KHDRBS1

Functionⁱ

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).By similarity6 Publications

Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.1 Publication

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 1374686
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10332027
- 10749975
poly(A) binding
Source: MGI
Inferred from direct assayⁱ
- 21984414
poly(U) RNA binding
Source: MGI
Inferred from direct assayⁱ
- 21984414
protein-containing complex binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10749975
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1374686
SH3/SH2 adaptor activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 9045636
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest
Source: ProtInc
Traceable author statementⁱ
- 9013542
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 9013542
cell surface receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 9045636
G2/M transition of mitotic cell cycle Source: UniProtKB
mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 1374686
negative regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of RNA export from nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 21613532
positive regulation of translational initiation
Source: UniProtKB
Inferred from direct assayⁱ
- 21613532
protein complex oligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 10332027
- 10749975
regulation of mRNA splicing, via spliceosome Source: Ensembl
regulation of RNA export from nucleus Source: UniProtKB
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9013542
spermatogenesis Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Cell cycle, mRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing
SignaLinkⁱ	Q07666
SIGNORⁱ	Q07666

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: KH domain-containing, RNA-binding, signal transduction-associated protein 1 Alternative name(s): GAP-associated tyrosine phosphoprotein p62 Src-associated in mitosis 68 kDa protein Short name: Sam68 p21 Ras GTPase-activating protein-associated p62 p68
Gene namesⁱ	Name:KHDRBS1Imported Synonyms:SAM681 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000121774.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18116 KHDRBS1
MIMⁱ	602489 gene
neXtProtⁱ	NX_Q07666

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	103	Y → S: Impairs homodimerization. 1 Publication	1
Mutagenesisⁱ	110	E → A: Impairs homodimerization. 1 Publication	1
Mutagenesisⁱ	118	F → S: Disrupts homodimerization, impairs influence on alternative splicing. 1 Publication	1
Mutagenesisⁱ	229	V → F: Disrupts binding to poly(A), impairs interaction with BCL2L1 modulation of BCL2L1 alternative splicing. 1 Publication	1
Mutagenesisⁱ	241	Y → E: Fails to influence alternative splicing of CD44, NRXN2 and NRXN3. 1 Publication	1
Mutagenesisⁱ	381	E → K: Disrupts interaction with APC. 1 Publication	1
Mutagenesisⁱ	383	Y → K: Impairs interaction with APC. 1 Publication	1
Mutagenesisⁱ	384	E → K: Disrupts interaction with APC. 1 Publication	1
Mutagenesisⁱ	435	Y → F: No effect on the nuclear localization. 1 Publication	1
Mutagenesisⁱ	440	Y → F: Completely blocks nuclear localization. 1 Publication	1
Mutagenesisⁱ	443	Y → F: No effect on the nuclear localization. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10657
Open Targets More...OpenTargetsⁱ	ENSG00000121774
PharmGKBⁱ	PA30092

Polymorphism and mutation databases

DMDMⁱ	62511098

DMDMⁱ

62511098

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050124	1 – 443	KH domain-containing, RNA-binding, signal transduction-associated protein 1Add BLAST		443

