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Entry version 141 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Protein HBT1

Gene

HBT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polarity-determining protein which forms a conjugate with the ubiquitin-like modifier HUB1. Involved in bud site selection and cellular morphogenesis during conjugation. Required for survival during stationary phase.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell shape, Conjugation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein HBT1
Alternative name(s):
HUB1 target protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HBT1
Synonyms:Crem
Ordered Locus Names:YDL223C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000002382, HBT1

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
FungiDB:YDL223C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002330101 – 1046Protein HBT1Add BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei491PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei855PhosphotyrosineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei1005PhosphoserineCombined sources1
Modified residuei1034PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q07653

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q07653

PRoteomics IDEntifications database

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PRIDEi
Q07653

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q07653

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q07653

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07653

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Conjugated with HUB1. HUB1 has not the classical C-terminal Gly residue, so it is still unknown how conjugation may occur.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
31823, 115 interactors

Protein interaction database and analysis system

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IntActi
Q07653, 3 interactors

STRING: functional protein association networks

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STRINGi
4932.YDL223C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q07653, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi151 – 254His-richAdd BLAST104
Compositional biasi967 – 1001His-richAdd BLAST35

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502SEJI, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012135_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07653

Identification of Orthologs from Complete Genome Data

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OMAi
PVTHTHG

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMNESISKD GQGEEEQNNF SFGGKPGSYD SNSDSAQRKK SFSTTKPTEY
60 70 80 90 100
NLPKEQPEST SKNLETKAKN ILLPWRKKHN KDSETPHEDT EADANRRANV
110 120 130 140 150
TSDVNPVSAD TKSSSGPNAT ITTHGYSYVK TTTPAATSEQ SKVKTSPPTS
160 170 180 190 200
HEHSNIKASP TAHRHSKGDA GHPSIATTHN HSTSKAATSP VTHTHGHSSA
210 220 230 240 250
TTSPVTHTHG HASVKTTSPT NTHEHSKANT GPSATATTHG HINVKTTHPV
260 270 280 290 300
SHGHSGSSTG PKSTAAAQDH SSTKTNPSVT HGHTSVKDNS SATKGYSNTD
310 320 330 340 350
SNSDRDVIPG SFRGMTGTDV NPVDPSVYTS TGPKSNVSSG MNAVDPSVYT
360 370 380 390 400
DTSSKSADRR KYSGNTATGP PQDTIKEIAQ NVKMDESEQT GLKNDQVSGS
410 420 430 440 450
DAIQQQTMEP EPKAAVGTSG FVSQQPSYHD SNKNIQHPEK NKVDNKNISE
460 470 480 490 500
RAAEKFNIER DDILESADDY QQKNIKSKTD SNWGPIEYSS SAGKNKNLQD
510 520 530 540 550
VVIPSSMKEK FDSGTSGSQN MPKAGTELGH MKYNDNGRDN LQYVAGSQAG
560 570 580 590 600
SQNTNNNIDM SPRHEAEWSG LSNDATTRNN VVSPAMKDED MNEDSTKPHQ
610 620 630 640 650
YGLDYLDDVE DYHENDIDDY SNAKKNDLYS KKAYQGKPSD YNYEQREKIP
660 670 680 690 700
GTFEPDTLSK SVQKQDEDPL SPRQTTNRAG METARDESLG NYEYSNTSGN
710 720 730 740 750
KKLSDLSKNK SGPTPTRSNF IDQIEPRRAK TTQDIASDAK DFTNNPETGT
760 770 780 790 800
TGNVDTTGRM GAKSKTFSSN PFDDSKNTDT HLENANVAAF DNSRSGDTTY
810 820 830 840 850
SKSGDAETAA YDNIKNADPT YAKSQDITGM THDQEPSSEQ KASYGSGGNS
860 870 880 890 900
QNQEYSSDDN IDVNKNAKVL EEDAPGYKRE VDLKNKRRTD LGGADASNAY
910 920 930 940 950
AAEVGNFPSL IDPHVPTYGF KDTNTSSSQK PSEGTYPETT SYSIHNETTS
960 970 980 990 1000
QGRKVSVGSM GSGKSKHHHN HHRHSRQNSS KGSDYDYNNS THSAEHTPRH
1010 1020 1030 1040
HQYGSDEGEQ DYHDDEQGEE QAGKQSFMGR VRKSISGGTF GFRSEI
Length:1,046
Mass (Da):113,616
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC5E3EB5DDAFA405
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z74271 Genomic DNA Translation: CAA98802.1
BK006938 Genomic DNA Translation: DAA11642.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S67786

NCBI Reference Sequences

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RefSeqi
NP_010058.1, NM_001180283.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDL223C_mRNA; YDL223C; YDL223C

Database of genes from NCBI RefSeq genomes

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GeneIDi
851303

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDL223C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74271 Genomic DNA Translation: CAA98802.1
BK006938 Genomic DNA Translation: DAA11642.1
PIRiS67786
RefSeqiNP_010058.1, NM_001180283.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31823, 115 interactors
IntActiQ07653, 3 interactors
STRINGi4932.YDL223C

PTM databases

CarbonylDBiQ07653
iPTMnetiQ07653

Proteomic databases

MaxQBiQ07653
PaxDbiQ07653
PRIDEiQ07653
TopDownProteomicsiQ07653

Genome annotation databases

EnsemblFungiiYDL223C_mRNA; YDL223C; YDL223C
GeneIDi851303
KEGGisce:YDL223C

Organism-specific databases

SGDiS000002382, HBT1
VEuPathDBiFungiDB:YDL223C

Phylogenomic databases

eggNOGiENOG502SEJI, Eukaryota
HOGENOMiCLU_012135_0_0_1
InParanoidiQ07653
OMAiPVTHTHG

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q07653
RNActiQ07653, protein

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHBT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07653
Secondary accession number(s): D6VRD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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