DLX2

Functionⁱ

Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	152 – 211	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 1354641
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
single-stranded RNA binding Source: Ensembl
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: ProtInc
Traceable author statementⁱ
- 7590232
branching morphogenesis of a nerve Source: Ensembl
cartilage development Source: Ensembl
cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
embryonic cranial skeleton morphogenesis Source: Ensembl
hippocampus development Source: Ensembl
negative regulation of Notch signaling pathway Source: Ensembl
negative regulation of oligodendrocyte differentiation Source: Ensembl
negative regulation of photoreceptor cell differentiation Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: Ensembl
odontogenesis of dentin-containing tooth Source: Ensembl
olfactory bulb development Source: Ensembl
positive regulation of amacrine cell differentiation Source: UniProtKB
positive regulation of cell differentiation Source: UniProtKB
proximal/distal pattern formation Source: Ensembl
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: Ensembl
subpallium development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q07687

SIGNORⁱ

Q07687

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein DLX-2
Gene namesⁱ	Name:DLX2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115844.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2915 DLX2
MIMⁱ	126255 gene
neXtProtⁱ	NX_Q07687

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1746
Open Targets More...OpenTargetsⁱ	ENSG00000115844
PharmGKBⁱ	PA27370

Polymorphism and mutation databases

BioMutaⁱ	DLX2
DMDMⁱ	2506529

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049023	1 – 328	Homeobox protein DLX-2Add BLAST		328

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	232	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q07687
PeptideAtlas More...PeptideAtlasⁱ	Q07687
PRIDEⁱ	Q07687
ProteomicsDBⁱ	58526

PTM databases

iPTMnetⁱ	Q07687
PhosphoSitePlusⁱ	Q07687

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000115844 Expressed in 99 organ(s), highest expression level in forebrain
CleanExⁱ	HS_DLX2
ExpressionAtlasⁱ	Q07687 baseline and differential
Genevisibleⁱ	Q07687 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056965

HPAⁱ

HPA056965

Interactionⁱ

Subunit structureⁱ

Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction enhances retinal ganglion cell (RGC) differentiation.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GRN	P28799	3	EBI-3908234,EBI-747754

With

Entry

#Exp.

IntAct

Notes

GRN

P28799

3

EBI-3908234,EBI-747754

Protein-protein interaction databases

BioGridⁱ	108090, 13 interactors
IntActⁱ	Q07687, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q07687
STRINGⁱ	9606.ENSP00000234198

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q07687
SMRⁱ	Q07687
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	41 – 46	Poly-Ser	6
Compositional biasⁱ	75 – 81	Poly-Gly	7
Compositional biasⁱ	251 – 259	Poly-Gly	9
Compositional biasⁱ	309 – 315	Poly-His	7
Compositional biasⁱ	316 – 319	Poly-Gly	4

Sequence similaritiesⁱ

Belongs to the distal-less homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0850 Eukaryota ENOG410ZHZR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148979
HOGENOMⁱ	HOG000231940
HOVERGENⁱ	HBG005493
InParanoidⁱ	Q07687
KEGG Orthology (KO) More...KOⁱ	K18488
OMAⁱ	FLGNYPW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P17
PhylomeDBⁱ	Q07687
TreeFamⁱ	TF350606

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR022135 Distal-less_N IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12413 DLL_N, 1 hit PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q07687-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP 
        60         70         80         90        100
QESPTLPVST ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV 
       110        120        130        140        150
PYSAKSSYDL GYTAAYTSYA PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK 
       160        170        180        190        200
KVRKPRTIYS SFQLAALQRR FQKTQYLALP ERAELAASLG LTQTQVKIWF 
       210        220        230        240        250
QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS WDFGVPQRMA 
       260        270        280        290        300
GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL 
       310        320 
HPTQTPQPHH HHHHHGGGGA PVSAGTIF

Length:328

Mass (Da):34,243

Last modified:November 1, 1997 - v2

Checksum:ⁱBB6A077256F58022

GO

Isoform 2 (identifier: Q07687-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
197-217: KIWFQNRRSKFKKMWKSGEIP → GLAPCRGEESAGLRWLGSRRV
218-328: Missing.