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	18	PhosphoserineCombined sources	1
Modified residueⁱ	20	PhosphoserineCombined sources	1
Modified residueⁱ	29	PhosphoserineCombined sources	1
Modified residueⁱ	33	PhosphothreonineCombined sources	1
Modified residueⁱ	45	Asymmetric dimethylarginine; by PRMT11 Publication	1
Modified residueⁱ	52	Asymmetric dimethylarginine; partial; by PRMT11 Publication	1
Modified residueⁱ	58	PhosphoserineCombined sources	1
Modified residueⁱ	84	Phosphothreonine; by MAPK1By similarity	1
Cross-linkⁱ	96	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	102	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	113	PhosphoserineBy similarity	1
Cross-linkⁱ	139	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	150	PhosphoserineCombined sources	1
Modified residueⁱ	175	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	175	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	183	PhosphothreonineCombined sources	1
Modified residueⁱ	282	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	284	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	291	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	304	Asymmetric dimethylarginine; by PRMT11 Publication	1
Modified residueⁱ	310	Omega-N-methylarginine; by PRMT11 Publication	1
Modified residueⁱ	315	Omega-N-methylarginine; by PRMT11 Publication	1
Modified residueⁱ	320	Dimethylated arginine; in A2780 ovarian carcinoma cell line1 Publication	1
Modified residueⁱ	320	Omega-N-methylarginine; by PRMT11 Publication	1
Modified residueⁱ	325	Omega-N-methylarginine; by PRMT11 Publication	1
Modified residueⁱ	331	Asymmetric dimethylarginine; alternateBy similarity	1
Modified residueⁱ	331	Dimethylated arginine; in A2780 ovarian carcinoma cell line1 Publication	1
Modified residueⁱ	331	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	331	Omega-N-methylated arginine; by PRMT1; alternate1 Publication	1
Modified residueⁱ	340	Dimethylated arginine; in A2780 ovarian carcinoma cell line1 Publication	1
Modified residueⁱ	340	Omega-N-methylarginine; by PRMT1Combined sources	1
Modified residueⁱ	387	Phosphotyrosine1 Publication	1
Modified residueⁱ	390	PhosphoserineCombined sources	1
Cross-linkⁱ	432	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	435	Phosphotyrosine; by PTK61 Publication	1
Modified residueⁱ	440	Phosphotyrosine; by PTK61 Publication	1
Modified residueⁱ	443	Phosphotyrosine; by PTK61 Publication	1

Post-translational modificationⁱ

Tyrosine phosphorylated by several non-receptor tyrosine kinases including LCK, FYN and JAK3. Also tyrosine phosphorylated by the non-receptor tyrosine kinase SRMS in an EGF-dependent manner (PubMed:29496907). Negatively correlates with ability to bind RNA but required for many interactions with proteins. Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nuclear localization of KHDRBS1. Phosphorylation at Tyr-387 disrupts interaction with APC. Phosphorylation at tyrosine residues by FYN inverts activity on modulation of BCL2L1 alternative splicing.6 Publications

Acetylated. Positively correlates with ability to bind RNA.1 Publication

Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30.3 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q07666
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q07666
PaxDbⁱ	Q07666
PeptideAtlas More...PeptideAtlasⁱ	Q07666
PRIDEⁱ	Q07666
ProteomicsDBⁱ	58523 58524 [Q07666-2] 58525 [Q07666-3]
TopDownProteomicsⁱ	Q07666-1 [Q07666-1] Q07666-3 [Q07666-3]

PTM databases

iPTMnetⁱ	Q07666
PhosphoSitePlusⁱ	Q07666
SwissPalmⁱ	Q07666

Miscellaneous databases

PMAP-CutDBⁱ	Q07666

PMAP-CutDBⁱ

Q07666

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.1 Publication

Developmental stageⁱ

Isoform 3 is only expressed in growth-arrested cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000121774 Expressed in 237 organ(s), highest expression level in forebrain
CleanExⁱ	HS_KHDRBS1
Genevisibleⁱ	Q07666 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005355 HPA051280 HPA056813

