UniProtKB - Q07699 (SCN1B_HUMAN)
Sodium channel subunit beta-1
SCN1B
Functioni
Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
8 PublicationsCell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth (PubMed:21994374).
Has no regulatory function on the SCN2A sodium channel complex (PubMed:14622265).
2 PublicationsGO - Molecular functioni
- sodium channel inhibitor activity Source: BHF-UCL
- sodium channel regulator activity Source: UniProtKB
- transmembrane transporter binding Source: GO_Central
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: BHF-UCL
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: BHF-UCL
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential Source: BHF-UCL
GO - Biological processi
- axon guidance Source: BHF-UCL
- cardiac conduction Source: BHF-UCL
- cardiac muscle cell action potential involved in contraction Source: BHF-UCL
- cardiac muscle contraction Source: BHF-UCL
- cell adhesion Source: UniProtKB-KW
- corticospinal neuron axon guidance Source: BHF-UCL
- locomotion Source: BHF-UCL
- membrane depolarization Source: BHF-UCL
- membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
- membrane depolarization during Purkinje myocyte cell action potential Source: BHF-UCL
- neuronal action potential propagation Source: BHF-UCL
- positive regulation of neuron projection development Source: BHF-UCL
- positive regulation of sodium ion transport Source: BHF-UCL
- regulation of atrial cardiac muscle cell membrane depolarization Source: BHF-UCL
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- regulation of ventricular cardiac muscle cell membrane repolarization Source: BHF-UCL
- sodium ion transmembrane transport Source: BHF-UCL
Keywordsi
Molecular function | Ion channel, Sodium channel, Voltage-gated channel |
Biological process | Cell adhesion, Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q07699 |
Reactomei | R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-5576892, Phase 0 - rapid depolarisation R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
SignaLinki | Q07699 |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel subunit beta-1 |
Gene namesi | Name:SCN1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10586, SCN1B |
MIMi | 600235, gene |
neXtProti | NX_Q07699 |
VEuPathDBi | HostDB:ENSG00000105711 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication5 Publications; Single-pass type I membrane protein 1 Publication1 Publication
Other locations
- Perikaryon By similarity
- Cell projection By similarity
- axon By similarity
Note: Detected at nodes of Ranvier on the sciatic nerve.By similarity
Extracellular region or secreted
- Secreted 1 Publication
Other locations
- Perikaryon 1 Publication
- Cell projection 1 Publication
Note: Detected on Purkinje cells and their cell projections and on neuronal cell projections.1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- T-tubule Source: BHF-UCL
- voltage-gated sodium channel complex Source: UniProtKB
Other locations
- intercalated disc Source: BHF-UCL
- node of Ranvier Source: BHF-UCL
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 160 | Extracellular1 PublicationAdd BLAST | 142 | |
Transmembranei | 161 – 182 | Helical1 PublicationAdd BLAST | 22 | |
Topological domaini | 183 – 218 | Cytoplasmic1 PublicationAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Generalized epilepsy with febrile seizures plus 1 (GEFS+1)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010165 | 121 | C → W in GEFS+1; can rescue the loss of function and defective trafficking to cell membrane phenotype of the SCN1A variant Thr-1852. 2 PublicationsCorresponds to variant dbSNP:rs104894718EnsemblClinVar. | 1 | |
Natural variantiVAR_067341 | 125 | R → L in GEFS+1. 1 PublicationCorresponds to variant dbSNP:rs759839781Ensembl. | 1 |
Brugada syndrome 5 (BRGDA5)1 Publication
Atrial fibrillation, familial, 13 (ATFB13)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070219 | 85 | R → H in ATFB13; the mutant results in highly reduced sodium currents and altered channel gating when coexpressed with SCN5A in a heterologous expression system. 1 PublicationCorresponds to variant dbSNP:rs16969925EnsemblClinVar. | 1 | |
