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Protein

Galectin-3-binding protein

Gene

Lgals3bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity).By similarity

GO - Molecular functioni

  • scavenger receptor activity Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Cyp-C-associated protein
Short name:
CyCAP
Lectin galactoside-binding soluble 3-binding protein
Protein MAMA
Gene namesi
Name:Lgals3bp
Synonyms:Cycap, Mama
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99554 Lgals3bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000035703519 – 577Galectin-3-binding proteinAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 113PROSITE-ProRule annotation
Disulfide bondi62 ↔ 123PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi93 ↔ 103PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ07797
MaxQBiQ07797
PaxDbiQ07797
PeptideAtlasiQ07797
PRIDEiQ07797

PTM databases

PhosphoSitePlusiQ07797

Expressioni

Tissue specificityi

Detected in embryo, liver, spleen, kidney, lung, heart, intestine, thymus and lymph node.2 Publications

Inductioni

Up-regulated by TNF and IFNG.1 Publication

Gene expression databases

BgeeiENSMUSG00000033880 Expressed in 191 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiQ07797 baseline and differential
GenevisibleiQ07797 MM

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity). Interacts with PPIC (in vitro). The unglycosylated form interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction may connect a pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi202330, 51 interactors
IntActiQ07797, 51 interactors
MINTiQ07797
STRINGi10090.ENSMUSP00000035579

Structurei

3D structure databases

ProteinModelPortaliQ07797
SMRiQ07797
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 124SRCRPROSITE-ProRule annotationAdd BLAST101
Domaini153 – 221BTBPROSITE-ProRule annotationAdd BLAST69
Domaini260 – 360BACKAdd BLAST101

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY2Y Eukaryota
ENOG410YBYF LUCA
GeneTreeiENSGT00530000063814
HOGENOMiHOG000113318
HOVERGENiHBG052323
InParanoidiQ07797
KOiK17300
OMAiIGYENKA
OrthoDBiEOG091G0MFZ
PhylomeDBiQ07797
TreeFamiTF331368

Family and domain databases

Gene3Di3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00202 SR, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF56487 SSF56487, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q07797-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLWLLSVF LLVPGTQGTE DGDMRLVNGA SANEGRVEIF YRGRWGTVCD
60 70 80 90 100
NLWNLLDAHV VCRALGYENA TQALGRAAFG PGKGPIMLDE VECTGTESSL
110 120 130 140 150
ASCRSLGWMV SRCGHEKDAG VVCSNDTTGL HILDLSGELS DALGQIFDSQ
160 170 180 190 200
QGCDLFIQVT GQGYEDLSLC AHTLILRTNP EAQALWQVVG SSVIMRVDAE
210 220 230 240 250
CMPVVRDFLR YFYSRRIEVS MSSVKCLHKL ASAYGATELQ DYCGRLFATL
260 270 280 290 300
LPQDPTFHTP LDLYAYARAT GDSMLEDLCV QFLAWNFEPL TQSESWSAVP
310 320 330 340 350
TTLIQALLPK SELAVSSELD LLKAVDQWST ETIASHEDIE RLVEQVRFPM
360 370 380 390 400
MLPQELFELQ FNLSLYQDHQ ALFQRKTMQA LEFHTVPVEV LAKYKGLNLT
410 420 430 440 450
EDTYKPRLYT SSTWSSLVMA STWRAQRYEY NRYNQLYTYG YGSVARYNSY
460 470 480 490 500
QSFQTPQHPS FLFKDKQISW SATYLPTMQS CWNYGFSCTS NELPVLGLTT
510 520 530 540 550
SSYSNPTIGY ENRVLILCGG YSVVDVTSFE GSKAPIPTAL DTNSSKTPSL
560 570
FPCASGAFSS FRVVIRPFYL TNSTDMV
Length:577
Mass (Da):64,491
Last modified:November 1, 1996 - v1
Checksum:i9D4181A7BEC2BD7C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5X5E9Q5X5_MOUSE
Galectin-3-binding protein
Lgals3bp
204Annotation score:
F6VRP8F6VRP8_MOUSE
Galectin-3-binding protein
Lgals3bp
139Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25R → G in AAA37499 (PubMed:8341703).Curated1
Sequence conflicti228H → P in AAA37499 (PubMed:8341703).Curated1
Sequence conflicti347R → C in BAE29246 (PubMed:16141072).Curated1
Sequence conflicti370Q → K in BAE31894 (PubMed:16141072).Curated1
Sequence conflicti465D → E in BAE31013 (PubMed:16141072).Curated1
Sequence conflicti466 – 467KQ → NE in AAA37499 (PubMed:8341703).Curated2
Sequence conflicti573 – 577STDMV → LH in AAA37499 (PubMed:8341703).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16894 mRNA Translation: AAA37499.1
X67809 mRNA Translation: CAA48010.1
AK079915 mRNA Translation: BAC37782.1
AK137836 mRNA Translation: BAE23505.1
AK150021 mRNA Translation: BAE29246.1
AK152182 mRNA Translation: BAE31013.1
AK153313 mRNA Translation: BAE31894.1
AK153396 mRNA Translation: BAE31958.1
AK155031 mRNA Translation: BAE33003.1
AL591404 Genomic DNA Translation: CAM23110.1
CH466558 Genomic DNA Translation: EDL34661.1
CH466558 Genomic DNA Translation: EDL34662.1
BC090658 mRNA Translation: AAH90658.1
CCDSiCCDS25701.1
PIRiA53202
RefSeqiNP_035280.1, NM_011150.2
UniGeneiMm.3152