HPAⁱ

CAB005355
HPA051280
HPA056813

Interactionⁱ

Subunit structureⁱ

Self-associates to form homooligomers when bound to RNA, oligomerization appears to be limited when binding to proteins; dimerization increases RNA affinity (PubMed:26758068, PubMed:20610388). Interacts with KHDRBS3/SLIM-2 (PubMed:10332027). Interacts with KHDRBS2/SLIM-1; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (By similarity). Interacts with RASA1, LCK, FYN, PTPN6, PLCG1, GRB2, CBL, JAK3, PIK3R, STAT3, APC, HNRNPA1 (PubMed:1374686, PubMed:9045636, PubMed:10332027, PubMed:11585385, PubMed:17371836, PubMed:22000517). Interacts with PTK6 (via SH3 and SH2 domains) (PubMed:10913193). Forms a complex with ILF2, ILF3, YLPM1, RBMX, NCOA5 and PPP1CA (PubMed:17890166). Does not interact with TPR (PubMed:22253824). Interacts with RBMY1A1, PRMT1 (By similarity). Binds WBP4/FBP21 (via WW domains), FNBP4/FBP30 (via WW domains). Interacts (via Arg/Gly-rich-flanked Pro-rich regions) with FYN (via the SH3 domain) (By similarity). Interacts with the non-receptor tyrosine kinase SRMS; the interaction leads to phosphorylation of KHDRBS1 (PubMed:29496907).By similarity9 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-1364,EBI-1364
APC	P25054	3	EBI-1364,EBI-727707
FYN	P06241	4	EBI-1364,EBI-515315
GRB2	P62993	8	EBI-1364,EBI-401755
HCK	P08631	4	EBI-1364,EBI-346340
HNRNPA1	P09651	9	EBI-1364,EBI-352662
JAK3	P52333	2	EBI-1364,EBI-518246
LCK	P06239	5	EBI-1364,EBI-1348
Lck	P06240	2	EBI-1364,EBI-1401	From Mus musculus.
PIK3R1	P23727	2	EBI-1364,EBI-520244	From Bos taurus.
PLCG1	P19174	2	EBI-1364,EBI-79387
SMARCA2	P51531	2	EBI-1364,EBI-679562
SRC	P12931	3	EBI-1364,EBI-621482
STAT3	P40763	2	EBI-1364,EBI-518675
VAV1	P15498	3	EBI-1364,EBI-625518
ZBTB7A	O95365	9	EBI-1364,EBI-2795384

GO - Molecular functionⁱ

identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10332027
- 10749975
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10749975
SH3/SH2 adaptor activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 9045636
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115900, 174 interactors
CORUMⁱ	Q07666
Database of interacting proteins More...DIPⁱ	DIP-29007N
IntActⁱ	Q07666, 81 interactors
Molecular INTeraction database More...MINTⁱ	Q07666
STRINGⁱ	9606.ENSP00000313829

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	100 – 113	Combined sources		14
Helixⁱ	119 – 134	Combined sources		16

Show more details

3D structure databases

ProteinModelPortalⁱ	Q07666
SMRⁱ	Q07666
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q07666

EvolutionaryTraceⁱ

Q07666

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	171 – 197	KHPROSITE-ProRule annotationAdd BLAST		27

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	100 – 260	Involved in homodimerization1 PublicationAdd BLAST		161
Regionⁱ	351 – 443	Interaction with HNRNPA11 PublicationAdd BLAST		93

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	34 – 41	Pro-richSequence analysis	8
Compositional biasⁱ	44 – 55	DMA/Gly-richSequence analysisAdd BLAST	12
Compositional biasⁱ	59 – 89	Pro-richSequence analysisAdd BLAST	31
Compositional biasⁱ	282 – 292	DMA/Gly-richSequence analysisAdd BLAST	11
Compositional biasⁱ	295 – 301	Pro-richSequence analysis	7
Compositional biasⁱ	302 – 332	Arg/Gly-richSequence analysisAdd BLAST	31
Compositional biasⁱ	334 – 363	Pro-richSequence analysisAdd BLAST	30

Domainⁱ

The KH domain is required for binding to RNA.By similarity

The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the KHDRBS family.Sequence analysis

Keywords - Domainⁱ

SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG1588 Eukaryota COG5176 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074434
HOGENOMⁱ	HOG000230771
HOVERGENⁱ	HBG079164
InParanoidⁱ	Q07666
KEGG Orthology (KO) More...KOⁱ	K13198
OMAⁱ	FLFPDMM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EED
PhylomeDBⁱ	Q07666
TreeFamⁱ	TF314878

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR032571 Qua1_dom IPR032335 Sam68-YY
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013 KH_1, 1 hit PF16274 Qua1, 1 hit PF16568 Sam68-YY, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 1 hit
SUPFAMⁱ	SSF54791 SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 11 Publication (identifier: Q07666-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG 
        60         70         80         90        100
SRGGARASPA TQPPPLLPPS ATGPDATVGG PAPTPLLPPS ATASVKMEPE 
       110        120        130        140        150
NKYLPELMAE KDSLDPSFTH AMQLLTAEIE KIQKGDSKKD DEENYLDLFS 
       160        170        180        190        200
HKNMKLKERV LIPVKQYPKF NFVGKILGPQ GNTIKRLQEE TGAKISVLGK 
       210        220        230        240        250
GSMRDKAKEE ELRKGGDPKY AHLNMDLHVF IEVFGPPCEA YALMAHAMEE 
       260        270        280        290        300
VKKFLVPDMM DDICQEQFLE LSYLNGVPEP SRGRGVPVRG RGAAPPPPPV 
       310        320        330        340        350
PRGRGVGPPR GALVRGTPVR GAITRGATVT RGVPPPPTVR GAPAPRARTA 
       360        370        380        390        400
GIQRIPLPPP PAPETYEEYG YDDTYAEQSY EGYEGYYSQS QGDSEYYDYG 
       410        420        430        440 
HGEVQDSYEA YGQDDWNGTR PSLKAPPARP VKGAYREHPY GRY