Natural variantiVAR_070220 | 153 | D → N in ATFB13; the mutant results in reduced sodium currents when coexpressed with SCN5A in a heterologous expression system. 1 PublicationCorresponds to variant dbSNP:rs72550247EnsemblClinVar. | 1 |
Developmental and epileptic encephalopathy 52 (DEE52)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078019 | 106 | I → T in DEE52; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_078020 | 125 | R → C in DEE52; severely decreased channel localization at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1135401736EnsemblClinVar. | 1 |
Keywords - Diseasei
Atrial fibrillation, Brugada syndrome, Disease variant, EpilepsyOrganism-specific databases
DisGeNETi | 6324 |
GeneReviewsi | SCN1B |
MalaCardsi | SCN1B |
MIMi | 604233, phenotype 612838, phenotype 615377, phenotype 617350, phenotype |
OpenTargetsi | ENSG00000105711 |
Orphaneti | 130, Brugada syndrome 33069, Dravet syndrome 1934, Early infantile epileptic encephalopathy 334, Familial atrial fibrillation 871, Familial progressive cardiac conduction defect 36387, Generalized epilepsy with febrile seizures-plus |
PharmGKBi | PA302 |
Miscellaneous databases
Pharosi | Q07699, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523668 CHEMBL4523669 CHEMBL4523670 CHEMBL4523671 CHEMBL4523672 CHEMBL4630760 CHEMBL4630762 CHEMBL4630763 CHEMBL4630765 |
DrugBanki | DB05541, Brivaracetam DB00907, Cocaine DB13269, Dichlorobenzyl alcohol DB13961, Fish oil DB00776, Oxcarbazepine DB00252, Phenytoin DB00243, Ranolazine DB00313, Valproic acid DB00909, Zonisamide |
DrugCentrali | Q07699 |
Genetic variation databases
BioMutai | SCN1B |
DMDMi | 1705868 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014926 | 19 – 218 | Sodium channel subunit beta-1Add BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 21 ↔ 43 | Combined sources2 Publications | ||
Disulfide bondi | 40 ↔ 121 | Combined sources2 Publications | ||
Glycosylationi | 93 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q07699 |
PaxDbi | Q07699 |
PeptideAtlasi | Q07699 |
PRIDEi | Q07699 |
ProteomicsDBi | 58527 [Q07699-1] 58528 [Q07699-2] |
PTM databases
GlyGeni | Q07699, 4 sites |
iPTMneti | Q07699 |
PhosphoSitePlusi | Q07699 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105711, Expressed in right hemisphere of cerebellum and 111 other tissues |
ExpressionAtlasi | Q07699, baseline and differential |
Genevisiblei | Q07699, HS |
Organism-specific databases
HPAi | ENSG00000105711, Group enriched (brain, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits (PubMed:15525788, PubMed:21994374, PubMed:30190309).
Interacts with SCN4A (PubMed:8125980).
Interacts with NFASC.
Interacts with SCN10A (By similarity).
Interacts with SCN1A (PubMed:15525788, PubMed:21994374, PubMed:17928445).
Interacts with SCN3A (PubMed:21994374).
Interacts with SCN5A (PubMed:21994374).
Interacts with SCN8A (PubMed:26900580).
By similarity6 PublicationsBinary interactionsi
Isoform 1 [Q07699-1]
With | #Exp. | IntAct |
---|---|---|
SCN4A [P35499] | 2 | EBI-20974499,EBI-16813249 |
GO - Molecular functioni
- transmembrane transporter binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112229, 16 interactors |
IntActi | Q07699, 4 interactors |
MINTi | Q07699 |
STRINGi | 9606.ENSP00000396915 |
Chemistry databases
BindingDBi | Q07699 |
Miscellaneous databases
RNActi | Q07699, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q07699 |
SMRi | Q07699 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 150 | Ig-like C2-typeAdd BLAST | 129 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R0UM, Eukaryota |
GeneTreei | ENSGT00390000018560 |
HOGENOMi | CLU_096296_0_0_1 |
InParanoidi | Q07699 |
OMAi | DRIDWNG |
OrthoDBi | 1041959at2759 |
PhylomeDBi | Q07699 |
TreeFami | TF332097 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set IPR027098, Na_channel_b1/b3 IPR044568, Na_chnl_b1 |
PANTHERi | PTHR10546, PTHR10546, 1 hit PTHR10546:SF2, PTHR10546:SF2, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRLLALVVG AALVSSACGG CVEVDSETEA VYGMTFKILC ISCKRRSETN
60 70 80 90 100
AETFTEWTFR QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD
110 120 130 140 150
LQDLSIFITN VTYNHSGDYE CHVYRLLFFE NYEHNTSVVK KIHIEVVDKA
