UniProtKB - Q07687 (DLX2_HUMAN)
Protein
Homeobox protein DLX-2
Gene
DLX2
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 152 – 211 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- single-stranded RNA binding Source: Ensembl
GO - Biological processi
- brain development Source: ProtInc
- branching morphogenesis of a nerve Source: Ensembl
- cartilage development Source: Ensembl
- cell differentiation Source: GO_Central
- cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
- embryonic cranial skeleton morphogenesis Source: Ensembl
- forebrain neuron differentiation Source: Ensembl
- hippocampus development Source: Ensembl
- negative regulation of Notch signaling pathway Source: Ensembl
- negative regulation of oligodendrocyte differentiation Source: Ensembl
- negative regulation of photoreceptor cell differentiation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- odontogenesis of dentin-containing tooth Source: Ensembl
- olfactory bulb development Source: Ensembl
- positive regulation of amacrine cell differentiation Source: UniProtKB
- positive regulation of cell differentiation Source: UniProtKB
- proximal/distal pattern formation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- subpallium development Source: Ensembl
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q07687 |
SIGNORi | Q07687 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein DLX-2 |
Gene namesi | Name:DLX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2915, DLX2 |
MIMi | 126255, gene |
neXtProti | NX_Q07687 |
VEuPathDBi | HostDB:ENSG00000115844.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1746 |
OpenTargetsi | ENSG00000115844 |
PharmGKBi | PA27370 |
Miscellaneous databases
Pharosi | Q07687, Tbio |
Genetic variation databases
BioMutai | DLX2 |
DMDMi | 2506529 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049023 | 1 – 328 | Homeobox protein DLX-2Add BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 232 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q07687 |
MassIVEi | Q07687 |
PaxDbi | Q07687 |
PeptideAtlasi | Q07687 |
PRIDEi | Q07687 |
ProteomicsDBi | 58526 [Q07687-1] 7050 |
PTM databases
iPTMneti | Q07687 |
PhosphoSitePlusi | Q07687 |
Expressioni
Gene expression databases
Bgeei | ENSG00000115844, Expressed in forebrain and 111 other tissues |
ExpressionAtlasi | Q07687, baseline and differential |
Genevisiblei | Q07687, HS |
Organism-specific databases
HPAi | ENSG00000115844, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction enhances retinal ganglion cell (RGC) differentiation.
By similarityBinary interactionsi
Q07687
With | #Exp. | IntAct |
---|---|---|
GRN [P28799] | 3 | EBI-3908234,EBI-747754 |
Protein-protein interaction databases
BioGRIDi | 108090, 13 interactors |
IntActi | Q07687, 10 interactors |
MINTi | Q07687 |
STRINGi | 9606.ENSP00000234198 |
Miscellaneous databases
RNActi | Q07687, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 46 | Poly-Ser | 6 | |
Compositional biasi | 75 – 81 | Poly-Gly | 7 | |
Compositional biasi | 251 – 259 | Poly-Gly | 9 | |
Compositional biasi | 309 – 315 | Poly-His | 7 | |
Compositional biasi | 316 – 319 | Poly-Gly | 4 |
Sequence similaritiesi
Belongs to the distal-less homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0850, Eukaryota |
GeneTreei | ENSGT00940000160127 |
HOGENOMi | CLU_074733_1_1_1 |
InParanoidi | Q07687 |
OMAi | YQYHTSG |
PhylomeDBi | Q07687 |
TreeFami | TF350606 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR022135, Distal-less_N IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF12413, DLL_N, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q07687-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP
60 70 80 90 100
QESPTLPVST ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV
110 120 130 140 150