Length:443

Mass (Da):48,227

Last modified:November 1, 1996 - v1

Checksum:ⁱ59FB4DB6FB4DBE98

GO

Isoform 2Curated (identifier: Q07666-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
37-61: Missing.

« Hide

        10         20         30         40         50
MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPP LLPPSATGPD 
        60         70         80         90        100
ATVGGPAPTP LLPPSATASV KMEPENKYLP ELMAEKDSLD PSFTHAMQLL 
       110        120        130        140        150
TAEIEKIQKG DSKKDDEENY LDLFSHKNMK LKERVLIPVK QYPKFNFVGK 
       160        170        180        190        200
ILGPQGNTIK RLQEETGAKI SVLGKGSMRD KAKEEELRKG GDPKYAHLNM 
       210        220        230        240        250
DLHVFIEVFG PPCEAYALMA HAMEEVKKFL VPDMMDDICQ EQFLELSYLN 
       260        270        280        290        300
GVPEPSRGRG VPVRGRGAAP PPPPVPRGRG VGPPRGALVR GTPVRGAITR 
       310        320        330        340        350
GATVTRGVPP PPTVRGAPAP RARTAGIQRI PLPPPPAPET YEEYGYDDTY 
       360        370        380        390        400
AEQSYEGYEG YYSQSQGDSE YYDYGHGEVQ DSYEAYGQDD WNGTRPSLKA 
       410 
PPARPVKGAY REHPYGRY

Note: No experimental confirmation available.Curated

Show »

Length:418

Mass (Da):45,861

Checksum:ⁱ36B5B877E35D9A2C

GO

Isoform 31 Publication (identifier: Q07666-3) [UniParc]FASTA Add to basket

Also known as: DeltaKH1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
169-207: Missing.

« Hide

        10         20         30         40         50
MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG 
        60         70         80         90        100
SRGGARASPA TQPPPLLPPS ATGPDATVGG PAPTPLLPPS ATASVKMEPE 
       110        120        130        140        150
NKYLPELMAE KDSLDPSFTH AMQLLTAEIE KIQKGDSKKD DEENYLDLFS 
       160        170        180        190        200
HKNMKLKERV LIPVKQYPKE EELRKGGDPK YAHLNMDLHV FIEVFGPPCE 
       210        220        230        240        250
AYALMAHAME EVKKFLVPDM MDDICQEQFL ELSYLNGVPE PSRGRGVPVR 
       260        270        280        290        300
GRGAAPPPPP VPRGRGVGPP RGALVRGTPV RGAITRGATV TRGVPPPPTV 
       310        320        330        340        350
RGAPAPRART AGIQRIPLPP PPAPETYEEY GYDDTYAEQS YEGYEGYYSQ 
       360        370        380        390        400
SQGDSEYYDY GHGEVQDSYE AYGQDDWNGT RPSLKAPPAR PVKGAYREHP 

YGRY

Show »

Length:404

Mass (Da):44,027

Checksum:ⁱ0E6334E3447CCA5F

GO

Sequence cautionⁱ

The sequence AAH10132 differs from that shown. Intron retention.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_051719	37 – 61	Missing in isoform 2. 1 PublicationAdd BLAST		25
Alternative sequenceⁱVSP_051720	169 – 207	Missing in isoform 3. 1 PublicationAdd BLAST		39