160 170 180 190 200
NRDMASIVSE IMMYVLIVVL TIWLVAEMIY CYKKIAAATE TAAQENASEY
210
LAITSESKEN CTGVQVAE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PR05 | A0A1W2PR05_HUMAN | Sodium channel subunit beta-1 | SCN1B | 185 | Annotation score: | ||
A0A6Q8PGS1 | A0A6Q8PGS1_HUMAN | Sodium channel subunit beta-1 | SCN1B | 227 | Annotation score: | ||
A0A1W2PS68 | A0A1W2PS68_HUMAN | Sodium channel subunit beta-1 | SCN1B | 235 | Annotation score: | ||
A0A6Q8PHF7 | A0A6Q8PHF7_HUMAN | Sodium channel subunit beta-1 | SCN1B | 166 | Annotation score: | ||
B4DI92 | B4DI92_HUMAN | Sodium channel subunit beta-1 | SCN1B | 147 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062523 | 25 | D → N Probable disease-associated variant found in a patient with idiopathic childhood epilepsy; de novo mutation; loss of function in increasing sodium channel activity. 2 PublicationsCorresponds to variant dbSNP:rs786205837EnsemblClinVar. | 1 | |
Natural variantiVAR_070219 | 85 | R → H in ATFB13; the mutant results in highly reduced sodium currents and altered channel gating when coexpressed with SCN5A in a heterologous expression system. 1 PublicationCorresponds to variant dbSNP:rs16969925EnsemblClinVar. | 1 | |
Natural variantiVAR_062524 | 87 | E → Q Probable disease-associated variant found in a patient with non-specific cardiac conduction defects. 1 PublicationCorresponds to variant dbSNP:rs121434627EnsemblClinVar. | 1 | |
Natural variantiVAR_078019 | 106 | I → T in DEE52; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_010165 | 121 | C → W in GEFS+1; can rescue the loss of function and defective trafficking to cell membrane phenotype of the SCN1A variant Thr-1852. 2 PublicationsCorresponds to variant dbSNP:rs104894718EnsemblClinVar. | 1 | |
Natural variantiVAR_078020 | 125 | R → C in DEE52; severely decreased channel localization at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1135401736EnsemblClinVar. | 1 | |
Natural variantiVAR_067341 | 125 | R → L in GEFS+1. 1 PublicationCorresponds to variant dbSNP:rs759839781Ensembl. | 1 | |
Natural variantiVAR_062525 | 138 | V → I1 PublicationCorresponds to variant dbSNP:rs72558029EnsemblClinVar. | 1 | |
Natural variantiVAR_070220 | 153 | D → N in ATFB13; the mutant results in reduced sodium currents when coexpressed with SCN5A in a heterologous expression system. 1 PublicationCorresponds to variant dbSNP:rs72550247EnsemblClinVar. | 1 | |
Natural variantiVAR_062526 | 208 | K → I1 PublicationCorresponds to variant dbSNP:rs780958012EnsemblClinVar. | 1 | |
Natural variantiVAR_062527 | 211 | C → Y1 PublicationCorresponds to variant dbSNP:rs150721582EnsemblClinVar. | 1 | |
Natural variantiVAR_062528 | 213 | G → D1 PublicationCorresponds to variant dbSNP:rs201209882EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041982 | 150 – 218 | ANRDM…VQVAE → GESGAACPFTVTHRRARWRD RWQAVDRTGWLCAWPANRPQ QRAEGEGSSPSCPLQLWPLF LSSPRRGQSMPVPHRRSGYR TQLCHLCCMTSGRCLLSLSQ RVVLGLPGIIIRCVSRGVV in isoform 2. 1 PublicationAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10338 mRNA Translation: AAA60391.1 L16242 mRNA Translation: AAA61277.1 U12193 , U12189, U12190, U12191, U12192 Genomic DNA Translation: AAB97608.1 AY391842 mRNA Translation: AAR25552.1 AK313279 mRNA Translation: BAG36087.1 DQ677665 Genomic DNA Translation: ABQ01236.1 BT019923 mRNA Translation: AAV38726.1 AC020907 Genomic DNA No translation available. BC067122 mRNA Translation: AAH67122.1 |
CCDSi | CCDS12441.1 [Q07699-1] CCDS46047.1 [Q07699-2] |
PIRi | A55734 |
RefSeqi | NP_001028.1, NM_001037.4 [Q07699-1] NP_001308534.1, NM_001321605.1 NP_950238.1, NM_199037.4 [Q07699-2] |
Genome annotation databases
Ensembli | ENST00000262631.11; ENSP00000262631.3; ENSG00000105711.14 ENST00000415950.5; ENSP00000396915.2; ENSG00000105711.14 [Q07699-2] ENST00000638536.1; ENSP00000492022.1; ENSG00000105711.14 |
GeneIDi | 6324 |
KEGGi | hsa:6324 |
MANE-Selecti | ENST00000262631.11; ENSP00000262631.3; NM_001037.5; NP_001028.1 |