PYSAKSSYDL GYTAAYTSYA PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK
160 170 180 190 200
KVRKPRTIYS SFQLAALQRR FQKTQYLALP ERAELAASLG LTQTQVKIWF
210 220 230 240 250
QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS WDFGVPQRMA
260 270 280 290 300
GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL
310 320
HPTQTPQPHH HHHHHGGGGA PVSAGTIF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 178 | A → V in BAG59916 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054287 | 197 – 217 | KIWFQ…SGEIP → GLAPCRGEESAGLRWLGSRR V in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_054288 | 218 – 328 | Missing in isoform 2. 1 PublicationAdd BLAST | 111 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51003 Genomic DNA Translation: AAB40902.1 AK297503 mRNA Translation: BAG59916.1 AK316129 mRNA Translation: BAH14500.1 AC104801 Genomic DNA No translation available. BC032558 mRNA Translation: AAH32558.1 L07919 mRNA Translation: AAA19663.1 |
CCDSi | CCDS2248.1 [Q07687-1] |
PIRi | B53495 G02469 |
RefSeqi | NP_004396.1, NM_004405.3 [Q07687-1] |
Genome annotation databases
Ensembli | ENST00000234198; ENSP00000234198; ENSG00000115844 [Q07687-1] ENST00000466293; ENSP00000446904; ENSG00000115844 [Q07687-2] |
GeneIDi | 1746 |
KEGGi | hsa:1746 |
UCSCi | uc010zdx.2, human [Q07687-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51003 Genomic DNA Translation: AAB40902.1 AK297503 mRNA Translation: BAG59916.1 AK316129 mRNA Translation: BAH14500.1 AC104801 Genomic DNA No translation available. BC032558 mRNA Translation: AAH32558.1 L07919 mRNA Translation: AAA19663.1 |
CCDSi | CCDS2248.1 [Q07687-1] |
PIRi | B53495 G02469 |
RefSeqi | NP_004396.1, NM_004405.3 [Q07687-1] |
3D structure databases
SMRi | Q07687 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108090, 13 interactors |
IntActi | Q07687, 10 interactors |
MINTi | Q07687 |
STRINGi | 9606.ENSP00000234198 |
PTM databases
iPTMneti | Q07687 |
PhosphoSitePlusi | Q07687 |
Genetic variation databases
BioMutai | DLX2 |
DMDMi | 2506529 |
Proteomic databases
jPOSTi | Q07687 |
MassIVEi | Q07687 |
PaxDbi | Q07687 |
PeptideAtlasi | Q07687 |
PRIDEi | Q07687 |
ProteomicsDBi | 58526 [Q07687-1] 7050 |
Protocols and materials databases
Antibodypediai | 19409, 349 antibodies |
DNASUi | 1746 |
Genome annotation databases
Ensembli | ENST00000234198; ENSP00000234198; ENSG00000115844 [Q07687-1] ENST00000466293; ENSP00000446904; ENSG00000115844 [Q07687-2] |
GeneIDi | 1746 |
KEGGi | hsa:1746 |
UCSCi | uc010zdx.2, human [Q07687-1] |
Organism-specific databases
CTDi | 1746 |
DisGeNETi | 1746 |
GeneCardsi | DLX2 |
HGNCi | HGNC:2915, DLX2 |
HPAi | ENSG00000115844, Tissue enhanced (brain) |
MIMi | 126255, gene |
neXtProti | NX_Q07687 |
OpenTargetsi | ENSG00000115844 |
PharmGKBi | PA27370 |
VEuPathDBi | HostDB:ENSG00000115844.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0850, Eukaryota |
GeneTreei | ENSGT00940000160127 |
HOGENOMi | CLU_074733_1_1_1 |
InParanoidi | Q07687 |
OMAi | YQYHTSG |
PhylomeDBi | Q07687 |
TreeFami | TF350606 |
Enzyme and pathway databases
PathwayCommonsi | Q07687 |
SIGNORi | Q07687 |
Miscellaneous databases
BioGRID-ORCSi | 1746, 14 hits in 1024 CRISPR screens |
GeneWikii | DLX2 |
GenomeRNAii | 1746 |
Pharosi | Q07687, Tbio |
PROi | PR:Q07687 |
RNActi | Q07687, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115844, Expressed in forebrain and 111 other tissues |
ExpressionAtlasi | Q07687, baseline and differential |
Genevisiblei | Q07687, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR022135, Distal-less_N IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF12413, DLL_N, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DLX2_HUMAN | |
Accessioni | Q07687Primary (citable) accession number: Q07687 Secondary accession number(s): B4DMK4, B7ZA14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families