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88108 mRNA Translation: AAA59990.1 U78971 mRNA Translation: AAB47504.1 AK091346 mRNA Translation: BAC03643.1 AL139249, AL445248 Genomic DNA Translation: CAI21971.1 AL139249, AL445248 Genomic DNA Translation: CAI21972.1 AL445248, AL139249 Genomic DNA Translation: CAH71944.1 AL445248, AL139249 Genomic DNA Translation: CAH71945.1 CH471059 Genomic DNA Translation: EAX07576.1 CH471059 Genomic DNA Translation: EAX07577.1 BC000717 mRNA Translation: AAH00717.1 BC010132 mRNA Translation: AAH10132.1 Sequence problems. BC019109 mRNA Translation: AAH19109.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS350.1 [Q07666-1] CCDS60067.1 [Q07666-3]
PIRⁱ	A38219
NCBI Reference Sequences More...RefSeqⁱ	NP_001258807.1, NM_001271878.1 [Q07666-3] NP_006550.1, NM_006559.2 [Q07666-1]
UniGeneⁱ	Hs.445893

Genome annotation databases

Ensemblⁱ	ENST00000327300; ENSP00000313829; ENSG00000121774 [Q07666-1] ENST00000492989; ENSP00000417731; ENSG00000121774 [Q07666-3]
GeneIDⁱ	10657
KEGGⁱ	hsa:10657
UCSC genome browser More...UCSCⁱ	uc001bua.3 human [Q07666-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07666	KH domain containing, RNA binding, signal transduction associated 1, isoform CRA_b		HUMAN		347	UniRef100_Q07666
KH RNA binding domain containing, signal transduction associated 1		CALJA		547
KH RNA binding domain containing, signal transduction associated 1		SAIBB		368
KH domain-containing, RNA-binding, signal transduction-associated protein 1		wild yak		347
KH domain containing, RNA binding, signal transduction associated 1 (Fragment)		MUSPF		235
+17
Q07666-3	KH RNA binding domain containing, signal transduction associated 1		CALJA		508	UniRef100_F7GTD2
KH RNA binding domain containing, signal transduction associated 1		PANTR		404
KH RNA binding domain containing, signal transduction associated 1		MACMU		404
KHDRBS1 isoform 4		PONAB		404
KH RNA binding domain containing, signal transduction associated 1		CERAT		404
+12

Protein	Similar proteins		Species	Score	Length	Source
Q07666	KH domain-containing, RNA-binding, signal transduction-associated protein 1		MOUSE		443	UniRef90_Q07666
KH domain-containing, RNA-binding, signal transduction-associated protein 1		RAT		443
KH domain containing, RNA binding, signal transduction associated 1, isoform CRA_b		HUMAN		347
KH RNA binding domain containing, signal transduction associated 1		CALJA		547
KH RNA binding domain containing, signal transduction associated 1		SAIBB		368
+84
Q07666-2	KH domain-containing, RNA-binding, signal transduction-associated protein 1		HETGA		436	UniRef90_Q07666-2
Uncharacterized protein (Fragment)		AILME		418
UPI00032B08B3		OCHPR		522
UPI00093EBA75		great roundleaf bat		435
Q07666-3	KH RNA binding domain containing, signal transduction associated 1		CALJA		508	UniRef90_F7GTD2
KH RNA binding domain containing, signal transduction associated 1		PANTR		404
KH RNA binding domain containing, signal transduction associated 1		MACMU		404
KHDRBS1 isoform 4		PONAB		404
KH RNA binding domain containing, signal transduction associated 1		CERAT		404
+13

Protein	Similar proteins		Species	Score	Length	Source
Q07666	KH domain-containing, RNA-binding, signal transduction-associated protein 1		MOUSE		443	UniRef50_Q07666
KH domain-containing, RNA-binding, signal transduction-associated protein 1		RAT		443
KH domain containing, RNA binding, signal transduction associated 1, isoform CRA_b		HUMAN		347
KH RNA binding domain containing, signal transduction associated 1		CALJA		547
KH RNA binding domain containing, signal transduction associated 1		SAIBB		368
+114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88108 mRNA Translation: AAA59990.1 U78971 mRNA Translation: AAB47504.1 AK091346 mRNA Translation: BAC03643.1 AL139249, AL445248 Genomic DNA Translation: CAI21971.1 AL139249, AL445248 Genomic DNA Translation: CAI21972.1 AL445248, AL139249 Genomic DNA Translation: CAH71944.1 AL445248, AL139249 Genomic DNA Translation: CAH71945.1 CH471059 Genomic DNA Translation: EAX07576.1 CH471059 Genomic DNA Translation: EAX07577.1 BC000717 mRNA Translation: AAH00717.1 BC010132 mRNA Translation: AAH10132.1 Sequence problems. BC019109 mRNA Translation: AAH19109.1
CCDSⁱ	CCDS350.1 [Q07666-1] CCDS60067.1 [Q07666-3]
PIRⁱ	A38219
RefSeqⁱ	NP_001258807.1, NM_001271878.1 [Q07666-3] NP_006550.1, NM_006559.2 [Q07666-1]
UniGeneⁱ	Hs.445893