UCSCi | uc002nxo.3, human [Q07699-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10338 mRNA Translation: AAA60391.1 L16242 mRNA Translation: AAA61277.1 U12193 , U12189, U12190, U12191, U12192 Genomic DNA Translation: AAB97608.1 AY391842 mRNA Translation: AAR25552.1 AK313279 mRNA Translation: BAG36087.1 DQ677665 Genomic DNA Translation: ABQ01236.1 BT019923 mRNA Translation: AAV38726.1 AC020907 Genomic DNA No translation available. BC067122 mRNA Translation: AAH67122.1 |
CCDSi | CCDS12441.1 [Q07699-1] CCDS46047.1 [Q07699-2] |
PIRi | A55734 |
RefSeqi | NP_001028.1, NM_001037.4 [Q07699-1] NP_001308534.1, NM_001321605.1 NP_950238.1, NM_199037.4 [Q07699-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AGF | electron microscopy | 3.20 | B | 1-218 | [»] | |
6J8G | electron microscopy | 3.20 | B | 1-218 | [»] | |
6J8H | electron microscopy | 3.20 | B | 1-218 | [»] | |
6J8I | electron microscopy | 3.20 | B | 1-218 | [»] | |
6J8J | electron microscopy | 3.20 | B | 1-218 | [»] | |
AlphaFoldDBi | Q07699 | |||||
SMRi | Q07699 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112229, 16 interactors |
IntActi | Q07699, 4 interactors |
MINTi | Q07699 |
STRINGi | 9606.ENSP00000396915 |
Chemistry databases
BindingDBi | Q07699 |
ChEMBLi | CHEMBL4523668 CHEMBL4523669 CHEMBL4523670 CHEMBL4523671 CHEMBL4523672 CHEMBL4630760 CHEMBL4630762 CHEMBL4630763 CHEMBL4630765 |
DrugBanki | DB05541, Brivaracetam DB00907, Cocaine DB13269, Dichlorobenzyl alcohol DB13961, Fish oil DB00776, Oxcarbazepine DB00252, Phenytoin DB00243, Ranolazine DB00313, Valproic acid DB00909, Zonisamide |
DrugCentrali | Q07699 |
PTM databases
GlyGeni | Q07699, 4 sites |
iPTMneti | Q07699 |
PhosphoSitePlusi | Q07699 |
Genetic variation databases
BioMutai | SCN1B |
DMDMi | 1705868 |
Proteomic databases
MassIVEi | Q07699 |
PaxDbi | Q07699 |
PeptideAtlasi | Q07699 |
PRIDEi | Q07699 |
ProteomicsDBi | 58527 [Q07699-1] 58528 [Q07699-2] |
Protocols and materials databases
Antibodypediai | 29258, 218 antibodies from 29 providers |
DNASUi | 6324 |
Genome annotation databases
Ensembli | ENST00000262631.11; ENSP00000262631.3; ENSG00000105711.14 ENST00000415950.5; ENSP00000396915.2; ENSG00000105711.14 [Q07699-2] ENST00000638536.1; ENSP00000492022.1; ENSG00000105711.14 |
GeneIDi | 6324 |
KEGGi | hsa:6324 |
MANE-Selecti | ENST00000262631.11; ENSP00000262631.3; NM_001037.5; NP_001028.1 |
UCSCi | uc002nxo.3, human [Q07699-1] |
Organism-specific databases
CTDi | 6324 |
DisGeNETi | 6324 |
GeneCardsi | SCN1B |
GeneReviewsi | SCN1B |
HGNCi | HGNC:10586, SCN1B |
HPAi | ENSG00000105711, Group enriched (brain, skeletal muscle, tongue) |
MalaCardsi | SCN1B |
MIMi | 600235, gene 604233, phenotype 612838, phenotype 615377, phenotype 617350, phenotype |
neXtProti | NX_Q07699 |
OpenTargetsi | ENSG00000105711 |
Orphaneti | 130, Brugada syndrome 33069, Dravet syndrome 1934, Early infantile epileptic encephalopathy 334, Familial atrial fibrillation 871, Familial progressive cardiac conduction defect 36387, Generalized epilepsy with febrile seizures-plus |
PharmGKBi | PA302 |
VEuPathDBi | HostDB:ENSG00000105711 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R0UM, Eukaryota |
GeneTreei | ENSGT00390000018560 |
HOGENOMi | CLU_096296_0_0_1 |
InParanoidi | Q07699 |
OMAi | DRIDWNG |
OrthoDBi | 1041959at2759 |
PhylomeDBi | Q07699 |
TreeFami | TF332097 |
Enzyme and pathway databases
PathwayCommonsi | Q07699 |
Reactomei | R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-5576892, Phase 0 - rapid depolarisation R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
SignaLinki | Q07699 |
Miscellaneous databases
BioGRID-ORCSi | 6324, 14 hits in 1076 CRISPR screens |
GeneWikii | SCN1B |
GenomeRNAii | 6324 |
Pharosi | Q07699, Tbio |
PROi | PR:Q07699 |
RNActi | Q07699, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105711, Expressed in right hemisphere of cerebellum and 111 other tissues |
ExpressionAtlasi | Q07699, baseline and differential |
Genevisiblei | Q07699, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set IPR027098, Na_channel_b1/b3 IPR044568, Na_chnl_b1 |
PANTHERi | PTHR10546, PTHR10546, 1 hit PTHR10546:SF2, PTHR10546:SF2, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCN1B_HUMAN | |
Accessioni | Q07699Primary (citable) accession number: Q07699 Secondary accession number(s): Q5TZZ4, Q6TN97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 201 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families