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UniProtKB - Q07660 (BRE4_YEAST)
Protein
Protein BRE4
Gene
BRE4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May be involved in intracellular vesicle transport.
1 PublicationMiscellaneous
Deletion of the gene leads to brefeldin A-sensitivity.
GO - Biological processi
- endocytosis Source: SGD
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein BRE4Alternative name(s): Brefeldin A-sensitivity protein 4 |
Gene namesi | Name:BRE4 Ordered Locus Names:YDL231C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002390, BRE4 |
VEuPathDBi | FungiDB:YDL231C |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 143 | CytoplasmicSequence analysisAdd BLAST | 143 | |
Transmembranei | 144 – 164 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 165 – 176 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 177 – 194 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 195 – 198 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 227 | ExtracellularSequence analysis | 8 | |
Transmembranei | 228 – 248 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 249 – 254 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 255 – 275 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 276 – 284 | ExtracellularSequence analysis | 9 | |
Transmembranei | 285 – 305 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 306 – 706 | CytoplasmicSequence analysisAdd BLAST | 401 | |
Transmembranei | 707 – 727 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 728 – 750 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 751 – 771 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 772 – 780 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 781 – 801 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 802 – 843 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 844 – 864 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 865 – 1125 | CytoplasmicSequence analysisAdd BLAST | 261 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239634 | 1 – 1125 | Protein BRE4Add BLAST | 1125 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 830 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q07660 |
PaxDbi | Q07660 |
PRIDEi | Q07660 |
PTM databases
iPTMneti | Q07660 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 31880, 35 interactors |
DIPi | DIP-5168N |
IntActi | Q07660, 1 interactor |
STRINGi | 4932.YDL231C |
Miscellaneous databases
RNActi | Q07660, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 426 – 449 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 427 – 446 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the BRE4 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4711, Eukaryota |
HOGENOMi | CLU_004486_0_0_1 |
InParanoidi | Q07660 |
OMAi | FWGWAAN |
Family and domain databases
InterProi | View protein in InterPro IPR018820, BRE4-related_DUF2421 IPR023244, Brefeldin_A-sensitivity_4 |
Pfami | View protein in Pfam PF10334, ArAE_2, 1 hit |
PRINTSi | PR02047, BREFELDNASP4 |
i Sequence
Sequence statusi: Complete.
Q07660-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRYERDRSP TPDPDIVKGS YSQTSLRSLH ELNYKNPAGI SGLSFAGSPQ
60 70 80 90 100
QSVASLSQMR LENLVKDKHW EEVEDFGLEE LRDGFFDAAF TKPDSKARSP
110 120 130 140 150
NSDIDDDNGA ARKKLQSGFT KLSEYVWTAI YRPIIHFPRD IRKNGVSIFK
160 170 180 190 200
FFIAYFIAIV ICVIRPSGRW IGHEFRYFLP IAVLIHHPVR NIGVQLEMTI
210 220 230 240 250
SSIIGASFGL GWSALAWYIS TATKPTANYQ GGILFQSLTM ALLFAIWLRS
260 270 280 290 300
VYRRFFYFTT SFSISIIFTH TVRLASSKFD LKWQIFWDFG ISYLFGLLLS
310 320 330 340 350
LLVCVCVSPH SGNAELMEHY NKCLQTTKTF LMALVDTELI KSKEQIYLAQ
360 370 380 390 400
VKMVKTLNID LSQGFRDFVN QLTISRFDLQ SLKSLRNSLT AMETSLRVLP
410 420 430 440 450
IAPKIFNDDE LKKMYEELEK YRSDSATLSK EASASPQSSG IPTRENTPSA
460 470 480 490 500
FKPIGPGLLK NEIYINALKA SFSKSIFNLI LEMIFVLENL SRVLKKYESP
510 520 530 540 550
NQKNNLDECV KILSHSHSKL KRKIYKLDVC YRDFVNSSFF SQELLNDEES
560 570 580 590 600
VDIFLFLRYL RNSARQLVTV IHDCQVLGEN IHWRIALPSY PLSRALTRLP
610 620 630 640 650
KQCVLDEGAG NVLHYFEAKR DVDEIFERVY NTYTSRHKYN KGEEEALRLD
660 670 680 690 700
SQGGDEKSQN RKNHTISIRA IDHNDFNFHT TQNPWRFKLW KLSRILSGDE
710 720 730 740 750
CKWTLKITFC MIFLCLPTWL PESYHWYQEF HCWWAPLTFY LLAHRRYSGN
760 770 780 790 800
WALVMRRLIC GIVGIFWGWA ANQSRHFGSP YVVCTFAGLI VVPFSINFLV
810 820 830 840 850
YRNTKSSFTA LMCFTIIALE PYSKPNRHYN LTTAGIWKST WVTGLALIIG
860 870 880 890 900
ILVSIPINWI VWPFRARTEL RDSMSSLLAH LGQSYQTVAD RYLYRDADDA
910 920 930 940 950
PTDLTFAFSH IREVRLTQSL EAIRELLKKA RHEPIIISNF NPEKYASLIN
960 970 980 990 1000
SCQFLLSKII EARISGAFFE IWDQDFDIET TRALLSLRRD SVSSVIFVFY
1010 1020 1030 1040 1050
ILSNCFRSKN KIPRYLPNPI MSRKKLYHFI KKFSEMKDQS HSNLNSGGNS
1060 1070 1080 1090 1100
MEKNLFKKIY QQKASSSGQQ QLPLPSVANS SEIDSEKMHW TEVHGIAFAR
1110 1120
AFTDISEALF QVESCAKDIL GEENF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z74279 Genomic DNA Translation: CAA98810.1 BK006938 Genomic DNA Translation: DAA11635.1 |
PIRi | S67794 |
RefSeqi | NP_010050.1, NM_001180291.1 |
Genome annotation databases
EnsemblFungii | YDL231C_mRNA; YDL231C; YDL231C |
GeneIDi | 851367 |
KEGGi | sce:YDL231C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z74279 Genomic DNA Translation: CAA98810.1 BK006938 Genomic DNA Translation: DAA11635.1 |
PIRi | S67794 |
RefSeqi | NP_010050.1, NM_001180291.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 31880, 35 interactors |
DIPi | DIP-5168N |
IntActi | Q07660, 1 interactor |
STRINGi | 4932.YDL231C |
PTM databases
iPTMneti | Q07660 |
Proteomic databases
MaxQBi | Q07660 |
PaxDbi | Q07660 |
PRIDEi | Q07660 |
Genome annotation databases
EnsemblFungii | YDL231C_mRNA; YDL231C; YDL231C |
GeneIDi | 851367 |
KEGGi | sce:YDL231C |
Organism-specific databases
SGDi | S000002390, BRE4 |
VEuPathDBi | FungiDB:YDL231C |
Phylogenomic databases
eggNOGi | KOG4711, Eukaryota |
HOGENOMi | CLU_004486_0_0_1 |
InParanoidi | Q07660 |
OMAi | FWGWAAN |
Miscellaneous databases
PROi | PR:Q07660 |
RNActi | Q07660, protein |
Family and domain databases
InterProi | View protein in InterPro IPR018820, BRE4-related_DUF2421 IPR023244, Brefeldin_A-sensitivity_4 |
Pfami | View protein in Pfam PF10334, ArAE_2, 1 hit |
PRINTSi | PR02047, BREFELDNASP4 |
MobiDBi | Search... |
Entry informationi
Entry namei | BRE4_YEAST | |
Accessioni | Q07660Primary (citable) accession number: Q07660 Secondary accession number(s): D6VRC5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - SIMILARITY comments
Index of protein domains and families