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2XA6	NMR	-	A/B	97-135	[»]
	3QHE	X-ray	2.40	B/D	365-419	[»]
ProteinModelPortalⁱ	Q07666
SMRⁱ	Q07666
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115900, 174 interactors
CORUMⁱ	Q07666
DIPⁱ	DIP-29007N
IntActⁱ	Q07666, 81 interactors
MINTⁱ	Q07666
STRINGⁱ	9606.ENSP00000313829

PTM databases

iPTMnetⁱ	Q07666
PhosphoSitePlusⁱ	Q07666
SwissPalmⁱ	Q07666

Polymorphism and mutation databases

DMDMⁱ	62511098

DMDMⁱ

62511098

Proteomic databases

EPDⁱ	Q07666
MaxQBⁱ	Q07666
PaxDbⁱ	Q07666
PeptideAtlasⁱ	Q07666
PRIDEⁱ	Q07666
ProteomicsDBⁱ	58523 58524 [Q07666-2] 58525 [Q07666-3]
TopDownProteomicsⁱ	Q07666-1 [Q07666-1] Q07666-3 [Q07666-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10657
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000327300; ENSP00000313829; ENSG00000121774 [Q07666-1] ENST00000492989; ENSP00000417731; ENSG00000121774 [Q07666-3]
GeneIDⁱ	10657
KEGGⁱ	hsa:10657
UCSCⁱ	uc001bua.3 human [Q07666-1]

Organism-specific databases

CTDⁱ	10657
DisGeNETⁱ	10657
EuPathDBⁱ	HostDB:ENSG00000121774.17
GeneCardsⁱ	KHDRBS1
HGNCⁱ	HGNC:18116 KHDRBS1
HPAⁱ	CAB005355 HPA051280 HPA056813
MIMⁱ	602489 gene
neXtProtⁱ	NX_Q07666
OpenTargetsⁱ	ENSG00000121774
PharmGKBⁱ	PA30092
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1588 Eukaryota COG5176 LUCA
GeneTreeⁱ	ENSGT00550000074434
HOGENOMⁱ	HOG000230771
HOVERGENⁱ	HBG079164
InParanoidⁱ	Q07666
KOⁱ	K13198
OMAⁱ	FLFPDMM
OrthoDBⁱ	EOG091G0EED
PhylomeDBⁱ	Q07666
TreeFamⁱ	TF314878

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing
SignaLinkⁱ	Q07666
SIGNORⁱ	Q07666

Miscellaneous databases

ChiTaRSⁱ	KHDRBS1 human
EvolutionaryTraceⁱ	Q07666
GeneWikiⁱ	KHDRBS1
GenomeRNAiⁱ	10657
PMAP-CutDBⁱ	Q07666
Protein Ontology More...PROⁱ	PR:Q07666
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000121774 Expressed in 237 organ(s), highest expression level in forebrain
CleanExⁱ	HS_KHDRBS1
Genevisibleⁱ	Q07666 HS

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR032571 Qua1_dom IPR032335 Sam68-YY
Pfamⁱ	View protein in Pfam PF00013 KH_1, 1 hit PF16274 Qua1, 1 hit PF16568 Sam68-YY, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 1 hit
SUPFAMⁱ	SSF54791 SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KHDR1_HUMAN
Accessionⁱ	Q07666Primary (citable) accession number: Q07666 Secondary accession number(s): D3DPP3 , Q6PJX7, Q8NB97, Q99760
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - Q07666 (KHDR1_HUMAN)

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KH domain-containing, RNA-binding, signal transduction-associated protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