« Hide

        10         20         30         40         50
MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP 
        60         70         80         90        100
QESPTLPVST ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV 
       110        120        130        140        150
PYSAKSSYDL GYTAAYTSYA PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK 
       160        170        180        190        200
KVRKPRTIYS SFQLAALQRR FQKTQYLALP ERAELAASLG LTQTQVGLAP 
       210 
CRGEESAGLR WLGSRRV

Note: No experimental confirmation available.

Show »

Length:217

Mass (Da):23,021

Checksum:ⁱE8A2C00A99499ABA

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	178	A → V in BAG59916 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054287	197 – 217	KIWFQ…SGEIP → GLAPCRGEESAGLRWLGSRR V in isoform 2. 1 PublicationAdd BLAST		21
Alternative sequenceⁱVSP_054288	218 – 328	Missing in isoform 2. 1 PublicationAdd BLAST		111

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U51003 Genomic DNA Translation: AAB40902.1 AK297503 mRNA Translation: BAG59916.1 AK316129 mRNA Translation: BAH14500.1 AC104801 Genomic DNA No translation available. BC032558 mRNA Translation: AAH32558.1 L07919 mRNA Translation: AAA19663.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2248.1 [Q07687-1]
PIRⁱ	B53495 G02469
NCBI Reference Sequences More...RefSeqⁱ	NP_004396.1, NM_004405.3 [Q07687-1]
UniGeneⁱ	Hs.419

Genome annotation databases

Ensemblⁱ	ENST00000234198; ENSP00000234198; ENSG00000115844 [Q07687-1] ENST00000466293; ENSP00000446904; ENSG00000115844 [Q07687-2]
GeneIDⁱ	1746
KEGGⁱ	hsa:1746
UCSC genome browser More...UCSCⁱ	uc010zdx.2 human [Q07687-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07687	Distal-less homeobox 2		HUMAN		328	UniRef100_Q07687
Distal-less homeobox 2 isoform A (Fragment)		HUMAN		328

Protein	Similar proteins		Species	Score	Length	Source
Q07687	Homeobox protein DLX-2		MOUSE		332	UniRef90_P40764
Homeobox protein DLX-2 (Fragment)		RAT		83
Distal-less homeobox 2		PANPA		401
DLX2 isoform 1		PANTR		328
Distal-less homeobox 2		GORGO		328
+82
Q07687-2	DLX2 isoform 2 (Fragment)		PONAB		218	UniRef90_Q07687-2
DLX2 isoform 2		PANTR		217
Distal-less homeobox 2		HORSE		195
UPI000B536827		TARSY		241

Protein	Similar proteins		Species	Score	Length	Source
Q07687	Homeobox protein DLX-2		MOUSE		332	UniRef50_P40764
Homeobox protein DLX-2 (Fragment)		RAT		83
Distal-less homeobox 2		PANPA		401
DLX2 isoform 1		PANTR		328
Distal-less homeobox 2		GORGO		328
+91
Q07687-2	DLX2 isoform 2 (Fragment)		PONAB		218	UniRef50_Q07687-2
DLX2 isoform 2		PANTR		217
Distal-less homeobox 2		HORSE		195
Distal-less homeobox 2		MYOLU		199
Homeobox protein DLX-2 (Fragment)		ESCRO		229
+13

Entry informationⁱ

Entry nameⁱ	DLX2_HUMAN
Accessionⁱ	Q07687Primary (citable) accession number: Q07687 Secondary accession number(s): B4DMK4, B7ZA14
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 1, 1997
	Last modified:	September 12, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q07687 (DLX2_HUMAN)

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Homeobox protein DLX-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