Genome annotation databases

EnsembliENSMUST00000043722; ENSMUSP00000035579; ENSMUSG00000033880
GeneIDi19039
KEGGimmu:19039
UCSCiuc007moz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16894 mRNA Translation: AAA37499.1
X67809 mRNA Translation: CAA48010.1
AK079915 mRNA Translation: BAC37782.1
AK137836 mRNA Translation: BAE23505.1
AK150021 mRNA Translation: BAE29246.1
AK152182 mRNA Translation: BAE31013.1
AK153313 mRNA Translation: BAE31894.1
AK153396 mRNA Translation: BAE31958.1
AK155031 mRNA Translation: BAE33003.1
AL591404 Genomic DNA Translation: CAM23110.1
CH466558 Genomic DNA Translation: EDL34661.1
CH466558 Genomic DNA Translation: EDL34662.1
BC090658 mRNA Translation: AAH90658.1
CCDSiCCDS25701.1
PIRiA53202
RefSeqiNP_035280.1, NM_011150.2
UniGeneiMm.3152

3D structure databases

ProteinModelPortaliQ07797
SMRiQ07797
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202330, 51 interactors
IntActiQ07797, 51 interactors
MINTiQ07797
STRINGi10090.ENSMUSP00000035579

PTM databases

PhosphoSitePlusiQ07797

Proteomic databases

EPDiQ07797
MaxQBiQ07797
PaxDbiQ07797
PeptideAtlasiQ07797
PRIDEiQ07797

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043722; ENSMUSP00000035579; ENSMUSG00000033880
GeneIDi19039
KEGGimmu:19039
UCSCiuc007moz.1 mouse

Organism-specific databases

CTDi3959
MGIiMGI:99554 Lgals3bp

Phylogenomic databases

eggNOGiENOG410IY2Y Eukaryota
ENOG410YBYF LUCA
GeneTreeiENSGT00530000063814
HOGENOMiHOG000113318
HOVERGENiHBG052323
InParanoidiQ07797
KOiK17300
OMAiIGYENKA
OrthoDBiEOG091G0MFZ
PhylomeDBiQ07797
TreeFamiTF331368

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiLgals3bp mouse
PROiPR:Q07797
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033880 Expressed in 191 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiQ07797 baseline and differential
GenevisibleiQ07797 MM

Family and domain databases

Gene3Di3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00202 SR, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF56487 SSF56487, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLG3BP_MOUSE
AccessioniPrimary (citable) accession number: Q07797
Secondary accession number(s): O35649
, Q3U631, Q3U8K4, Q3UDL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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