Q07812
OpenTargetsⁱ	ENSG00000087088
PharmGKBⁱ	PA25269
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWQJ Eukaryota ENOG4112738 LUCA
GeneTreeⁱ	ENSGT00730000111112
HOVERGENⁱ	HBG003606
InParanoidⁱ	Q07812
KOⁱ	K02159
OMAⁱ	EQGGWEG
OrthoDBⁱ	EOG091G0YWR
PhylomeDBⁱ	Q07812
TreeFamⁱ	TF315834

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111457 Release of apoptotic factors from the mitochondria R-HSA-114294 Activation, translocation and oligomerization of BAX R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-9603505 NTRK3 as a dependence receptor
SIGNORⁱ	Q07812

Miscellaneous databases

ChiTaRSⁱ	BAX human
EvolutionaryTraceⁱ	Q07812
GeneWikiⁱ	Bcl-2-associated_X_protein
GenomeRNAiⁱ	581
PMAP-CutDBⁱ	Q07812
Protein Ontology More...PROⁱ	PR:Q07812
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000087088 Expressed in 197 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_BAX
ExpressionAtlasⁱ	Q07812 baseline and differential
Genevisibleⁱ	Q07812 HS

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR026304 BAX IPR002475 Bcl2-like IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR020728 Bcl2_BH3_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF42 PTHR11256:SF42, 1 hit
Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit
PRINTSⁱ	PR01862 BCL2FAMILY
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01259 BH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BAX_HUMAN
Accessionⁱ	Q07812Primary (citable) accession number: Q07812 Secondary accession number(s): A8K4W1 Q9UQD6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	December 5, 2018
	This is version 205 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q07812 (BAX_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Apoptosis regulator BAX

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Other locations

Other locations

Other locations

Other locations

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