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Entry version 122 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Protein BRE4

Gene

BRE4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in intracellular vesicle transport.

1 Publication

Miscellaneous

Deletion of the gene leads to brefeldin A-sensitivity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • endocytosis Source: SGD
  • protein transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein BRE4
Alternative name(s):
Brefeldin A-sensitivity protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRE4
Ordered Locus Names:YDL231C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002390, BRE4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDL231C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 143CytoplasmicSequence analysisAdd BLAST143
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 176ExtracellularSequence analysisAdd BLAST12
Transmembranei177 – 194HelicalSequence analysisAdd BLAST18
Topological domaini195 – 198CytoplasmicSequence analysis4
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 227ExtracellularSequence analysis8
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 254CytoplasmicSequence analysis6
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 284ExtracellularSequence analysis9
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 706CytoplasmicSequence analysisAdd BLAST401
Transmembranei707 – 727HelicalSequence analysisAdd BLAST21
Topological domaini728 – 750ExtracellularSequence analysisAdd BLAST23
Transmembranei751 – 771HelicalSequence analysisAdd BLAST21
Topological domaini772 – 780CytoplasmicSequence analysis9
Transmembranei781 – 801HelicalSequence analysisAdd BLAST21
Topological domaini802 – 843ExtracellularSequence analysisAdd BLAST42
Transmembranei844 – 864HelicalSequence analysisAdd BLAST21
Topological domaini865 – 1125CytoplasmicSequence analysisAdd BLAST261

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002396341 – 1125Protein BRE4Add BLAST1125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi830N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q07660

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07660

PRoteomics IDEntifications database

More...
PRIDEi
Q07660

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07660

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31880, 35 interactors

Database of interacting proteins

More...
DIPi
DIP-5168N

Protein interaction database and analysis system

More...
IntActi
Q07660, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YDL231C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q07660, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni426 – 449DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi427 – 446Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BRE4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4711, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004486_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07660

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWGWAAN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018820, BRE4-related_DUF2421
IPR023244, Brefeldin_A-sensitivity_4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10334, ArAE_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02047, BREFELDNASP4

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07660-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRYERDRSP TPDPDIVKGS YSQTSLRSLH ELNYKNPAGI SGLSFAGSPQ
60 70 80 90 100
QSVASLSQMR LENLVKDKHW EEVEDFGLEE LRDGFFDAAF TKPDSKARSP
110 120 130 140 150
NSDIDDDNGA ARKKLQSGFT KLSEYVWTAI YRPIIHFPRD IRKNGVSIFK
160 170 180 190 200
FFIAYFIAIV ICVIRPSGRW IGHEFRYFLP IAVLIHHPVR NIGVQLEMTI
210 220 230 240 250
SSIIGASFGL GWSALAWYIS TATKPTANYQ GGILFQSLTM ALLFAIWLRS
260 270 280 290 300
VYRRFFYFTT SFSISIIFTH TVRLASSKFD LKWQIFWDFG ISYLFGLLLS
310 320 330 340 350
LLVCVCVSPH SGNAELMEHY NKCLQTTKTF LMALVDTELI KSKEQIYLAQ
360 370 380 390 400
VKMVKTLNID LSQGFRDFVN QLTISRFDLQ SLKSLRNSLT AMETSLRVLP
410 420 430 440 450
IAPKIFNDDE LKKMYEELEK YRSDSATLSK EASASPQSSG IPTRENTPSA
460 470 480 490 500
FKPIGPGLLK NEIYINALKA SFSKSIFNLI LEMIFVLENL SRVLKKYESP
510 520 530 540 550
NQKNNLDECV KILSHSHSKL KRKIYKLDVC YRDFVNSSFF SQELLNDEES
560 570 580 590 600
VDIFLFLRYL RNSARQLVTV IHDCQVLGEN IHWRIALPSY PLSRALTRLP
610 620 630 640 650
KQCVLDEGAG NVLHYFEAKR DVDEIFERVY NTYTSRHKYN KGEEEALRLD
660 670 680 690 700
SQGGDEKSQN RKNHTISIRA IDHNDFNFHT TQNPWRFKLW KLSRILSGDE
710 720 730 740 750
CKWTLKITFC MIFLCLPTWL PESYHWYQEF HCWWAPLTFY LLAHRRYSGN
760 770 780 790 800
WALVMRRLIC GIVGIFWGWA ANQSRHFGSP YVVCTFAGLI VVPFSINFLV
810 820 830 840 850
YRNTKSSFTA LMCFTIIALE PYSKPNRHYN LTTAGIWKST WVTGLALIIG
860 870 880 890 900
ILVSIPINWI VWPFRARTEL RDSMSSLLAH LGQSYQTVAD RYLYRDADDA
910 920 930 940 950
PTDLTFAFSH IREVRLTQSL EAIRELLKKA RHEPIIISNF NPEKYASLIN
960 970 980 990 1000
SCQFLLSKII EARISGAFFE IWDQDFDIET TRALLSLRRD SVSSVIFVFY
1010 1020 1030 1040 1050
ILSNCFRSKN KIPRYLPNPI MSRKKLYHFI KKFSEMKDQS HSNLNSGGNS
1060 1070 1080 1090 1100
MEKNLFKKIY QQKASSSGQQ QLPLPSVANS SEIDSEKMHW TEVHGIAFAR
1110 1120
AFTDISEALF QVESCAKDIL GEENF
Length:1,125
Mass (Da):129,725
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E0E04F6916A7E74
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z74279 Genomic DNA Translation: CAA98810.1
BK006938 Genomic DNA Translation: DAA11635.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S67794

NCBI Reference Sequences

More...
RefSeqi
NP_010050.1, NM_001180291.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDL231C_mRNA; YDL231C; YDL231C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851367

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDL231C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74279 Genomic DNA Translation: CAA98810.1
BK006938 Genomic DNA Translation: DAA11635.1
PIRiS67794
RefSeqiNP_010050.1, NM_001180291.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31880, 35 interactors
DIPiDIP-5168N
IntActiQ07660, 1 interactor
STRINGi4932.YDL231C

PTM databases

iPTMnetiQ07660

Proteomic databases

MaxQBiQ07660
PaxDbiQ07660
PRIDEiQ07660

Genome annotation databases

EnsemblFungiiYDL231C_mRNA; YDL231C; YDL231C
GeneIDi851367
KEGGisce:YDL231C

Organism-specific databases

SGDiS000002390, BRE4
VEuPathDBiFungiDB:YDL231C

Phylogenomic databases

eggNOGiKOG4711, Eukaryota
HOGENOMiCLU_004486_0_0_1
InParanoidiQ07660
OMAiFWGWAAN

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q07660
RNActiQ07660, protein

Family and domain databases

InterProiView protein in InterPro
IPR018820, BRE4-related_DUF2421
IPR023244, Brefeldin_A-sensitivity_4
PfamiView protein in Pfam
PF10334, ArAE_2, 1 hit
PRINTSiPR02047, BREFELDNASP4

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRE4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07660
Secondary accession number(s): D6VRC5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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