Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 170 (03 Jul 2019)
Sequence version 2 (28 Mar 2018)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Trefoil factor 3

Gene

TFF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).1 Publication

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9018519 Estrogen-dependent gene expression

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q07654

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trefoil factor 3
Alternative name(s):
Intestinal trefoil factor
Short name:
hITF
Polypeptide P1.B
Short name:
hP1.B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFF3
Synonyms:ITF, TFI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11757 TFF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600633 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07654

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7033

Open Targets

More...
OpenTargetsi
ENSG00000160180

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36472

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TFF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
585328

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 352 PublicationsAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002346536 – 94Trefoil factor 3Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi46 ↔ 72PROSITE-ProRule annotation
Disulfide bondi56 ↔ 71PROSITE-ProRule annotation
Disulfide bondi66 ↔ 83PROSITE-ProRule annotation
Disulfide bondi92Interchain

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q07654

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07654

PeptideAtlas

More...
PeptideAtlasi
Q07654

PRoteomics IDEntifications database

More...
PRIDEi
Q07654

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58522

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160180 Expressed in 142 organ(s), highest expression level in sigmoid colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q07654 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035464

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer; disulfide-linked.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112891, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q07654, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000430690

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07654

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q07654

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 87P-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0FX Eukaryota
ENOG41114KR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162416

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000121778

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07654

KEGG Orthology (KO)

More...
KOi
K22454

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLQETEC

Database of Orthologous Groups

More...
OrthoDBi
1563185at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07654

TreeFam database of animal gene trees

More...
TreeFami
TF336092

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00111 Trefoil, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13826 PTHR13826, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00088 Trefoil, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00680 PTREFOIL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00018 PD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q07654-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRVLSCVPE PTVVMAARAL CMLGLVLALL SSSSAEEYVG LSANQCAVPA
60 70 80 90
KDRVDCGYPH VTPKECNNRG CCFDSRIPGV PWCFKPLQEA ECTF
Length:94
Mass (Da):10,181
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02276443AEE4CEA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3S7X6R3S7_HUMAN
Trefoil factor 3
TFF3
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYT0H7BYT0_HUMAN
Trefoil factor 3
TFF3
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA59981 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA83628 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH17859 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL28111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA95531 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti88 – 90QEA → TRKT in AAA36766 (PubMed:8454642).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25657, U25654, U25656 Genomic DNA Translation: AAA83628.1 Different initiation.
AB038162 Genomic DNA Translation: BAB13731.1 Different initiation.
AP001746 Genomic DNA Translation: BAA95531.1 Different initiation.
AP001623 Genomic DNA No translation available.
AF432265 mRNA Translation: AAL28111.1 Different initiation.
L15203 mRNA Translation: AAA59981.1 Different initiation.
BC017859 mRNA Translation: AAH17859.1 Different initiation.
L08044 mRNA Translation: AAA36766.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33565.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A48284

NCBI Reference Sequences

More...
RefSeqi
NP_003217.3, NM_003226.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000518498; ENSP00000430690; ENSG00000160180

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7033

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7033

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25657, U25654, U25656 Genomic DNA Translation: AAA83628.1 Different initiation.
AB038162 Genomic DNA Translation: BAB13731.1 Different initiation.
AP001746 Genomic DNA Translation: BAA95531.1 Different initiation.
AP001623 Genomic DNA No translation available.
AF432265 mRNA Translation: AAL28111.1 Different initiation.
L15203 mRNA Translation: AAA59981.1 Different initiation.
BC017859 mRNA Translation: AAH17859.1 Different initiation.
L08044 mRNA Translation: AAA36766.1
CCDSiCCDS33565.2
PIRiA48284
RefSeqiNP_003217.3, NM_003226.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E9TNMR-A36-94[»]
1PE3NMR-1/236-94[»]
SMRiQ07654
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112891, 5 interactors
IntActiQ07654, 3 interactors
STRINGi9606.ENSP00000430690

Polymorphism and mutation databases

BioMutaiTFF3
DMDMi585328

Proteomic databases

jPOSTiQ07654
PaxDbiQ07654
PeptideAtlasiQ07654
PRIDEiQ07654
ProteomicsDBi58522

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7033
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518498; ENSP00000430690; ENSG00000160180
GeneIDi7033
KEGGihsa:7033

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7033
DisGeNETi7033

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TFF3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016137
HGNCiHGNC:11757 TFF3
HPAiHPA035464
MIMi600633 gene
neXtProtiNX_Q07654
OpenTargetsiENSG00000160180
PharmGKBiPA36472

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0FX Eukaryota
ENOG41114KR LUCA
GeneTreeiENSGT00940000162416
HOGENOMiHOG000121778
InParanoidiQ07654
KOiK22454
OMAiPLQETEC
OrthoDBi1563185at2759
PhylomeDBiQ07654
TreeFamiTF336092

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiQ07654

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TFF3 human
EvolutionaryTraceiQ07654

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Trefoil_factor_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7033

Protein Ontology

More...
PROi
PR:Q07654

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160180 Expressed in 142 organ(s), highest expression level in sigmoid colon
ExpressionAtlasiQ07654 baseline and differential

Family and domain databases

CDDicd00111 Trefoil, 1 hit
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PANTHERiPTHR13826 PTHR13826, 1 hit
PfamiView protein in Pfam
PF00088 Trefoil, 1 hit
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 1 hit
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07654
Secondary accession number(s): A0A0A6YYJ4
, E9PBB5, Q96NX0, Q9UDA5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 28, 2018
Last modified: July 3, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again